Clinical trials: Ocular Surface Disease
Dry Eye Disease
A Study to Investigate the Effect of 0.003% AR-15512 on Subjects With Dry Eye Disease
The purpose of this study is to evaluate the effect of AR-15512 ophthalmic solution 0.003% (0.003% AR-15512) on ocular surface characteristics of subjects with dry eye disease (DED).
- Trial name
- NCT06544694
- Testing
- 0.003% AR-15512 ophthalmic solution, Artificial Tears
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Alcon Research
Open Angle Glaucoma, Ocular Hypertension
Travoprost APS Versus Xalatan® in Patient Reported Outcomes and Ocular Surface Health
The purpose of this study is to understand differences in visual function-related patient-reported outcomes between a non-BAK medication (Travoprost APS) and a BAK-preserved medication (XALATAN®) in patients with open-angle…
- Trial name
- NCT00892762
- Testing
- Travoprost APS 40 micrograms/ml eye drop solution, Latanoprost 50 micrograms/ml eye drop solution
- Volunteers
- 434 people
- Sponsor
- Alcon Research
Palpebral Pathologies, Ocular Surface Disease
Management of Eyelid Disorders by Ophthalmologists in Usual Medical Practice
The purpose of this study is to determine the incidence and characteristics of eyelid inflammatory disorders during general ophthalmological consultations and to demonstrate association between palpebral pathologies and ocular…
- Conditions
- Palpebral Pathologies, Ocular Surface Disease, Meibomian Gland Dysfunction
- Trial name
- MEIBUM (NCT01552174)
- Where
- 2 sites in Germany, Spain
- Volunteers
- 185 people
- Sponsor
- Laboratoires Thea
Glaucoma, Open-Angle, Ocular Hypertension
Ocular Surface Tolerability Study of Prostaglandin Analogues in Patients With Open-Angle Glaucoma or Ocular Hypertension
This study evaluated the ocular surface tolerability of the prostaglandin analogues bimatoprost ophthalmic solution 0.01% (Lumigan® 0.01%), travoprost ophthalmic solution 0.004% (Travatan Z®) and latanoprost ophthalmic solution…
- Trial name
- NCT01253902
- Testing
- bimatoprost ophthalmic solution 0.01%, travoprost ophthalmic solution 0.004%, latanoprost ophthalmic solution 0.005%
- Where
- 2 sites in United States, Canada
- Volunteers
- 164 people
- Sponsor
- Allergan
Glaucoma, Ocular Hypertension
Effects of Travatan Z and Xalatan on Ocular Surface Health
The purpose of this randomized, double-masked, parallel-group, multicenter study is to evaluate ocular surface effects after the administration of travoprost with SofZia® preservative system or Xalatan once daily for 12 weeks.
- Trial name
- NCT00708422
- Testing
- Travoprost ophthalmic solution 0.004% with SofZia® preservative system (TRAVATAN Z®), Latanoprost ophthalmic solution 0.005% (XALATAN®)
- Volunteers
- 231 people
- Sponsor
- Alcon Research
Glaucoma
Safety and Tolerability of the Preservative-free Ophthalmic Solution PRO-122 Compared With Krytantek Ofteno®
Therapeutic indication: Ocular hypotensive Use: Primary open-angle glaucoma and ocular hypertension. Objectives: To evaluate the safety and tolerability of the preservative-free formulation PRO-122 manufactured by Sophia…
- Trial name
- PRO-122/I (NCT03966365)
- Testing
- PRO-122, Krytantek Ofteno®
- Where
- Mexico
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Open Angle Glaucoma, Ocular Hypertension
DuoTrav APS Versus XALACOM® in Ocular Surface Health
To demonstrate superiority of DuoTrav APS over XALACOM® in Ocular Surface Health in patients with open angle glaucoma or ocular hypertension.
- Trial name
- NCT00912054
- Testing
- DuoTrav APS, Xalacom
- Where
- Belgium
- Volunteers
- 240 people
- Sponsor
- Alcon Research
Dry Eye Disease
Study on Safety and Performance of an Artificial Tear in Dry Eye Treatment in Subjects With Ocular Surface Inflammation
This is post-market study to evaluate the safety and efficacy of MDI - 101 a novel tear substitute for the treatment of dry eye (DE) in subjects with evidence of inflammation of the ocular surface.
- Trial name
- NCT04633863
- Testing
- Artificial tear MDI - 101
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- MD Italy
Dry Eye
Efficacy and Safety Study of FID 119515A
The purpose of this study was to compare the effect of FID 119515A to Blink® Tears on the integrity of tear film in adults with a history of dry eye in both eyes.
- Trial name
- NCT01833117
- Testing
- FID 119515A, Blink® Tears
- Volunteers
- 75 people
- Sponsor
- Alcon Research
Eyelid Diseases
Evaluation of Satisfaction Regarding Patient's Management of Ocular Surface Diseases
Multicentric study, open label, uncontrolled phase IV in 140 patients with meibomian glands dysfunction . Its objective is to Collect information from patients and ophthalmologists specialized in ocular surface and eyelids to…
- Trial name
- ESPOIR Ext (NCT01189474)
- Testing
- Blephasteam
- Where
- 29 sites in France
- Volunteers
- 104 people
- Sponsor
- Laboratoires Thea
Eye Pain
A Clinical Study to Determine What Effect the EyeCool Treatment Has on the Eye's Surface Anatomy and Inflammation Response After Being Treated for Having Chronic Ocular Surface Pain (COSP)
The goal of this clinical trial is to understand what effect a cold treatment with an investigational device, ETX-4143, has on the anatomical structures and the inflammatory response of the surface of the eye in those people who…
- Trial name
- NCT07059754
- Testing
- Topical Ophthalmic Cooling
- Where
- Australia
- Volunteers
- 5 people
- Sponsor
- EyeCool Therapeutics, Inc.
Eyelid Diseases
Evaluation of Satisfaction Regarding Patient's Management of Ocular Surface Diseases
Multicentric study, open label, uncontrolled phase IV in 30 patients with meibomian glands dysfunction . Its objective is to Collect information from patients and ophthalmologists specialized in ocular surface and eyelids to…
- Trial name
- ESPOIR (NCT01091311)
- Testing
- Blephasteam
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Laboratoires Thea
Graft Versus Host Disease, Ocular Surface Disease
Study of Brimonidine Tartrate Nanoemulsion Eye Drops in Patients With Ocular Graft-vs-Host Disease
This study evaluates the use of Brimonidine tartrate nanoemulsion eye drop solution in the treatment of ocular Graft Verses Host Disease (oGVHD).
- Conditions
- Graft Versus Host Disease, Ocular Surface Disease, oGVHD, Ocular Graft vs Host Disease
- Trial name
- oGVHD (NCT03591874)
- Testing
- Brimonidine Tartrate
- Where
- 13 sites in United States
- Volunteers
- 59 people
- Sponsor
- Ocugen
Chronic Ocular Pain
Study of Efficacy and Safety of SAF312 Eye Drops in Subjects With Post-operative Corneal Induced Chronic Pain (CICP)
The study was designed to demonstrate the safety and efficacy of two dose concentrations of SAF312 eye drops (5 mg/mL and 15 mg/mL) in subjects with CICP persisting at least for 4 months after refractive or cataract surgery and…
- Trial name
- NCT04630158
- Testing
- SAF312
- Where
- 28 sites in United States, Japan and 1 more
- Volunteers
- 153 people
- Sponsor
- Novartis Pharmaceuticals
Open-angle Glaucoma, Ocular Hypertension
Examination of Ocular Surface Effects With Administration of Travatan Z and XALATAN
The purpose of this study is to compare two ophthalmic solutions in patients with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00798759
- Testing
- Travoprost ophthalmic solution 0.004% with SofZia® preservative system (TRAVATAN Z®), Latanoprost ophthalmic solution 0.005% (XALATAN®)
- Volunteers
- 236 people
- Sponsor
- Alcon Research
Dry Eye Syndromes, Dry Eye
The Effect of Rinsing on Ocular Inflammation and Symptoms in Patients With Dry Eye Disease
The central hypothesis is that inflammation contributes to dry eye and that rinsing the palpebral conjunctiva, bulbar conjunctiva, and fornices will reduce the inflammatory burden on the ocular surface.
- Conditions
- Dry Eye Syndromes, Dry Eye, Ocular Surface Disease
- Trial name
- RINSE-A (NCT07618364)
- Testing
- Rinsada
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Rinsada
Dry Eye Disease
Management of the Ocular Surface With Preservative-Free Lubricants in Patients With Dry Eye
Observational and prospective cohort study that seek to evaluate the epidemiological characteristics and changes in the ocular surface of patients diagnosed with dry eye disease who are treated with preservative-free lubricating…
- Trial name
- NCT06162442
- Testing
- Preservative-free sterile ophthalmic solution, with 0.3% propylene glycol and 0.4% polyethylene glycol (400)
- Where
- Colombia
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Tecnoquimicas
Pterygia
Efficacy of Topical Cyclosporine 0.05% in the Prevention of Ocular Surface Inflammation Secondary to Pterygia
To Determine if topical cyclosporine 0.05% BID prevents recurrent inflammation and improves comfort in eyes with pterygia.
- Trial name
- NCT00383396
- Testing
- Topical Cyclosporine
- Where
- United States
- Sponsor
- Innovative Medical
Primary Open-Angle Glaucoma (POAG), Ocular Hypertension
Dorzolamide/Brimonidine/Timolol Impact on Ocular Surface, Glaucoma Progression & Chatbot Follow-up: GLAUCO-TECH
The primary objective of this study is to evaluate the ocular surface safety of an ophthalmic solution indicated for the management of glaucoma, containing the active ingredients dorzolamide, timolol, and brimonidine, in patients…
- Trial name
- GLAUCO-TECH (NCT07690397)
- Testing
- Preservative-free dorzolamide-timolol-brimonidine combination, Preservative dorzolamide-timolol-brimonidine combination
- Where
- Colombia
- Volunteers
- 140 people
- Sponsor
- Tecnoquimicas
Dry Eye, Dry Eye Syndrome of Unspecified Lacrimal Gland
Safety and Tolerability of the Ophthalmic Gel PRO-167 Versus Corneregel® on Healthy Subjects.
Title of the study: Phase I clinical trial, to evaluate the safety and tolerability of the ophthalmic gel PRO-167 versus Corneregel®, on the ocular surface of ophthalmological and clinically healthy subjects.
- Trial name
- PRO-167/I (NCT03520348)
- Testing
- PRO-167, Corneregel
- Where
- Mexico
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.