Clinical trials: Ocular Diseases
Amblyopia, Strabismus
Attention-based Binocular Training for Impaired Stereopsis (BRAVE)
This study evaluates a novel attention-based binocular visual search training paradigm designed to improve stereopsis (stereo vision) in individuals with impaired binocular vision.
- Conditions
- Amblyopia, Strabismus, Anisometropia, Binocular Vision Abnormalities
- Trial name
- BRAVE (NCT07803458)
- Testing
- Attention-Guided Dichoptic Visual Search Training, Zero-Disparity Dichoptic Visual Search Task
- Where
- 2 sites in Hong Kong
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Centre for Eye and Vision Research
Myopia
Efficacy of Myopia-control Lenses in a Population of Young Adults : the OPTIMA Study
The goal of this clinical trial is to learn if myopia-control eyeglass lenses (Essilor® Stellest® 2.0) can slow down the progression of short-sightedness (myopia) in young adults, compared with standard single-vision lenses.
- Trial name
- OPTIMA (NCT07804043)
- Testing
- Essilor® Stellest® 2.0 myopia-slowing lenses, Standard lenses
- Where
- France
- Volunteers
- 134 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Primary Angle Closure Glaucoma, Primary Angle Glaucoma Closure Suspect
Effect of Multifocal Intraocular Lens on Contrast Sensitivity in Primary Angle-Closure Patients
This prospective study included patients with primary angle-closure (PAC or primary angle-closure glaucoma (PACG) and visually significant cataract.
- Conditions
- Primary Angle Closure Glaucoma, Primary Angle Glaucoma Closure Suspect, Senile Cataract
- Trial name
- NCT04972435
- Testing
- Contrast sensitivity
- Where
- Thailand
- Volunteers
- 35 people
- Sponsor
- Siriraj Hospital
Sjogren's Syndrome, Mesenchymal Stem Cells
Allogeneic Mesenchymal Stem Cells Transplantation for Primary Sjögren's Syndrome (pSS)
This study will explore safety and efficacy of allogeneic mesenchymal stem cells transplantation (MSCT) to treat patients with diagnosis of primary Sjögren's Syndrome (pSS) who have been resistant to multiple standard treatments.
- Trial name
- NCT00953485
- Testing
- Allogeneic Mesenchymal Stem Cells (AlloMSC)
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Age-related Macular Degeneration, Depression
Low Vision Depression Prevention Trial for Age Related Macular Degeneration
This randomized, controlled clinical trial, the Low Vision Depression Prevention TriAL (VITAL), will test the efficacy of collaborative low vision rehabilitation (LVR) to prevent depressive disorders in Age-Related Macular…
- Trial name
- VITAL (NCT00769015)
- Testing
- BA-LVR, ST-LVR
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- Thomas Jefferson University
Glaucoma
Is There a Response of Glaucoma to Baduanjin Exercise in Elders?
glaucoma is prevalent between elders. Baduanjin exercise is a suitable exercise for elders. elders with glaucoma will divided to group I or group II. each/every group will contain 30 elders.
- Trial name
- NCT07163676
- Testing
- Baduanjin exercise
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Myopia, Intraocular Lens Complication
Trifocal Intraocular Lens in High Myopic Patients With Different Meta-PM Grading
Study the postoperative visual quality and safety of trifocal intraocular lenses implanted in patients with different levels of myopic maculopathy stages according to Meta-PM staging (stage 0-2).
- Trial name
- NCT05718076
- Testing
- cataract surgery
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Aier School of Ophthalmology, Central South University
Cataract
Study of Corneas Undergoing Balanced Salt Solution(BSS ®) Versus Glucose-bicarbonate-Ringer Lactate in Cataract Surgery
This is a study aimed at evaluating the effectiveness and impact of two intraocular irrigating solution (BSS ® versus glucose-bicarbonate-Ringer Lactate - GBRL) on the health of the cornea after cataract surgery by…
- Trial name
- NCT01334658
- Testing
- Phacoemulsification cataract surgery, Glucose-bicarbonate-Ringer Lactate (GBRL), Balanced Salt Solution (BSS®)
- Volunteers
- 64 people
- Sponsor
- Grupo de Estudos em Oftalmologia Clínica e Cirúrgica
Infant, Newborn, Infant, Low Birth Weight
Single-Dose Intravenous Inositol Pharmacokinetics in Preterm Infants
This pilot study was a randomized, placebo-controlled, clinical trial to measure changes in blood and urine levels of inositol in premature infants at high risk for retinopathy of prematurity (ROP) following a single intravenous…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- INS-1 (NCT00349726)
- Testing
- Inositol lower volume, Inositol higher volume
- Where
- 11 sites in United States
- Volunteers
- 74 people
- Sponsor
- NICHD Neonatal Research Network
Blindness
Do Blue-Blocking Lenses Block Blue Colour From Our Lives?
To measure colour vision in patients with a blue light filtering lens implant in one eye and non-tinted implant in the other eye (and compared this group with a control group with bilateral non-tinted implants) and to determine…
- Trial name
- NCT00403143
- Testing
- cataract surgery
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- London North West Healthcare NHS Trust
Corenal Diseases
A Single-Center Clinical Study to Evaluate the Efficacy and Safety of Sutureless Ophthalmic Hydrogel for Corneal Wound Repair
Corneal blindness is one of the leading causes of blindness worldwide. For various infectious and non-infectious corneal diseases, current clinical repair strategies include corneal lesion debridement, conjunctival flap coverage…
- Trial name
- NCT07638215
- Testing
- Sutureless Ophthalmic Hydrogel for Corneal Stromal Defects
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Suxia Li
Dry Eye
Evaluation of the Performance of MAF-1217 on Cataract Surgery
MAF-1217 is meant as the medical device which is to be effective in most forms of DED; therefore, it is expected that study patients benefit from study participation, and can reduce the signs and symptoms of surgery induced DED…
- Trial name
- NCT03833908
- Testing
- MAF-1217
- Where
- 2 sites in Italy
- Volunteers
- 46 people
- Sponsor
- VISUfarma SpA
Vernal Keratoconjunctivitis
Topical Tacrolimus in Vernal Keratoconjunctivitis
The main aim of this study is to evaluate the efficacy and safety of topical tacrolimus 0.01% eyedrops in patients with vernal keratoconjunctivitis.
- Trial name
- NCT02456025
- Testing
- Topical tacrolimus
- Where
- Saudi Arabia
- Volunteers
- 20 people
- Sponsor
- The Eye Center and The Eye Foundation for Research in Ophthalmology
Trichiasis
Study of Azithromycin to Prevent Recurrent Trichiasis Following Surgery in Ethiopia
Trachoma, an ocular infection caused by C. trachomatis, is the second leading cause of blindness worldwide.Years of repeated infection with C.
- Trial name
- STAR (NCT00347776)
- Testing
- azithromycin, topical tetracycline
- Where
- United States
- Volunteers
- 1,452 people
- Sponsor
- Johns Hopkins University
Dry Eye Syndromes, Meibomian Gland Dysfunction
Photobiomodulation With REd vs BluE Light (REBEL)
The use of photobiomodulation or low-level light therapy (LLLT) in the ophthalmic field stemmed from dermatology which has shown impact on skin blood flow and regeneration.
- Conditions
- Dry Eye Syndromes, Meibomian Gland Dysfunction, Blepharitis
- Trial name
- NCT06371300
- Testing
- Red LLLT, Blue LLLT
- Where
- 2 sites in New Zealand, United Kingdom
- Volunteers
- 36 people
- Sponsor
- Aston University
Ocular Albinism (OA), Oculocutaneous Albinism (OCA)
The Effects of Lutein and Zeaxanthin Supplementation on Vision in Patients With Albinism
The LUVIA study is a randomized placebo-controlled trial designed to investigate the effects of lutein and zeaxanthin supplementation on macular pigment and visual function in ocular or oculocutaneous albinism.
- Trial name
- LUVIA (NCT02200263)
- Testing
- Lutein plus Zeaxanthin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Uveitis
Everolimus for the Treatment of Uveitis Unresponsive to Cyclosporine A
Study efficacy of everolimus on course of uveitis: obtain quiescence of inflammation after start of treatment duration to obtain quiescence of inflammation number of patients with quiescence of inflammation
- Trial name
- NCT00803816
- Testing
- everolimus
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Carsten Heinz
Glaucoma, Glaucoma Patient
Long-Term Clinical Results of Ab-Interno Trabeculotomy in Glaucoma Management
Glaucoma is one of the leading causes of irreversible vision loss worldwide. Elevated intraocular pressure (IOP) is the most important risk factor for the development and progression of the disease.
- Conditions
- Glaucoma, Glaucoma Patient, GLAUCOMA 1, OPEN ANGLE, D (Disorder), Glaucoma Following Surgery
- Trial name
- NCT07780916
- Testing
- Ab-interno trabeculotomy
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Wuerzburg University Hospital
Uveitis
Ustekinumab (STELARA) for the Treatment of Active Sight-Threatening Uveitis (STAR Study)
Background: Uveitis is an inflammation of the eye that can cause vision loss. It is treated with medications and sometimes surgery. However, in many people, treatment does not always prevent loss of vision.
- Trial name
- NCT02911116
- Testing
- Ustekinumab
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Eye Institute (NEI)
Pterygium of the Conjunctiva and Cornea
Randomized Controlled Trial of Subconjunctival Bevacizumab Injection in Impending Recurrent Pterygium
Hypothesis: Subconjunctival bevacizumab injection may potentially suppress neovascularization in pterygium, preventing or retarding the progression of recurrence.
- Trial name
- NCT01288404
- Testing
- Fluorometholone, Bevacizumab
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ramathibodi Hospital
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