Clinical trials: Occlusion Carotid
Atherosclerosis
Efficacy and Safety of Simvastatin-ezetimibe Combination Therapy Among Patients With SLE
This is a randomized single-blind trial. This study aimed to determine if intensive lipid-lowering therapy (simvastatin-ezetimibe combination therapy) could reduce the progression of atherosclerosis effectively and safely among…
- Trial name
- NCT02548936
- Testing
- Ezetimibe+Simvastatin Drug Combination
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College Hospital
Atherosclerosis, Chronic Kidney Disease
Vitamin D Supplementation in CKD - Vascular Function, Structure and Immune Regulation
A pilot study to assess feasibility of methods of an observer-blinded randomised controlled trial of the effect of vitamin D supplementation in Chronic Kidney Disease and low vitamin D levels on markers of vascular function (Flow…
- Trial name
- NCT04380467
- Testing
- Vitamin D (cholecalciferol)
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- St George's, University of London
Carotid Stenosis
Evaluation of the Carotid Plaque Stability by Ultrafast-ultrasound Imaging (UF)
Unstable plaques are characterized by lower segmental stiffness and intimal neovascularization compared to stable plaques. Our objective is to determine the capacity of the elastographic parameters obtained by the UF to…
- Trial name
- UF-Plaques (NCT03234257)
- Testing
- UF-ultrasound
- Where
- France
- Volunteers
- 69 people
- Sponsor
- French Cardiology Society
Internal Carotid Artery Stenosis
Ultrasound-guided Intermediate Cervical Plexus Block
The investigators test with the present study design, whether an ultrasound-guided blockade of the cervical plexus in combination with an additional application of local anesthetic to the superficial cervical ansa (facial nerve…
- Trial name
- NCT02794974
- Testing
- cervical plexus block, facial nerve block, perivascular block
- Where
- Germany
- Volunteers
- 29 people
- Sponsor
- Helios Research Center
Carotid Stenosis
Safety and Effectiveness of Ticagrelor in Patients Undergoing Carotid Stenting
patients undergoing carotid stenting take dual anti platelet therapy to prevent thrombotic complications usually used drugs are aspirin plus clopidogrel but there are patients not respond so ticagrelor may be an effective and…
- Trial name
- NCT04091074
- Testing
- Ticagrelor, Clopidogrel, Carotid stenting
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cardiovascular Diseases, Carotid Stenosis
Asymptomatic Carotid Artery Plaque Study (ACAPS)
To determine whether warfarin or lovastatin alone or in combination retarded the progression of atherosclerotic plaques in the carotid arteries of high risk individuals with asymptomatic carotid stenosis.
- Conditions
- Cardiovascular Diseases, Carotid Stenosis, Cerebral Arteriosclerosis, Cerebrovascular Disorders
- Trial name
- NCT00000469
- Testing
- aspirin, lovastatin
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Carotid Stenosis
Rho Kinase (ROCK) Inhibition in Carotid Atherosclerosis
To evaluate the causal relationship between Rho/Rho kinase overactivity and mechanisms of vascular dysfunction in patients with atherosclerosis.
- Trial name
- NCT00670202
- Testing
- Fasudil Hydrochloride
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Brigham and Women's Hospital
Carotid Stenosis
CARMEDAS: Cost-Effectiveness Analysis of Imaging Strategies in Symptomatic Carotid Stenosis
PURPOSE: The purpose of this clinical trial is to study the cost-effectiveness ratios of diagnostic strategies for the imaging assessment of symptomatic carotid stenosis.
- Trial name
- NCT00131001
- Testing
- contrast-enhanced magnetic resonance angiography
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Hospices Civils de Lyon
Cardiovascular Diseases, Heart Diseases
Arterial Endothelial Function--An Epidemiologic Study
To determine if risk factors measured in childhood can predict the development of atherosclerotic coronary and carotid artery disease in adulthood.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Arteriosclerosis, Carotid Artery Diseases
- Trial name
- NCT00005545
- Volunteers
- 600 people
- Sponsor
- University of Iowa
Atherosclerosis
Study to Investigate the Sensitivity and Specificity of 3.0 Tesla MRI for Carotid Artery Plaque
The aim of this study is to develop non-invasive MRI, and MRS approaches that will quantify the plaque composition and lipid content of plaques and will have the potential for repeated in vivo measurements.
- Trial name
- NCT01632254
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Carotid Artery Stenosis
Neuropsychological Functioning and Cerebral Perfusion Post Carotid Endarterectomy
The study aims to investigate the relationship between neuropsychological functioning and brain perfusion in patients undergoing carotid endarterectomy and control patients undergoing other peripheral vascular procedures.
- Trial name
- NCT04759859
- Where
- United States
- Sponsor
- CAMC Health System
Carotid Stenosis
Study of Carotid Artery Stenosis Through the Integration of Multimodal Imaging and Computational Fluid Dynamics
Ischemic stroke affects 2.5 to 3 million people annually in China, ranking as the leading cause of death and disability. Cervical artery stenosis is a significant contributor to this problem, with about 50% of patients…
- Trial name
- NCT06294496
- Testing
- CEA/CAS
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sichuan Provincial People's Hospital
Coronary Artery Disease, Carotid Artery Stenosis
A Real-World Study on Ultrasound-Based Screening and Integrated Therapeutic Strategies for Patients With Concomitant Coronary and Cervicocephalic Artery Stenosis
This prospective observational cohort study aims to investigate the prevalence and clinical significance of head and neck arterial stenosis in patients with coronary artery disease (CAD) undergoing or scheduled for percutaneous…
- Conditions
- Coronary Artery Disease, Carotid Artery Stenosis, Cerebrovascular Disorders
- Trial name
- ANGEL-UNIFY (NCT07034157)
- Testing
- Percutaneous Coronary Intervention, Cerebrovascular Intervention (CAS ）, No Intervention / Observation
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Anzhen Hospital
Carotid Artery Stenoses
Pre- and Post-operative Brain MRI in Carotid Endarterectomy
Patients undergoing carotid endarterectomy in the Department of Vascular Surgery at Oslo University Hospital are consecutively included in this evaluation og pre- and postoperative brain MRI.
- Trial name
- NCT04029259
- Testing
- Brain MRI
- Volunteers
- 320 people
- Sponsor
- Oslo University Hospital
Carotid Artery Stenosis
Improved Image Quality for Assessment of Carotid Artery Stenosis by Ultrafast Ultrasound FLOW Imaging
Objective: To evaluate the technical performance of a novel cascaded wave imaging technique compared to plane wave imaging for blood flow imaging in patients with and without carotid artery stenosis.
- Trial name
- CAS-iFLOW (NCT06170580)
- Testing
- Conventional duplex, Ultrasound-based flow imaging using plane wave imaging, Ultrasound-based flow imaging using cascaded wave imaging
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Atherosclerosis, Cardiovascular Diseases
Gene-by-Smoking Interactions and Risk of Atherosclerosis - Ancillary to ARIC
To evaluate common genetic variations, that in combination with exposure to tobacco smoke, may modify the risk of atherosclerosis.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Coronary Disease
- Trial name
- NCT00064545
- Volunteers
- 1,500 people
- Sponsor
- University of North Carolina, Chapel Hill
Carotid Artery Diseases, Thrombectomy
Thrombectomy In TANdem Occlusion
Tandem occlusion is defined by an acute ischemic stroke (AIS) with concomitant steno-occlusive disease of the extra cranial carotid artery and concerned about 10% of AIS patients.
- Conditions
- Carotid Artery Diseases, Thrombectomy, Tandem Occlusion, Stroke
- Trial name
- TITAN (NCT03978988)
- Testing
- Carotid Stenting, Procedural Aspirin, Dual dual antiplatelet therapy after 24-hours imaging follow-up
- Where
- France
- Volunteers
- 432 people
- Sponsor
- Central Hospital, Nancy, France
ST-segment Elevation Myocardial Infarction, Subclinical Carotid Atherosclerosis
Effect of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Carotid Intima-media Thickness (CIMT)
The aim of this study was to measure the effect of moderate and intensive lipid-lowering treatment with rosuvastatin on the carotid intima-media thickness (CIMT) as a surrogate marker of cardiovascular risk.
- Trial name
- NCT01203982
- Testing
- Rosuvastatin
- Where
- Denmark
- Volunteers
- 87 people
- Sponsor
- Odense University Hospital
Carotid Stenosis, Coronary Artery Disease
Simultaneous Cardiac Surgery and Micronet-covered Stent Carotid Revascularization in High Perioperative Stroke Risk Patients
Prospective, single-center, clinical registry of patients with symptomatic/critical carotid artery stenosis at risk of stroke coexisting with unstable or multivessel severe coronary artery disease and/or severe valvular heart…
- Conditions
- Carotid Stenosis, Coronary Artery Disease, Valvular Heart Disease, Myocardial Infarction
- Trial name
- SIM-GUARD (NCT04973579)
- Testing
- Simutaneous (single anaesthesia) carotid artery stenting with MicroNet covered stent (CGuard) and cardiac surgery (CABG or surgical valve replacement / repair procedure)
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- John Paul II Hospital, Krakow
Septic Shock
Carotid Doppler and EEOT for Fluid Responsiveness Prediction
Fluid responsiveness prediction prior to fluid challenge administration is a topic of interest, which has been extensively investigated, but remains challenging.
- Trial name
- NCT04470856
- Testing
- End-expiratory occlusion test (EEOT)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS