Clinical trials: Older Adult
Major Adverse Cardiac Events, Cerebrovascular Accident
Construction of a Prediction Model for MACCE in Elderly Patients After Elective Non-cardiac Surgery
Severe cardiovascular and cerebrovascular complications, including cardiac death, non-fatal angina/myocardial infarction, non-fatal heart failure, stroke, severe arrhythmia, etc., are one of the main types of postoperative…
- Conditions
- Major Adverse Cardiac Events, Cerebrovascular Accident, Postoperative Complications, Models
- Trial name
- NCT06391632
- Testing
- Revised Cardiac Risk Index
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Lymphoma, Chemotherapy-induced Neutropenia
Danish Elder Lymphoma Patient Hematopoietic Investigation
Every year approximately 300 Danish patients die from lymphoma. The median age at diagnosis is 70 years. Lymphoma can be efficiently treated with chemotherapy, and potentially cured.
- Conditions
- Lymphoma, Chemotherapy-induced Neutropenia, Chemotherapy-Related Leukemia, Chemotherapeutic Toxicity
- Trial name
- DELPHI (NCT05245487)
- Testing
- DNA repair gene mutation analysis
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Emotionality, Anxiety
Impact of Snoezelen Intervention and Reminiscence Therapy on Seniors' Emotionality and Anxiety
The aim of the study is to verify and compare the short-term and long-term effectiveness (retention) of Snoezelen intervention and reminiscence therapy and to analyze the dynamics of changes in the level of emotionality and…
- Trial name
- NCT07374887
- Testing
- Reminiscence therapy, Snoezelen intervention
- Where
- Slovakia
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Matej Bel University
COVID-19
Study of Monovalent and Bivalent Recombinant Protein Vaccines Against COVID-19 in Adults 18 Years of Age and Older
The purpose of this Phase III study is to assess the efficacy, safety, and immunogenicity of two CoV2 preS dTM-AS03 vaccines (monovalent and bivalent) as part of primary series vaccinations in a multi-stage approach, as well as a…
- Trial name
- VAT00008 (NCT04904549)
- Testing
- SARS-CoV-2 adjuvanted recombinant protein vaccine (monovalent D614) (primary series), SARS-CoV-2 adjuvanted recombinant protein vaccine (bivalent D614 + B.1.351) (primary series), SARS-CoV-2 adjuvanted recombinant protein vaccine (monovalent B.1.351) (booster dose) >= 4 months after last vaccination
- Where
- 86 sites in United States, Colombia and 9 more
- Volunteers
- 23,670 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Neurologic Manifestations, Neurobehavioral Manifestations
Training Cognitive Control Processes in Older Adults
Control processes are classes of brain activity that initiate, coordinate, synchronize, and regulate elemental cognitive functions for the conduct of goal-directed behavior.
- Trial name
- NCT00586638
- Testing
- Video game based training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Columbia University
Mild Cognitive Impairment
Effectiveness of an ACT-Based Cognitive Intervention on Quality of Life and Cognitive Function in Elderly Residents With MCI
This study investigates the effects of an Acceptance and Commitment Therapy (ACT)-based cognitive intervention on Quality of Life (QOL) and cognitive function among elderly residents with Mild Cognitive Impairment (MCI) in…
- Trial name
- EACT (NCT06753578)
- Testing
- Acceptance and Commitment Therapy (ACT), standard care
- Where
- Spain
- Volunteers
- 215 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Old Age; Atrophy, Aging
High-Speed Resistance Training Program in Independent Older Adults
The aims of the present investigation are: a) to determine the effects of a 16-weeks high-speed resistance training program on health parameters in independent older adults; and b) to verify the durability of the effects after 6…
- Trial name
- NCT05586087
- Testing
- Experimental group
- Where
- Portugal
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Évora
Oxidative Stress
Taurine as a Possible Anti-aging Therapy?
Among the strategies that can improve the body's ability to counteract oxidative stress, the use of nutritional antioxidants has been investigated.
- Trial name
- NCT05149716
- Testing
- Taurine
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Atrial Fibrillation, Rivaroxaban
Rivaroxaban in Elderly NVAF Patients With or Without Renal Impairment
Study Type and Design Prospective, Observational Study Rivaroxaban in Elderly AF patients with or without renal impairment in Korea This study will investigate effectiveness and safety in elderly patients, the result from…
- Conditions
- Atrial Fibrillation, Rivaroxaban, Elderly, Renal Insufficiency
- Trial name
- XAIENT (NCT04096547)
- Testing
- Rivaroxaban
- Where
- South Korea
- Volunteers
- 1,200 people
- Sponsor
- Samsung Medical Center
Congestive Heart Failure, Electric Muscle Stimulation
Electrical Muscle Stimulation in Congestive Heart Failure
This trial is to evaluate two types of electrical muscle Stimulation (EMS) stimulation (low intensity "conventional stimulation" vs.
- Conditions
- Congestive Heart Failure, Electric Muscle Stimulation, Severe Decondition, Elderly Person
- Trial name
- NCT03793647
- Testing
- Electrical muscle devise
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Kantonsspital Olten
Care Delivery, Geriatrics
Understanding the Preferences and Views of Older Adults on the Use of Geriatric and Objective Functional Assessments for Cancer Treatment Planning.
This Interventional clinical study aims to explore how receiving information about their health and physical abilities affects the treatment decisions of older adults.
- Conditions
- Care Delivery, Geriatrics, Geriatric Assessment
- Trial name
- NCT06652347
- Testing
- Cancer care delivery
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Fox Chase Cancer Center
Anxiety and Fear, Pain
The Effect of Projector Kaleidoscope and Cartoons on Anxiety, Fear, and Pain in Children
The research will be conducted with children hospitalized in Tarsus State Hospital Children's Clinics and who meet the sampling criteria.
- Conditions
- Anxiety and Fear, Pain, Surgery
- Trial name
- NCT06339047
- Testing
- Projector Kaleidoscope, Cartoon
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Tarsus University
Colorectal Cancer
An Evaluation of a Multi-target Stool DNA (Mt-sDNA) Test, Cologuard, for CRC Screening in Individuals Aged 45-49 and at Average Risk for Development of Colorectal Cancer: Act Now
The primary objective is to confirm the specificity of a multi-target stool DNA test (mt-sDNA), Cologuard, in an average risk population, ages 45-49.
- Trial name
- NCT03728348
- Testing
- mt-sDNA screening test, Colonoscopy
- Where
- 39 sites in United States
- Volunteers
- 983 people, healthy volunteers welcome
- Sponsor
- Exact Sciences Corporation
Chronic Kidney Disease Stage 3
A Study to Investigate the Safety, Tolerability, and Preliminary Efficacy With AION-301 Administered by Intravenous Infusion Compared With Placebo Administered by Intravenous Infusion Investigational Intervention in Participants Aged 35 to 75 Years of Age With Chronic Kidney Disease (CKD)
The goal of this clinical trial is to learn about the safety (good or bad) of giving two AION-301 intravenous (IV) infusions, in adults with Stage 3 Chronic Kidney Disease (CKD).
- Trial name
- UC-MSC-CKD (NCT06721143)
- Testing
- AION-301
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- AION Healthspan, Inc.
Chronic Obstructive Pulmonary Disease, Foot Deformities
The Effect of Foot Deformities on Physical Activity, Fatigue Level and Quality of Life in Elderly COPD Patients
The aim of this study is to investigate the effects of changes in foot structure on physical activity level, fatigue and quality of life in COPD patients.
- Conditions
- Chronic Obstructive Pulmonary Disease, Foot Deformities, Quality of Life, Activity, Motor
- Trial name
- NCT04627935
- Testing
- The COPD Assessment Test, Navicular Drop Test, International Physical Activity Questionnaires (IPAQ)
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Bacterial Infections.
A Single Dose Study To Investigate The Pharmacokinetics and Safety Of Dalbavancin In Hospitalized Children Aged 3 Months to 11 Years.
A phase one study to characterize the pharmacokinetics of dalbavancin in pediatric patients aged 3 months to 11 years (inclusive) following the intravenous administration of a single dose of dalbavancin.
- Trial name
- NCT01946568
- Testing
- Dalbavancin
- Where
- 12 sites in United States, Estonia
- Volunteers
- 36 people
- Sponsor
- Durata Therapeutics Inc., an affiliate of Allergan plc
TOF, Sex
Pharmacokinetics and Pharmacodynamics of Rocuronium in Closed-Loop Infusion System
To explore and compare the effects of propoful, sevoflurane, and a combination of both on the pharmacokinetics and pharmacodynamics of rocuronium.
- Trial name
- NCT02364934
- Testing
- Propofol, Sevoflurane
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Iron Overload, Oxidative Stress
Safety of Various Mode of Delivery of Iron Supplement on Iron Toxicity Markers in Preschool Children
The purpose of study is to evaluate and compare the effect of iron supplementation when given as iron tablet or fortified biscuit or combined with zinc in the form of tablet on morbidity and iron toxicity markers among children…
- Trial name
- NCT00980421
- Testing
- Iron Supplementation
- Where
- India
- Volunteers
- 240 people
- Sponsor
- Annamalai University
Mild Cognitive Impairment
Using fMRI-guided TMS to Increase Central Executive Function in Older Adults (MCI_Sub)
This is an administrative supplement to an existing project "Using fMRI-guided TMS to increase central executive function in older adults: NCT02767323" This award allows extending our existing fMRI-TMS paradigm to patients with a…
- Trial name
- MCI_Sub (NCT04176406)
- Testing
- rTMS
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Duke University
MASH - Metabolic Dysfunction-Associated Steatohepatitis
A Trial to Investigate Safety, Exposure, and Efficacy of HU6 Compared With Placebo in Adult Participants With Metabolic Dysfunction-associated Steatohepatitis (MASH)
Rivus Pharmaceuticals. Inc. is sponsoring this research study to assess the safety and tolerability of HU6 as a possible treatment for patients diagnosed with metabolic dysfunction-associated steatohepatitis (MASH).
- Trial name
- AMPLIFY (NCT07491458)
- Testing
- HU6
- Where
- 31 sites in United States
- Volunteers
- 180 people
- Sponsor
- Rivus Pharmaceuticals, Inc.