Clinical trials: Older Adults With Mild Neurocognitive Disorders
Elderly Adults, Mild Cognitive Impairment
Agility Training and Its Relations in Elderly Adults With and Without MCI
The following three-part proposal will focus on the effects of agility training as well as the relationship between agility ability and motor and cognitive function, and risk of falls in elderly adults with or without mild…
- Conditions
- Elderly Adults, Mild Cognitive Impairment, Healthy
- Trial name
- NCT05537363
- Testing
- Health education, Multicomponent training, Agility training
- Where
- Taiwan
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Mild Cognitive Impairment (MCI), Self-Reported Memory Concerns
Transcranial Direct Current Stimulation Combined With Tai Chi for Dual-Task Mobility and Cognitive Function in Older Adults With Cognitive Decline
This randomized clinical trial evaluated the effects of transcranial direct current stimulation (tDCS) combined with Tai Chi on dual-task mobility, cognitive function, and physical function in older adults with mild cognitive…
- Trial name
- NCT07863518
- Testing
- Tai Chi, Transcranial Direct Current Stimulation
- Where
- 2 sites in China
- Volunteers
- 61 people
- Sponsor
- Shanghai University of Sport
Alzheimer Disease, Anxiety
Cannabidiol Solution for the Treatment of Behavioral Symptoms in Older Adults With Mild Cognitive Impairment or Alzheimer's Dementia
This is an open label, eight week, clinical trial of a proprietary high CBD/low THC sublingual solution for the treatment of clinically significant anxiety and agitation in individuals with mild cognitive impairment (MCI) or mild…
- Conditions
- Alzheimer Disease, Anxiety, Agitation,Psychomotor, Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
- Trial name
- CBD (NCT04075435)
- Testing
- high CBD/low THC sublingual solution
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Mclean Hospital
Mild Cognitive Impairment (MCI), Dementia
Integration of VR and AR Dementia Prevention Health Education Progrom for Older Adults With Mild Cognitive Impairment
The goal of this randomized controlled trial is to evaluate the effectiveness of Virtual Reality (VR)-based cognitive health education for older adults with mild cognitive impairment (MCI) in Taiwan.
- Conditions
- Mild Cognitive Impairment (MCI), Dementia, Health Literacy, Self-Efficacy
- Trial name
- NCT06888986
- Testing
- VR Dementia Prevention Health Education Module
- Where
- Taiwan
- Volunteers
- 139 people
- Sponsor
- National Taiwan Normal University
Dementia, Alzheimer Disease
The Music, Sleep and Dementia Study
The specific aims of this studyare to examine the 1) feasibility; 2) acceptability; and 3) preliminary efficacy of a tailored music intervention in home-dwelling older adults with dementia suffering from sleep disruption.
- Conditions
- Dementia, Alzheimer Disease, Circadian Rhythm Disorders, Circadian Rhythm Sleep Disorder
- Trial name
- NCT04157244
- Testing
- Tailored music listening intervention
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Mild Cognitive Impairment (MCI)
Gamma tACS to Improve Cognitive Function in Mild Cognitive Impairment
Mild cognitive impairment (MCI) is a decline in memory and thinking that exceeds normal aging but does not substantially disrupt daily life, and it raises the risk of developing dementia.
- Trial name
- TACS-MCI (NCT07752316)
- Testing
- transcranial electrical stimulation
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- The National Brain Mapping Laboratory (NBML)
Mild Cognitive Impairment
Real-time fMRI Neurofeedback in Patients With MCI
Increased activity in the hippocampus (i.e., hyperactivity) during a fMRI memory task was found in patients with Mild Cognitive Impairment due to Alzheimer's disease (MCI).
- Trial name
- NCT04020744
- Testing
- real-time fMRI based neurofeedback from the hippocampus, real-time fMRI based neurofeedback from another brain area
- Where
- 2 sites in Switzerland
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Bern
Mild Cognitive Impairment
Dual Task Training in Elderly Using the BioRescue
Mild cognitive impairment (MCI) is accompanied by gait and balance problems while dual tasking. During a 6 to 8 weeks training with the BioRescue (virtual reality), institutionalized elderly people with MCI will relearn dual…
- Trial name
- NCT02681354
- Testing
- Biorescue training
- Where
- 2 sites in Belgium
- Volunteers
- 21 people
- Sponsor
- Hasselt University
Cognitive Dysfunction
Feasibility of the Memory and Attention Adaptation-Training Geriatrics Intervention in Older Cancer Survivors With Mild Cognitive Impairment
Cancer-related cognitive dysfunction (CRCD) affects up to 75% of patients receiving chemotherapy and older adults are at greater risk of developing CRCD, which can negatively affect their functional independence and quality of…
- Trial name
- urochester (NCT05258058)
- Testing
- Memory and Adaptation Training-Geriatrics
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Allison Magnuson
Mild Cognitive Impairment
The Effect of TPS on Cognitive Functions in Older Adults With MCI
The goal of this randomized controlled trial is to learn if Transcranial Pulse Stimulation (TPS) can improve cognitive functions in older adults with mild cognitive impairment (MCI). The study will also assess the safety of TPS.
- Trial name
- NCT06407141
- Testing
- transcranial pulse stimulation
- Where
- Hong Kong
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Mild Cognitive Impairment (MCI)
Creative Dance-Supported CO-OP Approach in Older Adults With Mild Cognitive Impairment
The goal of this clinical trial is to evaluate if the CO-OP (Cognitive Orientation to daily Occupational Performance) approach, supported by creative dance, can improve cognitive functions in older adults with mild cognitive…
- Trial name
- COOP-DANCE (NCT06644690)
- Testing
- CO-OP with Creative Dance, CO-OP Only
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Çankırı Karatekin University
Mild Cognitive Impairment, Subthreshold Depression
A One-year Trajectory of Depression Status Changes in Older Adults With MCI and SD: a Longitudinal Cohort Study
The purpose of this study is to investigate the one-year trajectory of changes in depression status in older adults with mild cognitive impairment and subthreshold depression, and to explore relevant risk factors for predicting…
- Conditions
- Mild Cognitive Impairment, Subthreshold Depression, Older Adults
- Trial name
- NCT06308627
- Where
- China
- Volunteers
- 466 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Mild Cognitive Impairment, Alzheimer's Disease
Passport to Brain Wellness in Sedentary Adults
Numerous modifiable lifestyle factors have been identified that may affect the risk of older adults developing mild cognitive impairment (MCI) and Alzheimer's disease (AD).
- Trial name
- NCT00979446
- Testing
- Guided, Self-directed
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Mild Cognitive Impairment
Improving Effects of Fish Oil Combined With Pine Bark Extract on Cognitive Decline
The purpose of this study is to evaluate the improving effects of ω-3 fatty acid from fish oil combined with polyphenolic extract from pine bark (PE) on cognitive functions and biological parameters in healthy people aged 55 to…
- Trial name
- NCT05573269
- Testing
- FOPE (fish oil + pine extract)
- Where
- 2 sites in Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Medical University
Mild Cognitive Impairment, So Stated
Feasibility Study of a Computerized Cognitive Stimulation
This non-pharmacological interventional feasibility study evaluate a computerized cognitive stimulation program in elderly with mild cognitive impairment.
- Trial name
- PSCogStim (NCT03195829)
- Testing
- Computerized Cognitive Stimulation, Multimedia-based internet
- Volunteers
- 20 people
- Sponsor
- Leila DJABELKHIR
Chronic Pain, Mild Cognitive Impairment
Managing Pain and Cognitions in Older Adults With Early Cognitive Decline and Chronic Pain
The investigators aim to conduct a fully powered randomized controlled trial to compare the efficacy of two symptom management programs for older adults with early cognitive decline (either self-reported or confirmed by testing)…
- Conditions
- Chronic Pain, Mild Cognitive Impairment, Older Adults, Physical Activity
- Trial name
- NCT05373745
- Testing
- Active Brains 1, Active Brains 2
- Where
- United States
- Volunteers
- 267 people
- Sponsor
- Massachusetts General Hospital
Alzheimer Disease, Dementia
Jigsawdio Multisensory Platform for People With Mild Cognitive Impairment, Alzheimer's Disease, or Related Dementias
This study will evaluate Jigsawdio, a personalized multisensory jigsaw puzzle platform, for adults aged 60 years and older with mild cognitive impairment or mild dementia.
- Conditions
- Alzheimer Disease, Dementia, Mild Cognitive Impairment
- Trial name
- NCT07839286
- Testing
- Jigsawdio Multisensory Puzzle Platform, Standard Jigsaw Puzzle Activity
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Callahan-Young LLC DBA Jigsawdio
Mild Cognitive Impairment
Arch Support Effects on Balance and Gait in Older Adults With Mild Cognitive Impairment
This study aims to explore the effects of arch support insoles on balance and gait performance in older adults with mild cognitive impairment (MCI). We will recruit 40 female older adults with MCI.
- Trial name
- NCT05470062
- Testing
- arch support insoles (FootDisc)
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
MCI
The Effect of Lavender Aromatherapy on Cognitive Function in Older Adults With Mild Cognitive Impairment
1. To analyze the therapeutic effects of lavender aromatherapy on memory function and overall cognitive function in older adults with Mild Cognitive Impairment (MCI); 2.
- Trial name
- NCT07688382
- Testing
- aromatherapy
- Volunteers
- 70 people
- Sponsor
- China Medical University, China
Mild Cognitive Impairment
Effect of Tablet-Based Games on Executive Functions in Older Adults With Mild Cognitive Impairment
The primary objective of this study is to investigate whether a tablet-based role-playing game is more effective than tablet-based word or image puzzles at improving executive functions in older adults with mild cognitive…
- Trial name
- NCT05468424
- Testing
- tablet (iPad or android) based role-playing game, tablet (iPad or android) based word puzzles and image puzzles
- Where
- 2 sites in Canada
- Volunteers
- 42 people
- Sponsor
- John Puxty