Clinical trials: Off Pump Coronary Artery Bypass Surgery
Cardiac Surgery
Dynamic Tests and Parameters to Predict Fluid Responsiveness After OPCAB
Objective: To assess the predictive value of dynamic tests and parameters for evaluation of fluid responsiveness after off-pump coronary artery bypass grafting (OPCAB).
- Trial name
- NCT04482946
- Testing
- Assessment of fluid responsiveness
- Where
- Russia
- Volunteers
- 32 people
- Sponsor
- Northern State Medical University
Coronary Artery Disease, Erector Spinae Plane Block
Effects of Erector Spinae Plane Block Method Used in Pain Management in Heart Surgery on Vascular Diameters
Off-pump coronary artery bypass grafting (OPCABG) is a bypass method performed on the working heart. Pain is a frequently seen side effect experienced following this surgery.
- Conditions
- Coronary Artery Disease, Erector Spinae Plane Block, Bypass Extremity Graft
- Trial name
- NCT04447560
- Testing
- Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Koç University
Hemodynamics
Levosimendan Versus Milrinone in Off Pump CABG Surgery
To compare the efficacy of Levosimendan versus Milrinone in supporting hemodynamics during off-pump coronary artery bypass grafting surgery in patients with low ejection fraction.
- Trial name
- NCT03855579
- Testing
- Levosimendan, Milrinone
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Coronary Artery Disease Amenable to Bypass Graft Surgery
Graft Patency in Beating Heart Vs. Conventional CABG Using Cardiac CT
The purpose of this study is to compare graft patency rates following coronary artery bypass graft surgery performed by beating heart vs. conventional techniques using cardiac CT scanning to evaluate the bypass grafts.
- Trial name
- NCT00259493
- Testing
- Off-Pump Coronary Artery Bypass Graft Surgery
- Where
- Canada
- Volunteers
- 350 people
- Sponsor
- Trillium Health Centre
A Total of 234 Patients With Acute Coronary Syndrome Who Will Undergo OPCAB.
Impact of High-dose Pretreatment of Rosuvastatin in Patients With Acute Coronary Syndrome Following Off-pump Coronary Artery Bypass: Results From the HIROP-ACS (HIgh-dose Pretreatment of Rosuvastatin During Off-Pump Coronary Bypass in Acute Coronary Syndrome) Study
Periprocedural treatment with high-dose statins is known to have cardioprotective and pleiotropic effects, such as anti-thrombotic and anti-inflammatory actions.
- Trial name
- NCT01971606
- Testing
- Rosuvastatin
- Where
- South Korea
- Volunteers
- 234 people
- Sponsor
- Yonsei University
Coronary Artery Disease, Stroke
Effects of Left Atrial Appendage Resection and Marshall Ligament Amputation on Clinical Outcome in Patients Undergoing Off-pump Coronary Artery Bypass
Surgical occlusion of the left atrial appendage (LAAO) is sometimes performed during the cardiac surgery to reduce long-term risk of stroke.A previous study found that LAAO may be associated with increased risk of postoperative…
- Conditions
- Coronary Artery Disease, Stroke, Atrial Fibrillation
- Trial name
- NCT04220047
- Testing
- Left Atrial Appendage Resection and Marshall Ligament Amputation
- Where
- China
- Volunteers
- 400 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Heart Disease
Studies of Application of Combined General Anesthesia and Bilateral TPVB in OPCABG
This study intends to compare the combination of general anesthesia (GA) and single-shot bilateral thoracic paravertebral block (TPVB) by ropivacaine in the patients undergoing off-pump coronary artery bypass surgery ( OPCAB)…
- Trial name
- NCT02727712
- Testing
- bilateral thoracic paravertebral block, Transesophageal Echocardiography（TEE）, Lung protection measure during the surgery（Dräger Primus）
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xiangya Hospital of Central South University
Off Pump Coronary Artery Bypass Surgery
Tranexamic Acid in Off-pump Coronary Surgery
The aim of this prospective, randomized, double-blinded, placebo-controlled study was to evaluate the effects of tranexamic acid, a synthetic antifibrinolytic drug, on the postoperative bleeding and transfusion requirements in…
- Trial name
- TAOPCAB (NCT01064167)
- Testing
- Tranexamic Acid
- Where
- China
- Volunteers
- 231 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Off Pump Coronary Artery Bypass Graft
Volatile Versus Propofol Anesthesia in OPCAB
Off pump coronary artery bypass graft (OPCAB) still requires myocardial protection owing to intermittent regional ischemic episode.
- Trial name
- NCT02222142
- Testing
- Isoflurane
- Where
- South Korea
- Volunteers
- 1,080 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease
Clinical Significance of Platelet Reactivity on Clopidogrel During Off-pump Coronary Artery Bypass
Objective: To evaluate the early and late prognoses of patients according to platelet reactivity after clopidogrel administration and determine whether the measurement of platelet inhibition predicted 1-year clinical outcomes…
- Trial name
- NCT01959191
- Testing
- Dual antiplatelet therapy including aspirin and clopidogrel after off-pump coronary bypass surgery
- Where
- South Korea
- Volunteers
- 859 people
- Sponsor
- Yonsei University
Coronary Artery Disease, Off Pump Coronary Artery Bypass Surgery
Early Cardioprotective Effect of Sevoflurane
In vitro studies and in vivo animal experiments have shown that halogenated volatile anesthetics have a protective effect on the ischemic myocardium.
- Trial name
- NCT00477737
- Testing
- Sevoflurane, propofol
- Where
- Croatia
- Volunteers
- 32 people
- Sponsor
- University Hospital Dubrava
Heart Disease
Study of NU172 as Anticoagulation in Patients Undergoing Off-pump CABG Surgery
This is a Phase 2, multicenter, open-label, single-arm, sequential cohort study to be conducted in up to 30 subjects. The study will evaluate subjects undergoing primary, elective, off-pump CABG surgery with median sternotomy.
- Trial name
- SNAP-CABG-OFF (NCT00808964)
- Testing
- NU172
- Volunteers
- 30 people
- Sponsor
- ARCA Biopharma, Inc.
Ischemic Heart Disease
Myocardial Injury in Remifentanil-based Versus Sevoflurane-sufentanil Balanced Regimens in OPCAB Surgery
In patients undergoing off-pump coronary artery bypass (OPCAB) surgery with different anesthesia regimens: remifentanil (0.75 mcg/kg/min) and propofol (TCI effect-site concentration 0.8-1.5 mcg/ml) (Group -RP); remifentanil (0.75…
- Trial name
- NCT02499445
- Testing
- Remifentanil, sevoflurane 1, sevoflurane 2
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Konkuk University Medical Center
Elective Off-pump Coronary Artery Bypass Grafting
Relation Between Mixed Venous Oxygen Saturation and Cerebral Oxygen Saturation Measured by Absolute and Relative Near-infrared Spectroscopy During Off-pump Coronary Artery Bypass Grafting.
In this clinical study the investigators compared mixed venous oxygen saturation (SmvO2) with relative and absolute cerebral oxygen saturation (rScO2) measurements.
- Trial name
- NCT01673841
- Testing
- Relative and absolute cerebral oxygen saturation (rScO2) measurements.
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- University Hospital, Ghent
Heart Failure, Coronary Arterial Disease
Effect of Dapagliflozin on Right Ventricular-Pulmonary Artery Coupling After Off-Pump Coronary Atery Bypass Grafting
This prospective, single-center observational study evaluates the effect of dapagliflozin 10 mg/day on right ventricular-pulmonary artery coupling measured by the TAPSE/PASP ratio in 72 patients with left ventricular ejection…
- Trial name
- DAPA-RV-CABG (NCT07601867)
- Where
- Russia
- Volunteers
- 72 people
- Sponsor
- Pyatigorsk City Clinical Hospital Number 1
Delirium
The Effects of Anaesthetic Agents on Postoperative Delirium
The purpose of this study is to prove the correlation between the post-operative delirium (POD) and anesthetic agents. The investigators hypothesized that intravenous anaesthetics would show the lower incidence of POD, compared…
- Trial name
- NCT02374177
- Volunteers
- 292 people
- Sponsor
- Konkuk University Medical Center
OPCABG
Study on the Myocardial Protective Effect of Upper Limb Ischemic Preconditioning in Patients Undergoing Off-pump Coronary Artery Bypass Grafting
The purpose of the study was to verify the myocardial protective effect of RIPC in patients undergoing OPCABG.
- Trial name
- NCT03340181
- Testing
- RIPC
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Shanghai Zhongshan Hospital
Complications Due to Coronary Artery Bypass Graft, Graft Failure
Patency-Coronary Trial
Heart bypass surgery is used to increase blood flow to the heart. This surgery is usually done using a heart-lung machine (on-pump surgery) allowing the surgeon to perform the procedure on a still heart.
- Trial name
- PATENCY (NCT01414049)
- Testing
- On-pump CABG, Off-pump CABG
- Where
- 3 sites in Canada
- Volunteers
- 1,200 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Coronary Artery Disease, Anesthesia
Xenon in Off-pump Coronary Artery Bypass Graft Surgery
Purpose of this study is to test whether xenon application during off-pump-coronary artery bypass (OPCAB)-surgery is safe and feasible.
- Trial name
- NCT01757106
- Testing
- Xenon, sevoflurane
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Coronary Disease
Comparison of the Risk of Stroke With On- Versus Off-Pump Coronary Artery Bypass Grafting
This study will compare the safety of coronary artery bypass grafting (CABG) with and without the use of heart-lung bypass during surgery (on- versus off-pump surgery).
- Trial name
- NCT00046410
- Where
- United States
- Volunteers
- 340 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)