Clinical trials: Older Adults With Cancer
Cognitive/Functional Effects, Depression
Study of Physical and Mental Health of Older Patients With Newly Diagnosed Cancer
RATIONALE: Gathering information from older patients with newly diagnosed cancer may help doctors learn more about the risks of functional decline.
- Conditions
- Cognitive/Functional Effects, Depression, Hematopoietic/Lymphoid Cancer, Malnutrition
- Trial name
- NCT00769951
- Testing
- medical chart review, questionnaire administration, cognitive assessment
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Case Comprehensive Cancer Center
Elderly Females, HER2 + Breast Cancer
Olaparib+Trastuzumab+Pertuzumab Neoadjuvant for Elderly HER2+ Breast Cancer
This is a single-center, interventional, prospective clinical study. A total of 45 patients aged ≥ 60 years with ECOG PS 0-1 who have histologically confirmed, treatment-naïve, unilateral primary invasive HER-2-positive breast…
- Conditions
- Elderly Females, HER2 + Breast Cancer, Neoadjuvant Therapy
- Trial name
- NCT07695259
- Testing
- olaparib combined with trastuzumab and pertuzumab
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Wen-Ming Cao
B-Cell Chronic Lymphocytic Leukemia
Study Of The Effectiveness & Safety Of Lenalidomide Versus Chlorambucil As First Line Therapy For Elderly Patients With B-Cell CLL (The ORIGIN Trial)
The purpose of this study is to determine the safety and efficacy of lenalidomide as a first line therapy in treating patients with B-cell Chronic Lymphocytic Leukemia.
- Trial name
- ORIGIN (NCT00910910)
- Testing
- Lenalidomide, Chlorambucil
- Where
- 165 sites in United States, Australia and 25 more
- Volunteers
- 450 people
- Sponsor
- Celgene
Cancer
Frailty and Body Composition in the Elderly Cancer Patients Treated With Chemotherapy
The investigators could hypothesize that age-related changes in body composition parameters play a role in the variable tolerance to chemotherapy in the elderly.
- Trial name
- FRACTION (NCT02806154)
- Testing
- DEXA
- Where
- 8 sites in France
- Volunteers
- 144 people
- Sponsor
- University Hospital, Toulouse
Cancer, Rectal
Study of Short Course Radiation Therapy for Elderly Patients With Rectal Cancer
This study will help determine if a short course of radiation therapy is effective to treat rectal cancer in older patients. A shorter course of radiation treatment may be better tolerated than a longer course or surgery for the…
- Trial name
- NCT04139967
- Testing
- Short course radiation therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Rochester
Abnormal Uterine Bleeding
Transvaginal Ultrasound in Women With Abnormal Uterine Bleeding
The objective of this study is to investigate the role of transvaginal ultrasound in detecting endometrial hyperplasia and endometrial cancer in women aged more than 35 presenting with abnormal uterine bleeding.
- Trial name
- NCT01786798
- Testing
- Transvaginal sonography
- Where
- Thailand
- Volunteers
- 560 people
- Sponsor
- Chulalongkorn University
Primary Brain Tumor, Glioblastoma
Temozolomide in Elderly Patients With KPS < 70
The management of glioblastoma in elderly patients with poor performance status (KPS<70) is unsettled. This single arm phase 2 trial trial was designed to evaluate the efficacy and safety of temozolomide alone in this population
- Trial name
- TAG (NCT01242566)
- Testing
- Temozolomide
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Central Nervous System Neoplasms, Primary
Use of Optune TTF With Radiation as an Alternative for Elderly Patients With Primary CNS Lymphoma
This study will compare the overall survival (OS) time of elderly patients who would not tolerate standard chemotherapy for PCNSL treated with WBXRT together with Optune-TTF to those treated with whole-brain radiotherapy alone.
- Trial name
- NCT03530605
- Testing
- Optune TTF device
- Sponsor
- Saint Luke's Health System
Acute Myeloid Leukemia
A Study Comparing Allogeneic Hematopoietic Cell Transplantation Versus Best Available Standard of Care Therapy in Elderly Patients With Acute Myeloid Leukemia
A subject of major interest for researchers, clinicians, patients, and payers, is the role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in the treatment of these older patients with AML.
- Trial name
- ALLO-BEST (NCT04822766)
- Testing
- Hematopoietic stem cell transplantation, Best chemotherapy treatment
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Peripheral T Cell Lymphoma, Unspecified, Angioimmunoblastic Lymphadenopathy
Immunotherapy in Peripheral T Cell Lymphoma - the Role of Alemtuzumab in Addition to Dose Dense CHOP
Peripheral T cell lymphomas comprise 10-15% of all malignant lymphomas. The prognosis is significantly worse than that of aggressive B cell lymphomas.
- Conditions
- Peripheral T Cell Lymphoma, Unspecified, Angioimmunoblastic Lymphadenopathy, Extranodal NK/T-cell Lymphoma
- Trial name
- A-CHOP-14 (NCT00725231)
- Testing
- alemtuzumab, chemotherapy
- Where
- Germany
- Volunteers
- 274 people
- Sponsor
- University of Göttingen
Non-Small-Cell Lung Cancer
Reduced-Dose vs Standard-Dose Thoracic Radiotherapy After Induction Chemoimmunotherapy in Older or Frail Stage III NSCLC
This is a multicenter, open-label, randomized phase III study in older or frail adults with unresectable stage III non-small cell lung cancer (NSCLC) who are considered unsuitable for concurrent chemoradiotherapy.
- Trial name
- NCT07908745
- Testing
- Reduced-Dose Thoracic Radiotherapy, Standard-Dose Thoracic Radiotherapy
- Volunteers
- 276 people
- Sponsor
- Ruijin Hospital
Lymphoma, Large B-cell, Diffuse
Geriatric Assessments in Elderly Diffuse Large B-cell Lymphoma Patients-2 (GERIAD2)
This study will validate the impact of comprehensive geriatric assessments using activity of daily living (ADL), instrumental activity of daily living (IADL), and Charlson's comorbidity index (CCI) on survival and toxicities in…
- Trial name
- NCT03211702
- Where
- 2 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Chonbuk National University Hospital
Digestive System Disease, Neoplasms
Multidisciplinary Evaluation of Elderly Patients With Digestive Cancer (EPODIG-G)
This is a monocentric, comparative, open-label, randomized parallel group study enrolling elderly subjects hospitalized in Strasbourg Europe Cancerology Institute (ICANS), starting chemotherapy or targeted therapy for the…
- Trial name
- EPODIG-G (NCT05066139)
- Testing
- EPODIG-G program (coordination of supportive care)
- Where
- France
- Volunteers
- 144 people
- Sponsor
- Centre Paul Strauss
Leukemia
Tipifarnib, Cytarabine, and Daunorubicin in Treating Older Patients With Acute Myeloid Leukemia
RATIONALE: Tipifarnib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cytarabine and daunorubicin, work in different ways to stop the growth of…
- Trial name
- NCT00101153
- Testing
- cytarabine, daunorubicin hydrochloride, tipifarnib
- Where
- 2 sites in Canada
- Volunteers
- 24 people
- Sponsor
- University Health Network, Toronto
Cognitive/Functional Effects, Colorectal Cancer
Combination Chemotherapy Plus Bevacizumab With or Without Oxaliplatin in Treating Older Patients With Metastatic Colorectal Cancer
This randomized phase III trial studies how well combination chemotherapy plus bevacizumab with or without oxaliplatin works in treating older patients with colorectal cancer that has spread to other places in the body.
- Conditions
- Cognitive/Functional Effects, Colorectal Cancer, Neurotoxicity
- Trial name
- NCT01279681
- Testing
- bevacizumab, capecitabine, fluorouracil
- Volunteers
- 32 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Adult Acute Lymphocytic Leukemia
German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
The study evaluates the efficacy and tolerability of a dose-reduced chemotherapy for the treatment of elderly patients with acute lymphoblastic leukemia.
- Trial name
- NCT00198978
- Testing
- Cyclophosphamide, Dexamethasone / Prednisolone, Cytarabine
- Where
- Germany
- Volunteers
- 377 people
- Sponsor
- Goethe University
Colorectal Cancer
Phase II Trial of Combination Therapy With Bevacizumab and S-1 in Elderly Patients With Unresectable or Recurrent Colorectal Cancer (BASIC)
The purpose of this study is to determine whether S-1 and bevacizumab are safe in the treatment of unresectable or recurrent colorectal cancer
- Trial name
- NCT00569699
- Testing
- S-1, Bevacizumab
- Where
- Japan
- Volunteers
- 56 people
- Sponsor
- Taiho Pharmaceutical Co., Ltd.
Leukemia
Maintenance Azacitidine in Elderly Patients With Acute Myeloid Leukemia (AML) in CR After Induction Chemotherapy
The purpose of this study is to find out if patients older than 60, with acute myeloid leukemia, who are in complete remission following initial chemotherapy, will live longer and have a lower rate of leukemia relapse when…
- Trial name
- NCT00387647
- Testing
- Azacitidine
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Gastric Cancer
Trial Comparing Capecitabine Plus Oxaliplatin (XELOX) and Capecitabine (X) as First-line Chemotherapy in Elderly Patients With Advanced Gastric Cancer
The objective of the trial is to compare Overall survival between capecitabine plus oxaliplatin (XELOX) and capecitabine (X) as first-line chemotherapy in elderly patients with advanced gastric cancer.
- Trial name
- NCT01470742
- Testing
- XELOX, XELODA
- Where
- South Korea
- Sponsor
- Samsung Medical Center
Leukemia, Myelodysplastic Syndromes
Combination Chemotherapy With or Without Gemtuzumab Ozogamicin or Tipifarnib in Treating Patients With Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00454480
- Testing
- alemtuzumab, arsenic trioxide, azacitidine
- Where
- 96 sites in United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- The University of New South Wales
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