Clinical trials: Occlusion, Cerebrovascular
Stroke, Acute, Basilar Artery Occlusion
Randomized Assessment of Rapid Endovascular Treatment in Basilar Artery Occlusion Stroke in 115 Hospital
This is a prospective, open lable studies conducted in 115 hospital to compare between thromboectomy and Recombinant Tisue Plasminogen Activator only to evaluate the eficacy and safety of endovascular treatment in basilar artery…
- Trial name
- RARETBAS (NCT04177615)
- Testing
- Thromboectomy
- Volunteers
- 109 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
ICAS - Intracranial Atherosclerosis, Cerebral Small Vessel Diseases
Feedback Loop Between Intracranial Atherosclerosis and Cerebral Small Vessel Disease
The present study aims at verifying the mutual effects between intracranial large artery atherosclerosis and cerebral small vessel disease on disease progression and prognosis by magnetic resonance imaging, and providing…
- Trial name
- NCT05677607
- Testing
- Magnetic resonance imaging
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chinese PLA General Hospital
Ischemic Stroke
A Pivotal Study Evaluating Safety and Effectiveness of Adaptative Tip Catheter in Patients With Acute Ischemic Stroke
The purpose of this study is to assess the safety and the effectiveness of the Adaptive Tip Catheter (ATC) used as a first line direct aspiration thrombectomy technique for patients suffering of an acute ischemic stroke.
- Trial name
- PHAST (NCT07367100)
- Testing
- Adaptive Tip Catheter
- Where
- 10 sites in Belgium, France and 1 more
- Volunteers
- 74 people
- Sponsor
- Neuravi Limited
Acute Ischemic Stroke
Intravenous Tirofiban After Bridging Therapy for Acute Stroke With Atherosclerotic Large Artery Occlusion
The investigators propose to assess the efficacy and safety of intravenous tirofiban after bridging therapy (endovascular therapy [EVT] following intravenous Tenecteplase) for acute ischemic stroke due to intracranial…
- Trial name
- RESCUE-AS (NCT07335107)
- Testing
- Intravenous Tirofiban, Standard Medical Therapy
- Where
- China
- Volunteers
- 564 people
- Sponsor
- Beijing Tiantan Hospital
Stroke
Combined Recanalization Therapy for Acute Large Vessel Occlusion Stroke
The purpose of this clinical trial is to evaluate the efficacy and safety of combined recanalization therapy in patients who cannot be recanalized by acute large vessel occlusive stroke.
- Trial name
- CRTALVOS (NCT07115511)
- Testing
- Surgery
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Tianjin Huanhu Hospital
Coronary Artery Disease
Assessment of Coronary Artery Disease in Stroke Patients
This study is to evaluate the prevalence, plaque characteristics (plaque types, stenosis degree, remodeling) and predictors of coronary atherosclerosis in stroke patients with coronary CT angiography.
- Trial name
- ACADIS (NCT01850693)
- Where
- South Korea
- Volunteers
- 1,657 people
- Sponsor
- Seoul National University Hospital
Myocardial Infarction, Ischemic Stroke
Understanding the Role of Autoimmune Disorders on the Initial Presentation of Cardiovascular Disease
Autoimmune diseases are diseases in which inappropriate immune responses that have the capability of harming host cells play an important role.
- Conditions
- Myocardial Infarction, Ischemic Stroke, Stroke, Subarachnoid Haemorrhage
- Trial name
- NCT02062021
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Carotid Artery Stenoses
SPI-guided Analgesia During CEA Under RA
The aim of this randomized prospective trial is to assess the utility of Adequacy of Anaesthesia technique (Response Entropy and Surgical Pleth Index) for monitoring pain perception intraoperatively, maintainance of hemodynamic…
- Trial name
- CEA (NCT04500249)
- Testing
- infiltration rescue intraoperative analgesia, rescue IA, rescue antyhypertensive medication
- Where
- Poland
- Volunteers
- 105 people
- Sponsor
- Medical University of Silesia
Ischemic Stroke, Acute
Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events-5
The trial is a multicentre, prospective, open-label, blinded endpoint (PROBE), phase 3, randomized controlled design. Patients with acute ischemic stroke due to basilar artery occlusion presenting within 24 hours will be…
- Trial name
- TRACE-5 (NCT06196320)
- Testing
- Tenecteplase, Best Practice (which may include intravenous Alteplase)
- Where
- 59 sites in China
- Volunteers
- 452 people
- Sponsor
- Beijing Tiantan Hospital
Large Vessel Occlusion, Stroke
Head of Bed After Ischemic Stroke Thrombectomy (HoBIT)
Endovascular thrombectomy (EVT), also known as clot retrieval, is a procedure that improves recovery for people who suffer a stroke by removing blood clots from large blood vessels in the brain.
- Conditions
- Large Vessel Occlusion, Stroke, Ischemic Stroke
- Trial name
- HoBIT (NCT07367633)
- Testing
- Head of bed position of 0-degrees, Head of bed position of 30-degrees or greater
- Where
- 2 sites in Canada
- Volunteers
- 2,240 people
- Sponsor
- Population Health Research Institute
Dementia, Alzheimer Disease
Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling
To develop a model to predict disease progression in a large cohort of patients across a variety of neurodegenerative diseases, including Mild Cognitive Impairment (MCI) and dementia due to any neurodegenerative disease…
- Conditions
- Dementia, Alzheimer Disease, Dementia With Lewy Bodies, Vascular Dementia
- Trial name
- CRND TorCA (NCT06529744)
- Where
- 4 sites in Canada
- Volunteers
- 500 people
- Sponsor
- University Health Network, Toronto
Stroke
Precision Reperfusion Therapy for Disabling Minor Stroke With Large Vessel Occlusion Beyond Time Window
To verify the efficacy and safety of intravenous tenecteplase (TNK) in patients with disabling minor stroke and large vessel occlusion (LVO) within a 4.5-24 hour time window.
- Trial name
- TIME-MINOR (NCT07476898)
- Testing
- Tenecteplase (0.25mg/kg), Standard Medical Management
- Where
- 30 sites in China
- Volunteers
- 864 people
- Sponsor
- First Hospital of China Medical University
Atherosclerosis, Cardiovascular Diseases
Carotid Intraplaque Neovascularization Combined With Stress Echo
The root cause of heart attacks and strokes is atherosclerosis, the hardening and thickening of blood vessels due to the presence of "plaque" which is a build-up of fat and cholesterol in the walls of vessels.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Acute Coronary Syndrome, Ischemic Heart Disease
- Trial name
- CIRCE (NCT05416385)
- Testing
- Carotid Contrast Enhanced Ultrasound
- Where
- 6 sites in Canada
- Volunteers
- 1,500 people
- Sponsor
- Dr. Amer Johri
Stroke, Aortic Valve Stenosis
Acute STROke Complicating TAVI - Management and Outcomes
Periprocedural complications of trans catheter aortic valve implantation, and particularly the occurrence of stroke has a marked impact on survival and quality of life.
- Conditions
- Stroke, Aortic Valve Stenosis, Periprocedural Complication
- Trial name
- ASTRO-TAVI (NCT05241821)
- Testing
- Mechanical thrombectomy, Thrombolytic Agent
- Where
- Israel
- Volunteers
- 484 people
- Sponsor
- Rabin Medical Center
Parkinson Disease, Parkinsonism
More Than a Movement Disorder: Applying Palliative Care to Parkinson's Disease
This is a two-center (University of Colorado, University of California San Francisco) community-based comparative effectiveness study of outpatient palliative care for Parkinson's disease (PD) and related disorders (progressive…
- Conditions
- Parkinson Disease, Parkinsonism, Lewy Body Disease, Supranuclear Palsy, Progressive
- Trial name
- MTMD (NCT03076671)
- Testing
- Palliative Care
- Where
- 2 sites in United States
- Volunteers
- 783 people
- Sponsor
- University of Colorado, Denver
Cardiovascular Diseases, Heart Diseases
Stanford Five-City Multifactor Risk Reduction Study
To conduct a large-scale demonstration and education project designed to evaluate the feasibility and effectiveness of long-term community health education directed toward lowering cardiovascular disease risk, morbidity, and…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Coronary Disease
- Trial name
- NCT00005143
- Volunteers
- 2,504 people
- Sponsor
- Stanford University
HIV Infection, Carotid Atherosclerosis
Influence of Pravastatin on Carotid Artery Structure and Function in HIV-infected Patients Under Antiretroviral Therapy
The advent of new antiretroviral agents, in particular Highly Active Antiretroviral Therapy (HAART), spectacularly reduced HIV-associated morbidity and mortality.
- Conditions
- HIV Infection, Carotid Atherosclerosis, Dyslipidemia
- Trial name
- NCT00147797
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Saint Antoine University Hospital
Ischemic Stroke, Carotid Stenosis
Research on Ultrasound Diagnostic Criteria for Intracranial and Extracranial Arterial Serial Stenosis
This study utilized different hemodynamic parameters of transcranial color-coded Doppler (TCCD) and transcranial Doppler (TCD) to conduct ultrasonic grading evaluation on middle cerebral artery (MCA) stenosis severity in patients…
- Trial name
- NCT06947720
- Testing
- stenting
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Xuanwu Hospital, Beijing
Carotid Atherosclerosis, Carotid Intimal Medial Thickness 1
Effects of Lutein Supplementation on Subclinical Atherosclerosis
This study is to investigate the possible positive effects of lutein and lycopene supplementation on early atherosclerosis in Beijing.
- Trial name
- NCT01534533
- Testing
- Lutein group, Combination group, Normal lutein control group
- Where
- China
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Peking University
Cardiovascular Disease (CVD), Stroke
A Genomic Approach for Clopidogrel in Caribbean Hispanics
Clopidogrel is a prescription medicine used to minimize blood clot formation in patients with cardiovascular disease, particularly those undergoing heart catheterization and stroke.
- Conditions
- Cardiovascular Disease (CVD), Stroke, Acute Coronary Syndrome, Peripheral Arterial Disease
- Trial name
- NCT03419325
- Testing
- CYP2C19 test, P2RY12 assay
- Where
- 2 sites in Puerto Rico
- Volunteers
- 150 people
- Sponsor
- University of Puerto Rico
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