Clinical trials: Older Adults With Mild Neurocognitive Disorders
Cognitive Dysfunction, Cognitive Disorder
Effects of Video Games and Ball Tossing on Eye Hand Coordination in Elderly With Mild Cognitive Impairment.
One of the key challenges faced by individuals with mild cognitive impairment (MCI) is the decline in cognitive and motor abilities, particularly eye-hand coordination (EHC), which is essential for performing daily activities and…
- Conditions
- Cognitive Dysfunction, Cognitive Disorder, Cognitive Decline
- Trial name
- NCT07182396
- Testing
- Experimental Group, Control Group
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
Mild Cognitive Impairment (MCI)
Validation of Population Characteristics and Dosage Prescriptions for Cognitive Function Intervention Benefits of Different Doses of Tai Chi in Elderly Patients With Mild Cognitive Impairment: A Real-World Cross-Sectional Study
This is a companion real-world external validation study of two pre-registered parent randomized controlled trials (RCTs, protocol IDs: FujianUTCM-1 and FujianUTCM-2).
- Trial name
- NCT07608510
- Testing
- 24-form Simplified Tai Chi (Observational Behavioral Exposure)
- Volunteers
- 150 people
- Sponsor
- Lidian Chen
Mild Cognitive Impairment
Tai Chi Versus Conventional Exercise to Improve Cognitive Performance in Older Adults With Mild Cognitive Impairment
This randomized controlled trial aims to evaluate the effectiveness of Tai Chi and conventional exercise on improving cognitive function in older adults with mild cognitive impairment (MCI).
- Trial name
- NCT05540613
- Testing
- Health Education, Conventional Exercise, Tai Chi
- Where
- Hong Kong
- Volunteers
- 315 people
- Sponsor
- The University of Hong Kong
Cognitive Impairment, Mild
Effects of an Adaptogenic Extract on Electrical Activity of the Brain in Elderly Subjects With Cognitive Impairment
A randomized, double-blind, placebo-controlled, two arm cross-over study to determine whether a specific combination of Andrographis paniculata and Withania somnifera can be regarded as a safe and effective treatment for…
- Trial name
- NCT03780621
- Testing
- Andrographis and Withania
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- EuroPharma, Inc.
Mild Cognitive Impairment
Effects of Dietary Interventions on the Brain in Mild Cognitive Impairment (MCI)
The study will investigate whether dietary modification could provide positive effects on brain functions in elderly people with mild cognitive impairment.
- Trial name
- NCT01219244
- Testing
- caloric restriction, omega-3 supplementation, resveratrol supplementation
- Where
- Germany
- Volunteers
- 330 people
- Sponsor
- Charite University, Berlin, Germany
Mild Cognitive Impairment, Mild Dementia
Computer-based Cognitive Rehabilitation Program for Healthy Older Adults, Older People With Mild Cognitive Impairment and Mild Dementia
This study will adopt a newly developed computer-based cognitive rehabilitation program targeting the encoding stage of memory. The aims of the study are: 1.
- Conditions
- Mild Cognitive Impairment, Mild Dementia, Healthy Older Adults
- Trial name
- NCT03430401
- Testing
- Perceptual-based memory encoding, Semantic-based memory encoding, Cognitive stimulation
- Where
- Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Western Sydney
Mild Cognitive Impairment
Neurological Changes With a Memory Self-efficacy Training Protocol
Confidence in one's ability to accomplish a task, more formally known as self-efficacy, is an important psychological variable that can influence how the investigators perform on various tasks.
- Trial name
- NCT04077320
- Testing
- Memory Self-Efficacy Training, General Education
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- Western University, Canada
Dementia
Effects of Step Training in Older Adults with Mild Dementia
Step training has been shown to be effective at reducing the incidence of falls and improving related risk factors, including choice stepping, in healthy older adults.
- Trial name
- NCT05655403
- Testing
- Step training program
- Where
- Hong Kong
- Volunteers
- 145 people
- Sponsor
- The Hong Kong Polytechnic University
Depression, Pain
A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD
The purpose of the study is to examine the effect of Problem Adaptation Therapy for Pain (PATH-Pain) on cognitive functioning, depression and pain-related disability in 100 older adults with cognitive impairment, chronic pain…
- Conditions
- Depression, Pain, Cognitive Impairment
- Trial name
- PATH-Pain (NCT05081596)
- Testing
- PATH-Pain
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Weill Medical College of Cornell University
Dementia, Cognitive Impairment, Mild
Repeated Transcranial Magnetic Stimulation in the Elderly With Cognitive Impairment
Introduction and Purpose: In recent years, non-pharmacological treatment methods for dementia patients have been gradually explored.
- Trial name
- NCT06192433
- Testing
- High-frequency repetitive transcranial magnetic stimulation (40Hz), Moderately high-frequency repetitive transcranial magnetic stimulation (10Hz)
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- Taipei Hospital, Ministry of Health and Welfare
Mild Cognitive Impairment (MCI), Virtual Reality
An AI-Based Prediction of Cognitive Capacity in Older Adults and Individuals With Mild Cognitive Impairment During Virtual Reality Driving Tasks
Driving ability in older adults is essential for independent mobility and social participation, yet declines under high cognitive load or distraction often lead to visual attention failures such as "look-but-fail-to-see,"…
- Conditions
- Mild Cognitive Impairment (MCI), Virtual Reality, Eye Movement Disorder, Multimodal Monitoring
- Trial name
- NCT07656389
- Where
- Taiwan
- Volunteers
- 192 people
- Sponsor
- National Cheng-Kung University Hospital
Mild Cognitive Impairment
Neurofeedback Training for Older Adults With Mild Cognitive Impairment: a Protocol Study
This is a non-pharmacological study evaluating the effects of SMR/delta ratio and beta1/theta ratio neurofeedback trainings on cognitive performance and electrical brain activity in elderly with mild cognitive impairment.
- Trial name
- NCT03526692
- Testing
- Neurofeedback
- Volunteers
- 60 people
- Sponsor
- Fabienne Marlats
Mild Cognitive Impairment, Aging
Supporting Aging Through Green Exercise (SAGE)
Aerobic exercise is an evidence-based approach to mitigate cognitive decline in older adults with mild cognitive impairment (MCI).
- Trial name
- SAGE (NCT05036304)
- Testing
- Aerobic Exercise Indoors, Aerobic Exercise Outdoors
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Chronic Disease, Mild Cognitive Impairment
Virtual Outreach and Individualized Coaching Extension
This study tests whether a nurse-led program that uses a voice-controlled smart speaker in the home helps older adults better manage their chronic health conditions.
- Trial name
- VOICE (NCT07836114)
- Testing
- Virtual Outreach and Individualized Coaching Extension
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Emory University
Alzheimer's Disease (AD)
Study to Assess Adverse Events, Change in Disease Activity and How Oral ABBV-552 Capsules Moves Through the Body of Participants Aged 50 to 90 Years With Mild Alzheimer's Disease
Alzheimer's disease (AD) is a progressive, irreversible neurological disorder and is the most common cause of dementia in the elderly population.
- Trial name
- Abroad (NCT05771428)
- Testing
- ABBV-552
- Where
- 64 sites in United States, Australia and 5 more
- Volunteers
- 263 people
- Sponsor
- AbbVie
Mild Cognitive Impairment, Fall
Motor Signature, Falls Risk, and Home-Based Interventions in Older Adults With Mild Cognitive Impairment
A single-blinded, randomized controlled trial is designed to compare the effects of social interaction, computerized cognitive training, lower extremity strengthening, and tai chi chuan on improving cognitive functions and…
- Trial name
- NCT03839576
- Testing
- Exercise, Computerized training
- Where
- Taiwan
- Volunteers
- 252 people
- Sponsor
- Taipei Medical University
Dementia, Mild, Mild Cognitive Impairment
CAPABLE Family Pilot - Adapting CAPABLE for Older Adults With Mild Cognitive Impairment (MCI)/Early Stage Dementia and Their Care Partners
The purpose of this study is to test the adapted protocol, CAPABLE Family which builds upon the evidenced based CAPABLE program to address older adults with co-occurring physical disability and mild cognitive impairment or early…
- Conditions
- Dementia, Mild, Mild Cognitive Impairment, Disability Physical, Impairment, Cognitive
- Trial name
- NCT05187117
- Testing
- CAPABLE Family - Open Label Pilot, CAPABLE Family - Randomized Control Trial
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Mild Cognitive Impairment (MCI), Major Depressive Disorder, Remitted
Validating the On-line Creyos Cognitive Assessment Platform in Older Adults With Major Depressive Disorder or Mild Cognitive Impairment
The goal of this observational study is to validate the Creyos online cognitive assessment platform in individuals with mild cognitive impairment, or remitted major depressive disorder.
- Conditions
- Mild Cognitive Impairment (MCI), Major Depressive Disorder, Remitted, Healthy Controls Group - Age and Sex-matched
- Trial name
- Creyos-MD (NCT06780917)
- Where
- 3 sites in Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Mild Cognitive Impairment (MCI), Oral Health
To Exam the Efficacy of Oral Health and Mediterranean Diet Interventions in Preventing Cognitive Decline Among Older Adults With Mild Cognitive Impairment
At present, many literatures have confirmed that the Mediterranean diet has the effect of delaying cognitive degeneration in patients with mild cognitive impairment, and can also slow down the speed of brain atrophy.
- Conditions
- Mild Cognitive Impairment (MCI), Oral Health, Mediterranean Diet
- Trial name
- NCT05865340
- Testing
- oral health + MED diet, oral health, MED diet
- Where
- Taiwan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Mild Cognitive Impairment
Virtual Exercise For Older Adults With Mild Cognitive Impairment
This project is designed to develop and evaluate an Internet-based exercise intervention (tai ji quan Moving to Improve Brain Health) using real-time videoconferencing for older adults with mild cognitive impairment (MCI).
- Trial name
- NCT05318703
- Testing
- tai ji quan, Stretching
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Oregon Research Institute