Clinical trials: Older Adults With Cognitive Decline
Mild Cognitive Impairment (MCI), Moderate Cognitive Impairment
Comparative Effects of Integrated Versus Sequential Approaches to Dual-Task Training in Elderly With Mild to Moderate Cognitive Impairment
Mild and Moderate cognitive impairment is a condition characterized by a noticeable decline in cognitive abilities, including memory and thinking skills, which is greater than expected for an individual's age but does not…
- Trial name
- nill (NCT07775079)
- Testing
- Integrated Dual-Task Training, Sequential Dual-Task Training
- Where
- Pakistan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Shifa Tameer-e-Millat University
Alzheimer's Disease, Mild Cognitive Impairment
Brain-Computer Interface System for Training Memory and Attention in Elderly
The primary objective is to examine the efficacy of 8-weeks of a locally developed brain-computer interface based system intervention for improving attention and memory in healthy elderly and those with age related cognitive…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Age-Related Cognitive Decline, Dementia
- Trial name
- NCT02228187
- Testing
- Brain-Computer Interface
- Where
- Singapore
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Parkinson's Disease (PD), Alzheimer's Disease (AD) and Related Disorders
Moving Yourself in Space and Time: MYSTIC
This study is being done to answer the question: Do people with Parkinson's benefit from a new stepping therapy, and how do people with Parkinson's best learn new steps and rhythms set to music? Researchers will also compare…
- Conditions
- Parkinson's Disease (PD), Alzheimer's Disease (AD) and Related Disorders, Older Adults (60 - 85 Years Old)
- Trial name
- MYSTIC (NCT07697664)
- Testing
- Complex Rhythmic Movement Sequences (CRMS) Sessions
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Emory University
Aging, Mild Cognitive Impairment
Modulating Cortical Dynamics of Dual-task Standing in MCI
The investigators have designed a brain stimulation study to understand its effect on an individual's standing, walking, and thinking abilities in older adults with and without mild cognitive impairments (MCI).
- Trial name
- NCT05680701
- Testing
- real tACS
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hebrew SeniorLife
Glucose Metabolism Disorders (Including Diabetes Mellitus), Cognitive Decline
Glucose Variability and Cognition in Prediabetes
This study examines the association of variability in glucose values over a 10-day period with cognitive function and AD risk markers among individuals with prediabetes, aged 50 or older.
- Conditions
- Glucose Metabolism Disorders (Including Diabetes Mellitus), Cognitive Decline, PreDiabetes, Aging
- Trial name
- NCT04201600
- Testing
- Continuous Glucose Monitoring System (CGMS)
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Cognitive Dysfunction
Acupressure on Cognitive Function and Quality of Life
The study aims to (1)compare differences of global cognitive function, working memory, executive function, language function, and quality of life between institutionalized older adults with MCI and with mild AD.
- Trial name
- NCT04441645
- Testing
- Acupressure
- Where
- Taiwan
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Participants Must be Women Aged 25 Years or Older, Participants Should Have no Self-reported History of Heart Disease or Stroke
RCT of HeartBot in Women
The goal of this clinical trial is to find out whether an app-based program called HeartBot II, which uses an artificial intelligence (AI) chatbot, can help improve women's awareness and knowledge of heart attacks in women.
- Conditions
- Participants Must be Women Aged 25 Years or Older, Participants Should Have no Self-reported History of Heart Disease or Stroke, Participants Should Have no Terminal Illness or Diagnosed Cognitive Impairment, Including Alzheimer's Disease, Participants Should Not be a Healthcare Professionals or Healthcare Trainees
- Trial name
- HeartBot II (NCT07416734)
- Testing
- HeartBot II Program, Waitlist Control
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alzheimer Disease or Associated Disorder, Dementia
Door-Through-Door Companion Rideshare Technology for Individuals With Alzheimer's Disease and Related Dementias (AD/ADRD)
The goal of this pilot randomized controlled trial is to assess the impact of D2D rideshare services with a trained companion driver on the rate of medical appointments for older adults and individuals with AD/ADRD.
- Conditions
- Alzheimer Disease or Associated Disorder, Dementia, Cognitive Decline
- Trial name
- NCT06850870
- Testing
- Door-through-door companion rideshare, Curb-to-curb rideshare services
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Onward Health, Inc
Age-related Cognitive Decline
ItaliaN Study With Tailored Multidomain Interventions to Prevent Functional and Cognitive Decline in Community-dwelling Older Adults
The goal of this interventional non-pharmacological study is to investigate the effects of a multi-domain intervention ( "active intervention"), compared to that followed by normal clinical practice ("self-guided intervention")…
- Trial name
- IN TeMPO (NCT06248723)
- Testing
- Nutritional intervention, Physical exercise, Cognitive training
- Where
- Italy
- Volunteers
- 1,340 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
Music Listening
Impact of Individualized Music Listening for People With Dementia on Anxiety: A Quasi-experimental Study
This pilot study was designed to evaluate the effects of Individualized music listening (IML) implemented on older adults with mild cognitive impairment (MCI) and PwD.
- Trial name
- NCT06032897
- Testing
- Individualized music listening (IML)
- Where
- Taiwan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Healthy, Mild Cognitive Impairment
tES Effects on Associative Memory Performance
Previous studies showed that transcranial electric stimulation (tES) applied over the prefrontal cortex improves cognitive performance in healthy elderly adults as well as in patients suffering from mild cognitive impairment or…
- Conditions
- Healthy, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT03351452
- Testing
- real anodal transcranial direct current stimulation, real transcranial alternating current stimulation
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Bern
Dementia, Cognitive Impairment
Functionally-tailored Oral Care Intervention for Community-dwelling Older Adults With Dementia and Their Caregivers
The specific aims of this study are: Aim 1. Develop a staged and modifiable dyadic oral care intervention to provide functionally-tailored oral care rehabilitation for community-dwelling persons with dementia (PWD) and need-based…
- Trial name
- NCT04238520
- Testing
- Functionally Tailored Oral Care Intervention, Control Intervention
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Xi Chen
Mild Cognitive Impairment
Effectiveness of Tongue Resistance Exercises on Tongue and Swallowing Function in Frail Older Adults With MCI
The purpose of this study is to explore the effects of tongue resistance exercises on tongue muscle strength and swallowing function in frail older adults with mild cognitive impairment living in the community.
- Trial name
- NCT06766487
- Testing
- Tongue resistance exercises, cheek bulging exercises
- Where
- Taiwan
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Chang Gung Medical Foundation
Cognitive Impairment
Dual Task Aerobic Exercise for Older Adults With Cognitive Impairment (HM2)
The investigators proposed research will establish whether combining aerobic exercise with cognitive challenges is feasible and effective in community dwelling older adults with early signs of cognitive impairment.
- Trial name
- HM2 (NCT01572311)
- Testing
- Exercise Intervention, Exercise Control
- Where
- Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Parkwood Hospital, London, Ontario
Cognitive Dysfunction
Efficacy Study of Yi-Zhi-An-Shen Granules For Older Adults With Amnestic Mild Cognitive Impairment
The main purpose of this study is to investigate the safety and efficacy of Yi-Zhi-An-Shen Granules in participants with amnestic mild cognitive impairment (aMCI).
- Trial name
- NCT03601000
- Testing
- Yi-Zhi-An-Shen
- Where
- 2 sites in China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chengdu University of Traditional Chinese Medicine
At Risk for AD-dementia, With Subjective Cognitive Decline
Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in At-risk Older Adults (The Exergames Telerehabilitation Study)
Significance of Research Question/Purpose: Subjective cognitive decline (SCD) is regarded as the first clinical manifestation in the AD-dementia continuum and currently has a prevalence of 11.2% in adults over the age of 45, with…
- Trial name
- NCT06340659
- Testing
- HbAEx, HbExergame
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Choroid Disease, Caregiver
Dyadic Management Intervention in Older People With Co-occurring Cognitive Impairment and Diabetes as a Supplementary Approach to Chronic Diseases Self-Management Program
The goal of this study is to evaluate the effectiveness and implementation of a dyadic management of the Chronic Disease Self-Management Program (CDSMP) for older adults with co-occurring cognitive impairment and diabetes with…
- Conditions
- Choroid Disease, Caregiver, Self-management, Diabetes
- Trial name
- NCT07496359
- Testing
- CDSMP + caregiver support, Usual Care
- Where
- Hong Kong
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Age-related Hearing Loss, Cognitive Decline
Auditory-Cognitive Dual-Task Intervention for Older Adults With Hearing Loss
Background: Age-related hearing loss (ARHL) is a common and irreversible condition that has been recently associated with cognitive decline and dementia. Hence, if ARHL is treated earlier, the risk of dementia might decrease.
- Conditions
- Age-related Hearing Loss, Cognitive Decline, Loneliness, Social Isolation
- Trial name
- NCT06486285
- Testing
- Auditory-cognitive dual-task training (ACDT)
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Mild Cognitive Impairment, Insomnia
Multicomponent Behavioral Sleep Intervention for Insomnia in Older Adults With Mild Cognitive Impairment
Insomnia symptoms in older adults with mild cognitive impairment represent a significant public health burden in terms of impaired quality of life, risks from untreated insomnia, and risks from pharmaceutical insomnia treatment.
- Trial name
- MBSI-I (NCT04364191)
- Testing
- Multicomponent Behavioral Sleep Intervention for Insomnia, Active Control
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Aging, Cardiovascular Risk Factor
A Combined Multidomain Intervention to Prevent Cognitive Decline Associated With Cardiovascular Risk Factors.
The ACTIONcardioRisk trial is designed to investigate the effect of aerobic and progressive resistance training exercises combined with cognitive training, on neurocognitive functioning of sedentary older adults with and without…
- Trial name
- ACTIONcR (NCT04962061)
- Testing
- Cognitive Training, Aerobic and resistance exercises, Stretching and Toning
- Where
- Canada
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Louis Bherer