Clinical trials: Old Age; Dementia
Chronic Low Back Pain, Hip Ostearthritis
Making Better Lives: Patient-Focused Care for Low Back Pain (LBP)
Back pain is a huge problem for millions of Americans, including nearly 11 million Veterans. Our older Veterans suffer the most. Citizens spend billions of dollars, yet consistently get poor results.
- Conditions
- Chronic Low Back Pain, Hip Ostearthritis, Myofascial Pain Syndrome, Fibromyalgia
- Trial name
- NCT02697435
- Testing
- Patient-Centered Care, Imaging-Directed Care
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- VA Office of Research and Development
Alzheimer's Disease
Study Evaluating Safety, Tolerability, Pharmacokinetics and 5 HT1A Receptor Occupancy
The study will include a preliminary pharmacokinetics (PK) / safety / tolerability evaluation in healthy elderly subjects followed by the Receptor Occupancy (RO) evaluations in healthy elderly subjects and in Alzheimer's Disease…
- Trial name
- NCT00499200
- Testing
- SRA-444
- Where
- Sweden
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Periodontitis, Alzheimer Disease
Oral Bacterial and Viral Mapping by Dental Plaque in Elderly Patients With and Without Alzheimer's Disease(ORal MICrobiology in Alzheimer's Patients)
The neurological disorders that accompany aging represent a major public health problem. The management of these diseases is a major medical and social priority.
- Trial name
- ORAMICAL (NCT04869904)
- Testing
- dental and plaque sampling
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Elderly Housing Residents With Frailty or Dementia
Circadian Adjusted LED Light's Effect in People Living in Elderly Housing
Europe is undergoing a demographic change with a rapidly growing population of 65 years+. This challenges municipalities and hospitals as the ageing citizens need care and treatment due to an age-related decline in physical and…
- Trial name
- Lightel (NCT03263234)
- Testing
- 8 weeks of circadian adjusted LED-based lighting (CALED)
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- Ove Andersen
Alzheimer Disease, Cognitive Decline
40 Hz Transcranial Alternating Current Stimulation for Inducing Gamma Oscillations
This study aims to compare the efficacy of different 40 Hz tACS protocols in entraining gamma oscillations, which are linked to various cognitive functions and play a significant role in cognitive impairments like Alzheimer's…
- Trial name
- NCT06740864
- Testing
- Transcranial alternating current stimulation
- Where
- Iran
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The National Brain Mapping Laboratory (NBML)
Delirium in Old Age, Delirium of Mixed Origin
Music Therapy as a Treatment for Delirium in Acutely Hospitalized Older Patients
The purpose of this study is to assess feasibility and potential effectiveness of two different music interventions for managing delirium symptoms in acute geriatric patients.
- Conditions
- Delirium in Old Age, Delirium of Mixed Origin, Delirium Superimposed on Dementia, Delirium Confusional State
- Trial name
- NCT05398211
- Testing
- Preferred Recorded Music (PRM), Preferred Live Music (PLM)
- Where
- Norway
- Volunteers
- 26 people
- Sponsor
- Oslo University Hospital
Cognitive Decline, Alzheimer Disease
Effects of Real vs. Soundless Acoustic Stimulation During Deep Sleep on Brain Activity, Memory, and Blood Biomarkers in Older Adults (60-85) With Mild Memory Impairment
This study aims to explore a non-invasive way to improve memory and slow cognitive decline in older adults by enhancing sleep quality.
- Conditions
- Cognitive Decline, Alzheimer Disease, Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI)
- Trial name
- NCT06669546
- Testing
- Phase-locked auditory stimulation (PLAS)
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Bern
Cognitive Changes Due to Organic Disorder (Finding), Dementia
Gerontology Research Programme: The Singapore Longitudinal Ageing Studies (SLAS I & II)
The Gerontology Research Programme (GRP) in the National University Singapore's Department of Psychological Medicine, was formed to coordinate and facilitate the conduct of multi-disciplinary research on in a wide range of…
- Conditions
- Cognitive Changes Due to Organic Disorder (Finding), Dementia, Mild Cognitive Impairment, Frailty
- Trial name
- SLAS (NCT03405675)
- Testing
- SLAS 1, SLAS 2
- Where
- Singapore
- Volunteers
- 6,183 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Alzheimer Disease, Parkinson Disease
Telephone Call From Acute Care Physicians to Long Term Care Physicians: Impact on Transitional Care of Elderly Patients
A telephone call from a physician taking care of a patient in the hospital to a physician in the long term care setting at the time of discharge can improve transitional care for elderly patients.
- Conditions
- Alzheimer Disease, Parkinson Disease, Dysphagia
- Trial name
- NCT00281749
- Testing
- TELEPHONE CALL
- Where
- 2 sites in United States
- Sponsor
- Maimonides Medical Center
Alzheimer Disease, Sleep Initiation and Maintenance Disorders
Using Behavioral Programs to Treat Sleep Problems in Individuals With Alzheimer's Disease
This study will compare four different behavioral treatment programs to determine which is most effective in reducing night-time disturbances in individuals with Alzheimer's disease (AD).
- Trial name
- NCT00183378
- Testing
- Walking Program, Light Exposure Program, Combined Education, Walking and Light Exposure Program
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- University of Washington
Dementia
Effects of Snoezelen Multisensory Therapy on Older Adults With Dementia
This randomized, controlled, longitudinal clinical trial investigates the effects of Snoezelen Multisensory Therapy (SMT) as an adjunct to standard therapy (ST) in older adults with dementia.
- Trial name
- SMT (NCT07657208)
- Testing
- Snoezelen Multisensory Therapy, Standard Therapy
- Where
- Slovenia
- Volunteers
- 63 people
- Sponsor
- University of Primorska
Dementia, Hip Fracture
Communication for Early Mobilisation of People Living With Dementia Following Surgery for Hip Fracture
This goal of this study is to identify ways that healthcare professionals communicate that are effective in helping a person living with dementia to stand or walk after surgery for a broken hip (hip fracture).
- Conditions
- Dementia, Hip Fracture, Early Mobilisation, Communication Research
- Trial name
- VOICE-HF (NCT07418268)
- Volunteers
- 200 people
- Sponsor
- University of Nottingham
Periodontitis, Alzheimer Disease
Nalysis of the Periodontal Microbiota in Elderly Subjects With and Without Alzheimer's Disease: a Case Control Study
The neurological disorders that accompany aging represent a major public health problem. The management of these diseases is a major medical and social priority.
- Trial name
- ORAMICAL (NCT05077618)
- Testing
- sampling of dental plaque and blood sample during the treatment
- Where
- France
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Age-Related Memory Disorders
Effectiveness of a Cognitive Training Program (UMAM Method) in Elderly People Without Dementia
The study is oriented to analyze the effectiveness of a cognitive training method (UMAM) on cognitive functions, subjective memory and mood state in elderly people without dementia.
- Trial name
- NCT04245579
- Testing
- Multifactorial Memory Training Program (UMAM method)
- Where
- Spain
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Madrid Salud
Dementia
Montessori-Based Activities for Elderly Persons With Dementia
This study will determine whether montessori-based activities can help older adults with dementia become more responsive to others.
- Trial name
- NCT00079651
- Testing
- Montessori-based dementia programming
- Where
- 5 sites in United States
- Volunteers
- 300 people
- Sponsor
- Menorah Park
Dementia, Cognitive Impairment
Physical Activity and Cerebral Metabolism in the Elderly: a Randomised Controlled Trial
Physical activity exerts a variety of long-term health benefits in older adults.This randomised controlled trial investigates the effect of a 12-week physical exercise program on the change in cerebral metabolism as assessed with…
- Trial name
- SMART (NCT02343029)
- Testing
- Individualised aerobic exercise training, Waiting Control
- Where
- 2 sites in Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Professor Johannes Pantel
Healthy, Alzheimer Disease
A Study to Measure CSF Proteins in Elderly Healthy Volunteers and Volunteers With Mild Cognitive Impairment or Alzheimer's Disease
The purpose of this study is to investigate changes of cerebral spinal fluid (CSF) proteins over time using continuous CSF sampling for 36 hours in elderly healthy volunteers and volunteers with mild cognitive impairment or…
- Trial name
- NCT01436188
- Testing
- Standard CSR sampling procedure, Alternate frequency CSR sampling procedure, Standard frequent CSR sampling procedure with 800 mg ibuprofen
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Alzheimer's Disease
Multiple Ascending Dose Study of TC-5619 in Healthy Elderly Subjects and Subjects With Alzheimer's Disease
This is a Phase 1 study to examine the safety, tolerability and pharmacokinetics of TC-5619 in elderly subjects with and without Alzheimer's disease.
- Trial name
- NCT01254448
- Testing
- TC-5619
- Where
- 10 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Targacept Inc.
Alzheimer's Disease
[18F]MK-3328 as a Possible Novel Positron Emission Tomography (PET) Tracer for the Detection of Brain Amyloid Plaques (MK-3328-002)
The purpose of this study is to evaluate radiolabeled [18F]MK-3328 as a PET tracer for estimating the regional distribution and extent of amyloid plaques in participants suffering from amnestic mild cognitive impairment (aMCI)…
- Trial name
- NCT01385033
- Testing
- [18F]MK-3328
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Aging, Dementia Alzheimers
Localized Analysis of Normalized Distance From Scalp to Cortex and Personalized Evaluation (LANDSCAPE)
Scalp to cortex distance (SCD), as a key technological parameter of brain stimulation, has been highlighted in the guidelines of non-invasive brain stimulation.
- Conditions
- Aging, Dementia Alzheimers, Parkinson Disease, Dementia Frontotemporal
- Trial name
- NCT05967390
- Testing
- Transcranial Magnetic Stimulation
- Where
- Hong Kong
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong