Clinical trials: Older Adults With Cancer
Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Megakaryoblastic Leukemia (M7)
Clofarabine or Daunorubicin Hydrochloride and Cytarabine Followed By Decitabine or Observation in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia
This randomized phase III trial studies clofarabine to see how well it works compared with daunorubicin hydrochloride and cytarabine when followed by decitabine or observation in treating older patients with newly diagnosed acute…
- Conditions
- Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0), Adult Acute Monoblastic Leukemia (M5a)
- Trial name
- NCT02085408
- Testing
- Daunorubicin, Cytarabine, Clofarabine
- Where
- 269 sites in United States, India and 1 more
- Volunteers
- 727 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Leukemia, Lymphoblastic, Acute
Dasatinib and Low Intensity Chemotherapy for Ph+ Acute Lymphoblastic Leukemia
1. The use of imatinib in combination or in association with chemotherapy is now considered as the gold standard for the treatment of Ph+ ALL. The complete remission (CR) rate is 90% versus 20% to 40% with chemotherapy alone.
- Trial name
- EWALLPH01 (NCT02888990)
- Testing
- Dasatinib
- Where
- 64 sites in Belgium, France and 2 more
- Volunteers
- 71 people
- Sponsor
- Versailles Hospital
Hodgkin Lymphoma
Prognostic Model of Elderly Hodgkin Lymphoma in China
This multicenter observational cohort study is based on a patient registry designed to systematically collect uniform real-world clinical data from elderly patients with Hodgkin lymphoma (HL) in China.
- Trial name
- NCT07374068
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Follicular Lymphoma
BRIEF Bendamustine and Rituximab In Elderly Follicular
The objective of this study is to evaluate the complete response rate after a short induction treatment with rituximab (375mg/m2)and bendamustine (90mg/m2)in In Elderly (≥ 60 years old) patients with untreated Follicular…
- Trial name
- BRIEF (NCT01313611)
- Testing
- Rituximab + bendamustine
- Where
- 117 sites in Belgium, France
- Volunteers
- 62 people
- Sponsor
- The Lymphoma Academic Research Organisation
Newly Diagnosed Acute Myeloid Leukemia (AML), Elderly Patients
Venetoclax-Azacitidine in Combination With Chidamide and CAG in Fit Older Patients With Acute Myeloid Leukaemia
This study is a multicenter, prospective, randomized, controlled clinical trial, observing the efficacy and safety of the CACAG+Venetoclax regimen (Chidamide + Azacitidine + Aclarubicin + Cytarabine + Recombinant Human…
- Trial name
- NCT07514936
- Testing
- the standard "3+7" regimen, Azacytidine; Cytarabine; Aclacinomycin; Chidamide; Venetoclax; Granulocyte
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Chinese PLA General Hospital
Lymphoma
Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies such as rituximab can locate tumor cells and either kill them or deliver tumor-killing…
- Trial name
- NCT00052936
- Testing
- filgrastim, rituximab, CHOP regimen
- Where
- 174 sites in Germany, Switzerland
- Volunteers
- 1,506 people
- Sponsor
- German High-Grade Non-Hodgkin's Lymphoma Study Group
Lung Cancer Stage III, Lung Cancer Stage IV
Resilience Measurement in Older Adults With Late-Stage Lung Cancer
The purpose of this study to test measures of physical and psychological resilience while using Self-System therapy (SST), to treat depression and lung-cancer-related distress in older adults (65 years and older).
- Trial name
- SST Resilience (NCT04825912)
- Testing
- Self System Therapy for Older Adults with Advanced Lung Cancer (SST-LC) Resilience
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Duke University
Non-Small-Cell Lung Carcinoma
Phase II Iressa Versus Vinorelbine (INVITE)
This is a randomized, open label, parallel group, multi-centre, phase II study of progression free survival, comparing oral ZD1839 (IRESSA™) (250 mg tablet once daily) to vinorelbine 30 mg/m2 infusion on days 1 and 8 of a 21-day…
- Trial name
- NCT00256711
- Testing
- Gefitinib, Vinorelbine
- Where
- 55 sites in Australia, Brazil and 8 more
- Volunteers
- 192 people
- Sponsor
- AstraZeneca
Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL)
A Study of Idelalisib and Rituximab in Elderly Patients With Untreated CLL or SLL
This study is to evaluate the safety and clinical activity of idelalisib alone and in combination with rituximab in patients with CLL or SLL.
- Trial name
- NCT01203930
- Testing
- Idelalisib, Rituximab
- Where
- 6 sites in United States
- Volunteers
- 105 people
- Sponsor
- Gilead Sciences
Lymphoma
Rituximab and Combination Chemotherapy in Treating Older Patients With Diffuse Large B-Cell Lymphoma
RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread.
- Trial name
- NCT00101010
- Testing
- Filgrastim, Pegfilgrastim, Rituximab
- Where
- 7 sites in United States
- Volunteers
- 80 people
- Sponsor
- M.D. Anderson Cancer Center
Acute Myelogenous Leukemia
CD3/CD19 Depleted or CD3 Depleted/CD56 Selected Haploid Donor Natural Killer Cell Treatment in Older AML in First Complete Remission
This is a phase II trial designed to test the safety and efficacy (disease free survival [DFS]) of related donor HLA-haploidentical NK-cell based therapy for the treatment of acute myelogenous leukemia (AML).
- Trial name
- NCT01639456
- Testing
- CD3-/CD19- natural killer cells, CD3-CD56+ natural killer cells, CliniMACS® CD3 and CD19 Reagent System
- Where
- 2 sites in United States
- Sponsor
- Masonic Cancer Center, University of Minnesota
Mantle Cell Lymphoma (MCL)
Ibrutinib Combined With Bendamustine and Rituximab in Newly Diagnosed Mantle Cell Lymphoma Patients Who Aged > 65 Years
This study is a prospective observational clinical trial. A total of 19 research centers were involved in this study. Each site plans to enroll 2-3 patients, and a total of 60 patients will be enrolled.
- Trial name
- NCT05406154
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Esophageal Cancer, Radiation Therapy
Toripalimab Plus Radiotherapy for Elderly Esophageal Cancer Patients Treated With Non-chemotherapy Strategy
The goal of this clinical trial is to explore the therapeutic efficacy of immune checkpoint inhibitors combined with radical radiotherapy in elderly patients with esophageal cancer.
- Conditions
- Esophageal Cancer, Radiation Therapy, Immunotherapy, Chemotherapy
- Trial name
- NCT05817201
- Testing
- Toripalimab, Tegafur, IMRT
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Taizhou Hospital
Colorectal Cancer Metastatic
Colorectal Cancer (CRC) Cetuximab Elderly Frail
OBJECTIVE: The principal objective of the trial is to evaluate whether the addition of cetuximab associated with 5-fluorouracil in elderly patients with KRAS wild type advanced colorectal cancer (CRC) prolongs Progression Free…
- Trial name
- NCT01522612
- Testing
- Cetuximab, 5-fluorouracil, leucovorin
- Where
- 3 sites in Belgium, Cyprus and 1 more
- Volunteers
- 5 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Colorectal Cancer (CRC)
Transcutaneous Electrical Acustimulation on Postoperative Bowel Function Recovery in Elderly Patients
The goal of this clinical trial is to clarify the efficacy and safety of transcutaneous electrical acustimulation (TEA) in elderly patients with colorectal cancer, and to evaluate its clinical value in promoting postoperative…
- Trial name
- NCT07574502
- Testing
- TEA
- Where
- 2 sites in China
- Volunteers
- 190 people
- Sponsor
- Sir Run Run Shaw Hospital
Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS)
Treatment of Elderly Patients With Acute Myeloid Leukemia (AML) and High Risk Myelodysplastic (MD) Syndrome With Laromustine and Infusional Cytarabine
The purpose of the Phase I portion of this study is to evaluate the safety of this combination of medications and to determine the appropriate dose of VNP40101M to be used in combination with infusional cytarabine (araC) in…
- Trial name
- NCT00655395
- Testing
- Laromustine (VNP40101M) and Ara-C
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Viron Therapeutics Inc
Leukemia
Natural Killer Cells in Older Patients With Acute Myeloid Leukemia
RATIONALE: Studying natural killer cells in samples of blood from patients with cancer may help doctors find out how these cells are effected by chemotherapy.
- Trial name
- NCT00540956
- Testing
- cytarabine, laboratory biomarker analysis
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Institut Paoli-Calmettes
Colorectal Cancer
1st Line Chemotherapy Alone or With Bevacizumab in Treating Older Patients With Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as leucovorin calcium, fluorouracil, irinotecan hydrochloride, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them…
- Trial name
- NCT01417494
- Testing
- Chemotherapy ( FOLFIRI regimen, FOLFOX regimen or LV5FU2 regimen), Chemotherapy ( FOLFIRI regimen, FOLFOX regimen or LV5FU2 regimen) + bevacizumab
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Colorectal Cancer
First-Line Capecitabine and Cetuximab for Metastatic Colorectal Ca in Elderly Patients
This is a Phase II clinical trial measuring the effectiveness of the combination of Capecitabine and cetuximab for first line treatment of colorectal cancer in elderly patients and/or those with multiple comorbidities unable to…
- Trial name
- NCT00251186
- Testing
- Capecitabine and Cetuximab
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Acute Lymphoblastic Leukemia, Adult
Study in Adult Ph-positive ALL
An Open Label, 3-arm, Randomised Phase II Study to Compare the Safety and Efficacy of Ponatinib in Combination With Either Chemotherapy or Blinatumomab With Imatinib Plus Chemotherapy as Front-line Therapy for Patients Aged 55…
- Trial name
- EWALL-Ph-03 (NCT04688983)
- Testing
- Ponatinib, Blinatumomab, Imatinib
- Volunteers
- 180 people
- Sponsor
- Cardiff University
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