Clinical trials: Old Age
Elderly French Population, Age-related Macular Degeneration
Cohort Study on the Age-related Macular Degeneration: Incidence and Research for Predisposing Factors
Age-related Macular Degeneration (AMD) is the most cause of blindness in the industrialised countries. There are few epidemiological studies on the incidence of this disease.
- Trial name
- ECLAIR (NCT01918553)
- Testing
- clinical parameters, visual acuity exams, retinophotography
- Where
- France
- Volunteers
- 516 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Hypotension on Induction
Effect of Carotid Ultrasound-guided Fluid Management on Anesthetic-induced Hypotension in Elderly Patients Undergoing Gastrointestinal Surgery
The goal of this clinical trial is to learn about Whether carotid ultrasound guided fluid management can reduce the incidence of hypotension after general anesthesia induction in elderly patients undergoing gastrointestinal…
- Trial name
- NCT05891951
- Testing
- Fluid therapy under the guide of Carotid ultrasound
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Min Su
Cognitive Impairment, Alzheimer Disease
The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER) Study
A study in Finland found that a multidomain intervention of physical activity, nutritional guidance, cognitive training, social activities and management of vascular risk factors slowed cognitive decline in healthy older adults…
- Conditions
- Cognitive Impairment, Alzheimer Disease, Vascular Cognitive Impairment, Dementia
- Trial name
- SINGER (NCT05007353)
- Testing
- Structured Lifestyle Intervention, Self-Guided Intervention
- Where
- 3 sites in Singapore
- Volunteers
- 1,212 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Parkinson's Disease (PD), Mild to Moderate Parkinson's Disease
A Phase I Study in Healthy Volunteers and Parkinson's Disease (PD) Patients.
The goal of this trial is to learn if MTX325 can be developed as a potential disease-modifying treatment for Parkinson's Disease. Parts 1-4 complete, Part 5 (multiple doses in patients with Parkinson's Disease) in progress.
- Conditions
- Parkinson's Disease (PD), Mild to Moderate Parkinson's Disease, Early Stage Parkinson's Disease
- Trial name
- NCT07630545
- Testing
- MTX325
- Where
- 18 sites in Australia, France and 2 more
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Mission Therapeutics
Aging, Oxidative Stress
Whole Body Vibrations on Functional Capacity, Muscular Strength, and Biochemical Profile in Elders
This study is a randomized clinical trial that has as objective to evaluate the effects of training with a vibratory platform on body composition, muscular strength functional capacity, flexibility and biochemical profile on…
- Trial name
- NCT03030456
- Testing
- Power Plate®
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Santa Cruz do Sul
Geriatrics, Geriatric Rehabilitation
'Nordic Walking' on Geriatric Individuals
This study aimed to investigate the effects of Nordic Walking training on muscle strength and endurance, balance, fear of falling, aerobic capacity, fatigue, quality of life and activity level in geriatric individuals.
- Trial name
- NCT07158931
- Testing
- nordic walking, General walking
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Istanbul Rumeli University
Frailty Syndrome, Geriatric Health
Longitudinal Assessment of Lung Function and Respiratory Muscle Strength Following Training of the Inspiratory Muscles in Frail Older Adults (IMT-3)
This study aims to evaluate the effects of an 8-week inspiratory muscle training program on lung function and respiratory muscle strength in frail older adults aged 80 years and above.
- Conditions
- Frailty Syndrome, Geriatric Health, Respiratory Muscle Weakness, Age-Related Frailty
- Trial name
- NCT07556445
- Testing
- Inspiratory Muscle Training
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Francisco de Vitoria
Periodontal Diseases
Impact of SASP in the GCF on the Outcomes of Periodontal Regeneration
Objectives: To test the impact of clinical inflammation and molecular expression profile (senescence-associated secretory phenotype; SASP) in the gingival crevicular fluid (GCF) on the outcomes of minimally-invasive periodontal…
- Trial name
- NCT06354972
- Testing
- Minimally invasive surgical procedure
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Helmet Use, Cyclists
The Effect of Visual Patient Education on Helmet Use Behaviour in Elderly Patients After a Bicycle, E-bike, or Moped Accident
This is a multicenter randomized controlled trial (RCT) targeting individuals aged 60 and older who present to the emergency department following an accident.
- Conditions
- Helmet Use, Cyclists, Video Information
- Trial name
- HelmED RCT (NCT07773545)
- Testing
- Educational video
- Where
- 3 sites in Netherlands
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Alzheimer Disease, Mild Cognitive Impairment
Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy
Electrical activity in the brain known as "gamma" brainwaves help connect and process information throughout the brain. These gamma waves are diminished in Alzheimer's disease.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia, Cognition Disorders in Old Age
- Trial name
- AlzLife (NCT03657745)
- Testing
- Combination of 40Hz light and cognitive therapy (ALZLIFE)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Alzheimer's Light LLC
Aspiration; Liquids, Fasting
Gastric Emptying of Maltodextrin Solution in Elderly and in Adults
Gastric volume will be measured before, 5, 30, 60, 90 and 120 min after drinking 450ml of maltodextrin in young adults and elderly.
- Conditions
- Aspiration; Liquids, Fasting, Perioperative Pulmonary Aspiration
- Trial name
- GEMA (NCT04288466)
- Testing
- maltodextrin
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brasilia University Hospital
Aging
Systemic and Topical Geroprotective Rejuvenation Assessed by START/REST Aging Clocks
This study tests whether certain medicines and a skin treatment can slow down or partly reverse the body's aging process. As people age, the activity of their genes changes in predictable ways.
- Trial name
- NCT07888595
- Testing
- Topical anti-aging peptide serum
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Frontiers in Bioscience Research Institute and Aging
Influenza
Elderly Influenza Vaccine Immunogenicity Substudy
The body's immune system (fights infection) is known to decline during the aging process, resulting in an increased risk of catching infections.
- Trial name
- NCT00170482
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pulmonary Disease, Chronic Obstructive
Study of Danirixin in Japanese Healthy Elderly Male Subjects
Danirixin is a selective chemokine receptor antagonist being developed as a potential anti-inflammatory agent for the treatment of chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT03136380
- Testing
- GSK1325756H
- Where
- 2 sites in Japan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Sarcopenia
Dietary Strategies to Promote Muscle Protein Anabolism in the Elderly
Aging is associated with the loss of lean muscle mass, termed sarcopenia. Food intake and in particular the ingestion of protein or amino acids has been shown to be a powerful stimulus to promote net muscle protein anabolism.
- Trial name
- NCT00557388
- Testing
- Protein/Amino Acids, Physical exercise
- Where
- Netherlands
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Dysentery, Dysentery, Bacillary
Immunogenicity and Safety of S.Flexneriza-S.Sonnei Bivalent Conjugate Vaccine in Volunteers Aged From 3 Months to 5 Years Old
The purpose of this study is to evaluate immunogenicity and safety of S.flexneriza-S.sonnei Bivalent Conjugate Vaccine in healthy volunteers aged from 3 months to 5 years old.
- Trial name
- NCT04865497
- Testing
- S.Flexneriza-S.Sonnei Bivalent Conjugate Vaccine, Haemophilus b Conjugate Vaccine
- Where
- China
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd
Healthy
Glycemic and Insulinemic Index Determination of Two Products: Fructilight® and A Fruit Fructo-Oligosaccharides in Sweet Matrix
The aim of the study is to determine glycemic and insulinemic index of 2 sweet syrups : FructiLight® and fruit Fructo-oligosaccharides in sweet matrix compared to glucose.
- Trial name
- IGNUT (NCT01343797)
- Testing
- Glycemic and insulinemic index tests of a fruit fructose syrup and a fruit fructo-oligosaccharid syrup
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- CRITT Bio-Industries
Confusion, Inflammation
Confusion in the Elderly After Colon Surgery
A study will be conducted to determine if there is any cognitive benefit in elderly patients having open versus minimally invasive colon cancer surgery.
- Conditions
- Confusion, Inflammation, Acute Phase Reaction, Surgery
- Trial name
- NCT01623297
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- New York Hospital Queens
Mitochondrial Function, Bioenergetics, Muscle Function
Bioenergetics and Muscle Function Improvement With AMAZ-02 in Elderly Skeletal Muscle (ENERGIZE Trial)
This is a randomized, double-blind, single-center, placebo-controlled Phase 2 trial enrolling 66 healthy elderly subjects (33 placebo and 33 AMAZ-02 administration) who are ≥65 and ≤ 90 years of age with evidence of low…
- Conditions
- Mitochondrial Function, Bioenergetics, Muscle Function, Aging
- Trial name
- NCT03283462
- Testing
- Mitopure
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Healthy Older Adults, Postural Balance
INDIVIDUALIZED DUAL-TASK TRAINING FOR BALANCE AND MOBILITY IN OLDER ADULTS
The goal of this clinical trial is to prevent functional decline and improve mobility in healthy older adults aged 65 and over. The main questions it aims to answer are: What is the effect of individualized dual-task training on…
- Conditions
- Healthy Older Adults, Postural Balance, Dual Task Exercises in Elderly People, Dual Task Cost
- Trial name
- NCT07448961
- Testing
- Individualized Dual-Task Training, Standardized Dual-Task Training, Single-Task Motor Training
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sezen Karaborklu Argut
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