Clinical trials: Occlusion of Artery
Coronary Artery Disease
Comparison of the Everolimus Eluting With the Biolimus A9 Eluting Stent
This is a prospective, randomized, multi center study. Approximately 2700 patients will be entered in the study and will be randomized on a 2:1 basis.
- Trial name
- COMPARE-II (NCT01233453)
- Testing
- the everolimus eluting ® stent, the Biolimus A9 eluting NOBORI® stent
- Where
- 11 sites in Greece, Netherlands and 2 more
- Volunteers
- 2,700 people
- Sponsor
- Maasstad Hospital
Coronary Artery Disease
Dobutamine Stress Cardiac Magnetic Resonance Versus Echocardiography for the Assessment of Outcome. Are the Two Imaging Modalities Comparable?
Dobutamine stress echocardiography (DSE) and cardiac magnetic resonance (DCMR) are both established non-invasive techniques, used in the clinical routine for the diagnostic classification and risk stratification of patients with…
- Trial name
- NCT01568502
- Where
- Germany
- Volunteers
- 5,008 people
- Sponsor
- University Hospital Heidelberg
Peripheral Artery Disease
Registry Investigating the Clinical Use and Safety of the Lutonix Drug Coated Balloon for Treatment of BTK Arteries
The study will enroll patients presenting with claudication, or critical limb ischemia (Rutherford Category 3- 5) and an angiographically significant (≥ 70%) native artery lesion appropriate for angioplasty that is below the…
- Trial name
- BTKRegistry (NCT02554266)
- Testing
- Lutonix 014 Drug Coated Balloon PTA Catheter
- Where
- 26 sites in Austria, Belgium and 9 more
- Volunteers
- 371 people
- Sponsor
- C. R. Bard
Dyslipidemias, High Cholesterol
Randomized Study to Evaluate the Effect of Obicetrapib on Top of Maximum Tolerated Lipid-Modifying Therapies
This study will be a placebo-controlled, double-blind, randomized, phase 3 study in participants with underlying heterozygous familial hypercholesterolemia (HeFH) and/or ASCVD to evaluate the efficacy, safety, and tolerability of…
- Conditions
- Dyslipidemias, High Cholesterol, Hypercholesterolemia, Familial Hypercholesterolemia
- Trial name
- BROADWAY (NCT05142722)
- Testing
- Obicetrapib
- Where
- 181 sites in United States, China and 6 more
- Volunteers
- 2,530 people
- Sponsor
- NewAmsterdam Pharma
Type2 Diabetes, Coronary Artery Disease
Liraglutide Effects on Epicardial Fat Inflammatory Genes
Epicardial adipose tissue (EAT) is the visceral fat of the heart. EAT could locally affect the coronary arteries through local secretion of pro-inflammatory cytokines.
- Trial name
- NCT03260881
- Testing
- Liraglutide Pen Injector [Victoza]
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Miami
Coronary Arteriosclerosis, Non ST Segment Elevation Acute Coronary Syndrome
HARMONEE - Japan-USA Harmonized Assessment by Randomized, Multi-Center Study of OrbusNEich's Combo StEnt
This is a multi-center, single-blind, randomized, active-controlled, clinical trial in Percutaneous Coronary Intervention (PCI) subjects.
- Trial name
- HARMONEE (NCT02073565)
- Testing
- OrbusNeich Combo stent™, Everolimus Eluting Stent (EES)
- Where
- 50 sites in United States, Japan
- Volunteers
- 572 people
- Sponsor
- OrbusNeich
Basilar Artery Occlusion
Contact Aspiration Versus Stent Retriever for Recanalisation of Acute Stroke Patients With Basilar Artery Occlusion: The Posterior Circulation ASTER Randomized Trial Protocol
Acute ischemic stroke (AIS) patients with basilar artery occlusion (BAO) present a devastating, life-threatening prognosis. Urgent recanalization with endovascular mechanical thrombectomy is routinely performed in patients with…
- Trial name
- pc-ASTER (NCT05320263)
- Testing
- Contact aspiration Thrombectomy, Stent retriever thrombectomy
- Where
- 12 sites in France
- Volunteers
- 480 people
- Sponsor
- Hopital Foch
Ventricular Tachycardia, Coronary Artery Disease
Coronary Flow During Rapid Heart Rates
The goal of this observational study is to learn about the factors which determine how well ventricular tachycardia (VT) is tolerated. The main questions it aims to answer are: 1.
- Conditions
- Ventricular Tachycardia, Coronary Artery Disease, Heart Failure, Coronary Microvascular Dysfunction
- Trial name
- VT flow (NCT05841199)
- Testing
- Pressure and flow measurement during simulated VT
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Imperial College London
Peripheral Artery Disease
Post-operative Treatment of Diabetic Peripheral Arterial Disease Guided by Platelet Reactivity Unit
To compare the effect of PRU(platelet (P2Y12) reaction units)-guided treatment on the change in 1. time of initial leg pain and time of termination of exercise test by pain, evaluated on the graded stationary bicycle test, 2.
- Trial name
- NCT02762864
- Testing
- platelet (P2Y12) reaction units, ticagrelor, Comparator
- Volunteers
- 200 people
- Sponsor
- Chang Gung Memorial Hospital
Vascular Dementia
Efficacy and Safety of Donepezil Hydrochloride (Aricept) in Vascular Dementia
The purpose of this study is to examine the efficacy and safety of cholinesterase inhibitor (donepezil hydrochloride) Aricept in patients with vascular dementia (VaD).
- Trial name
- NCT00165763
- Testing
- donepezil hydrochloride (Aricept)
- Where
- 2 sites in Philippines
- Volunteers
- 36 people
- Sponsor
- Eisai Inc.
Exercise Test
Virtual Group Motivation in Exercise Treadmill Testing
Exercise stress testing is the most frequently used clinical tool for assessment of coronary artery disease. To ensure a high validity of the results, a good Patient compliance is crucial.
- Trial name
- NCT03704493
- Testing
- Video Group
- Volunteers
- 108 people
- Sponsor
- Kantonsspital Baden
Peripheral Artery Disease
Acoart SCB SFA: Sirolimus Coated Balloon Catheter in the Treatment of Femoropopliteal Artery Stenosis
A prospective randomized trial designed to compare the efficacy and safety of Sirolimus coated balloon (SCB) versus paclitaxel coated balloon (DCB) in the treatment of femoropopliteal artery stenosis
- Trial name
- NCT04982367
- Testing
- Sirolimus-eluting balloon catheter, Paclitaxel-eluting balloon catheter
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Acotec Scientific Co., Ltd
Insulin Resistance, Coronary Artery Disease
Insulin Resistance Indices and Coronary Artery Disease
In this retrospective study from professor Kojuri clinic registry, total number of 1017 patients with first angiography were included and all data were recorded from registry.
- Trial name
- NCT06237244
- Testing
- triglyceride to glucose ratio, triglycerdie to HDL ratio
- Where
- Iran
- Volunteers
- 1,017 people
- Sponsor
- Shiraz University of Medical Sciences
Coronary Artery Disease
The Beneficial Role of Percutaneous Coronary Intervention Over Optimal Medical Therapy in Elderly Patients With Coronary Artery Disease
The primary purpose of this study is to determine whether PCI added to OMT could be superior over OMT alone in the prevention of late adverse cardiac and cerebro-vascular events in elderly patients with coronary artery disease…
- Trial name
- BRAVE (NCT01508663)
- Testing
- Everolimus Eluting Stent or Zotalolimus Eluting Stent, ARB, CCB, ACE-inhibitor, statin, Nitrate, Antiplate etc.
- Where
- South Korea
- Volunteers
- 1,600 people
- Sponsor
- Yonsei University
Coronary Artery Disease, Exercise Addiction
Interval Aerobic Training and Continious Training
This research is comparing the effects of interval and continuous training which are the two types of aerobic training on persons' life quality and exercise capacity on coronary artery disease patients.
- Trial name
- NCT06525233
- Testing
- Physiotherapy and rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Coronary Artery Disease, Atherosclerosis
Balloon Inflation and Plaque Morphology in Revascularisation (BURST)
This study will look at the effects of standardised balloon inflation times, pressure and balloon types and atherosclerotic plaque morphology on the procedural results of percutaneous coronary intervention (PCI).
- Trial name
- BURST (NCT03538067)
- Testing
- Percutaneous coronary intervention (PCI)
- Volunteers
- 30 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
CMV
Effect of Atorvastatin on Subclinical Atherosclerosis
Statin administration is supposed to reduce subclinical atherosclerosis by decreasing LDL cholesterol levels, possibly via lipid-independent anti-inflammatory effect.
- Trial name
- NCT04101136
- Where
- Indonesia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Coronary Artery Disease, STEMI - ST Elevation Myocardial Infarction
AccuIMR Predicts Microvascular Obstruction and Infarct Size in STEMI Patients
In this study, we aimed to investigate the clinical significance of the angiography-based IMR calculation method (AccuIMR) and its prognostic assessment capability by evaluating the concordance or discordance between AccuIMR…
- Conditions
- Coronary Artery Disease, STEMI - ST Elevation Myocardial Infarction, Microvascular Coronary Artery Disease
- Trial name
- NCT06947564
- Testing
- CMR
- Where
- China
- Volunteers
- 843 people
- Sponsor
- RenJi Hospital
Atherosclerosis
Defining the Role of Endothelial Function Assessment Using EndoPAT in Cardiovascular Risk Screening : Comparison to Traditional Risk Assessment Tools and CIMT Testing
Our study aims to evaluate endothelial function using the non-invasive EndoPAT device, and compare this assessment to traditional cardiovascular risk calculation tools and carotid intima media thickness measurements.
- Trial name
- NCT05480332
- Testing
- EndoPAT
- Volunteers
- healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Coronary Disease, Coronary Artery Disease
EXecutive RCT: Evaluating XIENCE V® in a Multi Vessel Disease
The purpose of this two part study is the assessment of the performance of the XIENCE V® Everolimus Eluting Coronary Stent System (XIENCE V® EECSS) in the treatment of the specific setting of patients with Multi-Vessel Coronary…
- Conditions
- Coronary Disease, Coronary Artery Disease, Coronary Artery Stenosis, Coronary Artery Restenosis
- Trial name
- EXecutive (NCT00531011)
- Testing
- XIENCE V® Everolimus Eluting Coronary Stent System, TAXUS® Liberté™ Paclitaxel Eluting Coronary Stent System
- Where
- 24 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Abbott Medical Devices
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