Clinical trials: Off-Pump Coronary Artery Bypass Surgery
Ischemic Heart Disease
The Danish On-pump, Off-pump Randomization Study (DOORS)
Background: Coronary artery bypass grafting (CABG) can be performed either with or without the use of cardiopulmonary bypass (CPB) to obtain myocardial re-vascularisation.
- Trial name
- NCT00123981
- Testing
- Off-Pump Coronary Artery Bypass Grafting
- Where
- Denmark
- Volunteers
- 900 people
- Sponsor
- Kim Houlind
Coronary Artery Disease
Dexmedetomidine in Off Pump Coronary Artery Bypass Grafting
the study will assess the impact of intraoperative dexmedetomidine infusion on myocardial performance by investigating the left ventricular (LV) systolic and diastolic function and right ventricular (RV) fraction area change…
- Trial name
- NCT05577871
- Testing
- Dexmedetomidine, normal saline
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Suez Canal University
Cardiac Surgery
Dynamic Tests and Parameters to Predict Fluid Responsiveness After OPCAB
Objective: To assess the predictive value of dynamic tests and parameters for evaluation of fluid responsiveness after off-pump coronary artery bypass grafting (OPCAB).
- Trial name
- NCT04482946
- Testing
- Assessment of fluid responsiveness
- Where
- Russia
- Volunteers
- 32 people
- Sponsor
- Northern State Medical University
Off Pump Coronary Artery Bypass Surgery
Heparin Resistance: Predictors and Outcomes
The investigators evaluated clinical impact of reduced heparin responsiveness (HRreduced) on the incidence of perioperative myocardial infarction (MI) and restenosis at 6 months after off-pump coronary artery bypass graft surgery…
- Trial name
- NCT01044888
- Testing
- Heparin
- Where
- South Korea
- Volunteers
- 199 people
- Sponsor
- Yonsei University
Ischemic Heart Disease
Effect of Remote Ischemic Preconditioning on Cognitive Function After Off-Pump Coronary Artery Bypass Graft
The aim of this study is to evaluate the effects of remote ischemic preconditioning on cognitive function in patients undergoing off-pump coronary artery bypass graft.
- Trial name
- NCT00953368
- Testing
- remote ischemic preconditioning
- Where
- South Korea
- Volunteers
- 270 people
- Sponsor
- Asan Medical Center
Frail Elderly, Coronary Artery Disease
Off-pump Versus On-pump Coronary Artery Bypass Grafting in Frail Patients
Frailty is defined as a geriatric syndrome of impaired resiliency to stressors (such as cardiac surgery) that has been delineated recently in the cardiovascular literature.
- Trial name
- FRAGILE (NCT02338947)
- Testing
- Off-pump coronary-artery bypass grafting, On-pump coronary-artery bypass grafting
- Where
- 7 sites in United States, Brazil
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Microcirculation, Anesthetic Complication Spinal
Effect of Anesthetics on Microcirculation in Patients Undergoing Off-pump Coronary Artery Bypass Surgery
Volatile anesthetics, such as sevoflurane and desflurane, are commonly used in patients undergoing cardiac surgeries including off-pump coronary artery bypass.
- Trial name
- NCT03209193
- Testing
- Sevoflurane, Desflurane
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Seoul National University Hospital
Anesthesia
Anesthesia and Lymphocytes Apoptosis
Most researches revealed that volatile anesthetic sevoflurane has a more marked cardioprotective effect against ischemia compared with intravenous agent propofol.However, propofol has been suggested to be more benefit for…
- Trial name
- OPCAB (NCT01461551)
- Testing
- Sevoflurane, Propofol, combine of sevoflurane and propofol
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Ruijin Hospital
Hypoxemia, Recruitment
Comparison of Four Different Recruitment Maneuvers in Patients After Coronary Surgery
The risk of respiratory failure after cardiac surgery is high, and it may result in many complications. The maneuver of alveolar recruitment may improve the oxygen transport in the human organism.
- Trial name
- RECR-CABG (NCT01457651)
- Testing
- Alveolar recruitment
- Where
- Russia
- Volunteers
- 76 people
- Sponsor
- Northern State Medical University
Heart Disease
German Off Pump Coronary Artery Bypass in Elderly Study
Comparison of two operative techniques (on-pump vs off-pump)of coronary revascularisation of the best treatment concept for patients older or 75 years old.
- Trial name
- GOPCABE (NCT00719667)
- Testing
- coronary artery bypass grafting
- Where
- 2 sites in Germany
- Volunteers
- 2,000 people
- Sponsor
- German Off Pump Coronary Artery Bypass in Elderly Study Group
Cerebral Oxygenation, Oxidative Stress
Off-Pump and On-Pump Techniques and Oxidative Stress in CABG Surgery
CABG (coronary artery bypass graft) surgery is among the most common heart surgeries performed in the heart pump. In CABG surgery, operations performed on the beating heart without the use of CPB (off-pump) are frequently…
- Conditions
- Cerebral Oxygenation, Oxidative Stress, Myocardial Infarction
- Trial name
- CABG (NCT04834219)
- Testing
- On-Pump CABG, Off-Pump CABG
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Bozok University
Coronary Artery Bypass Grafting, Remote Ischemic Conditioning
Safety and Efficacy of Remote Ischemic Conditioning for Patients Taking Off-pump Coronary Artery Bypass Grafting
Remote ischemic conditioning (RIC) is the process of repeated ischemia and reperfusion in the peripheral vessels, which is proved in reducing IRI in vital organs.
- Conditions
- Coronary Artery Bypass Grafting, Remote Ischemic Conditioning, Ischemia-Reperfusion Injury
- Trial name
- IMPROVE (NCT06141525)
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 648 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Coronary Artery Bypass Grafting
Tissue Oxygenation During Heart Surgery
The goal of this study is to determine if off-pump CABG surgery is associated with better cerebral tissue oxygenation when compared with on-pump CABG.
- Trial name
- NCT01347827
- Testing
- measurements of brain tissue oxygenation
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen
Coronary Artery Disease, Off-pump Coronary Artery Bypass
The Effects of Preoperative Aspirin on Graft Patency and Cardiac Events in Off-pump Coronary Artery Bypass
Antiplatelet therapy is critical in the management of coronary artery disease.For patients undergoing off-pump coronary artery bypass graft,controversy remains regarding the safety of preoperative antiplatelet therapy.And there…
- Conditions
- Coronary Artery Disease, Off-pump Coronary Artery Bypass, Aspirin
- Trial name
- NCT01268917
- Testing
- aspirin
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Three Vessel Coronary Artery Disease
Association of Carotid Arterial Circumferential Strain With Left Ventricular Function and Hemodynamic Compromise During Off-pump Coronary Artery Bypass Surgery
This study is aimed to evaluate the association of common carotid artery circumferential strain with the echocardiographic parameters of left ventricular function and the degree of actual hemodynamic deterioration in patients…
- Trial name
- NCT01840969
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Yonsei University
Ischemic Heart Disease
Pulse Pressure Variation (PPV) to Predict Fluid Responsiveness During Cardiac Displacement in Patients Undergoing Off-pump Coronary Artery Bypass Surgery (OPCAB)
Pulse pressure variation (PPV) known as a dynamic preload index is increasingly being used for guide of fluid management under various clinical situations.
- Trial name
- NCT01041742
- Testing
- fluid loading
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- Seoul National University Hospital
Hemodynamic Instability, Postoperative Complications
Fluid Responsiveness: SVV vs esSVV in Mechanically Ventilated and Spontaneously Breathing Patients
Postoperative period after off-pump coronary artery bypass grafting (OPCAB) can be a challenging area for emerging methods for less-invasive continuous hemodynamic monitoring.
- Trial name
- NCT04786652
- Testing
- estimated stroke volume variation (esSVV, Nihon Kohden, Japan), Assessment of fluid responsiveness in mechanically ventilated patients after OPCAB, Assessment of fluid responsiveness in spontaneously breathing patients at 18 hrs of the postoperative period
- Where
- Russia
- Volunteers
- 32 people
- Sponsor
- Northern State Medical University
Coronary Artery Occlusive Disease
Effects of Ulinastatin on Coagulation in High Risk Patients Undergoing Off Pump Coronary Artery Bypass Graft Surgery
Ulinastatin reduce the amount of bleeding and fibrinolysis in high risk patients undergoing off-pump coronary bypass surgery (OPCAB).
- Trial name
- NCT01084044
- Testing
- ulinastatin, saline solution
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Yonsei University
Acute Kidney Injury
Effect of Sodium Bicarbonate on Prevention of Acute Kidney Injury in High Risk Patients Undergoing Off-pump Coronary Artery Bypass (OPCAB)
In this single-site, randomized, controlled and double-blind clinical trial, the investigators evaluate the effect of sodium bicarbonate on prevention of acute kidney injury in high risk patients undergoing off pump coronary…
- Trial name
- NCT01840241
- Testing
- sodium bicarbonate, normal saline
- Where
- South Korea
- Volunteers
- 162 people
- Sponsor
- Yonsei University
Coronary Artery Bypass Grafting, Off-pump Coronary Artery Bypass
Safety and Effectiveness of No-touch Technique for Ascending Aorta in MICS-CABG
The goal of this single-center prospective cohort study is to compare perioperative safety metrics and follow-up survival analyses in patients receiving Minimally Invasive Cardiac Surgery Coronary Artery Bypass…
- Conditions
- Coronary Artery Bypass Grafting, Off-pump Coronary Artery Bypass, Minimally Invasive Cardiac Surgery, Coronary Arterial Disease (CAD)
- Trial name
- NCT07172620
- Testing
- Non-extracorporeal multiple coronary artery bypass graft (CABG) performed under direct visualization through a small incision in the left side of the chest., Multi-branch coronary artery bypass grafting with conventional median open heart and off-pump circulation
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Peking University Third Hospital