Clinical trials: Occlusion Carotid
Prevention of Subclinical Atherosclerosis Progression, Prevention of Cognitive Decline
Nattokinase Atherothrombotic Prevention Study
The potential for nattokinase to "thin" blood and to reduce blood clotting by positive antithrombotic and fibrinolytic effects presents a unique opportunity to safely study such effects on cardiovascular disease and cognition.
- Trial name
- NAPS (NCT02080520)
- Testing
- Nattokinase
- Where
- United States
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- University of Southern California
CAROTID STENOSIS
Plaque and Brain Inflammation in Symptomatic Carotid Stenosis: Role of the Ficolin-2
Carotid artery stenosis is observed in about 3% of ≥ 60 years subjects and accounts for around 10-20% of all ischemic strokes. Beyond the degree of stenosis, plaque composition affects the risk of ischemic stroke.
- Trial name
- STATEMENT (NCT05850247)
- Testing
- [18F]DPA-714 PET/MRI
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
End-stage Renal Disease, Hemodialysis
Multiple Interventions Related to Dialysis Procedures in Order to Reduce Cardiovascular Morbidity and Mortality in HD Patients(EGESTUDY)
This study aims to investigate the effects of high flux dialyser use and ultra pure dialysate utilization on cardiovascular disease by evaluating cardiovascular morbidity and mortality, progression of carotid artery intima-media…
- Trial name
- NCT00295191
- Testing
- high-flux membrane, low-flux membrane, conventional dialysate
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 704 people
- Sponsor
- Ege University
Carotid Stenosis, Coronary Stenosis
Coronary Angiography Before Elective Carotid Endarterectomy in Patients With Asymptomatic Coronary Artery Disease
The purpose of this study is to evaluate the potential benefit of systematic preoperative coronary angiography followed by selective coronary artery revascularization on the incidence of myocardial infarction (MI) in patients…
- Trial name
- CACEA (NCT02260453)
- Testing
- Preoperative coronary angiography, Standard cardiac workup
- Volunteers
- 426 people
- Sponsor
- University of Roma La Sapienza
Smoking
Carotid Plaque Screening Trial in Smokers
The purpose of this study is to determine the impact of carotid plaque screening on smoking cessation and control of other cardiovascular risk factors.
- Trial name
- CAROSS (NCT00548665)
- Testing
- Carotid ultrasound for plaque screening, Brief advice for smoking cessation
- Where
- Switzerland
- Volunteers
- 536 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Atherosclerosis, Coronary Disease
Specific Lp(a) Apheresis for Regression of Coronary and Carotid Atherosclerosis
To evaluate whether specific lipoprotein(a) apheresis on the top of optimal medical therapy could affect atherosclerotic disease burden in coronary and carotid arteries of coronary heart disease patients with elevated Lp(a)…
- Conditions
- Atherosclerosis, Coronary Disease, Carotid Artery Diseases
- Trial name
- LaRCA (NCT02133807)
- Testing
- Specific Lp(a) apheresis
- Where
- Russia
- Volunteers
- 32 people
- Sponsor
- Russian Cardiology Research and Production Center
Internal Carotid Artery Stenosis
MICHI™ Neuroprotection System (NPS+f) Filter Debris Analysis Study (The F-1 Study)
This study will be conducted in up to 10 hospitals in Europe, up to 75 patients will be enrolled. The purpose of the study is to evaluate any debris that may be captured in the inline filter of the MICHI(TM) Neuroprotection…
- Trial name
- NCT01877174
- Testing
- MICHI(TM) NPS+f, transcarotid stenting
- Where
- 6 sites in Belgium, Germany and 1 more
- Volunteers
- 24 people
- Sponsor
- Silk Road Medical
Glaucoma, Retinal Vascular Disorder
Study of Human Ocular Hemodynamics by Holography Dopple
Prospective, interventional, non-randomized, open-label study, multi-center, Gehan-designed study with sequential inclusions in each subgroup, ranging from 4 subjects to a maximum 37 subjects per subgroup included
- Trial name
- HoLoEye (NCT06989996)
- Testing
- Images Acquisition
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Carotid Artery Plaque, Aortic Aneurysm
Use of Sublingual Microcirculation and FloTrac Monitoring During Major Vascular Surgery and Its Effect on Hospital LOS
the aim of this study is to determine whether an intraoperative optimization protocol using the enhanced flow-based hemodynamic parameters of the FloTrac/Vigileo device in combination with intraoperative measurement of the…
- Conditions
- Carotid Artery Plaque, Aortic Aneurysm, Aneurysm
- Trial name
- NCT04913493
- Testing
- Cytocam-IDF
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- Universitair Ziekenhuis Brussel
Moyamoya Disease
Effect of Surgical Revascularization on Hemorrhagic Moyamoya Disease
Moyamoya Disease(MMD), also known as spontaneous basilar artery occlusion, is characterized by the gradual thickening of arterial intima at the distal carotid artery and the proximal portion of anterior/middle cerebral artery…
- Trial name
- ESRHMMD (NCT03627975)
- Testing
- Conservative treatment
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Ischemic Stroke, Atrial Fibrillation
Atrial Fibrillation and Carotid Atherosclerosis in Ischemic Stroke Patients-(AFCAS)
The main aim of the study is to investigate the prevalence and characteristics of ischemic stroke patients with atrial fibrillation and concurrent carotid atherosclerosis.
- Conditions
- Ischemic Stroke, Atrial Fibrillation, Carotid Stenosis
- Trial name
- AFCAS (NCT04821700)
- Testing
- Carotid Stenosis
- Where
- Greece
- Volunteers
- 3,000 people
- Sponsor
- University of Thessaly
Carotid Artery Stenosis, Carotid Atherosclerosis
New Ischemic Cerebral Lesions After Endarterectomy vs. Stenting for the Treatment of Symptomatic Carotid Stenosis
Background and purpose. Even if periprocedural cerebral microembolism associated with carotid endarterectomy or stenting usually does not manifest as clinically overt stroke, neuropsychological disturbances resulting from these…
- Conditions
- Carotid Artery Stenosis, Carotid Atherosclerosis, Stroke, Ischemic
- Trial name
- CARECarotid (NCT03764306)
- Testing
- Carotid Artery Stenting, Endarterectomy carotid artery
- Volunteers
- 31 people
- Sponsor
- Jagiellonian University
Atherosclerosis
Acoustic Radiation Force Impulse (ARFI) Ultrasound for Noninvasive, Diagnostic Atherosclerosis Imaging
This is a pilot clinical trial to assess the ability of a new ultrasound-based imaging method, Acoustic Radiation Force Impulse (ARFI) ultrasound, to describe the composition and structure of atherosclerotic plaques.
- Trial name
- NCT01581385
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of North Carolina, Chapel Hill
Internal Carotid Artery Stenosis
SONOlysis in Prevention of Brain InfaRctions During Internal Carotid Endarterectomy
SONOBIRDIE Trial is a randomized, single-blind, sham-controlled study designed for a demonstration of the safety and effectiveness of sonolysis (continual transcranial Doppler (TCD) monitoring) in reduction of risk of stroke or…
- Trial name
- SONOBIRDIE (NCT02398734)
- Testing
- sonolysis
- Where
- Czechia
- Volunteers
- 1,492 people
- Sponsor
- University Hospital Ostrava
Type 2 Diabetes Mellitus (T2DM), Atherosclerosis
Colchicine for Primary Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes
This study will test whether a low-cost anti-inflammatory medicine called colchicine can help protect the blood vessels of people with type 2 diabetes.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Atherosclerosis, Cardiovascular Diseases
- Trial name
- Col-DM (NCT07837934)
- Testing
- Colchicine 0.5 MG Oral Tablet Once Daily
- Where
- Singapore
- Volunteers
- 300 people
- Sponsor
- Tan Tock Seng Hospital
Carotid Stenoses
Additional Neurological Symptoms Before Surgery of the Carotid Arteries - A Prospective Study (ANSYSCAP)
A single center observational study. Observing the time between cerebrovascular symptoms and Carotid Endarterectomy (CEA) and patient outcome.
- Trial name
- ANSYSCAP (NCT00514592)
- Testing
- New Guidelines
- Where
- Sweden
- Volunteers
- 230 people
- Sponsor
- Umeå University
Carotid Artery Plaque, Ultrasonic Diagnosis
Identification of Carotid Plague Vulnerability by Contrast Enhanced Ultrasound: Correlation With Plague Histopathology
OBJECTIVE/BACKGROUND: Intraplaque neovascularization is one of the most important risk factors for unstable carotid plaque. This study was designed to evaluate whether carotid intraplaque neovascularization (IPN) can be…
- Trial name
- NCT02820207
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Carotid Artery Stenosis, Carotid Artery Stenting
CAS for Stenosis With High-risk Features for CEA
The purpose of this prospective, multicenter, single-group target-value study is to evaluate the safety and efficacy of the carotid artery stent system in patients with high-risk features for carotid endarterectomy.
- Trial name
- HeartCare CAS (NCT07370246)
- Testing
- Carotid artery stent system
- Where
- 16 sites in China
- Volunteers
- 212 people
- Sponsor
- Beijing Tiantan Hospital
Carotid Artery Stenosis
Gao's Triple Eversion Carotid Endarterectomy
Carotid endarterectomy (CEA), an important surgical approach for managing carotid plaque, has evolved over more than 70 years but still cannot be applied to all tandem carotid lesions (TCLs) because of the wide range of these…
- Trial name
- NCT06722222
- Testing
- Gao's triple eversion carotid endarterectomy
- Where
- China
- Volunteers
- 11 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Coronary Artery Disease
Effect of Garlic Tablet Some Indicators Related to Atherosclerosis
The purpose of this study is to determine whether garlic in adjunct to conventional medical treatment is effective in improving carotid intima media thickness (CIMT), Flow mediated dilation (FMD) and plasma lipid profile or…
- Trial name
- NCT01948453
- Testing
- Garlic
- Where
- Iran
- Volunteers
- 56 people
- Sponsor
- Shahid Beheshti University