Clinical trials: Off-Pump Coronary Artery Bypass Surgery
Coronary Artery Bypass, Off-Pump, Intraoperative Hypotension
Intraoperative Hypotension and Acute Kidney Injury After Off-pump Coronary Artery Bypass Grafting Surgery
Acute renal injury (AKI) is a common complication after cardiac surgery and is associated with worse outcomes. Hypotension is an important risk factor for the development of AKI after noncardiac surgery.
- Conditions
- Coronary Artery Bypass, Off-Pump, Intraoperative Hypotension, Acute Kidney Injury
- Trial name
- NCT03889730
- Where
- China
- Volunteers
- 821 people
- Sponsor
- Peking University First Hospital
Coronary Artery Bypass, Off-Pump
Cell Savers and Blood Quality
Cell savers are routinely used in our hospital during off-pump coronary artery bypass grafting to retrieve and wash blood that is lost during the operation.
- Trial name
- NCT02046824
- Testing
- Xtra®, Sorin cellsaver, C.A.T.S.®, Fresenius cellsaver, CardioPAT®, Haemonetics, cellsaver
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- University Medical Center Groningen
Cardiac Surgery
Dynamic Tests and Parameters to Predict Fluid Responsiveness After OPCAB
Objective: To assess the predictive value of dynamic tests and parameters for evaluation of fluid responsiveness after off-pump coronary artery bypass grafting (OPCAB).
- Trial name
- NCT04482946
- Testing
- Assessment of fluid responsiveness
- Where
- Russia
- Volunteers
- 32 people
- Sponsor
- Northern State Medical University
Coronary Artery Disease
Effects of Low Dose Aspirin Pre-treatment on Platelet Activation Undergoing Off-pump Coronary Artery Bypass Surgery
Platelet activation after off pump coronary artery bypass (OPCAB) surgery may affect thrombus formation. The purpose of this study is to assess the effects of preoperative continuation of aspirin on platelet activation after off…
- Trial name
- NCT02209909
- Testing
- aspirin continuation, aspirin discontinuation
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Seoul National University Hospital
Frail Elderly, Coronary Artery Disease
Off-pump Versus On-pump Coronary Artery Bypass Grafting in Frail Patients
Frailty is defined as a geriatric syndrome of impaired resiliency to stressors (such as cardiac surgery) that has been delineated recently in the cardiovascular literature.
- Trial name
- FRAGILE (NCT02338947)
- Testing
- Off-pump coronary-artery bypass grafting, On-pump coronary-artery bypass grafting
- Where
- 7 sites in United States, Brazil
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Heart Disease
German Off Pump Coronary Artery Bypass in Elderly Study
Comparison of two operative techniques (on-pump vs off-pump)of coronary revascularisation of the best treatment concept for patients older or 75 years old.
- Trial name
- GOPCABE (NCT00719667)
- Testing
- coronary artery bypass grafting
- Where
- 2 sites in Germany
- Volunteers
- 2,000 people
- Sponsor
- German Off Pump Coronary Artery Bypass in Elderly Study Group
OPCABG
Study on the Myocardial Protective Effect of Upper Limb Ischemic Preconditioning in Patients Undergoing Off-pump Coronary Artery Bypass Grafting
The purpose of the study was to verify the myocardial protective effect of RIPC in patients undergoing OPCABG.
- Trial name
- NCT03340181
- Testing
- RIPC
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Artery Occlusive Disease
Intraoperative Epiaortic Scanning for Preventing Early Stroke After Off-pump Coronary Artery Bypass
Recently epiaortic ultrasound scanning (EAS) has been recommended as an intraoperative tool to accurately assess ascending aorta disease. To date, several studies have reported that EAS is superior to TEE and surgical palpation
- Trial name
- NCT01764763
- Volunteers
- 2,292 people
- Sponsor
- Yonsei University
Acute Normovolemic Hemodilution, Off-Pump Coronary Artery Bypass Surgery
Acute Normovolemic Hemodilution in Off-pump CABG
To study the effects of Acute normovolemic hemodilution on central and peripheral perfusion in patients Undergoing off-pump coronary artery bypass grafting surgery
- Trial name
- NCT04042883
- Testing
- Acute normovolemic hemodilution
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Coronary Artery Stenoses
Five-year Patency of No-touch Saphenous Vein Grafts in On-pump Versus Clamp-less Off-pump Coronary Artery Bypass Surgery
Randomised controlled trials (RCTs) have shown high long-term patency for no-touch saphenous vein grafts (NTSVGs), comparable to the internal thoracic artery in on-pump coronary artery bypass grafting (CABG).
- Trial name
- NCT03447197
- Testing
- The use of extracorporeal circulation
- Volunteers
- 59 people
- Sponsor
- Örebro County Council
Coronary Artery Disease
On-pump Versus Off-pump Coronary Artery Bypass Grafting , Short Term Outcomes , Sohag Experience
Coronary artery disease (CAD) and its sequlae, such as myocardial infarction, arrhythmia and heart failure, are among the leading causes of death around the world .
- Trial name
- NCT06069986
- Testing
- coronary artery bypass graft CABG
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Sohag University
A Total of 234 Patients With Acute Coronary Syndrome Who Will Undergo OPCAB.
Impact of High-dose Pretreatment of Rosuvastatin in Patients With Acute Coronary Syndrome Following Off-pump Coronary Artery Bypass: Results From the HIROP-ACS (HIgh-dose Pretreatment of Rosuvastatin During Off-Pump Coronary Bypass in Acute Coronary Syndrome) Study
Periprocedural treatment with high-dose statins is known to have cardioprotective and pleiotropic effects, such as anti-thrombotic and anti-inflammatory actions.
- Trial name
- NCT01971606
- Testing
- Rosuvastatin
- Where
- South Korea
- Volunteers
- 234 people
- Sponsor
- Yonsei University
Coronary Artery Disease (CAD), Bypass, Cardiopulmonary
Multivessel Minimally Invasive Coronary Bypass Grafting as HYBRID Revascularization Versus Conventional Off-pump Coronary Artery Bypass Grafting
The MICRA-HYBRID trial is a prospective, multicenter, randomized controlled study comparing multivessel hybrid coronary revascularization (HCR) as minimally invasive arterial bypass grafting to left-sided coronary targets (LAD…
- Conditions
- Coronary Artery Disease (CAD), Bypass, Cardiopulmonary, Minimally Invasive Coronary Revascularization Surgery, Off-pump Coronary Artery Bypass
- Trial name
- MICRA-HYBRID (NCT07314138)
- Testing
- Multivessel Hybrid Coronary Revascularization, Off-pump coronary arterial bypass grafting (OPCAB)
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Pulse Wave Analysis
Cardiac Output Monitoring With Estimated Continuous Cardiac Output (esCCO) vs. Transpulmonary Thermodilution (TPTD)
The main goal of our study is to assess the accuracy and reproducibility of continuous beat-to-beat cardiac output (CO) measurement using pulse wave transit time in patients undergoing off-pump coronary artery bypass grafting.
- Trial name
- NCT02352324
- Testing
- Fluid responsiveness tests
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Northern State Medical University
Coronary Artery Bypass Graft Triple Vessel
MicroRNA Mediates Volatile Anesthetics Preconditioning Induced Artery Protection
It has been reported that volatile anesthetics preconditioning mediates protection of organ via microRNA. We want to study on the effects of isoflurane preconditioning on expression of microRNA and mRNA in the specimens of…
- Trial name
- NCT02678650
- Testing
- volatile anesthetics(isoflurane), propofol intravenous anesthesia
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Liang Zhang
Acute Kidney Injury
Effect of Sodium Bicarbonate on Prevention of Acute Kidney Injury in High Risk Patients Undergoing Off-pump Coronary Artery Bypass (OPCAB)
In this single-site, randomized, controlled and double-blind clinical trial, the investigators evaluate the effect of sodium bicarbonate on prevention of acute kidney injury in high risk patients undergoing off pump coronary…
- Trial name
- NCT01840241
- Testing
- sodium bicarbonate, normal saline
- Where
- South Korea
- Volunteers
- 162 people
- Sponsor
- Yonsei University
Coronary Artery Occlusive Disease
The Effect of Tranexamic Acid on Postoperative Blood Loss and Coagulation in Patients With Preoperative Anemia Undergoing Off-Pump Coronary Artery Bypass Graft; Double Blind Randomized Control Study
The Effect of Tranexamic Acid on Postoperative Blood loss and Coagulation in Patients with Preoperative Anemia Undergoing Off-Pump Coronary Artery Bypass Graft; double blind randomized control study.
- Trial name
- NCT01067638
- Testing
- Tranexamic Acid
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Yonsei University
Coronary Artery Bypass, Off-Pump, Iron Deficiencies
Effect of Non-anemic Iron Deficiency on Outcome Following Off-pump Coronary Revascularization
This is a single center retrospective study of patients who underwent off pump coronary artery bypass surgery between 2016.11~2023.05.
- Trial name
- NCT06399627
- Where
- South Korea
- Volunteers
- 433 people
- Sponsor
- Yonsei University
Cardiac Surgical Procedures, Thoracic Surgical Procedures
Pulse Pressure Variation Measured During Valsalva Maneuver to Predict Fluid Responsiveness Under Open-chest Condition
Pulse pressure variation (PPV) is a well-known dynamic preload indicator to predict fluid responsiveness. However, its usefulness in open-chest conditions has been equivocal.
- Conditions
- Cardiac Surgical Procedures, Thoracic Surgical Procedures, Sternotomy
- Trial name
- NCT02457572
- Testing
- Valsalva maneuver, Fluid loading
- Where
- South Korea
- Volunteers
- 55 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease, Perioperative Bleeding
Oral Versus Intravenous Tranexamic Acid in Off-Pump Coronary Artery Bypass Surgery
Tranexamic acid is commonly administered intravenously during cardiac surgery to reduce perioperative bleeding. Oral tranexamic acid may offer a simpler and less costly alternative, but its effectiveness in patients undergoing…
- Trial name
- TRANSCAB (NCT07740330)
- Testing
- Oral tranexamic acid, Exacyl®
- Where
- Belgium
- Volunteers
- 160 people
- Sponsor
- Clinique Saint-Luc