Clinical trials: Off Pump Coronary Artery Bypass Surgery
Ischemic Heart Disease
Pulse Pressure Variation (PPV) to Predict Fluid Responsiveness During Cardiac Displacement in Patients Undergoing Off-pump Coronary Artery Bypass Surgery (OPCAB)
Pulse pressure variation (PPV) known as a dynamic preload index is increasingly being used for guide of fluid management under various clinical situations.
- Trial name
- NCT01041742
- Testing
- fluid loading
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- Seoul National University Hospital
Thrombocytopenia, Thrombosis
Angiomax in Patients With HIT/HITTS Type II Undergoing Off-Pump Coronary Artery Bypass Grafting (CABG) (CHOOSE)
The purpose of this study is to examine the safety and efficacy of Angiomax as an anticoagulation in patients with heparin-induced thrombocytopenia (HIT)/heparin-induced thrombocytopenia with thrombosis syndrome (HITTS)…
- Conditions
- Thrombocytopenia, Thrombosis, Cardiac Disease, Coronary Artery Bypass Surgery
- Trial name
- NCT00073580
- Testing
- Angiomax (bivalirudin) anticoagulant
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- The Medicines Company
Postoperative Cognitive Dysfunction (POCD)
Cohort Study of Postoperative Cognitive Dysfunction After Off-Pump Coronary Artery Bypass Grafting
This prospective cohort study aims to investigate postoperative cognitive dysfunction in patients undergoing off-pump coronary artery bypass grafting. Eligible patients will be enrolled before surgery and followed after surgery.
- Trial name
- OPCAB-POCD (NCT07643194)
- Testing
- Off-Pump Coronary Artery Bypass Grafting
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Occlusive Disease
Intraoperative Epiaortic Scanning for Preventing Early Stroke After Off-pump Coronary Artery Bypass
Recently epiaortic ultrasound scanning (EAS) has been recommended as an intraoperative tool to accurately assess ascending aorta disease. To date, several studies have reported that EAS is superior to TEE and surgical palpation
- Trial name
- NCT01764763
- Volunteers
- 2,292 people
- Sponsor
- Yonsei University
Coronary Artery Occlusive Disease(CAOD)
The Effect of Balanced Crystalloid Versus 5% Albumin on Endothelial Glycocalyx Degradation in Patients Undergoing Off-pump Coronary Artery Bypass Surgery
It is being revealed that the more severe the damage of the endothelial glycocalyx (EG) layer, the more likely it is that the prognosis of the patients is poor.
- Trial name
- NCT03699462
- Testing
- Plasma solution-A injection, 5% Albumin
- Where
- South Korea
- Volunteers
- 106 people
- Sponsor
- Yonsei University
Acute Normovolemic Hemodilution, Off-Pump Coronary Artery Bypass Surgery
Acute Normovolemic Hemodilution in Off-pump CABG
To study the effects of Acute normovolemic hemodilution on central and peripheral perfusion in patients Undergoing off-pump coronary artery bypass grafting surgery
- Trial name
- NCT04042883
- Testing
- Acute normovolemic hemodilution
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Acute Kidney Injury
Renal Oxygen Saturation During Off-pump Coronary Artery Bypass Graft Surgery
The purpose of this study is to evaluate changes in renal oxygen saturation (rrSO2) and its relationship with central venous oxygen saturation (cvSO2), cerebral cortical oxygen saturation (rcSO2), and hemodynamic parameters while…
- Trial name
- OPCAB (NCT04679337)
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Yeungnam University College of Medicine
Coronary Artery Disease Amenable to Bypass Graft Surgery
Graft Patency in Beating Heart Vs. Conventional CABG Using Cardiac CT
The purpose of this study is to compare graft patency rates following coronary artery bypass graft surgery performed by beating heart vs. conventional techniques using cardiac CT scanning to evaluate the bypass grafts.
- Trial name
- NCT00259493
- Testing
- Off-Pump Coronary Artery Bypass Graft Surgery
- Where
- Canada
- Volunteers
- 350 people
- Sponsor
- Trillium Health Centre
Coronary Artery Occlusive Disease
The Effect of 6% Hydroxyethyl Starch 130/0.4 on Blood Loss and Coagulation in Patients Medicated With Antiplatelet Agents Prior to Off-Pump Coronary Bypass Graft Surgery
HES 130/0.4 significantly solution will not affect on coagulation and blood loss in patients medicated with antiplatelet agents prior to off-pump coronary bypass surgery (OPCAB).
- Trial name
- NCT01051206
- Testing
- 6% hydroxyethyl Stach 130/0.4
- Where
- South Korea
- Volunteers
- 106 people
- Sponsor
- Yonsei University
Coronary Disease, Atrial Fibrillation
Carvedilol Versus Metoprolol for the Prevention of Atrial Fibrillation After Off-Pump Coronary Bypass Surgery
Postoperative new-onset atrial fibrillation (AF) is the most common complication stemming from coronary artery bypass graft surgery, and is associated with increased early and late mortality risk.
- Trial name
- NCT00198614
- Testing
- Carvedilol versus Metoprolol
- Where
- Japan
- Volunteers
- 650 people
- Sponsor
- Ministry of Health, Labour and Welfare, Japan
Cardiac Surgery
Effects of Colloid and Crystalloid on the Microcirculatory Alterations During Off-pump Coronary Artery Bypass Surgery
The purpose of this study is to compare the effects of crystalloid and colloid, which are used for pump priming solution, on the microcirculatory alterations during cardiac surgery.
- Trial name
- NCT01713166
- Testing
- plasmalyte solution, Hextend
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Seoul National University Hospital
Hemodynamics
Levosimendan Versus Milrinone in Off Pump CABG Surgery
To compare the efficacy of Levosimendan versus Milrinone in supporting hemodynamics during off-pump coronary artery bypass grafting surgery in patients with low ejection fraction.
- Trial name
- NCT03855579
- Testing
- Levosimendan, Milrinone
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Ischemic Heart Disease
Milrinone on Cardiac Performance During Off-pump Coronary Artery Bypass Surgery
The purpose of this study is to analyze the changes in cardiac performance before and after milrinone administration in order to find out whether milrinone improves LV performance in patients undergoing coronary artery bypass…
- Trial name
- NCT04153383
- Testing
- Milrinone Injection
- Volunteers
- 20 people
- Sponsor
- Konkuk University Medical Center
Coronary Artery Disease, Postoperative Complications
Intraoperative Targeted Versus Liberal Blood Pressure Management in Patients Undergoing Off-pump Coronary Artery Bypass Grafting
The goal of this clinical trial is to learn whether two approaches to anesthesia and blood pressure management can improve care for adults having off-pump coronary artery bypass grafting (OPCAB).
- Trial name
- NCT07787364
- Testing
- Targeted Blood Pressure Management, Liberal Blood Pressure Management, Remimazolam
- Volunteers
- 416 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Coronary Artery Disease, Cardiopulmonary Bypass
Long-Term Cognitive Decline After Coronary Artery Bypass Grafting: is Off-Pump Surgery Beneficial?
Coronary artery bypass surgery is associated with postoperative cognitive decline, which has largely been attributed to the use of the heart lung machine.
- Conditions
- Coronary Artery Disease, Cardiopulmonary Bypass, Cognition Disorders
- Trial name
- NCT00189215
- Testing
- cardiac stabilizer instead of cardiopulmonary bypass
- Where
- Netherlands
- Volunteers
- 280 people
- Sponsor
- UMC Utrecht
Coronary Disease
Electroacupuncture in Reducing the Dose of Analgesic in Patients Undergoing Off-pump Coronary Artery Bypass Grafting
A prospective, multiple-center, double-blinded, randomized, controlled clinical study to evaluate the antalgic effects between distal-proximal acupoints combination and regional acupoints combination stimulated with…
- Trial name
- NCT02443220
- Testing
- TEAS (transcutaneous electric acupoint stimulation), TEAS
- Where
- China
- Volunteers
- 315 people
- Sponsor
- Xijing Hospital
Coronary Artery Bypass Grafting
Tissue Oxygenation During Heart Surgery
The goal of this study is to determine if off-pump CABG surgery is associated with better cerebral tissue oxygenation when compared with on-pump CABG.
- Trial name
- NCT01347827
- Testing
- measurements of brain tissue oxygenation
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen
Ischemic Heart Disease
Effect of Remote Ischemic Preconditioning on Cognitive Function After Off-Pump Coronary Artery Bypass Graft
The aim of this study is to evaluate the effects of remote ischemic preconditioning on cognitive function in patients undergoing off-pump coronary artery bypass graft.
- Trial name
- NCT00953368
- Testing
- remote ischemic preconditioning
- Where
- South Korea
- Volunteers
- 270 people
- Sponsor
- Asan Medical Center
Coronary Artery Bypass Graft Triple Vessel
MicroRNA Mediates Volatile Anesthetics Preconditioning Induced Artery Protection
It has been reported that volatile anesthetics preconditioning mediates protection of organ via microRNA. We want to study on the effects of isoflurane preconditioning on expression of microRNA and mRNA in the specimens of…
- Trial name
- NCT02678650
- Testing
- volatile anesthetics(isoflurane), propofol intravenous anesthesia
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Liang Zhang
Ischemic Heart Disease
Effect of Remote Preconditioning in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery
In recent several clinical trials, remote preconditioning showed very powerful myocardial protection. However, the myocardial protective effect by remote preconditioning was not evaluated on the patients undergoing off pump…
- Trial name
- NCT00889811
- Testing
- remote ischemic preconditioning
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Seoul National University Hospital