Clinical trials: Ocular Hypertension Glaucoma
Glaucoma
Evaluation of a Novel Head-Mounted Device for Glaucoma Testing: A Proof-of-Concept Study
This proof-of-concept study aims to determine the feasibility and effectiveness of using a custom head-mounted device for visual field testing.
- Trial name
- NCT05030714
- Testing
- Visual Field Testing
- Where
- 2 sites in Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Brennan Eadie
Neuro-Ophthalmology, Optic Neuropathies
Optic Nerve Head Evaluation Through Multimodal Blood Flow Analysis: a Prospective Observational, Multi-center Study
OCT-A and eco-colordoppler are technologies which enable optic nerve head (ONH) blood perfusion detection. The aim of the study is to assess ONH vascular and structural components in optic neuropathies with and without ONH edema…
- Conditions
- Neuro-Ophthalmology, Optic Neuropathies, Optic Atrophy, Hereditary, Leber, Optic Neuropathy, Anterior Ischemic
- Trial name
- FlowONH (NCT07075887)
- Volunteers
- 70 people
- Sponsor
- Barboni
Open-Angle Glaucoma, Ocular Hypertension
Comparison of the Fixed Combinations of Brimonidine/Timolol and Dorzolamide/Timolol in Subjects With Open-Angle Glaucoma or Ocular Hypertension
This study compares the efficacy and tolerability/comfort of brimonidine/timolol and dorzolamide/timolol in patients with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00822055
- Testing
- brimonidine tartrate 0.2%/timolol maleate 0.5% fixed combination, dorzolamide hcl 2%/timolol maleate 0.5% fixed combination, brimonidine tartrate 0.2%/timolol maleate 0.5% fixed combination as adjunctive to current prostaglandin therapy
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- Allergan
Glaucoma, Glaucoma, Open-Angle
Electrical Stimulation for the Treatment of Glaucoma
The overall aim of this study is to see whether long-term electrical stimulation with a home-stimulation device works well and is safe for the treatment of open-angle glaucoma.
- Trial name
- rtACS (NCT05626491)
- Testing
- Repetitive, Transorbital Alternating Current Stimulation (rtACS)
- Where
- 4 sites in United States, Germany
- Volunteers
- 45 people
- Sponsor
- Stanford University
Congenital Glaucoma
Prospective Study of the Diagnostic and Therapeutic Management of Congenital Glaucoma in France
Evidence of a relationship between age at discovery of congenital glaucoma and visual acuity at 4 years of age. The delay in diagnosis is a factor of poor visual acuity.
- Trial name
- Conglau (NCT03077789)
- Testing
- TRABECULOTOMY
- Where
- 24 sites in France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Lille
Glaucoma
Effect of Prophylactic Aqueous Suppression on Hyperencapsulation of Ahmed Glaucoma Valves
After implantation of an Ahmed glaucoma valve in patients with glaucoma, hyperencapsulation phase is an unwanted postoperative phenomenon, typically occurring with the free 3 months postoperatively.
- Trial name
- NCT01535768
- Testing
- Aqueous Suppressant Eye Drops
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Credit Valley EyeCare
Open Angle Glaucoma
MIMS® Retrospective Chart Review
This is a post-market clinical follow-up, retrospective chart review of MIMS® surgical procedures conducted during time period between Sep 2023 and April 2025.
- Trial name
- NCT06614218
- Testing
- Minimally Invasive Micro Sclerostomy
- Where
- Armenia
- Volunteers
- 34 people
- Sponsor
- Sanoculis Ltd
Eye Diseases
Imaging of Corneal and Crystalline by Near Infrared Retro-illumination
Retroillumination photography is difficult. The reflections on the cornea and the lens are constant and prevent from obtaining a complete and clear image.
- Trial name
- RETRO-ILLUMI (NCT05717543)
- Testing
- Retro-illuminator
- Where
- France
- Volunteers
- 384 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Glaucoma
Ab Interno Gelatin Stent With Mitomycin C Using Targeted Supra-tenon's Placement
The Xen-45 gelatin microstent is a novel, bleb-forming microinvasive glaucoma surgery (MIGS). Despite demonstrating similar efficacy and safety to trabeculectomy (traditional surgery), the Xen-45 gelatin microstent continues to…
- Trial name
- NCT04454138
- Testing
- XEN-45 gelatin microstent
- Where
- Canada
- Volunteers
- 142 people
- Sponsor
- Prism Eye Institute
Glaucoma
The Effect of Direct Cyclophotocoagulation Using Endolaser in Silicon Induced Glaucoma: a Pilot Study.
Transcleral cyclophotocoagulation has been used to treat glaucoma secondary to silicone oil
- Trial name
- NCT05231252
- Testing
- Cyclophotocoagulation
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Kafrelsheikh University
Glaucoma, Glaucoma, Suspect
Reliability and Reproducibility of the Eye Check Tonometer
To investigate whether the new applanation tonometer (EyeCheck monitor) can provide intraocular pressure (IOP) measurements comparable to those of traditional tonometers such as the Goldmann applanation tonometer and the Tonopen.
- Trial name
- EyeCheck (NCT04639947)
- Testing
- EyeCheck, Traditional Tonometer (Goldmann and Tonopen)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Duke University
Glaucoma, Ocular Hypertension
Intraocular Pressure and Tolerability Study of Preservative-free Prostaglandins (Bimatoprost and Latanoprost) on Glaucoma and Ocular Hypertension: European, Multicentric, Investigator-led, Single Masked Study
Bimatoprost 0.03% preservative free monodose eye drops solution (BUDPF) is a new product composed of a synthetic prostamide, bimatoprost 0.3% in a preservative free formulation.
- Trial name
- SPORT (NCT01975714)
- Testing
- Preservative-free latanoprost, Preservative-free bimatoprost
- Where
- 7 sites in Austria, Belgium and 4 more
- Volunteers
- 67 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Glaucoma, Open-Angle
A Clinical Study To Assess The Safety And Effectiveness Of The OMNI® Surgical System
The purpose of this study is to evaluate the long-term safety and effectiveness of the OMNI® Surgical System in subjects who were treated under protocol #06213
- Trial name
- NCT05044793
- Testing
- OMNI® Surgical System
- Where
- 4 sites in United States
- Volunteers
- 70 people
- Sponsor
- Sight Sciences, Inc.
Open Angle Glaucoma, Ocular Hypertension
Efficacy Study of Travoprost APS Versus TRAVATAN
A Multi-Center Double-masked Study of the Safety and Efficacy of Travoprost APS Compared to TRAVATAN in Patients with Open-angle Glaucoma or Ocular Hypertension
- Trial name
- NCT00848536
- Testing
- Travoprost 0.004% (POLYQUAD-preserved) Eye Drops, Solution, Travoprost 0.004% (BAK-preserved) Eye Drops, Solution
- Volunteers
- 371 people
- Sponsor
- Alcon Research
Vision Impairment and Blindness, Glaucoma
Developing and Testing a Model to Identify Preventive Vision Loss Among Older Patients in General Practice
In this cohort study, the investigators will test vision screenings in Danish general practice for patients over 70 years of age with minimum one chronic condition.
- Conditions
- Vision Impairment and Blindness, Glaucoma, Age-Related Macular Degeneration, Cataract
- Trial name
- DETECT (NCT07015034)
- Testing
- focus on vision impairment in older patients in general practice
- Where
- 2 sites in Denmark
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Glaucoma, Corneal Damage
Corneal Endothelium After Glaucoma Surgery
The purpose of this trial is to study the change in corneal endothelial cell after glaucoma surgery, non-contact specular microscopic examination is performed for the patients who underwent glaucoma surgery; trabeculectomy and…
- Conditions
- Glaucoma, Corneal Damage, Intraocular Pressure
- Trial name
- NCT00863018
- Where
- South Korea
- Volunteers
- 61 people
- Sponsor
- Chungnam National University
Primary Open Angle Glaucoma or Ocular Hypertension
Study of Netarsudil Ophthalmic Solution in Subjects With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT)
To evaluate the effect on trabecular outflow facility of Netarsudil ophthalmic solution 0.02% compared to placebo
- Trial name
- NCT03233308
- Testing
- Netarsudil Ophthalmic Solution 0.02%
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Aerie Pharmaceuticals
Open Angle Glaucoma
A Comparison of Two Ab Interno Procedures in the Treatment of Glaucoma in Patients Undergoing Cataract Extraction
The purpose of this study is to compare the safety and efficacy of goniotomy performed with a novel ophthalmic knife compared to trabecular bypass stent implantation in mild to moderate glaucoma subjects who are also undergoing…
- Trial name
- NCT02784249
- Testing
- Goniotomy, Trabecular Micro-Bypass Stent, Cataract Extraction
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- New World Medical, Inc.
Glaucoma, Ocular Hypertension
Multiple Dose-escalation Study of AMA0076 in Patients With Ocular Hypertension or Primary Open-angle Glaucoma
The objective of this dose-escalation study is to evaluate the safety, tolerability and efficacy of AMA0076 in reduction of intraocular pressure in subjects with ocular hypertension or primary open-angle glaucoma.
- Conditions
- Glaucoma, Ocular Hypertension, Eye Disease
- Trial name
- NCT01693315
- Testing
- AMA0076
- Where
- 6 sites in United States
- Volunteers
- 82 people
- Sponsor
- Amakem, NV
Glaucoma
The Study of Ocular Hemodynamics With Glaucoma Progression
To determine the relationships between ocular hemodynamics and glaucomatous optic neuropathy progression.
- Trial name
- IGPS (NCT01145911)
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Indiana University
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