Clinical trials: Older Adults With Cancer
Philadelphia Positive Acute Lymphoblastic Leukemia, Lymphoid Blastic Phase of Chronic Myeloid Leukemia
Study Comparing Imatinib With Chemotherapy as Induction in Elderly Patients With Philadelphia Positive Acute Lymphoblastic Leukemia (ALL)
The aims of the study are to determine whether single agent imatinib (STI571; Glivec) is more effective as up-front remission induction therapy than conventional multi-agent induction chemotherapy for elderly patients with…
- Trial name
- NCT00199186
- Testing
- imatinib, vincristine, cyclophosphamide
- Where
- Germany
- Sponsor
- Johann Wolfgang Goethe University Hospital
Ovarian Cancer
EWOC-1 Trial: Carboplatin +/- Paclitaxel in Vulnerable Elderly Patients With Stage III-IV Advanced Ovarian Cancer
The current standard of first-line chemotherapy in advanced ovarian cancer is the combination of carboplatin AUC 5mg/mL/min and paclitaxel 175 mg.m-².
- Trial name
- EWOC-1 (NCT02001272)
- Testing
- Paclitaxel + Carboplatin every 3 weeks, Carboplatin monotherapy every 3 weeks, Weekly Paclitaxel and Carboplatin
- Where
- 63 sites in Canada, Denmark and 4 more
- Volunteers
- 120 people
- Sponsor
- Hospices Civils de Lyon
Lymphoma
Clinical Trial to Evaluate R-COMP Versus R-CHOP in Newly Diagnosed Patients With Non-localised Diffuse Large B-cell Lymphoma (DLBCL)/Follicular Lymphoma Grade IIIb
The Phase II study proposed here assesses the hypothesis that replacing doxorubicin by Myocet® in the R-CHOP regimen would yield comparable antitumour efficacy with a lower cardiotoxicity for first-line treatment in elderly…
- Trial name
- NCT02012088
- Testing
- RCOMP, RCHOP
- Where
- 14 sites in Spain
- Volunteers
- 91 people
- Sponsor
- Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea
Leukemia
Azacitidine in Treating Patients With Newly Diagnosed Previously Untreated or Secondary Acute Myeloid Leukemia Who Are Unsuitable For Intensive Chemotherapy
RATIONALE: Drugs used in chemotherapy, such as azacitidine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00739388
- Testing
- azacytidine
- Where
- 11 sites in Switzerland
- Volunteers
- 47 people
- Sponsor
- Swiss Cancer Institute
Old Injury
Prehabilitation & Rehabilitation in Oncogeriatrics: Adaptation to Deconditioning Risk and Accompaniment of Patients' With Cancer
With the conjunction of increased life expectancy and the increasing incidence of cancer with aging, older patient represent an increasing proportion of cancer patients.
- Trial name
- PROADAPT (NCT03659123)
- Testing
- standardized geriatric intervention
- Where
- 10 sites in France
- Volunteers
- 148 people
- Sponsor
- Hospices Civils de Lyon
Ovarian Cancer
Normethermic Intraperitoneal Chemotherapy - a Novel Concept for Local Treatment of the Elderly and Fragile Women With Advanced Ovarian Cancer?
The purpose of this feasibility study is to investigate whether NIPEC with carboplatin after surgery is safe for the elderly and frail women with advanced ovarian cancer.
- Trial name
- NICE-C (NCT07733505)
- Testing
- Normethermic Intraperitoneal Chemotherapy with carboplatin
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Odense University Hospital
Acute Myelogenous Leukemia
Plerixafor and Clofarabine in Frontline Treatment of Elderly Patients With Acute Myelogenous Leukemia (AML)
The goal of Part 1 of this clinical research study is to learn about the safety of the combination of plerixafor and clofarabine when given to patients with previously untreated AML who are at least 60 years old.
- Trial name
- NCT01160354
- Testing
- Plerixafor, Clofarabine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- M.D. Anderson Cancer Center
Other Cancer
A Geriatric Oncology Collaborative Care Intervention for Older Adults With Advanced Cancer
The purpose of this research study is to develop a geriatric oncology collaborative care intervention to enhance the quality of life, symptom burden, and functional outcomes of older adults with advanced gastrointestinal (GI) and…
- Trial name
- NCT03721926
- Testing
- Usual Care, Geriatric Oncology Collaborative Care
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Massachusetts General Hospital
Chemotherapy, Diffuse Large B-Cell Lymphoma (DLBCL), Nos
Assessment of Survival and Autonomy With Rituximab Plus Chemotherapy or Rituximab Plus Lenalidomide for Elderly Patients With Relapsed Diffuse Large B-cell Lymphoma
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma. Annual incidence increases with age and achieves more than 30 per 100 000 patients 65 years old or over.
- Conditions
- Chemotherapy, Diffuse Large B-Cell Lymphoma (DLBCL), Nos, Elderly
- Trial name
- Relyage (NCT04113226)
- Testing
- Rituximab, Lenalidomide 20 MG, Comprehensive Geriatric Assessment (CGA)
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Armonea Nursing Homes Residents
Cancer in Nursing Home Residents
Cancer is a disease of the elderly. Cancer incidence is 11-fold higher in persons over the age of 65, than in younger ones. Approximately 60% of all cancers and 70% of cancer mortality occurs in people older than 65 years.
- Trial name
- NCT01910376
- Where
- Belgium
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Plasma Cell Myeloma
Evaluation of Comprehensive Geriatric Assessment and Laboratory Biomarkers in Elderly Patients With Multiple Myeloma
This study evaluates the association between a comprehensive geriatric assessment and laboratory biomarkers with the side effects of chemotherapy in older patients with multiple myeloma (MM).
- Trial name
- NCT05918185
- Testing
- Biospecimen Collection, Comprehensive Geriatric Assessment, Electronic Health Record Review
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Mayo Clinic
Cognitive/Functional Effects, Depression
Physical and Mental Assessment of Older Patients With Newly Diagnosed Acute Myeloid Leukemia
RATIONALE: Learning about physical ability and mental function over time in older patients with acute myeloid leukemia may help doctors learn about the long-term effects of treatment and plan the best treatment.
- Conditions
- Cognitive/Functional Effects, Depression, Leukemia
- Trial name
- NCT00499785
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Wake Forest University Health Sciences
Hematologic Malignancies
The Safety and Efficacy of the Regimen of Thiotepa + Fludarabine +Granulocyte Colony-Stimulating Factor+ Cytarabine + Busulfan in Single Unrelated Umbilical Cord Blood Transplantation
This trial is a prospective, single-arm, single-center clinical study. A total of 44 elderly (aged 60 to 69 years) patients with hematological malignancies who need to receive a single-unit unrelated umbilical cord blood…
- Trial name
- NCT07441967
- Testing
- Thiotepa, Fludarabine, G-CSF
- Volunteers
- 44 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Acute Myeloid Leukemia, Induction Chemotherapy
Study of DAC Combined With HAAG Regimen in Newly Diagnosed AML Patients Older Than 60
The purpose of this study is to evaluate the safety and efficacy of DAC combined with HAAG regimen in the induction treatment of newly diagnosed AML patients older than 60 years.
- Trial name
- NCT04083911
- Testing
- Decitabine, Homoharringtonine, Aclarubicin, Cytarabine and G-CSF
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Rectal Cancer
Early-onset Rectal Cancer
The present study aimed to review the characteristics and outcome of early-onset rectal cancer in a subset of Egyptian patients aged 40 years or less.
- Trial name
- NCT04496765
- Testing
- Total mesorectal excision
- Where
- Egypt
- Volunteers
- 244 people
- Sponsor
- Mansoura University
Eating Disorder
Reducing Eating Disorder Risk Factors Among College-Aged Males
The purpose of the present study was to investigate the acceptability and efficacy of a cognitive dissonance-based (DB) intervention in reducing eating disorder and muscle dysmorphia risk factors in men with body dissatisfaction.
- Trial name
- NCT03013244
- Testing
- The Body Project: More Than Muscles
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Florida State University
Colorectal Cancer
Capecitabine and Oxaliplatin in Treating Older Patients With Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00104689
- Testing
- capecitabine, oxaliplatin
- Where
- 9 sites in France
- Volunteers
- 60 people
- Sponsor
- UNICANCER
Leukemia, Myeloid, Acute
Treatment of Non Promyelocytic Acute Myeloid Leukaemia on Elderly Patients by Low Dose Cytosar Plus Arsenic Trioxide
Our purpose in this study is to explore the feasibility of treatment of non promyelocytic Acute myeloid leukaemia on elderly patients.
- Trial name
- NCT00850304
- Testing
- Cytosar, Arsenic trioxide
- Where
- Iran
- Volunteers
- 10 people
- Sponsor
- Tehran University of Medical Sciences
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Study of Zanubrutinib in Older Patients With Previously Untreated Chronic Lymphocytic Leukemia (CLL)
This phase II, open-label, multicenter study evaluates zanubrutinib in patients aged 80 years and older with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who require treatment.
- Trial name
- ZEN-CLL (NCT07739459)
- Testing
- Zanubrutinib
- Where
- 17 sites in France
- Volunteers
- 95 people
- Sponsor
- The Lymphoma Academic Research Organisation
Stomach Cancer, Stomach Neoplasm
Second-Line Chemotherapy With Ramucirumab +/- Paclitaxel in Elderly Advanced Gastric or Gastroesophageal Junction Cancer Patients
The primary objective is to evaluate six months survival rate and quality of life at 4 months of ramucirumab alone or in combination with paclitaxel in patients aged 70 years or more who have stomach or GEJ adenocarcinoma and…
- Conditions
- Stomach Cancer, Stomach Neoplasm, Gastric Cancer, Gastroesophageal Junction Adenocarcinoma
- Trial name
- SOCRATE (NCT03760822)
- Testing
- Ramucirumab, Paclitaxel
- Where
- 38 sites in France
- Volunteers
- 112 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
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