Clinical trials: Off-Pump Coronary Artery Bypass Surgery
Ischemic Heart Disease
Milrinone on Cardiac Performance During Off-pump Coronary Artery Bypass Surgery
The purpose of this study is to analyze the changes in cardiac performance before and after milrinone administration in order to find out whether milrinone improves LV performance in patients undergoing coronary artery bypass…
- Trial name
- NCT04153383
- Testing
- Milrinone Injection
- Volunteers
- 20 people
- Sponsor
- Konkuk University Medical Center
Pulse Wave Analysis
Cardiac Output Monitoring With Estimated Continuous Cardiac Output (esCCO) vs. Transpulmonary Thermodilution (TPTD)
The main goal of our study is to assess the accuracy and reproducibility of continuous beat-to-beat cardiac output (CO) measurement using pulse wave transit time in patients undergoing off-pump coronary artery bypass grafting.
- Trial name
- NCT02352324
- Testing
- Fluid responsiveness tests
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Northern State Medical University
Cardiac Surgery
Effects of Colloid and Crystalloid on the Microcirculatory Alterations During Off-pump Coronary Artery Bypass Surgery
The purpose of this study is to compare the effects of crystalloid and colloid, which are used for pump priming solution, on the microcirculatory alterations during cardiac surgery.
- Trial name
- NCT01713166
- Testing
- plasmalyte solution, Hextend
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease
Effect of Intravenous Ferric Carboxymaltose on Hemoglobin Response and Transfusion in Patients With Iron Deficiency Anemia After Off-Pump Coronary Artery Bypass Grafting
In this prospective open-label randomized tral, 100 patients with elective off-pump coronary artery bypass (OPCAB) or minimal invasive direct coronary bypass (MIDCAB) surgery were enrolled.
- Trial name
- NCT04898569
- Testing
- Ferinject, Normal Saline Flush
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Coronary Artery Occlusive Disease(CAOD)
The Effect of Balanced Crystalloid Versus 5% Albumin on Endothelial Glycocalyx Degradation in Patients Undergoing Off-pump Coronary Artery Bypass Surgery
It is being revealed that the more severe the damage of the endothelial glycocalyx (EG) layer, the more likely it is that the prognosis of the patients is poor.
- Trial name
- NCT03699462
- Testing
- Plasma solution-A injection, 5% Albumin
- Where
- South Korea
- Volunteers
- 106 people
- Sponsor
- Yonsei University
Ischemic Heart Disease (IHD), Off-pump Coronary Artery Bypass
Efficacy of Multiple Nerve Blocks on the Recovery of Patients Undergoing Off Pump CABG Surgeries
In cardiac surgery patients , effective pain control is crucial to support early extubation, mobilization, and cognitive recovery, yet systemic opioids carry substantial risks such as respiratory depression, delirium, and delayed…
- Conditions
- Ischemic Heart Disease (IHD), Off-pump Coronary Artery Bypass, Regional Block for Pain Control
- Trial name
- NCT07794527
- Testing
- regional nerve block with local anesthesia
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Coronary Artery Bypass Graft (CABG)
Aortic No-Touch vs Partial Aortic Clamping in Off-Pump CABG
To explore surgical strategies that reduce perioperative neurologic complications in cardiovascular surgery, with the aim of improving perioperative outcomes and quality of life while reducing the socioeconomic burden.
- Trial name
- PROTECT-CABG (NCT07302659)
- Testing
- Aortic no-touch coronary artery bypass grafting (RIMA-SVG), Conventional off-pump CABG with partial clamping of the ascending aorta (Ao-SVG)
- Where
- 4 sites in China
- Volunteers
- 380 people
- Sponsor
- China National Center for Cardiovascular Diseases
Patients Undergoing Off-pump Coronary Artery by Pass Surgery
Predictive Value of Postoperative Prognostic Nutritional Index Trajectory on 1-year Mortality After Off-pump Coronary Artery Bypass Surgery
This study investigated the changing pattern of postoperative Prognostic Nutritional Index (PNI) after off-pump coronary artery bypass surgery using a trajectory analysis.
- Trial name
- NCT06435416
- Testing
- No intervention
- Where
- South Korea
- Volunteers
- 983 people
- Sponsor
- Gangnam Severance Hospital
Ischemic Cardiomyopathy
Impella Supported OPCABG
The present study introduces a novel approach to coronary revascularization through the use of a short term minimally-invasive left ventricular assist device (LVAD) to minimize myocardial injury and eliminate low output state…
- Trial name
- NCT04339452
- Testing
- Impella 5.5 with SmartAssist Supported OPCABG
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Lucian Archambault Durham III
Coronary Artery Bypass, Off-Pump, Intraoperative Hypotension
Targeted Blood-pressure Management and Acute Kidney Injury After Coronary Artery Bypass Surgery
Acute renal injury (AKI) is a common complication after cardiac surgery and is associated with worse outcomes. It is now realized that intraoperative hypotension is an important risk factor for the development of AKI.
- Conditions
- Coronary Artery Bypass, Off-Pump, Intraoperative Hypotension, Acute Kidney Injury, Preventive Medicine
- Trial name
- NCT03629418
- Testing
- Targeted blood-pressure management, Routine blood-pressure management
- Where
- China
- Volunteers
- 612 people
- Sponsor
- Peking University First Hospital
Ischemic Heart Disease, Coronary Artery Bypass Grafting
Evaluation of Outcomes of Coronary Artery Bypass Grafting.
Evaluation of outcomes of coronary artery bypass grafting.
- Trial name
- EOCABG (NCT03786939)
- Testing
- On-pump CABG., Off-pump CABG., Pump-assisted CABG.
- Where
- Russia
- Volunteers
- 1,000 people
- Sponsor
- St. Petersburg State Pavlov Medical University
Coronary Heart Disease, Coronary Artery Disease
Study of Sivelestat Sodium in OPCABG
The goal of this clinical trial is to learn if drug Sivelestat Sodium works to improve the prognosis of off-pump coronary artery bypass grafting (OPCABG) in adults. It will also learn about the safety of drug Sivelestat Sodium.
- Conditions
- Coronary Heart Disease, Coronary Artery Disease, Coronary Arterial Disease (CAD)
- Trial name
- NCT07118930
- Testing
- Sivelestat Sodium injection 2 h after OPCABG for 72 h, Saline (0.9% NaCl)
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Affiliated Hospital of Nantong University
Multi Vessel Coronary Artery Disease
Dual Antiplatelet Therapy in Patients With Clopidogrel Resistance Following Off-Pump Coronary Artery Bypass
Ticagrelor, a direct-acting oral P2Y12-receptor antagonist, provides greater and more consistent platelet inhibition than clopidogrel.
- Trial name
- NCT05166538
- Testing
- Ticagrelor, Clopidogrel
- Where
- South Korea
- Volunteers
- 204 people
- Sponsor
- Yonsei University
Coronary Artery Disease, Myocardial Ischemia
Comparative Effectiveness of the Minimally Invasive Coronary Artery Bypass Grafting
The purpose of this study is to compare three different revascularization strategies in patients with multi-vessel coronary disease: MICS CABG, OPCABG and ONCABG.
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Heart Diseases
- Trial name
- NCT02047266
- Testing
- MICS CABG, OPCABG, ONCABG
- Where
- Belarus
- Volunteers
- 150 people
- Sponsor
- Vitebsk Regional Clinical Hospital
Cardiac Surgery, Coronary Artery Bypass Surgery
Comparing Angiomax to Heparin With Protamine Reversal in Patients OPCAB
The purpose of this study is to examine the safety and efficacy of Angiomax as an alternative anticoagulant to heparin with protamine reversal in patients undergoing off-pump coronary artery bypass graft surgery.
- Trial name
- OPCAB (NCT00073593)
- Testing
- Bivalirudin, Heparin, Protamine
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The Medicines Company
Coronary Artery Disease
Effects of Low Dose Aspirin Pre-treatment on Platelet Activation Undergoing Off-pump Coronary Artery Bypass Surgery
Platelet activation after off pump coronary artery bypass (OPCAB) surgery may affect thrombus formation. The purpose of this study is to assess the effects of preoperative continuation of aspirin on platelet activation after off…
- Trial name
- NCT02209909
- Testing
- aspirin continuation, aspirin discontinuation
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Occlusive Disease
Intraoperative Epiaortic Scanning for Preventing Early Stroke After Off-pump Coronary Artery Bypass
Recently epiaortic ultrasound scanning (EAS) has been recommended as an intraoperative tool to accurately assess ascending aorta disease. To date, several studies have reported that EAS is superior to TEE and surgical palpation
- Trial name
- NCT01764763
- Volunteers
- 2,292 people
- Sponsor
- Yonsei University
Coronary Artery Bypass, Off-Pump
The Effects of Dexmedetomidine on cTnI and GP-BB in Patients Undergoing OPCABG
The purpose of this study is to observe the impact of dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in patients undergoing off-pump coronary artery bypass Grafting.
- Trial name
- NCT03163693
- Testing
- dexmedetomidine, normal saline
- Where
- China
- Volunteers
- 40 people
- Sponsor
- General Hospital of Ningxia Medical University
Coronary Artery Occlusive Disease
The Effect of 6% Hydroxyethyl Starch 130/0.4 on Blood Loss and Coagulation in Patients Medicated With Antiplatelet Agents Prior to Off-Pump Coronary Bypass Graft Surgery
HES 130/0.4 significantly solution will not affect on coagulation and blood loss in patients medicated with antiplatelet agents prior to off-pump coronary bypass surgery (OPCAB).
- Trial name
- NCT01051206
- Testing
- 6% hydroxyethyl Stach 130/0.4
- Where
- South Korea
- Volunteers
- 106 people
- Sponsor
- Yonsei University
Coronary Artery Disease
Epidural Anesthesia and Postoperative Analgesia With Ropivacaine and Fentanyl
The aim of the present study was to assess the efficacy of thoracic epidural anesthesia followed by postoperative epidural infusion and patient-controlled epidural analgesia with ropivacaine/fentanyl in off-pump coronary artery…
- Trial name
- NCT01384175
- Testing
- intravenous analgesia, epidural infusion, patient-controlled epidural analgesia
- Where
- Russia
- Volunteers
- 93 people
- Sponsor
- Northern State Medical University