Clinical trials: Ocular Diseases
Normal Tension Glaucoma
Autonomic Nervous System Activity and Normal Tension Glaucoma
Evidence has accumulated that systemic and ocular mechanisms, responsible for regulating blood flow in the area of the optic disc, such as reduced ocular perfusion pressure, abnormal autoregulation and vascular dysregulation may…
- Trial name
- ANS (NCT01192061)
- Where
- Poland
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Military Institute od Medicine National Research Institute
Congenital Fibrosis of Extraocular Muscles, Duane Retraction Syndrome
Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies
The purpose of this study is to identify genes associated with impaired development and function of the cranial nerves and brainstem, which may result in misalignment of the eyes (strabismus) and related conditions.
- Conditions
- Congenital Fibrosis of Extraocular Muscles, Duane Retraction Syndrome, Duane Radial Ray Syndrome, Mobius Syndrome
- Trial name
- NCT03059420
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Glaucoma
Assessment of the Ability to Distinguish Odors in Glaucoma Patients
Glaucoma is one of the leading causes of blindness worldwide. The key feature of glaucoma is damage to the optic nerve head with loss of retinal ganglion cells and local tissue remodeling.
- Trial name
- NCT00304824
- Volunteers
- 30 people
- Sponsor
- University Hospital, Basel, Switzerland
Primary Open Angle Glaucoma or Ocular Hypertension
Study of Netarsudil Ophthalmic Solution in Japanese/Japanese-American Subjects With Open-angle Glaucoma or Ocular Hypertension
To test the safety and effectiveness of AR-13324 0.02% and 0.04% ophthalmic solution relative to placebo in Japanese/Japanese-American subjects with open-angle glaucoma or ocular hypertension in US.
- Trial name
- NCT03310580
- Testing
- AR-13324 Ophthalmic Solution 0.02%, AR-13324 Ophthalmic Solution 0.04%
- Where
- 40 sites in United States
- Volunteers
- 42 people
- Sponsor
- Aerie Pharmaceuticals
Presbyopia
Reading Glass on Livelihoods and Quality of Life in Rural Bangladesh
The issue of uncorrected Presbyopia is an emerging health and livelihoods problem in Bangladesh. Presbyopia is easily corrected with an appropriate pair of reading glasses.
- Trial name
- NCT03719196
- Testing
- Reading glass
- Where
- Bangladesh
- Volunteers
- 824 people
- Sponsor
- Brac
Ocular Surface Disease
LK Scleral Lens for Patients With Intractable Ocular Surface Diseases
Scleral lenses have emerged as an efficacious treatment option for various types of intractable ocular surface diseases with many advantageous results.
- Trial name
- NCT04535388
- Testing
- LK scleral lens
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Susac Syndrome
Physiotherapy Approach for Susac Syndrome
Susac's syndrome is a rare autoimmune disorder characterised by a triad of encephalopathy (brain dysfunction), branch retinal artery occlusion (loss of vision) and sensorineural hearing loss.
- Trial name
- NCT06349603
- Where
- Bosnia and Herzegovina
- Volunteers
- 1 people
- Sponsor
- Rehabilitation Centre Zivot
Diabetic Retinopathy
Comparison of Aurora Fundus Camera With Traditional Camera in Diabetic Retinopathy With Visual Artificial Intelligence
This study aims to compare the effect of Aurora handheld fundus camera with traditional desktop fundus camera in the fundus photography screening of diabetic patients, and to evaluate the effect of artificial intelligence…
- Trial name
- NCT03903042
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Exudative Age-related Macular Degeneration
Indocyanine Angiographic Changes of Choroidal Neovascularization by Ranibizumab
Exudative age-related macular degeneration (ARMD) is complicated by choroidal neovascularization (CNV). Although anti-vascular endothelial growth factor treatment is the gold standard treatment, recurrence is the main limitation…
- Trial name
- NCT01810042
- Testing
- ranibizumab
- Where
- 2 sites in South Korea
- Volunteers
- 49 people
- Sponsor
- Pusan National University Hospital
Cataract
Evaluation of Efficacy and Long-term Safety for the InFo - Instant Focus © Lens / PMCF
This is a monocentric, longitudinal, prospective, observational post-market follow-up study. 30 patients with a cataract will receive an InFo - Instant Focus © lens implant.
- Trial name
- INFOLO (NCT02841670)
- Testing
- InFo - Instant Focus (c) lens implantation
- Volunteers
- 30 people
- Sponsor
- SAV-IOL SA
Open Angle Glaucoma, Ocular Hypertension
MRCT Evaluating NCX 470 vs. Latanoprost in Subjects With Open-Angle Glaucoma or Ocular Hypertension
The objective of this clinical study is to evaluate the safety and efficacy of NCX 470 Ophthalmic Solution in lowering intraocular pressure (IOP) in subjecs with ocular hypertension or open-angle glaucoma.
- Trial name
- Denali (NCT04630808)
- Testing
- NCX 470 0.1%, Latanoprost 0.005%
- Where
- 88 sites in United States, China
- Volunteers
- 696 people
- Sponsor
- Nicox Ophthalmics, Inc.
Sjogren's Syndrome
Cyclosporine A in the TReatment of Interstitial Pneumonitis Associated With Sjogren's Syndrome
The purpose of this large multicenter, randomized, double-blinded, controlled clinical study is to investigate the efficacy and safety of Cyclosporin A for primary Sjogren's syndrome associated pneumonitis(pSS-IP), which has…
- Trial name
- CTRIPS (NCT02370550)
- Testing
- Cyclosporin A, Prednisone, Calcium carbonate D
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Peking University People's Hospital
Astigmatism
Observational Study - TA- 2025-1
This multi-centric, prospective observational study collects biometric datasets as well as associated video recordings of the surgical procedure.
- Trial name
- TA OS 2025-1 (NCT07007897)
- Testing
- Optical Biometry, Cataract Surgery
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Haag-Streit AG
Age-Related Maculopathy
Intravitreal Injections of rhuFab V2 in Combination With Visudyne in Subjects With Age Related Macular Degeneration (AMD)
The primary purpose of this study is to determine if injections of rhuFab V2 into the eye in combination with verteporfin photodynamic therapy (PDT) is a safe and efficacious treatment for patients with age-related macular…
- Trial name
- NCT00056823
- Testing
- rhuFab V2 (ranibizumab)
- Volunteers
- 168 people
- Sponsor
- Genentech, Inc.
Diabetic Retinopathy, Diabetes Mellitus
Sorbinil Retinopathy Trial (SRT)
To evaluate the safety and efficacy of the investigational drug sorbinil, an aldose reductase inhibitor, in preventing the development of diabetic retinopathy and neuropathy in persons with insulin-dependent diabetes.
- Trial name
- NCT00000159
- Testing
- Sorbinil
- Sponsor
- National Eye Institute (NEI)
Corneal Edema, Visual Acuity
Effect of Topical Brimonidine on Post Cataract Surgery Corneal Edema
Most patients undergoing cataract surgery suffer from corneal edema after the surgery. Brimonidine drops are a well known and safe Anti-glaucoma medication.
- Trial name
- NCT00800423
- Testing
- Brimonidine Tartrate 0.2%, Timolol maleate 0.5%
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Rabin Medical Center
Keratoconjunctivitis Sicca
A Study Of Tasocitinib In Dry Eye Subjects
This is a phase 2 study to further evaluate the safety and efficacy of tasocitinib (CP-690,550) in the subjects with moderate to severe dry eye disease.
- Trial name
- NCT01226680
- Testing
- Tasocitinib, vehicle for Tasocitinib
- Sponsor
- Pfizer
Leber Congenital Amaurosis 10, Inherited Retinal Dystrophies
Single Ascending Dose Study in Participants With LCA10
The purpose of this study is to evaluate the safety, tolerability and efficacy of a single escalating doses of EDIT-101 administered via subretinal injection in participants with LCA10 caused by a homozygous or compound…
- Conditions
- Leber Congenital Amaurosis 10, Inherited Retinal Dystrophies, Eye Diseases, Hereditary, Retinal Disease
- Trial name
- NCT03872479
- Testing
- EDIT-101
- Where
- 5 sites in United States
- Volunteers
- 34 people
- Sponsor
- Editas Medicine, Inc.
Glaucoma
Brimonidine vs ALTP in Progressing Human Glaucoma
This study is evaluating possible non-intraocular pressure (IOP) related effects of the alpha-1 agonist brimonidine in human subjects affected by a progressive glaucomatous optic neuropathy.
- Trial name
- NCT00466479
- Testing
- brimonidine, laser trabeculoplasty
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Parma
Eye Trauma
Playtime Open Globe Injuries in Children
This study investigated the epidemiology, aetiologies, and complications of playtime open-globe injuries in children at the Assiut University Hospital, Egypt, between January to July 2016.
- Trial name
- NCT04497896
- Testing
- Repair of open globe injury
- Volunteers
- 81 people
- Sponsor
- Assiut University
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