Clinical trials: Occlusion of Artery
Chronic Obstructive Pulmonary Disease
Losmapimod in Chronic Obstructive Pulmonary Disease Patients Stratified by Fibrinogen.
The main purpose of this study is to determine the effect of Losmapimod on blood vessels in patients with Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- EVOLUTION (NCT01541852)
- Testing
- Losmapimod
- Where
- 2 sites in United Kingdom
- Volunteers
- 72 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Interscalene Block, Superficial Cervical Block
Comparison Of The Effects Of Regional Anesthesia On Brain And Carotid Artery Oxygenation In Shoulder Surgery
The aim of our study was to compare the effects of interscalene block alone and the combination of interscalene block and superficial cervical block on cerebral oxygenation, carotid artery diameter, intraoperative hemodynamics…
- Conditions
- Interscalene Block, Superficial Cervical Block, Cerebral Perfusion, Shoulder Surgeries
- Trial name
- NCT07398352
- Testing
- Interscalene brachial plexus block, Interscalene brachial plexus block and superficial cervical plexus block
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
CORONARY ARTERY DISEASE
Multisensor Array for the Localisation of Coronary Artery Stenosis (MALCAS)
This is a proof of concept study involving a novel medical device, developed to investigate the potential for detecting and localising coronary artery stenosis.
- Trial name
- MALCAS (NCT04647448)
- Testing
- Application of sensor patch
- Volunteers
- healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Dementia, Alzheimer Disease
The Healthy Patterns Sleep Study
The Healthy Patterns Study intervention is a home-based activity intervention designed to improve symptoms of circadian rhythm disorders (CRD) and quality of life (QOL) in home-dwelling persons with dementia.
- Conditions
- Dementia, Alzheimer Disease, Circadian Rhythm Disorders, Circadian Rhythm Sleep Disorder
- Trial name
- NCT03682185
- Testing
- Attention-Control Condition, Timed Activity Intervention
- Where
- United States
- Volunteers
- 421 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Stroke, Stroke, Ischemic
Evaluation of Low Dose Colchicine and Ticagrelor in Prevention of Ischemic Stroke in Patients With Stroke Due to Atherosclerosis
REDUCING INFLAMMATION IN ISCHEMIC STROKE WITH COLCHICINE, AND TICAGRELOR IN HIGH-RISK PATIENTS-EXTENDED TREATMENT IN ISCHEMIC STROKE.
- Conditions
- Stroke, Stroke, Ischemic, Atherosclerosis, Myocardial Infarction
- Trial name
- RIISC-THETIS (NCT05476991)
- Testing
- Colchicine 0.5 MG, Ticagrelor 90mg, Aspirin 75-300mg
- Where
- France
- Volunteers
- 2,800 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Artery Disease
Safety and Efficacy Between the Distal and Proximal Radial Vascular Access Technique
The investigators are conducting a randomized clinical trial, having as a primary objective, to compare vascular access time between distal and proximal radial approach.
- Trial name
- NCT05066074
- Testing
- Distal Radial Vascular Access
- Where
- Mexico
- Volunteers
- 64 people
- Sponsor
- Instituto Mexicano del Seguro Social
Coronary Arterial Disease (CAD)
Central vs Brachial BP, Exercise, and Coronary Artery Disease
High blood pressure (BP) is a major risk factor for coronary artery disease (CAD), with 30-70% of CAD patients having elevated BP.
- Trial name
- NCT06617117
- Testing
- High-intensity combined exercise, Moderate-intensity combined exercise
- Where
- Portugal
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Coronary Artery Disease
Tai Chi Exercises on Physical Activity and Pulmonary Function in CABG
To improve the cardiopulmonary endurance in Coronary artery bypass grafting (CABG) patients. Internationally in cardiac hospital facility of cardiac rehabilitation is available to improve the patient's physical activity and…
- Trial name
- NCT03857282
- Testing
- Aerobic Exercises, Tai Chi Exercises
- Where
- Pakistan
- Volunteers
- 74 people
- Sponsor
- Riphah International University
Popliteal Stenosis, Popliteal Artery Occlusion
DCB Compared Stenting in Popliteal Lesions
This is a randomized prospective study aiming to compare drug-coated balloons and stent deployment in Popliteal atherosclerotic occlusive lesions.
- Conditions
- Popliteal Stenosis, Popliteal Artery Occlusion, Diabetes
- Trial name
- NCT03739580
- Testing
- DCB angioplasty (Orchid, Acotec Scientific Co. Ltd.), Stent (Maris,Medtronic.USA or Sinus/Supera, Germany)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xuanwu Hospital, Beijing
Hypercholesterolemia, Coronary Heart Disease
12-week Open-label, Phase IIIb Comparing Efficacy and Safety of Rosuvastatin (CRESTOR™) in Combination With Ezetimibe
The purpose of this study is to determine whether treatment of Rosuvastatin (CRESTOR™) or Simvastatin given as monotherapy or given in combination with Ezetimibe, will lower the Low Density Lipoprotein Cholesterol (LDL-C) in…
- Conditions
- Hypercholesterolemia, Coronary Heart Disease, Atherosclerosis
- Trial name
- GRAVITY (NCT00525824)
- Testing
- Rosuvastatin (Crestor), Ezetimibe, Simvastatin
- Where
- 9 sites in United States, Argentina and 7 more
- Volunteers
- 1,743 people
- Sponsor
- AstraZeneca
PCI, Coronary Arterial Disease (CAD)
Comparison of 6F and 7F Sheaths for Coronary Intervention Via Distal Radial Artery Access
This is a multicenter, randomized controlled, prospective, non-inferiority, open-label study aiming to evaluate whether the efficacy and safety of using a 7F thin-walled sheath via distal radial artery (dTRA) access for coronary…
- Trial name
- NCT06585917
- Testing
- 7F Thin-Walled Sheath, 6F Thin-Walled Sheath
- Where
- China
- Volunteers
- 574 people
- Sponsor
- China National Center for Cardiovascular Diseases
Atherosclerosis, Oxidative Stress
Effects Vitamin D Suppletion on Postprandial Leukocyte Activation
Administration of vitamin D will have a beneficial effect on postprandial leukocyte activation, oxidative stress and arterial stiffness in vitamin D deficient females.
- Conditions
- Atherosclerosis, Oxidative Stress, Leukocyte Activation Disorder
- Trial name
- DOSFEM (NCT01967459)
- Testing
- Cholecalciferol
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sint Franciscus Gasthuis
Thromboangiitis Obliterans
Treatment of Thromboangiitis Obliterans (Buerguer's Disease) With Bosentan
This study assessed the effectiveness and safety of bosentan when administered to thromboangiitis obliterans (Buerger's disease)patients.
- Trial name
- NCT01447550
- Testing
- Bosentan
- Where
- 2 sites in Spain
- Volunteers
- 12 people
- Sponsor
- Hospital Universitario Getafe
Coronary Artery Disease, Acute Coronary Syndrome
Effect and Efficacy of Onyx™, Zotarolimus-eluting Stent for Coronary Atherosclerosis
The objectives of this study are 1. To establish a prospective registry of the whole patients who received percutaneous coronary intervention with Resolute Onyx™ stent. 2.
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Myocardial Infarction, Angina Pectoris
- Trial name
- HOST-ONYX (NCT03151018)
- Testing
- Resolute Onyx
- Where
- 16 sites in South Korea
- Volunteers
- 4,000 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease, Anxiety
The Effect of Mandala Painting on Anxiety in Coronary Heart Patients
This study was planned as a randomized controlled trial to determine the effect of mandala painting on the anxiety of coronary heart patients.
- Trial name
- NCT05307224
- Testing
- Mandala
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Marmara University
Peripheral Arterial Occlusive Disease
GORE PROPATEN Vascular Graft vs. Disadvantaged Autologous Vein Graft
The primary patency of the GORE PROPATEN Vascular Graft is equivalent to or better than disadvantaged autologous vein graft in an infragenicular peripheral bypass application at 12 months.
- Trial name
- PRODIGY (NCT00617279)
- Testing
- GORE PROPATEN Vascular Graft, Disadvantaged Autologous Vein Graft
- Where
- 17 sites in United States
- Volunteers
- 31 people
- Sponsor
- W.L.Gore & Associates
Coronary Artery Disease
Effect of Exercise Training on the Function of HDL-Cholesterol, Endothelial Function and Endothelial Progenitor Cells in Patients With Coronary Artery Disease (HERCET-Study)
Patients with coronary artery disease are characterized by an increased cardiovascular risk and they often have low blood high density lipoprotein (HDL)-cholesterol levels or HDL-cholesterol with modified vasculoprotective…
- Trial name
- HERCET (NCT00457379)
- Testing
- physical exercise
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Coronary Artery Disease, Coronary Stenosis
Transit Time Flow Measurement in Coronary Surgery
Transit-time flowmetry (TTFM) allows grafts quality control during coronary artery bypass surgery by measuring the flow volume through them.
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Coronary Bypass Graft Stenosis
- Trial name
- COLLATERAL (NCT06471062)
- Where
- Italy
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Alzheimer Disease, Vascular Dementia
A Study of the Safety and Effectiveness of Galantamine Versus Placebo in the Treatment of Patients With Vascular Dementia or Mixed Dementia
The purpose of this study is to evaluate the safety and efficacy of galantamine (a drug for treating dementia) compared to placebo in the treatment of patients with dementia related to cerebrovascular disease (vascular dementia)…
- Trial name
- NCT00261573
- Testing
- galantamine hydrobromide
- Volunteers
- 593 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Coronary Atherosclerosis, Coronary Artery Disease
Natural History of Coronary Atherosclerosis in Real-World Stable Chest Pain Patients Underwent Computed Tomography Angiography in Comparison With Invasive Multimodality Imaging
In a prospective international multicenter observational study, 1080 stable chest pain patients (REALITY Advanced registry of CCTA patients) with the suspected chronic coronary syndrome will be enrolled.
- Conditions
- Coronary Atherosclerosis, Coronary Artery Disease, Contrast-induced Nephropathy, Cerebrovascular Disease
- Trial name
- REALITY (NCT02440646)
- Testing
- Coronary computed tomography angiography, Quantitative coronary angiography, intravascular imaging with percutaneous intervention
- Where
- 4 sites in Estonia, Netherlands and 1 more
- Volunteers
- 1,080 people
- Sponsor
- Central Clinical Hospital of the Russian Academy of Sciences
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