Clinical trials: Ocular Pain
Blepharoptosis
Comparison of Postoperative Pain With Two Different Types of Local Anesthesia in Surgery for a Drooping Eyelid
Conjunctival Mullerectomy is a well known procedure used to correct upper lid ptosis via a posterior approach. Patients who undergo this procedure are often given local anesthesia to alleviate intraoperative and postoperative…
- Trial name
- NCT01350024
- Testing
- Frontal nerve block with 2% lidocaine with 1:100,000 dilution of epinephrine, Subconjunctival injection of 2% lidocaine with 1:100,000 dilution with epinephrine
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Miami
Rheumatic Diseases, Lupus Erythematosus, Systemic
Pain Phenotyping of Rheumatic Diseases - An Observational Study
Background: Rheumatic diseases can affect the joints, ligaments, tendons, bones, muscles, and skin. They can also cause inflammation, damage body tissues, and change nerve signals in the brain.
- Conditions
- Rheumatic Diseases, Lupus Erythematosus, Systemic, Lupus Vasculitis, Central Nervous System, Arthritis
- Trial name
- NCT07829497
- Testing
- Bedside quantitative sensory testing
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Neck Pain, Visual Disturbances
Correlation Between Neck Pain and Visual Disturbances in Smartphone Users
the goal of this study is to Investigate the correlation between neck pain and visual disturbances in smartphone users.
- Trial name
- NCT06446700
- Testing
- neck disability index and visual functional questionnaire
- Where
- Egypt
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pain, Postoperative, Pain, Chronic
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
- Conditions
- Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury
- Trial name
- NCT04439552
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Retinal Disease
SteRilizing Eye SoLution to ImprovE Patient ComFort (RELIEF)
This is a randomized, double-masked study to evaluate the tolerability and safety of IRX-101 versus 5% povidone-iodine (PI) in subjects receiving intravitreal anti-VEGF injections.
- Trial name
- RELIEF (NCT05747430)
- Testing
- IRX-101, Providone-Iodine
- Where
- 7 sites in United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- iRenix Medical, Inc.
Migraine, Headache
Migraine Headache Mitigation Utilizing Avulux
This will be a randomized double blind cross over interventional trial to determine if Avulux lenses are able to reduce headache symptoms in patients
- Conditions
- Migraine, Headache, Photophobia
- Trial name
- NCT06149000
- Testing
- Avulux Lenses
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Normal Physiology, Healthy Volunteers
Sociocultural & Biobehavioral Influences on Pain Expression and Assessment
Objective The current proposal investigates behavioral, psychophysiological, and social processes that may help explain biases and disparate outcomes in pain.
- Conditions
- Normal Physiology, Healthy Volunteers, Pain
- Trial name
- NCT03258580
- Testing
- Medoc thermal stimulator, Electric shock stimulator, Cold water bath
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Autoimmune Diseases, Dry Eye
Use of Acthar Gel Single-Dose Pre-Filled SelfJectTM Injector in Patients With Moderate-Severe Keratitis and Autoimmune Disease
Single-site, open label pilot study of 20 autoimmune patients diagnosed with dry eye demonstrating via the proparacaine challenge some peripheral corneal pain component.
- Conditions
- Autoimmune Diseases, Dry Eye, Neurotrophic Keratitis
- Trial name
- MNK (NCT06964269)
- Testing
- Acthar Gel 80 UNT/ML Injectable Solution
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Toyos Clinic
Therapeutics
EMDR on Pain in Patients With in Patients Rheumatoid Arthritis
They explained the improvement of pain in patients with EMDR treatment in chronic pain with Shapiro's adaptive information processing model. According to this model; The nociceptive sense is related to the emotional response.
- Trial name
- NCT05944302
- Testing
- EMDR group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Mersin University
Chronic Neck Pain
The Effects of Spinal Manipulation on Performance on Neck Pain Patients During a Fitts' Task
The objective of this study is to quantify motor performance, this study will use an eye movement Fitts' task to examine the effects of cervical spine manipulation on participants with chronic neck pain and the subsequent changes…
- Trial name
- NCT04347551
- Testing
- High velocity/low amplitude cervical spine manipulation
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Retina--Diseases, Retinal Detachment
Evaluation of Discomfort Associated With Scleral Depression During Retina Examinations
Scleral depression is an important technique used to examine the peripheral retina but often causes patient discomfort. The goal of this study was to compare levels of discomfort during scleral depression with a Schocket scleral…
- Conditions
- Retina--Diseases, Retinal Detachment, Retinal Degeneration
- Trial name
- DEPRESS (NCT04115917)
- Testing
- Schocket scleral depressor, Cotton tipped applicator
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- New York City Health and Hospitals Corporation
Behcet's Disease, Central Sensitisation
Assessment of Central Sensitization, Neuropathic Pain, Sleep Quality and Daily Life Activities in Behcet's Disease
There are few studies in the literature regarding increased frequency of neuropathic pain and sleep disturbance and decreased quality of life in Behçet's disease.
- Trial name
- NCT03531385
- Testing
- Central sensitisation, Neuropathic pain, Sleep disturbance
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Refractive Surgery
The RESTORE Study, A Randomized, Controlled, Masked (Reading Center) Prospective Study
To determine patient preference and treatment outcomes with an intracanalicular dexamethasone (0.4mg) insert compared to standard steroid drop regimen in the contralateral eye following bilateral PRK surgery.
- Trial name
- NCT04396990
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, Topical Prednisolone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision
Computer Vision Syndrome, Asthenopia
Yogic Eye Exercises for Computer Vision Syndrome in Female Design Students
Computer vision syndrome (CVS) is a cluster of eye and musculoskeletal complaints - dryness, redness, blurred vision, foreign body sensation, excessive tearing, and neck, shoulder or back pain - that arises from prolonged work at…
- Conditions
- Computer Vision Syndrome, Asthenopia, Eye Strain, Dry Eye
- Trial name
- NCT07816419
- Testing
- Yogic eye exercise programme
- Where
- Saudi Arabia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- King Saud University
Myopia, Hyperopia
Comparison of Acular LS Versus Nevanac for Pain Control in Eyes Undergoing PRK
To determine the ability of two topical Nonsteroidal Anti-inflammatory drops (Acular LS \& Nevanac) to help control pain following Photorefractive Keratectomy (PRK).
- Trial name
- NCT00347204
- Testing
- ketorolac (Acular LS), Nepafenac (Nevanac)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Center For Excellence In Eye Care
Dermatochalasis, Blepharoptosis
Vibration-Assisted Anaesthesia
Aim of study is to investigate whether a small, non-invasive vibrating device applied to the forehead during local anaesthetic administration reduces the pain of the injection.
- Trial name
- NCT00793988
- Testing
- Vibration-assisted anaesthesia, Switched-off vibrating device
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Phacoemulsification
Clinical Analysis of Ocular Parameters Contributing to Intraoperative Pain During Standard Phacoemulsification
Charts of 142 patients who underwent standard phacoemulsification under topical anesthesia between March and August 2016 were reviewed.
- Trial name
- NCT03031652
- Testing
- Phacoemulsification
- Where
- South Korea
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Kyungpook National University Hospital
Cataract
"A Prospective Study of the Efficacy of Intracameral Dexamethasone (Dexycu™) Compared to Standard of Care Treatment for Post-Cataract Surgical Pain and Anterior Chamber Inflammation"
Cataract surgery is the most common surgical procedure performed on humans today. The postoperative regimen includes a combination of steroids, NSAIDs (non-steroidal anti-inflammatory drugs) and antibiotics.
- Trial name
- NCT04781335
- Testing
- Dexycu, Standard of Care post operative eye drops (steroid, antibiotic, NSAID)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- The Eye Institute of West Florida
Endometrial Cancer, Endometrial Diseases
Virtual Reality's Role in See&Treat Hysteroscopy
The aim of the study is to evaluate the feasibility and effectiveness of virtual reality technology in outpatient hysteroscopy to improve pain and anxiety management and spread the diffusion of see \& treat philosophy.
- Conditions
- Endometrial Cancer, Endometrial Diseases, Myoma;Uterus, Endometrial Hyperplasia
- Trial name
- NCT06524934
- Testing
- Use of virtual reality during the hysteroscopic procedure
- Where
- Italy
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Federico II University
Back Pain, Healthy Control
Computer-vision Aided Community Back Pain Physiotherapy Services
Back pain affects one-third of the UK population every year with a huge impact on the health service and economy. The aim of this study is to test the validity of a computer-vision (CV) technology that uses cameras on…
- Trial name
- CV (NCT04895826)
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University