Clinical trials: Ocular Graft Versus Host Disease
Graft vs Host Disease, Congenital Aniridia
Safety and Performance Study of the ARGOS-IO System in Patients Undergoing Boston Keratoprosthesis Implantation
The ARGOS-IO pressure sensor is intended to be implanted in the human eye in combination with Boston Keratoprosthesis (BKPro) surgery and to remain in place indefinitely.
- Conditions
- Graft vs Host Disease, Congenital Aniridia, Chemical Burns, Stevens-Johnson Syndrome
- Trial name
- NCT02945176
- Testing
- ARGOS-IO system
- Where
- 2 sites in Germany
- Volunteers
- 13 people
- Sponsor
- Implandata Ophthalmic Products GmbH
Ocular Graft-versus-host Disease
RHPRG4 FOR THE TREATMENT OF OCULAR GRAFT-VERSUS-HOST DISEASE (OGVHD)
rhPRG4-GVHD-001 is a prospective multi-center study conducted in Australia to evaluate the safety and efficacy of topically-applied rhPRG4 in subjects with moderate to severe dry eye secondary to chronic GVHD.
- Trial name
- NCT06495307
- Testing
- rhPRG4
- Where
- 2 sites in Australia
- Volunteers
- 3 people
- Sponsor
- Lubris Bio Pty Ltd
Ocular Graft Versus Host Disease
Evaluation of the Safety and Effectiveness of omniLenz in Patient With Ocular Graft vs Host Disease
A case series of patients presented with graft versus host disease with ocular involvement . The study recruited a total of 3 patients who were referred to cornea clinic of Farwaniya Hospital, Kuwait between April 2022 and April…
- Trial name
- NCT07066865
- Testing
- omniLenz
- Where
- Kuwait
- Volunteers
- 3 people
- Sponsor
- Farwaniya Hospital
Ocular Graft vs Host Disease, Dry Eye
rhDNase Eye Drops in Patients With Ocular Graft-Vs.-Host Disease
The purpose of this study is to evaluate the tolerability and preliminary efficacy of rhDNase I eye drops in patients with ocular Graft-vs.-Host disease (oGVHD).
- Trial name
- NCT02702518
- Testing
- rhDNase I, Vehicle
- Where
- 2 sites in United States
- Volunteers
- 58 people
- Sponsor
- University of Illinois at Chicago
Chediak-Higashi Syndrome, Graft Versus Host Disease
Pilot Study of Unrelated Donor Hematopoietic Stem Cell Transplantation in Patients With Life Threatening Hemophagocytic Disorders
OBJECTIVES: I. Determine the efficacy of unrelated donor hematopoietic stem cell transplantation in the treatment of patients with life threatening hemophagocytic disorders. II.
- Conditions
- Chediak-Higashi Syndrome, Graft Versus Host Disease, X-Linked Lymphoproliferative Syndrome, Familial Erythrophagocytic Lymphohistiocytosis
- Trial name
- NCT00006056
- Testing
- anti-thymocyte globulin, busulfan, cyclophosphamide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Fairview University Medical Center
Graft-Versus-Host Disease
The Natural History of Graft-Versus-Host Disease in the Eyes
Background: Stem cell transplantation (SCT) is used to treat some kinds of cancer, blood cell disorders, and immune disorders. Stem cells from a donor s blood are used to replace the recipient s stem cells in the bone marrow.
- Trial name
- NCT01369914
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- National Eye Institute (NEI)
Graft Versus Host Disease
Ocular Graft Versus Host Disease After Hematopoietic Stem Cell Transplantation in Adults
The purpose of this study is to evaluate the presence and manifestations of ocular graft versus host disease in adults that had hematopoietic stem cell transplantation in the past 3 years at the sheba medical center, Israel.
- Trial name
- NCT00912067
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Sheba Medical Center
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Tacrolimus and Mycophenolate Mofetil in Preventing Graft-Versus-Host Disease in Patients Who Have Undergone Total-Body Irradiation With or Without Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant for Hematologic Cancer
This phase II trial studies how well tacrolimus and mycophenolate mofetil works in preventing graft-versus-host disease in patients who have undergone total-body irradiation (TBI) with or without fludarabine phosphate followed by…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Trial name
- NCT00089011
- Testing
- fludarabine phosphate, total-body irradiation, mycophenolate mofetil
- Where
- 5 sites in United States, Italy
- Volunteers
- 150 people
- Sponsor
- Fred Hutchinson Cancer Center
Ocular Graft-versus-host Disease
Safety and Efficacy of Pro-ocular™ 1% in Daily Scleral Lens Wearing Patients With Ocular Graft-versus-Host Disease
This clinical study seeks to evaluate the safety and efficacy of Pro-ocular™1% topical gel in patients with ocular Graft-versus-Host Disease who wear scleral lenses daily.
- Trial name
- NCT04769648
- Testing
- Pro-ocular™ Topical Gel 1%
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Glia, LLC
Dry Eye
Effect of UMSCs Derived Exosomes on Dry Eye in Patients With cGVHD
The purpose of this study is to determine whether Umbilical Mesenchymal Stem Cells (UMSCs) derived Exosomes could alleviate dry eye symptoms in patients with chronic Graft Versus Host Diseases (cGVHD).
- Trial name
- NCT04213248
- Testing
- Umbilical Mesenchymal Stem Cells derived Exosomes
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Graft Vs Host Disease, Haematological Malignancy
oGVHD After Bone Marrow Transplantation: a Territory-wide Cohort
Allogeneic Haematopoietic stem cell transplantation (HSCT) is an effective treatment for all array of blood or blood-producing organ disorders.
- Conditions
- Graft Vs Host Disease, Haematological Malignancy, Cancer
- Trial name
- NCT05170347
- Where
- Hong Kong
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Dry Eye, Ocular Graft vs Host Disease
Brimonidine Eye Drops for Treatment of Ocular Graft-vs-Host Disease (oGVHD)
The objective of this study is to establish whether patients with dry eye disease (DED) are able to tolerate receiving Brimonidine: 0.15% eye drops two times a day for twelve weeks (primary tolerability objective) and to…
- Conditions
- Dry Eye, Ocular Graft vs Host Disease, Meibomian Gland Dysfunction
- Trial name
- NCT02975557
- Testing
- Brimonidine 0.15%, Brimonidine 0.075%
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Sandeep Jain, MD
Dacryocystitis; Chronic
Nasolacrimal Sac Biopsy in Endoscopic Dacryocystorhinostomy
During dacryocystorhinostomy (DCR), the lacrimal sac wall biopsy is not routinely performed, but it is recommended if there is a suspicion of underlying disease other than preoperatively or intraoperatively chronic inflammation.
- Trial name
- NCT04793230
- Testing
- biopsying
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Al-Azhar University
Dry Eye, GVHD
Ocular Surface Disease in Chronic Graft-Versus-Host Disease (GVHD) Patients
This study aims to profile the ocular surface inflammation of chronic Graft-Versus-Host Disease patients by investigating conjunctival cells, and clinical imaging for conjunctival redness and tear stability.
- Trial name
- NCT02712762
- Testing
- Cross-sectional study
- Where
- Singapore
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Xerostomia, Graft-versus-host-disease
Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical Xerostomia
The goal of this clinical trial is to evaluate the safety and tolerability of injecting certain cells produced in bone marrow called mesenchymal stromal cells (MSCs) into salivary glands.
- Conditions
- Xerostomia, Graft-versus-host-disease, Sjogren's Disease
- Trial name
- NCT06392711
- Testing
- Mesenchymal Stromal Cells (MSC) Dose Level 0, Mesenchymal Stromal Cells (MSC) Dose Level 1
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Wisconsin, Madison
Chronic Ocular Graft-versus-host Disease
Electrostimulation Study for Ocular Graft vs. Host Disease
This trial is testing to see if electrostimulation treatment (ET) will be effective in treating those with ocular Graft vs. Host Disease.
- Trial name
- NCT07166848
- Testing
- Electrodes with Currents, Electrodes without Currents
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Zhonghui K. Luo, MD, PhD
Dry Eyes
Treatment of Ocular Graft-versus-Host Disease (GVHD) With Topical Loteprednol Etabonate 0.5%
The purpose of this research is to: 1. Evaluate the safety and efficacy of a steroid eye drop (Lotemax) in patients who have been diagnosed with graft-versus-host disease (GVHD), which is a complication that may occur after bone…
- Trial name
- Lotemax_BMT (NCT01695668)
- Testing
- Lotemax, Restasis
- Volunteers
- 75 people
- Sponsor
- University of Michigan
Ocular Graft Versus Host Disease
Study for the Treatment of Ocular Chronic Graft-Versus-Host Disease (GVHD) With Amniotic Fluid Eye Drops (AFED)
A Randomized, Double-blinded, Placebo-Controlled Study for the Treatment of Ocular Chronic Graft Verses Host Disease with Processed Amniotic Fluid (pAF) Drops.
- Trial name
- NCT03298815
- Testing
- Amniotic Fluid Eye Drops (AFED), Saline Solution
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Utah
Dry Eye Disease (DED), Graft-Versus-Host Disease(GVHD)
Evaluation of Allogenic Mesenchymal Stem Cell (MSC) Injection Therapy for Refractory Graft-versus-Host Disease (GVHD) Unresponsive to Conventional Treatments
This Phase IIB, multicenter, double-blind, randomized, and uncontrolled clinical trial aims to assess the efficacy and safety of subconjunctival injection of Mesenchymal Stem Cells (MSCs) in patients with Graft-versus-Host…
- Trial name
- TER-EYE (NCT06905834)
- Testing
- Subconjuntival injection of expanded allogenic adult adipose tissue-derived mesenchymal stem cells (ASC
- Volunteers
- 30 people
- Sponsor
- Instituto de Investigación Biomédica de Salamanca
Superior Limbic Keratoconjunctivitis, Dry Eye Syndromes
Diadenosine Polyphosphates and Mucin Associated With Ocular Surface Disorders
Dry eye disease, ocular graft-versus-host disease (GVHD), and superior limbic keratoconjunctivitis (SLK) are all ocular surface disorders which mostly involve the outer surface of the eye.
- Conditions
- Superior Limbic Keratoconjunctivitis, Dry Eye Syndromes, Graft Vs Host Disease
- Trial name
- NCT03731624
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation