Clinical trials: Ocular Diseases
Anxiety, Strabismus
Does Anxiety in Children on the Day of Surgery Impact Compliance in the Ophthalmology Clinic?
The hypothesis is that pediatric patients with increased levels of anxiety on the day of surgery, in particular at point of anesthetic induction, will demonstrate decreased compliance with assessment in ophthalmology clinic…
- Conditions
- Anxiety, Strabismus, Compliance
- Trial name
- NCT02704442
- Where
- Canada
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Queen's University
Dry Age-related Macular Degeneration, Geographic Atrophy
A Multiple Dose Study of Repeat Intravitreal Injections of GEM103 in Dry Age-related Macular Degeneration
This study is designed to investigate the safety, PK/PD, biomarker and early clinical effects of repeat GEM103 IVT injections.
- Conditions
- Dry Age-related Macular Degeneration, Geographic Atrophy, Macular Degeneration, Retinal Disease
- Trial name
- NCT04643886
- Testing
- GEM103
- Where
- 29 sites in United States
- Volunteers
- 62 people
- Sponsor
- Gemini Therapeutics, Inc.
Abetalipoproteinemia
Vitamin Replacement in Abetalipoproteinemia
This study will determine whether short term intravenous infusion of vitamins A and E in patients with abetalipoproteinemia can reverse disease symptoms in these patients.
- Trial name
- NCT00004574
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Mydriasis
Evaluation of Pupil Dilation Speed With the MAP Dispenser
1 mist or 2 mists of the study drug will be administered to both eyes according to a pre-specified randomization plan to determine the effect on pupil dilation
- Trial name
- SPEED (NCT04907474)
- Testing
- tropicamide-phenylephrine fixed combination ophthalmic solution
- Where
- Mexico
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Eyenovia Inc.
Myopia, Refractive Errors
Effect of Repeated Low-Level Red-Light Therapy on Retinal Function and Structure
The purpose of this clinical trial is to evaluate the effect of repeated low-level red-light (RLRL) therapy on the retinal function and structure among myopic teenagers.
- Conditions
- Myopia, Refractive Errors, Eye Diseases, Retina; Change
- Trial name
- NCT05597397
- Testing
- RLRL
- Where
- China
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Uveitis, JIA
Adalimumab in JIA-associated Uveitis Stopping Trial
The proposed study is a stratified, block-randomized, double-masked, controlled trial to determine the feasibility of discontinuing adalimumab treatment in patients with quiescent uveitis associated with juvenile idiopathic…
- Trial name
- ADJUST (NCT03816397)
- Testing
- Adalimumab
- Where
- 21 sites in United States, Australia and 1 more
- Volunteers
- 87 people
- Sponsor
- Nisha Acharya
Ischemic Optic Neuropathy, Optic Neuritis
Diffusion Weighted Magnetic Resonance Imaging and the Optic Nerve Neuropathy.
The aim of the project is to create a new, non-invasive and safe protocol for the early diagnosis of various types of optic neuropathies with the use of diffusion magnetic resonance imaging
- Conditions
- Ischemic Optic Neuropathy, Optic Neuritis, Compressive Optic Neuropathy, Traumatic Optic Neuropathy
- Trial name
- NCT05353413
- Testing
- Neuroimaging, VEP - visual evoked potential, Ophthalmology examination.
- Where
- Poland
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Macular Edema With Central Retinal Vein Occlusions
NEWTON: Aflibercept Injection for Previously Treated Macular Edema Associated With Central Retinal Vein Occlusions
The purpose of the study is to determine the effect of Intravitreal Aflibercept Injection (IAI) on previously treated Central Retinal Vein Occlusions (CRVOs) with other Anti-VEGF agents.
- Trial name
- NEWTON (NCT01870427)
- Testing
- Aflibercept (2.0 mg)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northern California Retina Vitreous Associates
Ophthalmopathy
Single Superior ILM/ERM Flap for the FTMH.
In this study, the investigators will make the only upper flap either from the internal limiting membrane or from the epiretinal membrane to cover the full thickness macular hole.
- Trial name
- NCT05494242
- Testing
- Surgical intervention
- Where
- Iraq
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Omer Othman Abdullah
Glaucoma, Pulmonary Hypertension
Changes in Eye Pressure and Anterior Chamber Depth With Oral Endothelin Antagonist Therapy
There is growing evidence that a cause of glaucoma is linked to circulatory problems and poor auto-regulation of blood flow to the optic nerve.
- Trial name
- NCT00452283
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Colorado, Denver
Axial Length, Myopia
Study of the Intervention Effect of Outdoor Activity Period Patterns in Promoting Myopia Among Preschool Children
This study is a randomized controlled trial based on outdoor activity interventions at specific time periods, involving preschool children aged 4 to 5 years.
- Trial name
- NCT06607640
- Testing
- Increase outdoor activity time during specific time periods
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Fangbiao Tao
Diabetes Complications
Dynamic Parameters of Glucose Control in Relation to Biomarkers in Serum and Intraocular Fluid in Patients With Diabetes
Our project investigates the new characteristics of diabetic retinopathy using liquid eye biopsy in combination with novel parameters of glucose control obtained with continuous glucose monitoring.
- Trial name
- NCT05944640
- Testing
- Intraocular surgery
- Where
- Czechia
- Volunteers
- 213 people
- Sponsor
- Charles University, Czech Republic
Decision Making, Computer Aided Diagnosis
Project 3 Example: Human-AI Collaboration Tester (HAICT) Exp. 7
The study is one part of a "bundle" of experiments that constitute Project Three of a National Eye Institute grant. Project Three includes a series of experiments that investigate how changing the input from a simulated AI can…
- Trial name
- NCT05272189
- Testing
- Simulated Second Reader AI, Target Prevalence
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Healthy Subjects
Water Drinking Test During Intraocular Pressure Fluctuation (IOP) Monitoring
The purpose of this study is to investigate the investigational device capacity to detect an intraocular pressure increase (IOP)induced by water intake.
- Trial name
- NCT01362868
- Testing
- SENSIMED Triggerfish®
- Where
- Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Sensimed AG
Thyroid Eye Disease
A Trial Investigating Lu AG22515 in Adult Participants With Moderate-to-Severe Thyroid Eye Disease
This trial will evaluate the effects of Lu AG22515 in adult men and women with moderate-to-severe thyroid eye disease (TED). TED is an autoimmune condition closely related to Graves' Disease.
- Trial name
- NCT06557850
- Testing
- Lu AG22515
- Where
- 6 sites in Bosnia and Herzegovina, Bulgaria and 1 more
- Volunteers
- 20 people
- Sponsor
- H. Lundbeck A/S
Macular Edema, Retinal Vein Occlusion
Safety and Efficacy of AGN208397 in the Treatment of Macular Edema Associated With Retinal Vein Occlusion (RVO)
This study will evaluate the safety and efficacy of a single intravitreal injection of AGN208397 to treat Macular Edema associated with Retinal Vein Occlusion.
- Trial name
- NCT01027650
- Testing
- AGN208397 intravitreal injection, dexamethasone intravitreal implant
- Where
- 5 sites in United States, Australia and 3 more
- Volunteers
- 121 people
- Sponsor
- Allergan
Myopia, Refractive Errors
Community Intervention and Demonstration Area Construction
The objective of this intervention study was to understand the visual health status of nearly one million children and adolescents in ten provinces in China, and then to conduct intervention and evaluate the effect of…
- Trial name
- NCT05715424
- Testing
- Six interventions for children and adolescents
- Where
- China
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Anhui Medical University
Glaucoma
The AVB Study: Prospective Study Comparing the Ahmed Valve and the Baerveldt Implant for Treating Refractory Glaucoma
The purpose of this study is to compare the safety and efficacy of the Ahmed valve and the Baerveldt implant in treating refractory glaucoma.
- Trial name
- NCT00940823
- Testing
- Ahmed FP7 Valve, Baerveldt-350 Tube
- Where
- 6 sites in United States, Canada and 1 more
- Volunteers
- 238 people
- Sponsor
- Credit Valley EyeCare
Brain and Nervous System, Eye and Orbit
Nivolumab Consolidation in Older (≥ 65) Patients With Primary CNS Lymphoma
The primary objective of Stage 1 is to evaluate the safety of nivolumab consolidation after completion of HD-MTX containing induction chemotherapy in older subjects with PCNSL in terms of a tolerated dose (based on dose-limiting…
- Trial name
- NCT04022980
- Testing
- Nivolumab
- Where
- 4 sites in United States
- Volunteers
- 14 people
- Sponsor
- Wake Forest University Health Sciences
Myopia
MiSight 1 Day Safety Post-Approval Study
The purpose of this post-approval study is to confirm the safety of daily disposable soft contact lens wear among the intended patient population for the MiSight 1 Day lens in the US.
- Trial name
- NCT05285527
- Testing
- MiSight 1 Day
- Where
- 50 sites in United States, Canada
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
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