Clinical trials: Older Adults With Cognitive Decline
Alzheimer Disease, Mild Cognitive Impairment
Evaluation of the Effectiveness and Safety of Transcranial Direct Current Stimulation in Combination With Nasal Near Infrared Stimulation to Improve Cognitive Functions and Quality of Life in Elderly People With Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD).
Alzheimer's disease (AD) and mild cognitive impairment (MCI) are progressive neurodegenerative conditions with limited therapeutic options. Today, around 30 million people worldwide suffer from Alzheimer's dementia.
- Trial name
- NCT07290686
- Testing
- tDCS stimulation, tDCS, iNIRS stimulation
- Where
- Poland
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Cognitive Dysfunction, Alzheimer Disease
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults…
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Blood-Brain Barrier, Apolipoprotein E, Deficiency or Defect of
- Trial name
- NCT07392723
- Testing
- Alpha-Linolenic Acid (2.6 g/day)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michal Schnaider Beeri, Ph.D.
Cognitive Impairment, Dementia
Hainan Community Cognition Cohort
This is a community-based prospective cohort study in Hainan Province, China. The study was initialized in 2023 and included older residents for longitudinal follow-up.
- Conditions
- Cognitive Impairment, Dementia, Age Problems
- Trial name
- NCT06686186
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Hainan Medical College
Age-related Hearing Loss, Hearing Loss, Sensorineural
A Prospective Cohort Study On Change of Cognitive Function In Aged-related Hearing Loss With Hearing Aids
Background: Deafness is one of the nine potentially modifiable risk factors for dementia simulated by the Lancet dementia Prevention, intervention and Care Committee in 2017.
- Conditions
- Age-related Hearing Loss, Hearing Loss, Sensorineural, Hearing Aid, Cognitive Function Abnormal
- Trial name
- NCT05694039
- Testing
- Hearing Aids
- Where
- China
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Mild Cognitive Impairment
The Effectiveness of TECH: Tablet Enhancement of Cognition and Health
This study assess the effectiveness of novel cognitive intervention utilizing tablet apps (TECH protocol: Tablet Enhancement of Cognition and Health) to improve cognitive abilities, daily function and health-related quality of…
- Trial name
- TECH (NCT02955277)
- Testing
- TECH: Tablet Enhancement of Cognition and Health protocol, Standard care or active standard care
- Where
- Israel
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Assuta Hospital Systems
Reaction Time, Physical Fitness
Comparison of Physical Fitness, Walking Speed, Reaction Time In Older Adults With and Without Mild Cognitive Impairment
The aim of the study is to compare physical fitness, walking speed and hand reaction time measurements in older adults with different cognition levels according to the Montreal Cognitive Assessment Scale (MOCA).
- Trial name
- NCT05472727
- Testing
- reaction time test, Physical fitness test
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Memory Loss (Excluding Dementia), Healthy Lifestyle
Brain Health Program for Older Adults With Subjective Cognitive Decline
The investigators will compare two brain health programs in older adults with subjective cognitive decline and lifestyle risk factors for dementia.
- Conditions
- Memory Loss (Excluding Dementia), Healthy Lifestyle, Risk Reduction Behavior
- Trial name
- NCT05934136
- Testing
- My Healthy Brain 1, My Healthy Brain 2
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Sleep, Gut Microbiome
Impact of Nutritional Supplementation on Sleep Quality and Gut Microbiome Composition in Older Adults
The aim of this study is to assess the impact of 5-hydroxytryptophan (5-HTP) supplementation on sleep quality and gut microbiome composition in older adults with normal cognition vs.
- Trial name
- NCT04078724
- Testing
- 5-HTP, Without 5-HTP
- Where
- 2 sites in Singapore
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Alzheimer Disease, Cognitive Decline
40 Hz Transcranial Alternating Current Stimulation for Inducing Gamma Oscillations
This study aims to compare the efficacy of different 40 Hz tACS protocols in entraining gamma oscillations, which are linked to various cognitive functions and play a significant role in cognitive impairments like Alzheimer's…
- Trial name
- NCT06740864
- Testing
- Transcranial alternating current stimulation
- Where
- Iran
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The National Brain Mapping Laboratory (NBML)
Mild Cognitive Impairment, Mild Dementia
Validation of the German Version of the Amsterdam Instrumental Activities of Daily Living Questionnaire®
Pretest and validation of the German version of the Amsterdam instrumental activities of daily living questionaire short in elderly people with normal cognition, mild cognitive impairment (MCI) or mild dementia in the German…
- Trial name
- NCT04012398
- Testing
- Amsterdam IADL Questionnaire short, German version
- Where
- Switzerland
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Zurich University of Applied Sciences
Cognitive Impairment, Stroke
Effect of a fNIRS-based Personalized Multi-domain Intervention on Cognitive in Elderly Population With High Risk of Stroke
This functional near-infrared spectroscopy-based personalized multidomain intervention study aims to prevent cognitive impairment and reduce dementia and cerebrovascular events in 45-74 years old persons with high risk of stroke…
- Conditions
- Cognitive Impairment, Stroke, Dementia
- Trial name
- NCT05930249
- Testing
- Personalized multidomain intervention
- Where
- China
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Mild Cognitive Impairment, Age-associated Memory Impairment
Effectiveness of an Intervention Using Observation/Action Therapy Among Patients With Mild Cognitive Impairment
Mild cognitive impairment (MCI) is a transitional state between normal aging and early dementia, characterized by memory deficits without functional impairment.
- Trial name
- NCT05934344
- Testing
- Action observation training
- Where
- Spain
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
Mild Cognitive Impairment, Old Age; Debility
Dual Task Perturbation Training for OAwMCI
Studies have determined that compared to cognitively intact older adults (CIOA), older adults with mild cognitive impairment (OAwMCI) exhibit more pronounced balance and gait impairments which lead to an increased risk of falls…
- Trial name
- NCT04938349
- Testing
- Dual task perturbation training
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Elderly Adults, Mild Cognitive Impairment
Agility Training and Its Relations in Elderly Adults With and Without MCI
The following three-part proposal will focus on the effects of agility training as well as the relationship between agility ability and motor and cognitive function, and risk of falls in elderly adults with or without mild…
- Conditions
- Elderly Adults, Mild Cognitive Impairment, Healthy
- Trial name
- NCT05537363
- Testing
- Health education, Multicomponent training, Agility training
- Where
- Taiwan
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Mild Cognitive Impairment, Sleep
Home Sleep Therapy for Older Adults With MCI
The goal of this clinical trial is to learn about the ability of non-invasive brain stimulation during sleep to enhance people's deep sleep and its potential benefit on memory in people with mild cognitive impairment via home use…
- Conditions
- Mild Cognitive Impairment, Sleep, Transcranial Electrical Stimulation, Machine Learning
- Trial name
- NCT05771844
- Testing
- Transcranial Electrical Stimulation
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brain Electrophysiology Laboratory Company
PARKINSON DISEASE (Disorder), Older Adults (65-85 Years)
Perception of Action Opportunities for Obstacle Crossing in Parkinson's Disease
The study examines how individuals with Parkinson's disease, compared to healthy older adults, evaluate their ability to cross an obstacle, and the association between this evaluation, motor and cognitive status, and…
- Trial name
- NCT07907770
- Testing
- Obstacle Crossing Task
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Exercise Environment and Cognitive Performance in Older Adults
Outdoor vs. Indoor Exercises and Cognitive Functions in Older Adults
This observational, cross-sectional study aims to comparatively investigate the effects of outdoor versus indoor exercise environments on overall cognitive performance and its specific sub-domains (attention, memory, and…
- Trial name
- NCT07728786
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Intra-abdominal and Intrapelvic Surgery
Comparison of Intravenous Anesthetics to Volatile Anesthetics on Postoperative Cognitive Dysfunction
Post-operative cognitive dysfunction (POCD) is a fairly well-documented clinical phenomenon. Most patients will receive general anesthesia during surgery. Two groups of general anesthetics are used for this purpose.
- Trial name
- NCT01809041
- Testing
- Sevoflurane, propofol, remifentanil
- Where
- China
- Volunteers
- 684 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Cognitive Dysfunction, Cognitive Disorder
Effects of Video Games and Ball Tossing on Eye Hand Coordination in Elderly With Mild Cognitive Impairment.
One of the key challenges faced by individuals with mild cognitive impairment (MCI) is the decline in cognitive and motor abilities, particularly eye-hand coordination (EHC), which is essential for performing daily activities and…
- Conditions
- Cognitive Dysfunction, Cognitive Disorder, Cognitive Decline
- Trial name
- NCT07182396
- Testing
- Experimental Group, Control Group
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
Parkinson's Disease with Cognitive Impairment, Healthy Elderly
Effectiveness of Attention/executivefunctions Training on Prospective Memory Abilities of Parkinson's Disease Subjects with Mild Cognitive Impairment and Healthy Aged Individuals: a Placebo-controlled Study with a Combined Immersive Virtual Reality and Telemedicine Approach
The goal of this randomized controlled trial is to evaluate the efficacy of attention and executive function training on prospective memory (PM) and executive functions in patients with Parkinson's disease and mild cognitive…
- Trial name
- NCT06801782
- Testing
- Experimental Cognitive training in Immersive Virtual Reality and Telemedicine approach, Active Comparator #1
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia