Clinical trials: Older Adults With Mild Neurocognitive Disorders
Mild Cognitive Impairment (MCI)
Evaluation of a PMT Rehabilitation Nursing Plan for the Older Adults With MCI to Promote Cognitive Health
With the aging of the population, the number of older adults with mild cognitive impairment (MCI) has increased year by year, which has caused serious social and family burdens.
- Trial name
- NCT07089654
- Testing
- A PMT rehabilitation nursing plan, General rehabilitation nursing
- Where
- 2 sites in China
- Volunteers
- 73 people
- Sponsor
- Jinzhou Medical University
Cognition Disorder, Nervous System Diseases
A Follow-up Study to Assess Safety and Tolerability of Galantamine Treatment in Individuals With Mild Cognitive Impairment
The purpose of this follow-up study is to assess the long-term safety and tolerability of galantamine in individuals with mild cognitive impairment who participated in a previous study with galantamine
- Conditions
- Cognition Disorder, Nervous System Diseases, Mental Disorders, Brain Diseases
- Trial name
- NCT00240695
- Testing
- galantamine hydrobromide
- Volunteers
- 724 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Mild Cognitive Impairment
The Effectiveness of TECH: Tablet Enhancement of Cognition and Health
This study assess the effectiveness of novel cognitive intervention utilizing tablet apps (TECH protocol: Tablet Enhancement of Cognition and Health) to improve cognitive abilities, daily function and health-related quality of…
- Trial name
- TECH (NCT02955277)
- Testing
- TECH: Tablet Enhancement of Cognition and Health protocol, Standard care or active standard care
- Where
- Israel
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Assuta Hospital Systems
Mild Cognitive Impairment
Dual-Task Zumba Gold for Improving the Cognition of Older Adults With MCI
The study aims to assess the preliminary efficacy of a Dual-Task Zumba Gold (DTZ) intervention that will support physical and cognitive training among community-dwelling persons with mild cognitive impairment (MCI).
- Trial name
- NCT04788238
- Testing
- Dual-Task Zumba Gold
- Where
- Philippines
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
MCI, SCD
Effects of the Fully Immersive VR Cognitive Training Based on Leisure Activities for the Elderly With MCI and SCD.
Mild cognitive impairment (MCI) and subjective cognitive decline (SCD) are risk groups for dementia, and thus appropriate interventions are required.
- Conditions
- MCI, SCD, Virtual Reality
- Trial name
- NCT04779671
- Testing
- VR cognitive training, Traditional cognitive training
- Where
- Taiwan
- Volunteers
- 190 people
- Sponsor
- Chang Gung Memorial Hospital
Alzheimer's Disease
A Study to Assess Regional Cerebral Blood Flow as an Alzheimer's Disease Biomarker Compared to Positron Emission Tomography in Patients With Mild-to-Moderate Alzheimer's Disease and Cognitively Normal Elderly Subjects (Study MK-0000-068)(COMPLETED)
The aim of the study is to determine if regional cerebral blood flow, measured by dynamic arterial spin labeling (dASL), can be a biomarker for stage of Alzheimer's disease.
- Trial name
- NCT00757939
- Testing
- MRI, FDG-PET
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Alzheimer's Disease, Healthy Non-elderly and Elderly Adults
Multiple Ascending Dose Safety, Tolerability, PK Study of AL001 in Alzheimer's Disease Patients & Healthy Adult Subjects
This is a Phase 1/2a, multi-center, placebo-controlled, double-blinded, randomized, multiple ascending dose (MAD) clinical trial to determine the safety and maximum tolerated dose of AL001.
- Trial name
- "MAD" (NCT05363293)
- Testing
- AL001
- Where
- 2 sites in United States, Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Alzamend Neuro, Inc.
Cognitive Impairment, Elderly
Pharmacokinetics Centella Asiatica Product (CAP) in Mild Cognitive Impairment
This study will measure the oral bioavailability and pharmacokinetics of known bioactive compounds from a standardized Centella asiatica water extract product (CAP) in mildly demented elders on cholinesterase inhibitor therapy.
- Trial name
- NCT03937908
- Testing
- 2g Centella asiatica water extract product, 4g Centella asiatica water extract product
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Oregon Health and Science University
Dementia, Mild Cognitive Impairment
Dual-task Exercise in People With Cognitive Impairment
The purpose of this study is to explore how performing two exercise-based tasks simultaneously (dual-task exercise) affects the neurovascular and cognitive responses of people with cognitive impairment, which is a growing concern…
- Conditions
- Dementia, Mild Cognitive Impairment, Older Adults
- Trial name
- NCT06389812
- Testing
- Dual-task exercise traning
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Frail Elderly Syndrome, Mild Cognitive Impairment
Spanish Linguistic Validation, Validity and Reliability Test of Frail´BESTest in Elderly Institutionalized Frail People
The aging of the global population presents significant social and health challenges. In Aragón, 15% of the population is between 65 and 79 years old, and the over-aging index is 16.6%, higher than the national average.
- Trial name
- NCT06438718
- Where
- Spain
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Mild Cognitive Impairment
The Effect of Vırtual Reality Application ın Elderly People With Mild Cognitive Impairment
This study was conducted to investigate the effect of virtual reality application on visual skills, perceived occupational performance and satisfaction in elderly individuals with mild cognitive impairment.
- Trial name
- NCT06500650
- Testing
- Person-centred Occupational Therapy Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Saglik Bilimleri Universitesi
Healthy, Mild Cognitive Impairment
Supporting Episodic Memory With Transcranial Direct Current Stimulation in Healthy Controls and Dementia Patients
Previous studies showed that anodal tDCS applied over the dorsolateral prefrontal cortex (DLPFC) improved episodic memory performance, indicating a possible use as an intervention for patients suffering from memory impairments.
- Conditions
- Healthy, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT03227185
- Testing
- real anodal transcranial direct current stimulation (tDCS)
- Where
- Switzerland
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Bern
Falls, Frailty
Preventing Falls in Older Adults With Cognitive Frailty
The Problem: The proposed trial will address the problem of how to effectively prevent subsequent falls in community-dwelling cognitively frail older adults with a history of falls.
- Conditions
- Falls, Frailty, Mild Cognitive Impairment
- Trial name
- ACTIVE (NCT06854731)
- Testing
- Balance and Strength Training Exercises with Health Coaching, Education Session
- Where
- Canada
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Mild Cognitive Impairment
Transcranial Magnetic Stimulation in Patients With Mild Cognitive Impairment - RCT Trial
The study is planned as a randomized, double-blind, and sham-controlled parallel trial, in which raters and participants will be blinded to the group selection.
- Trial name
- NCT05730296
- Testing
- TMS
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Wroclaw Medical University
Alzheimer's Disease, Cognitive Impairment
Effect of EGb761® on Brain Glucose Metabolism in Three Groups of Elderly Defined by Cognitive Functions
The aim of the study is to evaluate the effect of EGb761®, in comparison to placebo, on cerebral glucose metabolism, in three groups of elderly patients: newly diagnosed mild Alzheimer's disease (AD), memory complaint patients…
- Trial name
- NCT00814346
- Testing
- EGb761®
- Where
- 8 sites in France
- Volunteers
- 49 people
- Sponsor
- Ipsen
Postoperative Cognitive Dysfunction
Use of Transcranial Magnetic Stimulation in the Post-Operative Cognitive Dysfunction in Elderly
Postoperative Cognitive Dysfunction (POCD) is a prevalent condition with significant clinical, social, and financial impacts on patients and healthcare services.
- Trial name
- NCT06658769
- Testing
- Theta Burst Stimulation
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- University of Sao Paulo General Hospital
Hearing Loss, Sensorineural, Dementia of Alzheimer Type
Characterizing Variability in Hearing Aid Outcomes in Among Older Adults With Alzheimer's Dementia
This current translational project, funded by NIH, aims to better understand the impact of various signal modification strategies for older adults with Alzheimer's dementia and its potential precursor, known as amnestic mild…
- Conditions
- Hearing Loss, Sensorineural, Dementia of Alzheimer Type, Amnestic Mild Cognitive Impairment
- Trial name
- NCT04240561
- Testing
- High level of signal manipulation, Low level of signal manipulation
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Dementia, Mild, Depression
Decision Making Tool for Firearm Storage
This is a one-arm pilot study testing the feasibility and acceptability of a decision aid about safe firearm storage.
- Trial name
- NCT06382194
- Testing
- Decision aid
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Washington
Pain, Chronic, Dementia, Mild
Developing a Nonpharmacological Pain Intervention for Community-dwelling Older Adults With Dementia
The purpose of this study is to develop an exercise treatment program for knee osteoarthritis that works well for people with memory problems. This study will include two parts.
- Conditions
- Pain, Chronic, Dementia, Mild, Mobility Limitation, Physical Disability
- Trial name
- NCT06264362
- Testing
- Tailored Physical Activity Program
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Drexel University
Mild Cognitive Impairment
Vildagliptin in Older Adults With Diabetes and Mild Cognitive Impairment
This study investigates the effect of vildagliptin, an inhibitor of the enzyme DPP-4, on the cognitive functioning of elderly diabetic patients with mild cognitive impairment (MCI) documented at mini mental state examination…
- Trial name
- NCT03819127
- Testing
- Vildagliptin 50 MG Oral Tablet, Metformin Pill
- Volunteers
- 60 people
- Sponsor
- University of Catania