Clinical trials: Older Patient
Femoral Fracture
Analysis of the Relationship Between Early Postoperative Anemia and the Evolution of Autonomy at 6 Months in Patients 75 Years of Age and Older Operated on Following a Fracture of the Upper End of the Femur
Fracture of the upper extremity of the femur is a condition whose frequency increases with age. It is a serious disease, with multiple consequences such as a decrease in life expectancy, quality of life and patient autonomy.
- Trial name
- PAAF (NCT03810092)
- Where
- 5 sites in France
- Volunteers
- 255 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Severe Eosinophilic Asthma
Real World Evidence of Benralizumab in Eosinophilic Severe AsThma in Russia (BEST)
Benralizumab is a humanised, afucosylated, monoclonal antibody against the interleukin (IL)-5 receptor (IL-5R) α subunit that induces direct, rapid, and near-complete depletion of eosinophils in blood, airway tissue, and bone…
- Trial name
- NCT05271526
- Where
- Russia
- Volunteers
- 3 people
- Sponsor
- AstraZeneca
Breast Cancer
Radiation Therapy During Surgery in Treating Older Women With Invasive Breast Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Giving radiation during surgery may be an effective treatment for breast cancer.
- Trial name
- NRR (NCT00182728)
- Testing
- surgery, therapy, radiation therapy
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Malnutrition
The Dietetic Consultation: an Illuminative Evaluation
This study aims to understand the experience of the dietetic consultation from the perspective of nutritionally vulnerable older patients receiving oral nutrition support and dietitians, as well as other key stakeholders involved…
- Trial name
- NCT03509116
- Testing
- Observations, documents, Interviews, key stakeholders, documents
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- King's College London
Aging
Health TAPESTRY Ontario
The Health Teams Advancing Patient Experience: Strengthening Quality (Health TAPESTRY) is a community-based program led by primary care teams, that creates connections between trained community volunteers, interprofessional…
- Trial name
- NCT03397836
- Testing
- Health TAPESTRY Intervention, Usual Care
- Where
- Canada
- Volunteers
- 599 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cancer
A Single Arm Pilot Trial of a Social Network Intervention
The purpose of this study is to see if a social network support program (SOcial Networks to Activate Trust \& Adherence or SONATA) is helpful for older individuals receiving cancer treatment.
- Trial name
- SONATA (NCT05745038)
- Testing
- SONATA
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- University of Rochester
Age Associated Immune Deficiency, Elderly Infection
Immunophenotype of Risk in Older Patients Admitted for Pneumonia
The objective is to evaluate if the immune risk phenotype (IRP) in patients who have been admitted for pneumonia predisposes to worse long-term outcomes.
- Conditions
- Age Associated Immune Deficiency, Elderly Infection, Pneumonia, Nutrition Disorders in Old Age
- Trial name
- NCT04062799
- Testing
- no intervention
- Where
- Spain
- Volunteers
- 174 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Total Hip Arthroplasty (THA), Femoral Neck Fractures
PNB Anesthesia Improves Older Patients' Postoperative Early Recovery Outcomes After Total Hip Arthroplasty
Early postoperative rehabilitation is an important issue for total hip arthroplasty, especially in older patients. This retrospective clinical trial is to assess the impact of peripheral nerve block anesthesia versus general…
- Trial name
- NCT07163598
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 516 people
- Sponsor
- RenJi Hospital
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Open-label Phase 3 BTK Inhibitor Ibrutinib vs Chlorambucil Patients 65 Years or Older With Treatment-naive CLL or SLL
A Randomized, Multicenter, Open-label, Phase 3 Study of the Bruton's Tyrosine Kinase Inhibitor PCI-32765 versus Chlorambucil in Patients 65 Years or Older with Treatment-naive Chronic Lymphocytic Leukemia or Small Lymphocytic…
- Trial name
- NCT01722487
- Testing
- Ibrutinib, Chlorambucil
- Where
- 108 sites in United States, Australia and 14 more
- Volunteers
- 269 people
- Sponsor
- Pharmacyclics LLC.
Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
S0432 Tipifarnib in Treating Older Patients With Acute Myeloid Leukemia
This randomized phase II trial is studying 4 different tipifarnib regimens to compare how well they work in treating older patients with acute myeloid leukemia.
- Conditions
- Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0), Adult Acute Monoblastic Leukemia (M5a), Adult Acute Monocytic Leukemia (M5b)
- Trial name
- NCT00093418
- Testing
- tipifarnib
- Where
- United States
- Volunteers
- 296 people
- Sponsor
- National Cancer Institute (NCI)
Kidney Failure, Chronic
Deprescribing for Older Dialysis Patients
Aim 1 of the study is to identify the elements of a deprescribing intervention that address contextual factors specific to dialysis.
- Trial name
- NCT03631290
- Testing
- Deprescribing Intervention
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Duke University
Untreated Adult Acute Myeloid Leukemia
Guadecitabine With or Without Idarubicin or Cladribine in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia
This randomized phase II trial studies how well guadecitabine with or without idarubicin or cladribine works in treating older patients with previously untreated acute myeloid leukemia.
- Trial name
- NCT02096055
- Testing
- Cladribine, Guadecitabine, Idarubicin
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- M.D. Anderson Cancer Center
Adult Solid Neoplasm, Lymphoma
Improving Communication in Older Cancer Patients and Their Caregivers
Over 60% of cancers occur in older persons, and the number of older persons with cancer is expected to grow as the population ages.
- Trial name
- COACH (NCT02107443)
- Testing
- Geriatric Assessment Summary, Geriatric Assessment Targeted Recommendations, Geriatric Assessment (GA)
- Where
- 19 sites in United States
- Volunteers
- 546 people, healthy volunteers welcome
- Sponsor
- Supriya Mohile
CGA
Preoperative Comprehensive Geriatric Assessment (CGA) and Postoperative Delirium
The purpose of this research is to find out the best way to reduce delirium in frail, older patients undergoing planned surgery. Delirium is a state of confusion and difficulty concentrating that is temporary.
- Trial name
- NCT07059585
- Testing
- CGA, control
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Miami
Sarcopenia, Malnutrition
EAMA Sarcopenia in Acute Care Patients in 9+European Countries
This collaborative study in 9 geriatrics units across Europe aims to apply emerging research to clinical practice, following the "Action-Research Philosophy" (11).
- Trial name
- EAMA9+ (NCT04039620)
- Testing
- Observational study, no interventions expected
- Where
- Spain
- Volunteers
- 366 people
- Sponsor
- Parc de Salut Mar
Gastrointestinal Malignancy
Mobility and Activity Training (MAT) to Optimize Outcomes for Older Adult Abdominal Surgery Patients
In this pilot study a group of older adults undergoing midline laparotomy for gastrointestinal malignancy will participate in a mobility and activity training (MAT) program.
- Trial name
- MAT (NCT02007876)
- Testing
- Mobility and Activity Training
- Where
- 2 sites in United States
- Sponsor
- University of Michigan
Chronic Kidney Disease (CKD), Health Communication
Patient-centered Precision Medicine Lab Result Communication for Older Adults
For adults ≥65 years and their providers, the investigators will test the usability and design of a tool to replace standard uniform reporting of lab results to patients and their providers with a new personalized Electronic…
- Conditions
- Chronic Kidney Disease (CKD), Health Communication, Patient Comprehension
- Trial name
- NCT07391904
- Testing
- Chronic Kidney Disease (CKD) Lab Result Communication Tool
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- University of California, Los Angeles
Head and Neck Squamous Cell Carcinoma
Radiotherapy Combine With Raltitrexed Versus Radiotherapy Alone in Older Patients With HNSCC.
The purpose of this study is to evaluate the efficacy of radiotherapy combine with raltitrexed in older patients with head and neck squamous cell carcinoma.
- Trial name
- NCT03196843
- Testing
- Raltitrexed, Intensity Modulated Radiotherapy
- Where
- China
- Volunteers
- 202 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Sarcopenia
The Whole Body Vibration for Sarcopenic Hospitalized Patients Aged 80+ Years
Resistance training have been recommended for sarcopenic patients. However, the whole body vibration training would further benefit for sarcopenic patients on the basis of resistance training remains unclear.
- Trial name
- NCT04637789
- Testing
- the whole body vibration, resistance training
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Yuxiang Liang
Acute Myeloid Leukemia
FLUDARABINE-TREOSULFAN REDUCED INTENSITY CONDITIONING REGIMEN PRIOR HAPLOIDENTICAL STEM CELL TRANSPLANTATION WITH POST TRANSPLANTATION CYCLOPHOSPHAMIDE FOR OLDER AND/OR FRAIL PATIENTS WITH AML
Acute myeloid leukemia (AML) and high-risk myelodysplastic syndromes (MDS) predominantly affect older adults, and their incidence continues to rise with advanced age.
- Trial name
- FT-RIC-HAPLO (NCT07598110)
- Testing
- fludarabine and treosulfan
- Volunteers
- 77 people
- Sponsor
- Institut Paoli-Calmettes
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