Clinical trials: Olanzapine
Acute Agitation, Behavioural Emergency
IM Olanzapine Versus Haloperidol or Midazolam
The purpose of this study is to determine whether intramuscular olanzapine is safer (fewer adverse events) and more effective (shorter time to sedation) than conventional haloperidol or midazolam when used in the management of…
- Trial name
- NCT02380118
- Testing
- Olanzapine, Haloperidol, Midazolam
- Where
- 6 sites in Hong Kong
- Volunteers
- 167 people
- Sponsor
- The University of Hong Kong
Schizophrenia
Long-acting Paliperidone Palmitate Injection and Olanzapine for Schizophrenia
A randomized trial of olanzapine and Long-acting paliperidone palmitate injection in the treatment of 100 treatment- naive first-episode patients with schizophrenia.
- Trial name
- NCT02918825
- Testing
- Olanzapine, Paliperidone
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beijing HuiLongGuan Hospital
Schizophrenia
A Clinical Trial to Evaluate the Safety and Efficacy of Olanzapine Titration Schedule in Patients With Schizophrenia
The objective of this clinical trial is to evaluate the safety and efficacy of olanzapine titration schedule in patients with schizophrenia
- Trial name
- NCT06821945
- Testing
- BR5402A, BR5402A-1, BR5402B
- Where
- 2 sites in South Korea
- Volunteers
- 120 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Schizophrenia
Efficacy Study of Switching Stabilized Schizophrenic Patients From Conventional to Atypical Antipsychotic Treatment
The objective of this study is to demonstrate that there is a benefit in switching chronic schizophrenic patients from conventional antipsychotic to olanzapine in terms of efficacy, neurological safety and patient's outcome.
- Trial name
- NCT00191555
- Testing
- olanzapine, haloperidol
- Where
- 62 sites in France
- Volunteers
- 360 people
- Sponsor
- Eli Lilly and Company
Bipolar Disorder, Mania
Risperidone Versus Olanzapine for Mania in Preschool Children 4 to 6 Years of Age With Bipolar Disorder
The objectives of this study are to study the safety, effectiveness, tolerability and dosing regimen of risperidone, and olanzapine, in the treatment of mania in Bipolar Disorder I and Bipolar II Disorder in preschool children…
- Trial name
- NCT00181935
- Testing
- risperidone (Risperdal), olanzapine (Zyprexa)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Substance Withdrawal Syndrome
Utility of Olanzapine in the Treatment of Opioid Withdrawal in the ED
Withdrawal from opioids is a clinical scenario that emergency department physicians encounter frequently. Patients who present with opioid withdrawal display symptoms such as agitation, anxiety, myalgias, abdominal pain…
- Trial name
- NCT02643355
- Testing
- Olanzapine, Clonidine
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hennepin Healthcare Research Institute
Schizophrenia
A Study Comparing Rapid Acting Intramuscular Olanzapine and Placebo in Agitated Patients With Schizophrenia
The primary objectives of the study is to confirm if the efficacy of IM olanzapine in patients with schizophrenia is greater than IM placebo by comparing changes from baseline to 2 hours post first IM injection of agitation.
- Trial name
- NCT00640510
- Testing
- Rapid Acting Intramuscular Olanzapine, Isotonic sodium chloride solution
- Where
- 11 sites in Japan
- Volunteers
- 34 people
- Sponsor
- Eli Lilly and Company
Headache
Olanzapine for Acute Headaches
This trial is a prospective, randomized, feasibility trial with the primary aim of comparing how well oral rapidly dissolving olanzapine controls primary headache pain when compared to the current treatment strategies used in…
- Trial name
- Olanzapine (NCT03066622)
- Testing
- Standard of Care as per attending physician, 5mg rapidly dissolving olanzapine
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Psychosis, Substance Use Disorders
Clozapine Versus Olanzapine as Treatment for Comorbid Psychotic Disorder and Substance Use Disorder
The purpose of this trial is to determine if patients with comorbid psychotic disorder and substance use disorder will continue in treatment longer if treated with clozapine than with olanzapine, and will have greater reductions…
- Trial name
- NCT03857581
- Testing
- Clozapine, Olanzapine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Augusta University
Schizophrenia
Clozapine and Olanzapine Treatment of Aggression
This was a double-blind randomized study with three treatment arms: clozapine, olanzapine and haloperidol. We compared these three medications in the treatment of aggressive behavior over a 12 week period.
- Trial name
- NCT01123408
- Testing
- Clozapine, Olanzapine, Haloperidol
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Nathan Kline Institute for Psychiatric Research
Chemotherapy-induced Nausea and Vomiting
Feasibility of Olanzapine at REduced doSe in hIGHly Emetogenic chemoTherapy
Olanzapine is frequently used off-label as an adjunct antiemetic in clinical oncology settings. North American oncology guidelines recommend it as salvage therapy and as add-on to the standard triple regimen; some suggest it may…
- Trial name
- FORESIGHT (NCT04075955)
- Testing
- Zyprexa® (OLANZapine 5MG), Emend® (Aprepitant)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- CR-CSSS Champlain-Charles-Le Moyne
Bipolar Disorder I or II
Validation of Multidimensional Assessment of THYmic States (MATHYS): A Study in a Population of Bipolar Patients Treated With Olanzapine
A non randomized study to validate the MATHYS Scale in a population of in and outpatients greater than or equal to 18 years of age, suffering from Bipolar Disorder I or II, and treated with olanzapine.
- Trial name
- NCT00259272
- Testing
- olanzapine
- Where
- 16 sites in France
- Volunteers
- 141 people
- Sponsor
- Eli Lilly and Company
Healthy
Metabolic Effects of Olanzapine in Healthy Males
The purpose of this study is to look at how a two-week use of a medication called Olanzapine might change appetite, physical activity, resting metabolic rate, body composition, and weight in healthy men.
- Trial name
- NCT01496183
- Testing
- Olanzapine
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Bipolar Disorder
Olanzapine Versus Comparator in the Treatment of Bipolar Disorder
The purpose of this trial is compare the efficacy of olanzapine and Lithium Carbonate in the treatment of bipolar disorder, manic or mixed episodes, in Chinese patients.
- Trial name
- NCT00485680
- Testing
- Olanzapine Hydrochloride, Lithium Carbonate
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Eli Lilly and Company
Bipolar Disorder, Weight Gain
Topiramate vs. Placebo in Preventing Weight Gain in Bipolar Disorder Treated With Olanzapine
The primary objective of this study is to examine the efficacy of topiramate in combination with olanzapine for the prevention of weight gain in youth with bipolar disorder.
- Trial name
- NCT00394095
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Cincinnati
Early-onset Schizophrenia
5-HTR2A, DRD2,and COMT Genes Polymorphisms and Olanzapine Plasma Concentration in Treatment of Early-onset Schizophrenia
In this study,investigators will recruit 100 DSM-Ⅴdefined EOS Han patients, older than 7 years old and onset of illness before 17 years old, and all EOS patients will receive a 8-week systematic olanzepine titration treatment and…
- Trial name
- NCT02435654
- Testing
- olanzapine
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Kunming Medical University
Pathological Gambling
Safety and Efficacy Trial of Olanzapine in Outpatients With Pathological Gambling
The purpose of this research study is to evaluate the efficacy (effectiveness) and safety of olanzapine in treating pathological gambling.
- Trial name
- NCT00438776
- Testing
- olanzapine, sugar pill
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Lindner Center of HOPE
Schizophrenia
Examining Rapid Acting Intra-Muscular Olanzapine in Japanese Patients With Schizophrenia
The purpose of this study is to examine the clinical therapeutic dose in Japanese agitated patients with schizophrenia.
- Trial name
- NCT00485810
- Testing
- Olanzapine Hydrochloride
- Where
- Japan
- Volunteers
- 31 people
- Sponsor
- Eli Lilly and Company