Clinical trials: Oedema
Macular Edema, Retinal Vein Occlusion
A Study to Evaluate the Efficacy, Durability, and Safety of KSI-301 Compared to Aflibercept in Patients With Macular Edema Due to Retinal Vein Occlusion (RVO)
This Phase 3 study will evaluate the efficacy, durability, and safety of KSI-301 compared to aflibercept, in participants with macular edema due to treatment-naïve branch (BRVO) or central retinal vein occlusion (CRVO).
- Trial name
- BEACON (NCT04592419)
- Testing
- KSI-301, Aflibercept
- Where
- 141 sites in United States, Czechia and 10 more
- Volunteers
- 568 people
- Sponsor
- Kodiak Sciences Inc
Unilateral Acoustic Neuroma, Meniere's Disease
Cochlear Implantation After Labyrinthectomy or a Translabyrinthine Surgical Approach
The goal of this project is to determine whether subjects who have undergone labyrinthectomy or a translabyrinthine surgical approach as the treatment for vestibular schwannoma or Meniere's disease benefit from cochlear…
- Trial name
- NCT02309099
- Testing
- Cochlear Implant
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of North Carolina, Chapel Hill
Edematous Fibrosclerotic Panniculopathy (EFP), Cellulite
Effects of Mitigation Treatments on Bruising of CCH-aaes Treatment of Buttock Cellulite
This study will investigate treatments that may mitigate bruising after QWO™ (Collagenase clostridium histolyticum [CCH]-aaes) treatment of cellulite in the buttocks.
- Trial name
- MOBI (NCT04677712)
- Testing
- CCH-aaes, Compression, Cold Packs
- Where
- 8 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Central Retinal Vein Occlusion, Branch Retinal Vein Occlusion
Retrospective Study of the Effectiveness and Safety of Niacin and Steroid Eye Drops for Retinal Vein Occlusions
The aim of this study is to develop a less risky, yet effective and more sustainable treatment for retinal vein occlusions than the current commonly used approach of repeated intravitreal triamcinolone acetonide (Kenalog)…
- Trial name
- NCT00500045
- Testing
- nicotinic acid
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Palo Alto Medical Foundation
Intracranial Aneurysm, Brain Edema
Goal-Directed Intraoperative Fluid Management Using FloTrac© Monitoring in High-Risk Neurosurgical Patients
This is a prospective, randomized controlled trial to determine if using FloTrac/EV1000 system in neurosurgical patients undergoing craniotomies for aneurysm repair or tumor resection complicated by cerebral edema, or complex…
- Conditions
- Intracranial Aneurysm, Brain Edema, Scoliosis, Surgery
- Trial name
- NCT02701582
- Testing
- Phenylephrine, Epinephrine, Albumin
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- NYU Langone Health
Diabetic Macular Edema
Diabetic Macular Edema Treated With Ozurdex (DMEO)
To measure various pro-permeability factors in the aqueous humor of patients with persistent/recurrent diabetic macular edema
- Trial name
- DMEO (NCT01951066)
- Testing
- Dexamethasone Implant, Anti-VEGF injection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Cardiac Failure, Renal Failure
Protocolized Diuretic Strategy in Cardiorenal Failure
This research study is a randomized clinical trial to evaluate if taking diuretics (medications that increase urine production and help with fluid removal from the body) in a standardized fashion (using a guideline for adjusting…
- Conditions
- Cardiac Failure, Renal Failure, Kidney Failure
- Trial name
- ProDiuS (NCT01921829)
- Testing
- Protocolized Diuretic Strategy
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Kelly V. Liang, MD
Edema, Erythema
Pembrolizumab in Treating Patients With Stage IV Metastatic or Recurrent Inflammatory Breast Cancer or Triple-Negative Breast Cancer Who Have Achieved Clinical Response or Stable Disease to Prior Chemotherapy
This phase II trial studies how well pembrolizumab works in treating patients with stage IV inflammatory breast cancer or triple-negative breast cancer that has spread to other places in the body (metastatic) or has come back…
- Conditions
- Edema, Erythema, Estrogen Receptor Negative, HER2/Neu Negative
- Trial name
- NCT02411656
- Testing
- Laboratory Biomarker Analysis, Pembrolizumab
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- M.D. Anderson Cancer Center
Diabetic Macular Edema
The Ranibizumab for Edema of the mAcula in Diabetes-2 (READ-2) Study
This study is being done to see if the investigational drug Ranibizumab (RBZ) given by injection into the eye, is safe and effective to use in people with diabetic macular edema (DME).
- Trial name
- NCT00407381
- Testing
- Ranibizumab, Laser photocoagulation
- Where
- 20 sites in United States
- Volunteers
- 126 people
- Sponsor
- Johns Hopkins University
Hypertension
A Study to Evaluate Methodologies for Measuring Swelling of the Leg and Ankle (MK-0000-106)(COMPLETED)
This study will evaluate methodologies for measuring pedal edema associated with calcium channel blockers in middle-aged and elderly subjects and patients with hypertension.
- Trial name
- NCT00789321
- Testing
- Comparator: amlodipine besylate
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Inherited Ophthalmic Diseases, Inherited Retinal Degeneration
Interferon Gamma-1b Administered Topically for Macular Edema/Intraretinal Schisis Cysts in Rod-Cone Dystrophy (RCD) and Enhanced S-Cone Syndrome (ESCS)
Background: People with rod-cone dystrophy (RCD) or enhanced S-cone syndrome (ESCS) have excess fluid under the retina of their eye. This can cause vision loss.
- Trial name
- NCT02338973
- Testing
- Interferon gamma-1b
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- National Eye Institute (NEI)
Brain Swelling, Brain Edema
Furosemide vs Placebo for Brain Relaxation
Increased brain bulk may be problematic during brain surgery for tumors because it may limit surgical exposure and access to the surgical site.
- Conditions
- Brain Swelling, Brain Edema, Dehydration
- Trial name
- NCT01054404
- Testing
- Furosemide
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Northwestern University
Diabetic Macular Edema
Fluocinolone Acetonide Implant Compared to Sham Injection in Patients With Diabetic Macular Edema
This study will evaluate the safety and efficacy of an intravitreal insert of fluocinolone acetonide for the treatment of diabetic macular edema.
- Trial name
- FAME (NCT00344968)
- Testing
- fluocinolone acetonide, Standard of care laser photocoagulation
- Where
- United States
- Volunteers
- 956 people
- Sponsor
- Alimera Sciences
Macular Edema, Cystoid, Vision Disorders
Intraoperative Dexamethasone Implant Improves Outcome of Cataract Surgery With Diabetic Macular Edema
This study is undertaken to determine the effect of intravitreal long acting dexamethasone implant, (Ozurdex®) in improving outcome of cataract surgery in patients with diabetic macular edema.
- Conditions
- Macular Edema, Cystoid, Vision Disorders, Diabetic Macular Edema, Cystoid Macular Edema Following Cataract Surgery
- Trial name
- NCT01546402
- Testing
- Dexamethasone Drug delivery system (Ozurdex), Cataract surgery
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Acute Heart Failure, Cardiac Decompensation
Global rEgistry on decongestioN Therapy Using Less invasivE UltraFiltration
In patients with advanced volume overload, minimally invasive ultrafiltration treatment in the acute phase can have a positive effect on clinical outcome.
- Conditions
- Acute Heart Failure, Cardiac Decompensation, Volume Overload
- Trial name
- GENTLE-UF (NCT02769351)
- Testing
- periph. minimal invasive ultrafiltration
- Where
- 19 sites in Germany, Sweden and 1 more
- Volunteers
- 104 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Posterior Capsule Opacification, Retinal Degeneration
Changes of Macular Pigment and Parameters of Eyes After YAG Laser Treatment in Cases With Capsule Opacification
It has been hypothesized that potential effects of laser Nd: YAG laser posterior capsulotomy may affect macular pigment as well as choroidal thickness, macular thickness and anterior chamber parameters, so it was aimed to…
- Conditions
- Posterior Capsule Opacification, Retinal Degeneration, Retinal Detachment, Anterior Chamber Angle Congestion
- Trial name
- NCT03321253
- Testing
- Nd: YAG laser posterior capsulotomy
- Volunteers
- 38 people
- Sponsor
- Afyon Kocatepe University Hospital
Nephrotic Syndrome, Edema
Amiloride in Nephrotic Syndrome
The AMILOR study compares treatment of edema in nephrotic syndrome with Amiloride vs. Furosemide.
- Conditions
- Nephrotic Syndrome, Edema, Sodium Retention
- Trial name
- AMILOR (NCT05079789)
- Testing
- Amiloride, Furosemide
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Tuebingen
Corneal Endothelial Dystrophy, Corneal Edema
Loteprednol Etabonate 0.25% for Prevention of Cornea Transplant Rejection
The purpose of this study is to assess off-label use of loteprednol etabonate 0.25% ophthalmic suspension (Eysuvis) for prevention of immunologic rejection in the first year after Descemet membrane endothelial keratoplasty…
- Trial name
- NCT05136443
- Testing
- loteprednol etabonate 0.25% ophthalmic suspension
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Price Vision Group
Meniere Disease
Assessing the Efficacy of a Serotonin and Norepinephrine Reuptake Inhibitor for Improving Meniere's Disease Outcomes
As of yet, the cause of Meniere's disease is uncertain and there is no cure. Given the lack of high level evidence for treatments, we seek to perform a randomized, placebo-controlled, double-blind, crossover, pilot trial of…
- Trial name
- NCT04218123
- Testing
- Venlafaxine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical University of South Carolina
Macular Edema
Efficacy and Safety of VEGF Trap Eye in Diabetic Macular Edema (DME) With Central Involvement
To determine the efficacy of intravitreally (IVT) administered VEGF Trap-Eye on the best-corrected visual acuity (BCVA) assessed by the early treatment diabetic retinopathy study (ETDRS) chart in subjects with diabetic macular…
- Trial name
- VIVID EAST (NCT01783886)
- Testing
- Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321), Macular Laser Photocoagulation
- Where
- 25 sites in China, Hong Kong and 2 more
- Volunteers
- 381 people
- Sponsor
- Bayer