Clinical trials: Older Adults With Cancer
Head and Neck Cancer
Predicting Toxicity in Elderly Patients With Head and Neck Cancer
Predicting toxicity in elderly patients with head and neck cancer: validating a disease-oriented toxicity predictive tool and integrating it with avail-able screening tools for better outcomes.
- Trial name
- PREtoxEL (NCT06344208)
- Where
- Italy
- Volunteers
- 3 people
- Sponsor
- European Institute of Oncology
Colorectal Cancer
Bevacizumab and Capecitabine as First-Line Therapy in Treating Older Patients With Metastatic Colorectal Cancer
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT00107315
- Testing
- bevacizumab, capecitabine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Roswell Park Cancer Institute
Carcinoma, Hepatocellular
Characterizing Disease Biology, Treatment and Toxicity in Older Adults With Hepatocellular Carcinoma
This is an observational, prospective cohort study that will recruit a diverse sample of 84 participants with newly diagnosed with unresectable, advanced hepatocellular carcinoma (HCC) at the UT Health Cancer Center in San…
- Trial name
- NCT03894917
- Testing
- Comprehensive Geriatric Assessment (CGA)
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Metastatic Colorectal Cancer
Capecitabine Plus Oxaliplatin Plus Bevacizumab as First-line Treatment in Elderly Patients With Metastatic Colorectal Cancer
This trial will evaluate the efficacy and safety of the capecitabine and oxaliplatine plus bevacizumab combination as first-line treatment in elderly patients with metastatic colorectal cancer.
- Trial name
- NCT01024504
- Testing
- Oxaliplatin, Capecitabine, Bevacizumab
- Where
- 6 sites in Greece
- Volunteers
- 46 people
- Sponsor
- Hellenic Oncology Research Group
Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men
A Study to Learn What Happens to Elinzanetant in the Body When Taken With or Without Carbamazepine, and How Safe it is in Healthy Men and Women Aged 18 to 60 Years.
Researchers are looking for a better way to treat people who have symptoms caused by hormonal changes, such as hot flashes. Before a treatment can be approved for patients to take, researchers do clinical studies to better…
- Trial name
- NCT05028608
- Testing
- Elinzanetant (BAY3427080), Midazolam, Carbamazepine
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Bayer
Chronic Myeloid Leukemia
Intermittent Imatinib Treatment in Chronic Myeloid Leukemia and Philadelphia Chromosome (Ph+CML) Patients Who Achieved a Complete Cytogenetic Response (CCgR) on Standard Imatinib Therapy
Standard therapy with Imatinib (IM) significantly prolongs the survival of Ph+CML patients who obtain a complete cytogenetic response (CCgR).
- Trial name
- INTERIM0407 (NCT00858806)
- Testing
- Imatinib
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- Università degli Studi di Brescia
Elderly, Cancer
Suitability of an Organization With an Onco-geriatric Team to a Whole Region (Region Midt) of Denmark
A Feasibility study Geriatric assessment applied to patients with cancer of the head and neck, lung cancer, upper gastrointestinal cancer or colo-rectal cancer.
- Trial name
- NCT02072733
- Testing
- Comprehensive geriatric assessment
- Where
- Denmark
- Volunteers
- 320 people
- Sponsor
- University of Aarhus
Cancer
Comprehensive Geriatric Assessment and Management for Canadian Elders With Cancer
A multicentre two-group parallel single-blind (outcome assessor) randomized controlled trial (RCT). A cost effectiveness study alongside a clinical trial using a payer and societal perspective to study the cost-effectiveness of…
- Trial name
- NCT03154671
- Testing
- Geriatric assessment and management
- Where
- 2 sites in Canada
- Volunteers
- 351 people
- Sponsor
- University of Toronto
Nutrition Related Cancer, Aging
Effects of Chocolate Consumption in Elderly Patients With Cancer in Palliative Care
Elderly patients with advanced cancer stage constitute an important demand for palliative care, a scenario in which metabolic and nutritional status changes may be present.
- Trial name
- NCT04367493
- Testing
- Chocolate
- Volunteers
- 45 people
- Sponsor
- University of Sao Paulo
Sarcopenia, Gastrointestinal Neoplasms
Preoperative Sarcopenia and Postoperative Outcomes in Older Patients With Gastrointestinal Cancer
This prospective cohort study aims to evaluate the association between preoperative sarcopenia and postoperative outcomes in patients aged 60 years or older undergoing elective surgery for gastrointestinal cancer.
- Trial name
- NCT07817758
- Testing
- Preoperative Sarcopenia Status
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Van Training and Research Hospital
Acute Myeloid Leukemia
Modified-FLAI Induction and Consolidation Chemotherapy in Elderly Patient With Acute Myeloid Leukemia (AML)
A phase II clinical trial evaluating the efficacy and tolerability of induction and consolidation chemotherapy comprising Fludarabine, cytarabine and attenuated-dose Idarubicin (modified-FLAI) in the elderly patients with acute…
- Trial name
- m-FLAI (NCT01247493)
- Testing
- induction chemotherapy (fludarabine, cytarabine, idarubicin)
- Where
- South Korea
- Volunteers
- 108 people
- Sponsor
- Seoul National University Hospital
Gastrointestinal Cancers, Frailty
Longitudinal Geriatric Vulnerability, Chemotherapy Toxicity, and Functional Outcomes in Older Adults With Gastrointestinal Cancer
Older adults with gastrointestinal cancers may be more likely to experience side effects from chemotherapy and difficulties with everyday activities. These problems are not always explained by age alone.
- Conditions
- Gastrointestinal Cancers, Frailty, Sarcopenia in Elderly, Malnutrition Elderly
- Trial name
- VITAL-GI (NCT07184047)
- Testing
- Standard-of-Care Systemic Chemotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people
- Sponsor
- Ankara Etlik City Hospital
Acute Myeloid Leukemia (AML)
Study of Low-Dose Cytarabine and Etoposide With or Without All-Trans Retinoic Acid in Older Patients Not Eligible for Intensive Chemotherapy With Acute Myeloid Leukemia and NPM1 Mutation
This is a randomized, Phase-III, two-arm, open-label, multi-center study in adult patients with AML and NPM1 mutation ineligible for intensive chemotherapy.
- Trial name
- NCT01237808
- Testing
- Cytarabine, Etoposide, All-trans retinoic acid (ATRA)
- Where
- 33 sites in Germany
- Volunteers
- 144 people
- Sponsor
- University of Ulm
Gastric Cancer, Locally Advanced Malignant Neoplasm
D1 Versus D2 Lymphadenectomy in High Risk Elderly With Gastric Adenocarcinoma
Background: Literature often shows limited and discordant data regarding the prognostic value of age in gastric-cancer patients.
- Conditions
- Gastric Cancer, Locally Advanced Malignant Neoplasm, Perioperative/Postoperative Complications
- Trial name
- LELEGA (NCT03051152)
- Testing
- D1 gastrectomy, D2 gastrectomy
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Italian Research Group for Gastric Cancer
Head and Neck Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Head and Neck
Hypofractionated Radiotherapy in Older Adults With Head and Neck Squamous Cell Carcinoma
Standard radiotherapy for head and neck squamous cell carcinoma typically requires daily treatments over 6 to 7 weeks. For older adults, these prolonged treatment schedules can cause substantial physical fatigue, travel burden…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Head and Neck, Head and Neck Neoplasms
- Trial name
- NCT07847060
- Testing
- Hypofractionated Radiotherapy, Normofractionated Radiotherapy
- Volunteers
- 60 people
- Sponsor
- Assiut University
Esophageal Cancer
Gefitinib Combined With Radiotherapy in Elderly Patients With Esophageal Cancer
Elderly patients with esophageal cancer will receive thoracic radiation therapy 54-60Gy over 30 fractions, and concurrent with Gefitinib.
- Trial name
- NCT01291823
- Testing
- gefitinib, Thoracic radiotherapy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Zhejiang Cancer Hospital
Non-Hodgkin's Lymphoma
Pegylated Liposomal Doxorubicin Containing Chemotherapy in the Treatment of Older Non-Hodgkin's Lymphoma Patients
Currently there is no one standard of care for older patients with Non-Hodgkin's Lymphoma (NHL). The study will examine the tolerability and feasibility to the combination of Cyclophosphamide, Pegylated Liposomal Doxorubicin…
- Trial name
- NCT00120198
- Testing
- CDOP plus rituximab
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- Geriatric Oncology Consortium
Breast Cancer
A Real-World Study of Treatment Patterns, Tolerability and Effectiveness of CDK4/6 Inhibition in HR+, HER2-negative Metastatic Breast Cancer Patients
The aim of this study was to assess real-world treatment patterns and tolerability of ribociclib among patient populations historically underrepresented in clinical trials - specifically older adults and Black/African American…
- Trial name
- NCT07760714
- Where
- United States
- Volunteers
- 945 people
- Sponsor
- Novartis Pharmaceuticals
Cancer, Frailty
G8 Screening Tool Validation in Older Adults With Cancer in Portugal
The G8 screening tool is widely recommended for the identification of frailty in older adults with cancer. However, prospective validation data in the Portuguese population are currently lacking.
- Conditions
- Cancer, Frailty, Aged
- Trial name
- G8-PT (NCT07487298)
- Testing
- G8 Screening Tool, Comprehensive Geriatric Assessment
- Where
- Portugal
- Volunteers
- 150 people
- Sponsor
- Hospital de Braga
Rectal Cancer
External Beam Radiotherapy Combined With Endorectal High-dose-rate Brachytherapy in Elderly and Frail Patients With Rectal Cancer
ACO/ARO/AIO-22 - External beam radiotherapy combined with endorectal high-dose-ratebrachytherapy in elderly and frail patients with rectal cancer. A prospective multicentre trial of the German Rectal Cancer Study Group.
- Trial name
- ACO/ARO/AIO-22 (NCT06729645)
- Testing
- radiotherapy
- Where
- 4 sites in Germany
- Volunteers
- 80 people
- Sponsor
- University Hospital of Cologne
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