Clinical trials: Occlusion, Cerebrovascular
Moyamoya Disease, Remote Ischemic Conditioning
Remote Ischemic Conditioning in Adult Moyamoya Disease Patients
Remote ischemic conditioning (RIC) is a non-invasive therapeutic approach for protecting organs or tissue against the detrimental effects of acute ischemia-reperfusion injury.
- Trial name
- NCT05860946
- Testing
- Remote ischemic conditioning
- Volunteers
- 44 people
- Sponsor
- Huashan Hospital
Neurology
Assessment of Plaque Vulnerability Using a Novel Technique: Multi-spectral PhotoAcoustic Imaging.
Identification of intraplaque haemorrhage using MRI is technically demanding and sometimes uncomfortable. Photoacoustic imaging is a new non-invasive technique combining multi-wavelength infrared laser light and ultrasound…
- Trial name
- (CVENT-PAI) (NCT04763603)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier St Anne
Acute Ischemic Stroke, Mild Neurocognitive Disorder
Endovascular Therapy Versus Best Medical Treatment for Acute Large Vessel Occlusion Stroke With Low NIHSS
Patients presenting with mild symptoms of acute ischemic stroke are common and account for approximately half of all acute ischemic stroke. About 30% of patients with minor stroke have a 90-day functional disability.
- Conditions
- Acute Ischemic Stroke, Mild Neurocognitive Disorder, Thrombectomy
- Trial name
- NCT06143488
- Testing
- Endovascular therapy, Best medical management
- Where
- China
- Volunteers
- 264 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Intracranial Atherosclerosis, Stent Stenosis
Elucidate Outcomes of Elective High-grade/Total Occlusion Intracranial Arteries Using Low-profile Self-expanding Stent
Intracranial atherosclerotic disease (ICAD) is a high prevalent cause of stroke, especially in Asian population and can be categorized as either symptomatic (resulting in acute ischemic stroke) or asymptomatic.
- Conditions
- Intracranial Atherosclerosis, Stent Stenosis, Ischemic Stroke
- Trial name
- NCT05947994
- Testing
- Intracranial stenting with Credo® stent
- Where
- Vietnam
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Can Tho Stroke International Services Hospital
Vascular Dementia
A Clinical Trial to Evaluate the Safety and Efficacy of 20 ml Cerebrolysin in Patients With Vascular Dementia
This clinical trial was performed to assess the clinical efficacy and safety of two 4 week treatment courses of daily intravenous administration of Cerebrolysin (20mL [milliliter] IV [intravenous] per day).
- Trial name
- VascDem (NCT00947531)
- Testing
- Cerebrolysin, 0.9% Saline Solution
- Where
- 21 sites in Russia
- Volunteers
- 242 people
- Sponsor
- Ever Neuro Pharma GmbH
Coronary Artery Disease, Myocardial Infarction
Imaging Modalities in Detection of Coronary Artery Disease in End-stage Renal Disease Patients
This study investigates hypothesizes that the combination of dobutamine stress echocardiography with dobutamine stress echocardiography with real time perfusion myocardial contrast echocardiography and coronary computed…
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Stroke, Death
- Trial name
- NCT00726921
- Where
- United States
- Volunteers
- 189 people
- Sponsor
- University of Nebraska
Device Occlusion
Feasibility and Prognosis of Left Atrial Appendage Closure in Patients With Heart Failure and Atrial Fibrillation
Study hypotheses is that in patients with heart failure and atrial fibrillation, reduced left atrial appendage (LAA) emptying velocities leads to LAA thrombus formation therefore a higher rate of stroke and embolism are observed…
- Trial name
- LAAOHF (NCT04472871)
- Testing
- Left atrial appendage closure
- Volunteers
- 300 people
- Sponsor
- Assiut University
Revascularization, Carotid Artery Stenosis
Study on the Trans-Carotid Artery Occlusion Shunt System
The objective of the study is to evaluate the Safety and Efficacy of the Trans-Carotid Artery Occlusion Shunt System for Carotid Artery Revascularization during Endovascular Treatment
- Conditions
- Revascularization, Carotid Artery Stenosis, Carotid Artery Diseases
- Trial name
- NCT06924593
- Testing
- Trans-Carotid Artery Occlusion Shunt System
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Shenzhen Wecan Medical Technology Co.,Ltd
Stroke, Ischemic, Genetic Disease
CUHK Stroke Biobank
The purpose of the study are: 1. To make quality, characterized samples and related data available for future studies, including Genome Wide Association Studies (GWAS), genomics, and biomarker research; 2.
- Conditions
- Stroke, Ischemic, Genetic Disease, Atherosclerosis, Cerebral
- Trial name
- NCT03291392
- Testing
- Gene expression or biomarkers exploration
- Where
- Hong Kong
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Carotid Artery Stenosis
Effect of Remote Ischemic Preconditioning on Cerebral Circulation Time in Patients With Severe Carotid Artery Stenosis (RIP-CCT)
Cerebral circulation time in patients with severe carotid artery stenosis was found to be associated with hyperperfusion syndrome. Remote ischemic preconditioning can change the ability of cerebral autoregulation.
- Trial name
- NCT05451030
- Testing
- remote ischemic preconditioning
- Where
- China
- Volunteers
- 122 people
- Sponsor
- General Hospital of Shenyang Military Region
Intracranial Aneurysm
Complete Occlusion of Coilable Aneurysms
To compare the safety and effectiveness of Pipeline Embolization Device to coil embolization for the treatment of coilable wide-necked intracranial aneurysms
- Trial name
- COCOA (NCT00777907)
- Testing
- Pipeline Embolization Device (PED), Coil embolization
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Chestnut Medical Technologies
Mild Cognitive Impairment, Alzheimer Disease
Cerebral Haemodynamic Changes During Cognitive Testing: A fTCD Study
850,000 people live with dementia in the UK, with that number expected to rise to more than 1 million within the next 5 years. The most common type of dementia (55%) is Alzheimer's dementia, and vascular dementia is the second…
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Vascular Dementia, Healthy Controls
- Trial name
- NCT03134963
- Testing
- Transcranial doppler ultrasonography, Blood pressure monitoring, Heart rate monitoring
- Where
- 2 sites in United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Atrial Fibrillation, Stroke
Hemostatic Activity Following LAAO
The primary objective of this study is to prospectively investigate hemostatic activity following transcatheter left atrial appendage occlusion (LAAO).
- Trial name
- NCT05011981
- Testing
- Left Atrial Appendage Occlusion
- Where
- Denmark
- Volunteers
- 135 people
- Sponsor
- University of Aarhus
Acute Ischemic Stroke, Large Vessel Occlusion
Tenecteplase Before Interhospital Transfer for EVT in Acute Anterior Circulation LVO at 4.5-24 Hours
This study will address the efficacy and safety of Tenecteplase administered in non-endovascular capable center (nECC) in patients with acute ischemic stroke (AIS) caused by anterior circulation large vessel occlusion (acLVO) who…
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Transportation of Patients
- Trial name
- TREASURE (NCT07253181)
- Testing
- Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg)
- Where
- 2 sites in China
- Volunteers
- 572 people
- Sponsor
- Xuanwu Hospital, Beijing
Motor Activity
Variability of Healthy People and People After Stroke Results in the Box and Block Test
Main aim of the study is to find out how many attempts of each subtest in the Box and Block Test should be done in clinical practice during testing people after stroke who are 20-64 years old.
- Trial name
- NCT05925231
- Testing
- Box and Block Test
- Where
- 2 sites in Czechia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Organic, Including Symptomatic, Mental Disorders, Substance Use
Exploring the Comorbidity Between Mental Disorders and General Medical Conditions
Mental disorders have been shown to be associated with a number of general medical conditions (also referred to as somatic or physical conditions).
- Conditions
- Organic, Including Symptomatic, Mental Disorders, Substance Use, Schizophrenia, Mood [Affective] Disorders
- Trial name
- COMO-GMC (NCT03847753)
- Testing
- Organic Disorders, Substance Use Disorders, Schizophrenia Disorders
- Volunteers
- 5,940,299 people
- Sponsor
- University of Aarhus
Vascular Cognitive Impairment, Post-stroke Depression
Cognition and Affect After Stroke: a Prospective Evaluation of Risks
Stroke is a leading cause of disability, affecting about 34,000 to 41,000 individuals in the Netherlands of middle and old age every year.
- Conditions
- Vascular Cognitive Impairment, Post-stroke Depression, Post-stroke Apathy, Post-stroke Dementia
- Trial name
- CASPER (NCT02585349)
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- Maastricht University Medical Center
Dementia, Dementia, Vascular
Home-based Family Caregiver-delivered Music and Reading Interventions for People With Dementia
This international study evaluates the impact of home-based caregiver-delivered music and reading interventions for people with dementia.
- Conditions
- Dementia, Dementia, Vascular, Dementia With Lewy Bodies, Dementia, Mixed
- Trial name
- HOMESIDE (NCT03907748)
- Testing
- Music Intervention, Reading Intervention
- Where
- 5 sites in Australia, Germany and 3 more
- Volunteers
- 864 people
- Sponsor
- Anglia Ruskin University
Artery Stenosis, Carotid, Artery Stenosis
A Retrospective, Observational, Multicentre, Study to Evaluate the Safety and Performance of POLYPATCH ® Vascular Patch
POLYPATCH® study is RWE multicentre study which examine short and long-term outcomes of using POLYPATCH® when exposed to a larger and more varied population.
- Conditions
- Artery Stenosis, Carotid, Artery Stenosis, Occlusion of Artery, Stroke
- Trial name
- NCT04643743
- Testing
- Endarterectomy
- Where
- France
- Volunteers
- 198 people
- Sponsor
- Perouse Medical
Aneurysmal Subarachnoid Hemorrhage (aSAH), Headache Disorders
Efficacy of Scalp Block in Managing Post Subarachnoid Hemorrhage Headache in Critically Ill Patients. A Single Centre Randomized Controlled Trial
Subarachnoid hemorrhage (SAH) is a devastating neurological disorder associated with significant mortality and morbidity rates, arising not just from the hemorrhage itself but also because of the catastrophic multisystem sequelae…
- Trial name
- SAH-BLOCK (NCT07307508)
- Testing
- Levobupivacaine Scalp block, Conventional analgesic therapy
- Where
- Qatar
- Volunteers
- 22 people
- Sponsor
- Hamad Medical Corporation
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