Clinical trials: Occlusion
Adductor Magnus Plain Injection for Sciatic Nerve Block
Using the Adductor Magnus Plain Block as an Innovative Approach for Sciatic Nerve Block for Lower Limb Surgeries.
the goal of this clinical trial is to compare the efficacy of adductor magnus muscle plane injection as an approach for sciatic nerve block to sub-gluteal approach in combination with femoral nerve blocks as perioperative…
- Trial name
- NCT06852118
- Testing
- AMM Group: Adductor Magnus Muscle Plane approach + Femoral Nerve Blocks, SG Group: Sciatic nerve block by sub-gluteal approach + Femoral nerve blocks
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mohammed Gaber Saad
Hip Fractures
Analgesic Effect of Fascia Iliaca Compartment Block in Geriatric Patients With Hip Fracture
As population in Hong Kong is aging, incidence of geriatrics hip fractures rises. Operative treatment for selective patients offers pain control, early mobilization and reduction in medical morbidities and mortalities.
- Trial name
- NCT04478552
- Testing
- Fascia iliaca compartment block
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- United Christian Hospital
Carotid Artery Stenosis, Acute Ischemic Stroke
Acute Stroke of CArotid Artery Bifurcation Origin Treated With Use oF the MicronEt-covered CGUARD (SAFEGUARD-STROKE)
Prospective, single-center, clinical registry of patients with acute stroke of carotid artery bifurcation origin undergoing endovascular treatment using the Micronet-covered CGUARD Stent to seal the culprit lesion under proximal…
- Trial name
- NCT05195658
- Testing
- Thrombectomy and Stenting under neuroprotection
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- John Paul II Hospital, Krakow
MASTECTOMY
Erector Spina Plane Block Versus Deep Serratus Anterior Plane Block for Post Mastectomy Analgesia
Breast cancer surgery like Mastectomy and modified radical mastectomy are associated with significant postoperative pain, and management depends largely on patient controlled analgesia with intravenous Morphine or other opioids…
- Trial name
- NCT04108715
- Testing
- Erector spina plain block for mastectomy analgesia, Deep serratus anterior plane block
- Where
- Saudi Arabia
- Volunteers
- 80 people
- Sponsor
- King Saud University
Heart Failure, AV Block
Synchrony in Cardiac Conduction: Assessing the Effects of Pacing on Cardiac Performance Through Magnetic Resonance Imaging and Advanced ECG-imaging
Rationale Right ventricular pacing (RVP) is an established and effective therapy for patients with atrioventricular (AV) block. However, frequent RVP has been associated with left ventricular (LV) dyssynchrony and may progess…
- Trial name
- HARMONY (NCT06843135)
- Testing
- Ventricular pacing
- Volunteers
- 88 people
- Sponsor
- Amsterdam UMC, location VUmc
Cardiovascular Diseases, Heart Diseases
Genetic Epidemiology of Lipoprotein-Lipid Levels
To determine the contribution of polymorphic variation in candidate genes involved in lipid metabolism in determining quantitative lipoprotein-lipid levels and cardiovascular risk factors in Anglo and Hispanic populations of the…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis
- Trial name
- NCT00005335
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Stroke, Atherosclerosis
ParisK: Validation of Imaging Techniques
The possibility of the identification of the risk of rupture of a carotid plaque will have tremendous impact in clinical decision making.
- Trial name
- ParisK (NCT01208025)
- Testing
- Magnetic Resonance Imaging (MRI), Multidetector Computed Tomography (MDCT), Ultrasonography (US), Transcranial Doppler (TCD)
- Where
- 4 sites in Netherlands
- Volunteers
- 244 people
- Sponsor
- Maastricht University Medical Center
Coronary Artery Disease, Stent Restenosis
Intracoronary Optical Coherence Tomography Guidance Vs. Angiography Only Guidance for Treatment of Coronary In-stent Restenosis
Although advances in drug-eluting stents (DES) have substantially reduced the risk of coronary in-stent restenosis (ISR) and the need for target lesion revascularisation (TLR), ISR persists.
- Conditions
- Coronary Artery Disease, Stent Restenosis, STENT
- Trial name
- INSIDE OCT (NCT06779110)
- Testing
- Percutaneous Coronary Intervention
- Where
- 12 sites in Italy
- Volunteers
- 360 people
- Sponsor
- San Luigi Gonzaga Hospital
Coronary Heart Disease, Diabetes
OPtimized Stenting Using Intravascular Ultrasound(IVUS) in Long lEsion: Rationale for Simplified criteriA
Rationale IVUS has shown to be efficient for bare metal stent deployment, but has not been specifically studied for Drug Eluting Stents.
- Conditions
- Coronary Heart Disease, Diabetes, Vascular Lesions, Chronic Total Occlusion of Coronary Artery
- Trial name
- OPERA (NCT01861860)
- Testing
- TAXUS™ Element long stent
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Hip Arthropathy, Hip Osteoarthritis
PENG Block Optimization: Volume and Dexamethasone Effects
This randomized controlled trial investigates the impact of local anesthetic volume and perineural dexamethasone on the analgesic and anti-inflammatory effectiveness of the pericapsular nerve group (PENG) block in patients…
- Conditions
- Hip Arthropathy, Hip Osteoarthritis, Hip Arthritis
- Trial name
- NCT07023120
- Testing
- Ropivacaine 0.2% Injectable Solution, Dexamethasone 4mg
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Poznan University of Medical Sciences
Coronary Artery Disease, Percutaneous Coronary Intervention
Different Doses of Colchicine on hsCRP
Colchicine reduced atherothrombotic cardiovascular events in the COLCOT and LoDoCo2 studies. US Food and Drug Administration approved colchicine as the first anti-inflammatory drug for cardiovascular diseases on June, 2023.
- Trial name
- NCT06078904
- Testing
- Colchicine 0.5 MG, Colchicine 0.375 MG, Colchicine 0.25 MG
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Cardiopulmonary Failure, Myocardial Infarction (MI)
COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable
The COR-INSIGHT trial aims to evaluate the effectiveness of Peerbridge COR advanced ambulatory ECG wearables (COR 1.0 and COR 2.0) in accurately and non-invasively detecting cardiovascular and cardiopulmonary conditions using…
- Conditions
- Cardiopulmonary Failure, Myocardial Infarction (MI), Heart Decompensation, Heart Failure
- Trial name
- COR-INSIGHT (NCT06763549)
- Testing
- SUBPROTOCOL A, SUBPROTOCOL B, SUBPROTOCOL C
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Small Bowel Obstruction, Small Bowel Adhesion
Comparison of Early Operative Treatment and 48 h Conservative Treatment in Small Bowel Obstruction
This study will compare the results of early surgery after 12 h conservative treatment and 48 h conservative treatment of adhesive small bowel obstruction.
- Conditions
- Small Bowel Obstruction, Small Bowel Adhesion, Strangulation of Ileum
- Trial name
- COTACSO (NCT03139149)
- Testing
- Adhesiolysis, X-ray diagnostics, Computer tomography
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Pirogov Russian National Research Medical University
Heart Failure, Coronary Artery Disease
Ultrastructural Characteristics of Mitochondria in Cardiomyocytes in Heart Failure
According to modern concepts, mitochondrial dysfunction may be the fundamental basis for the development and progression of CHF, including in patients undergoing myocardial revascularization.
- Trial name
- MITOCH-HF (NCT05770349)
- Testing
- coronary artery bypass grafting
- Where
- Russia
- Volunteers
- 45 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Intermittent Theta Burst Stimulation, Repetitive Transcranial Magnetic Stimulation
Deep Versus Standard Prolonged Intermittent Theta Burst Stimulation for Depression
This study compares two types of non-invasive brain stimulation to treat major depression in patients who have not found relief from at least one antidepressant medication.
- Conditions
- Intermittent Theta Burst Stimulation, Repetitive Transcranial Magnetic Stimulation, Depression
- Trial name
- NCT07198438
- Testing
- Deep Prolonged Intermittent Theta Burst Stimulation, Standard Prolonged Intermittent Theta Burst Stimulation
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- National Taiwan University Hospital
Pain, Pain, Postoperative
Cryoablation of Intercostal Nerves for Post-Operative Pain Management in Opioid-Tolerant Patients
The main objective study is to compare the use of the cryoSPHERE probe to the standard-of-care method for pain management of patients receiving robotic-assisted thoracoscopic surgery, including reductions in opioid pain…
- Trial name
- NCT05276258
- Testing
- cryoSPHERE Ablation, Bupivacaine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- The Methodist Hospital Research Institute
Homozygous Familial Hypercholesterolemia (HoFH), Coronary Computed Tomography Angiography
Assessing the Impact of Intensification of Lipid Lowering Therapy With Guidelines-based Evinacumab Administration on Coronary Plaque Volumes Measured by Coronary Computed Tomography Angiography (CCTA) in Patients With Homozygous Familial Hypercholesterolemia (HoFH)
This observational, multicenter, retrospective and prospective study aims to evaluate the impact of intensified lipid-lowering therapy including Evinacumab on coronary atherosclerotic plaque burden in patients with Homozygous…
- Trial name
- EVOLVE-HoFH (NCT07447648)
- Where
- 13 sites in France, Italy and 2 more
- Volunteers
- 52 people
- Sponsor
- Fondazione SISA (Societa Italiana per lo Studio della Arteriosclerosi)
Branch Retinal Vein Occlusion
Comparison of Intravitreal Ranibizumab and Macular Laser Photocoagulation for ME Following Branch Retinal Vein Occlusion (BRVO)
This study is designed to evaluate the efficacy of intravitreal Ranibizumab in comparison with macular laser photocoagulation as treatments for macular edema secondary to branch retinal vein occlusion.
- Trial name
- NCT01189526
- Testing
- Ranibizumab, macular laser photocoagulation
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul Retina Investigator Group
Coronary Artery Disease
Ivabradine to Improve Endothelial Function in Patients With Coronary Artery Disease
This study evaluates the effect of ivabradine on endothelial function in patients with coronary artery disease (CAD) after complete revascularization with percutaneous coronary angioplasty (PCI).
- Trial name
- RIVENDEL (NCT02681978)
- Testing
- Ivabradine, Standard medical therapy
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Campus Bio-Medico University
Peripheral Arterial Disease, Peripheral Vascular Disease
Zilver® PTX™ Global Registry
The Zilver PTX Registry Study is a prospective, non-randomized, open-label, multicenter single-arm study enrolling patients in Europe, Asia, and North America with de novo or restenotic (including in-stent restenosis) lesions of…
- Trial name
- NCT01094678
- Testing
- Zilver® PTX™ Stent
- Where
- 4 sites in Germany, Italy
- Volunteers
- 788 people
- Sponsor
- Cook Group Incorporated