Clinical trials: Off-Pump Coronary Artery Bypass Surgery
Coronary Artery Bypass Graft Triple Vessel
Effect of Prewarming on Microcirculatory Response
Intraoperative hypothermia may affect tissue microcirculation and can induce myocardial injury, wound infection, and coagulopathy.
- Trial name
- NCT02186210
- Testing
- prewarming
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Insulin Resistance, Diabetes Mellitus, Type 2
Pre-operative Carbohydrates in Diabetic Patients Undergoing CABG
Preoperative carbohydrates (CHO) supplement has been shown to alleviate postoperative insulin resistance (IR) in nondiabetic patients undergoing a variety of surgeries.
- Conditions
- Insulin Resistance, Diabetes Mellitus, Type 2, Coronary Artery Bypass Surgery
- Trial name
- NCT05540249
- Testing
- carbohydrates
- Volunteers
- 62 people
- Sponsor
- China National Center for Cardiovascular Diseases
Off Pump Coronary Artery Bypass Graft
Volatile Versus Propofol Anesthesia in OPCAB
Off pump coronary artery bypass graft (OPCAB) still requires myocardial protection owing to intermittent regional ischemic episode.
- Trial name
- NCT02222142
- Testing
- Isoflurane
- Where
- South Korea
- Volunteers
- 1,080 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease
Dexmedetomidine's Cardiac and Cognitive Influence on Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery
The investigators hypothesized that dexmedetomidine as an anesthetic adjunct can be used in the setting of off-pump coronary bypass procedure and can provide benefits to cardiac function and cognitive performance on the ground of…
- Trial name
- NCT01704092
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Huazhong University of Science and Technology
Coronary Artery Disease
On-pump Versus Off-pump Coronary Artery Bypass Grafting , Short Term Outcomes , Sohag Experience
Coronary artery disease (CAD) and its sequlae, such as myocardial infarction, arrhythmia and heart failure, are among the leading causes of death around the world .
- Trial name
- NCT06069986
- Testing
- coronary artery bypass graft CABG
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Sohag University
Cardiac Revascularization
ICU Stay in Patients With Low Ejection Fraction Undergoing Cardiac Revascularization: Comparison of On-pump vs Off-pump Coronary Artery Bypass Grafting
Coronary artery bypass graft (CABG) surgery can result in severe postoperative complications, such as renal and pulmonary failure.
- Trial name
- NCT04639856
- Testing
- Coronary Artery Bypass Grafting
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Armed Forces Institute of Cardiology, Pakistan
Acute Kidney Injury
Renal Oxygen Saturation During Off-pump Coronary Artery Bypass Graft Surgery
The purpose of this study is to evaluate changes in renal oxygen saturation (rrSO2) and its relationship with central venous oxygen saturation (cvSO2), cerebral cortical oxygen saturation (rcSO2), and hemodynamic parameters while…
- Trial name
- OPCAB (NCT04679337)
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Yeungnam University College of Medicine
Ischemic Heart Disease
Effect of Remote Preconditioning in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery
In recent several clinical trials, remote preconditioning showed very powerful myocardial protection. However, the myocardial protective effect by remote preconditioning was not evaluated on the patients undergoing off pump…
- Trial name
- NCT00889811
- Testing
- remote ischemic preconditioning
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Seoul National University Hospital
Complications Due to Coronary Artery Bypass Graft, Graft Failure
Patency-Coronary Trial
Heart bypass surgery is used to increase blood flow to the heart. This surgery is usually done using a heart-lung machine (on-pump surgery) allowing the surgeon to perform the procedure on a still heart.
- Trial name
- PATENCY (NCT01414049)
- Testing
- On-pump CABG, Off-pump CABG
- Where
- 3 sites in Canada
- Volunteers
- 1,200 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Coronary Artery Occlusive Disease
The Effect of Carotid IMT (Intima Media Thickness) on Postoperative Cognitive Dysfunction in Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery
The patients who have undergone cardiac surgery have higher likelihood of postoperative cognitive dysfunction (POCD). The carotid intima-media thickness (IMT) is associated with cognitive dysfunction in the old.
- Trial name
- NCT02456493
- Where
- South Korea
- Volunteers
- 224 people
- Sponsor
- Yonsei University
Ischemic Heart Disease
Arrhythmia in on Pump vs. Off Pump Coronary Artery Bypass Grafting
The aim of this research is to know the incidence of arrhythmias in on vs. off pump CABG and to know their relations to the patient's morbidity and mortality, hospital stay and hospital costs.
- Trial name
- NCT04093817
- Testing
- cardio pulmonary bypass machine
- Volunteers
- 50 people
- Sponsor
- Assiut University
Coronary Artery Disease, Coronary Stenosis
Enhanced Recovery After Surgery (ERAS) in Coronary Artery Bypass Graft / Off Pump Coronary Artery Bypass (CABG/OPCAB)
It has been assumed that some elements of the ERAS protocol may contribute to the reduction of complications and improve the satisfaction of patients undergoing coronary artery bypass surgery.
- Trial name
- NCT03956420
- Testing
- Premedication visit, Preoperative period, Postoperative period
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Silesian University of Medicine
the Efficacy and Safety of Off-pump CABG
Coronary Artery Bypass Surgery (CABG) Off or On Pump Revascularization Study
I. Main Research Question: To compare the risks and benefits of Off-pump Coronary artery bypass surgery (CABG) to On-pump CABG and to determine if one is better than the other.
- Trial name
- CORONARY (NCT00463294)
- Testing
- Coronary Artery Bypass Graft with the use of CPB, Coronary Artery Bypass Graft without the use of CPB
- Where
- 52 sites in Argentina, Brazil and 11 more
- Volunteers
- 4,752 people
- Sponsor
- Population Health Research Institute
Coronary Artery Disease, Anesthesia
Xenon as an Adjuvant to Propofol Anaesthesia in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery.
The investigators hypothesize that the application of 30% xenon as an adjuvant to general anesthesia with a target-controlled infusion of propofol is superior to general anesthesia with propofol alone with respect to hemodynamic…
- Trial name
- NCT01948765
- Testing
- Xenon and propofol, propofol
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Coronary Artery Disease, Bypass Complication
Early Silent Graft Failure in Off-pump Coronary Artery Bypass Grafting: A Computed Tomography Analysis
Aortocoronary bypass surgery is one of the most common operations in the western world. The goal of the surgeon is to perform a complete revascularization of the coronary arteries with the best, available bypass material.
- Conditions
- Coronary Artery Disease, Bypass Complication, Graft Failure
- Trial name
- NCT03657199
- Testing
- Cardiac computed tomography
- Volunteers
- 192 people
- Sponsor
- Triemli Hospital
Coronary Artery Disease
Hemodynamic Changes in Off-pump Coronary Artery Bypass Grafting
The purpose of this study is to study the positioning and stabilization of different cardiac walls performed during off-pump coronary artery bypass grafting (CABG) may have dissimilar impact on hemodynamics.
- Trial name
- NCT00967278
- Where
- Brazil
- Sponsor
- University of Sao Paulo
Analgesic Effects, Systemic Stress Response
Bilateral Ultrasound Guided Pectoralis Nerve Block Induces Hemodynamic Stability With Reducing Systemic Stress Response for Off-pump Coronary Artery Bypass Graft
Opioids used in attenuation of the neuroendocrine stress response in patients undergoing off-pump coronary artery bypass graft (OPCAB) it produces predictable satisfactory analgesia and sedation but with side effects such as…
- Conditions
- Analgesic Effects, Systemic Stress Response, Hemodynamic Stability
- Trial name
- NCT03734848
- Testing
- Bilateral Ultrasound Guided Pectoralis Nerve Block.
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tanta University
Coronary Artery Disease
Long-term Comparison of Stenting Versus Off-pump Coronary Bypass Surgery
The randomized comparison of two strategies in coronary revascularization: bypass surgery without the use of a heart lung machine and coronary stenting procedure.
- Trial name
- OCTOSTENT (NCT00975858)
- Testing
- Coronary Revascularization
- Where
- Netherlands
- Volunteers
- 280 people
- Sponsor
- UMC Utrecht
Stroke Volume Variation
Effect of Wide Pulse Pressure on the Predictability of Stroke Volume Variation for Fluid Responsiveness in Patients Undergoing Off-pump Coronary Artery Bypass Graft
The investigators examined the predictability of stroke volume variation for fluid responsiveness in patients with wide pulse pressure undergoing off-pump coronary artery bypass graft
- Trial name
- NCT01404455
- Testing
- HES 130/0.4 (VoluvenⓇ, Fresenius Kabi, Graz, Austria) 500mL loading
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Severance Hospital
Heart Disease
Study of NU172 as Anticoagulation in Patients Undergoing Off-pump CABG Surgery
This is a Phase 2, multicenter, open-label, single-arm, sequential cohort study to be conducted in up to 30 subjects. The study will evaluate subjects undergoing primary, elective, off-pump CABG surgery with median sternotomy.
- Trial name
- SNAP-CABG-OFF (NCT00808964)
- Testing
- NU172
- Volunteers
- 30 people
- Sponsor
- ARCA Biopharma, Inc.