Clinical trials: Older Adults With Mild Neurocognitive Disorders
Creatine, Exercise
Creatine and Resistance Training in Older Adults With Mild Cognitive Impairment
The goal of this 26-week trial is to learn if creatine supplementation and resistance training (i.e., weightlifting; exercise that increases muscle mass), alone and together, impact cognition, brain health, and physical function…
- Conditions
- Creatine, Exercise, Mild Cognitive Impairment (MCI)
- Trial name
- NCT06948149
- Testing
- Creatine monohydrate, Resistance training
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- Western University, Canada
Active Aging Individuals Aged 65 and Over, Aging
Italian Validation of the dNA Scale and Its Correlation With Neurocognitive Variables
The goal of this experimental multicentric intervention study is to validate, in Italian, the dynamic Neurocognitive Adaptation (dNA) Scale, which has already been validated in English, among a healthy elderly population (aged 65…
- Conditions
- Active Aging Individuals Aged 65 and Over, Aging, Mild Cognitive Impairment (MCI), Dementia
- Trial name
- NCT07533084
- Where
- 8 sites in Italy
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Mild Cognitive Impairment
The Effect of TPS on Cognitive Functions in Older Adults With MCI
The goal of this randomized controlled trial is to learn if Transcranial Pulse Stimulation (TPS) can improve cognitive functions in older adults with mild cognitive impairment (MCI). The study will also assess the safety of TPS.
- Trial name
- NCT06407141
- Testing
- transcranial pulse stimulation
- Where
- Hong Kong
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Mild Cognitive Impairment
Effects of Brain Training Games on Cognitive Function and Quality of Life in MCI
The study aims to determine the effects of brain training games on cognitive function and Quality of life among older adults with MCI.
- Trial name
- NCT06437704
- Testing
- Brain training game Lumosity, Simulation game simcity buildit
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Dementia, Mild Cognitive Impairment
Effectiveness of Strength-based Intervention for Elderly With Dementia Living in the Community
In the realm of dementia care, the imperative to intervene at the earliest stages of cognitive decline is paramount. Recognizing this pivotal moment, the development of innovative and effective interventions becomes imperative in…
- Conditions
- Dementia, Mild Cognitive Impairment, Caregiver, Dementia Alzheimer Type
- Trial name
- STRENGTH-B (NCT07037550)
- Testing
- Strength-based intervention
- Where
- Hong Kong
- Volunteers
- 272 people
- Sponsor
- The University of Hong Kong
Mild Cognitive Impairment
Neurological Changes With a Memory Self-efficacy Training Protocol
Confidence in one's ability to accomplish a task, more formally known as self-efficacy, is an important psychological variable that can influence how the investigators perform on various tasks.
- Trial name
- NCT04077320
- Testing
- Memory Self-Efficacy Training, General Education
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- Western University, Canada
Technology
Therapeutic Effectiveness of PARO Companion Robot for Elderly With Mild Cognitive Impairment/Dementia in Elderly Residential Setting: A Quasi-experimental Study
The main trial is a 2-group quasi-experimental trial of comparing the outcome indicators between joining and not joining the 10-week personal assistive robot (PARO) training program in residents with dementia or mild cognitive…
- Trial name
- NCT05404802
- Testing
- Experimental group intervention, Control group intervention
- Where
- 2 sites in Hong Kong
- Volunteers
- 37 people
- Sponsor
- The University of Hong Kong
Mild Cognitive Impairment
Falls Prevention Through Physical And Cognitive Training in Mild Cognitive Impairment
This randomised controlled trial aims to determine the effectiveness of combined physical and cognitive training in preventing falls and decreasing risks of falls among community-dwelling older persons with mild cognitive…
- Trial name
- FallsPACT (NCT03167840)
- Testing
- Physical and Cognitive Training, Physical Training, Cognitive training
- Where
- Philippines
- Volunteers
- 95 people
- Sponsor
- The Hong Kong Polytechnic University
Mild Cognitive Impairment (MCI), Moderate Cognitive Impairment
Comparative Effects of Integrated Versus Sequential Approaches to Dual-Task Training in Elderly With Mild to Moderate Cognitive Impairment
Mild and Moderate cognitive impairment is a condition characterized by a noticeable decline in cognitive abilities, including memory and thinking skills, which is greater than expected for an individual's age but does not…
- Trial name
- nill (NCT07775079)
- Testing
- Integrated Dual-Task Training, Sequential Dual-Task Training
- Where
- Pakistan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Shifa Tameer-e-Millat University
Mild Cognitive Impairment
Effects of Multimodal Music Intervention on Mild Cognitive Impairment Elderly
The goal of this clinical trial is to learn about whether music therapy can ameliorate cognitive function, physical fitness and psychology in mild cognitive impairment and mild dementia population.
- Trial name
- NCT06324227
- Testing
- multimodal music therapy, no intervention
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Yang Ming Chiao Tung University
Sleep, Gut Microbiome
Impact of Nutritional Supplementation on Sleep Quality and Gut Microbiome Composition in Older Adults
The aim of this study is to assess the impact of 5-hydroxytryptophan (5-HTP) supplementation on sleep quality and gut microbiome composition in older adults with normal cognition vs.
- Trial name
- NCT04078724
- Testing
- 5-HTP, Without 5-HTP
- Where
- 2 sites in Singapore
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Healthy Older Adults, Memory Complaints
A Computer-based Memory Strategy Training Program for Older Adults
A computer-based cognitive rehabilitation program based on daily tasks utilising the semantic or perceptual encoding strategies called Enhancing Memory in Daily Life (E-MinD Life) has been developed for Chinese people.
- Conditions
- Healthy Older Adults, Memory Complaints, Mild Cognitive Impairment (MCI)
- Trial name
- NCT07039708
- Testing
- E-MinD Life Semantic, Cognitive stimulation
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Mild Cognitive Impairment (MCI), Exercises
High-Amplitude Functional Exercises in Older Adults With Mild Cognitive Impairment
This study will investigate the effects of dual-task-based high-amplitude functional exercises on balance and functional mobility in older adults with mild cognitive impairment.
- Trial name
- NCT07762235
- Testing
- Dual-Task-Based High-Amplitude Functional Exercise Program, Traditional Balance and Mobility Exercise Group
- Volunteers
- 36 people
- Sponsor
- Istinye University
Alzheimer´s Disease
Safety, Tolerability and Biomarker-based Efficacy of NPI-001 (AT-001) in Subjects With MCI or Alzheimer's Disease (AD)
The study aims to measure safety, tolerability and biomarker-based efficacy of NPI-001 (AT-001) in Subjects with MCI or Alzheimer's Disease (AD).
- Trial name
- AD Biomarker (NCT07741526)
- Testing
- NPI-001
- Where
- 4 sites in Denmark, Iceland
- Volunteers
- 33 people
- Sponsor
- Arctic Therapeutics
Mild Cognitive Impairment
Comparison of High-Intensity Interval Training and Moderate-Intensity Continuous Training in Mild Cognitive Impairment
This study aims to determine the effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) on cognitive and physical fitness in community-dwelling adults diagnosed with Mild Cognitive…
- Trial name
- NCT07248709
- Testing
- High-Intensity Interval Training (HIIT), Moderate-Intensity Continuous Training
- Where
- 2 sites in Pakistan
- Volunteers
- 68 people
- Sponsor
- Riphah International University
Parkinson Disease, Mild Cognitive Impairment
Adaptango Performance PRocess for Older Adults Community reHabilitation
This study is being done to answer the question: How do people with Parkinson's disease, people with Mild Cognitive Impairment, and younger people process difficult topics in conversation? It will also explore themes related to…
- Conditions
- Parkinson Disease, Mild Cognitive Impairment, Old Age; Dementia
- Trial name
- APPROACH (NCT07824128)
- Testing
- Adaptango Performance Process (APP) program
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Emory University
Mild Cognitive Impairment, Caregivers
iMeditate at Home for Older Adults With Mild Cognitive Impairment and Caregivers
Individuals diagnosed with mild cognitive impairment (MCI) are at a high risk of developing dementia and are an important target population for interventions that may reduce the risk of cognitive decline.
- Trial name
- NCT04184037
- Testing
- Mindfulness meditation delivered via a mobile app
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Baycrest
Mild Cognitive Impairment, Older Adults
Virtual Reality Cognitive Training for Older Adults With Mild Cognitive Impairment
This study aims to (1) develop and assess the feasibility of a fi-VRCT program based on IADL for older adults with MCI, (2) implement and evaluate the effectiveness of the fi-VRCT program based on IADL in older adults with MCI…
- Trial name
- NCT06392412
- Testing
- fi-VR Cognitive Training, Traditional Cognitive Training
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Da-Yeh University
Type 2 Diabetes, Mild Cognitive Impairment
Care Partner-Assisted Diabetes Self-Management Through Linking Continuous Glucose Monitoring With Mobile Health: Improving Outcomes for Older Adults With Mild Cognitive Impairment
Eligible older adults with Type 2 Diabetes-Mild Cognitive Impairment (T2D-MCI) will be provided a Continuous Glucose Monitoring (CGM) device and asked to share CGM data with their care partners for daily decision-making for…
- Trial name
- CP-CGMH (NCT05601583)
- Testing
- Continuous Glucose Monitor (CGM)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- NYU Langone Health
Mild Cognitive Impairment
Brazil Nuts Effects on Selenium Status and Cognitive Performance
Some studies reported that selenium status is associated with cognitive function. However only a few reports have investigated whether selenium supplementation can benefit cognitive performance and in most of them selenium…
- Trial name
- NCT02121457
- Testing
- Brazil nut, selenium
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- University of Sao Paulo