Clinical trials: Older Patient
Heart Failure, Diastolic
Mechanisms and Management of Exercise Intolerance in Older Heart Failure Patients
Heart failure with preserved ejection fraction (HFpEF) is the fastest growing form of heart failure with a high morbidity and mortality rate, and is associated with severe exercise intolerance.
- Trial name
- NCT03111017
- Testing
- Exercise Training
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Cancer Pain
Efficacy of Biofeedback-Based Serious Game for Pain Alleviation in Middle-Aged and Older Ovarian Cancer Patients: A Randomized Controlled Trial
Consistent pain affects most middle-aged and older ovarian cancer patients. Non-pharmacological pain interventions, such as serious games, offer a promising approach to alleviating this pain by providing an effective sense of…
- Trial name
- NCT06612489
- Testing
- biofeedback based dynamic-difficulty game, fixed difficulty game
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Anemia, Leukemia
Leridistim Compared With Filgrastim in Treating Older Patients With Acute Myeloid Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Colony-stimulating factors such as leridistim and filgrastim increase the number of immune cells found in…
- Conditions
- Anemia, Leukemia, Neutropenia, Thrombocytopenia
- Trial name
- NCT00004215
- Testing
- filgrastim, leridistim, cytarabine
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Osteoporosis, Older People
Tele-Rehabilitation Intervention in Community-Based Healthcare for Patients With Osteoporosis (DHEAL-COM-OP)
The DHEAL-COM-OP study is characterized as a feasibility study. The general objective is to evaluate the improvement in the physical performance of patients with osteoporosis detected through the Performance-Oriented Mobility…
- Trial name
- DHEAL-COM-OP (NCT06984380)
- Testing
- Telerehabilitation, Usual care
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Depression, Hypertension
Biological CVD Risk Factors in Older Depressed Patients
The purpose of this study is to determine if improvements in mood will ameliorate autonomic dysregulation, HPA dysfunction and typical (e.g.
- Conditions
- Depression, Hypertension, Hypercholesterolemia
- Trial name
- NCT00318864
- Testing
- Cognitive behavioral therapy
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Stanford University
Osteo Arthritis Knee
Comprehensive Geriatric Assessment in Knee Osteoarthritis
Osteoarthritis (OA) is the most common form of arthritis, and is characterized by joint pain and stiffness leading to functional decline and relevant loss in quality of life.
- Trial name
- NCT05659979
- Testing
- Comprehensive geriatric assessment
- Volunteers
- 30 people
- Sponsor
- University of Palermo
Advanced Cancer, Older Adults (65 Years and Older)
A Pilot Randomized Controlled Trial of a Social Network Intervention
This is a pilot randomized controlled trial to assess the feasibility, acceptability, appropriateness, and structure of the SONATA intervention.
- Conditions
- Advanced Cancer, Older Adults (65 Years and Older), Social Networks
- Trial name
- SONATA 2 (NCT07393529)
- Testing
- SONATA
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Rochester
Hip Replacement in Osteoarthritis Patients, Osteoarthritis, Hip
Prehabilitation in Older People Undergoing Total Hip Replacement
The goal of this clinical trial is to determine the effect of Resistance Exercise Training (RET)-based (p)rehabilitation versus usual care on skeletal muscle mass and function, as well as on underlying biological processes, in…
- Trial name
- PREHIP (NCT07048080)
- Testing
- (P)rehabilitation Progresive Resistance Exercise Training, Prehabilitation Group Deuterated Water, Usual Care Group Deuterated Water
- Where
- Chile
- Volunteers
- 70 people
- Sponsor
- Universidad de La Frontera
Polypharmacy (People Under Treatment With 5 or More Drugs), Elderly (People Aged 65 or More)
Prevalence of Inappropriate Prescriptions and Omitted Therapies in Hospitalized Elderly: STOPP/START Criteria Analysis
Evaluate the prevalence of potentially inappropriate prescriptions (PIPs) and potential omitted prescriptions (PPOs) in elderly patient upon admission to the acute geriatric department, based on adherence or non-adherence to the…
- Conditions
- Polypharmacy (People Under Treatment With 5 or More Drugs), Elderly (People Aged 65 or More), Deprescribing, Hospitalization
- Trial name
- SPIna (NCT07202962)
- Testing
- medication review and deprescribing
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Regione del Veneto - AULSS n. 7 Pedemontana
Type2 Diabetes Mellitus
High Protein Effect on Body Composition and Sarcopenia Markers in Older Patients With Type 2 Diabetes Mellitus
This study will investigate the impact of dietary protein intake on progressive muscle loss and functionality (sarcopenia) in older adults with type 2 diabetes mellitus.
- Trial name
- NCT05457088
- Testing
- 1.5 protein, 0.8 protein
- Where
- Greece
- Volunteers
- 25 people
- Sponsor
- National and Kapodistrian University of Athens
Leukemia
Gemtuzumab Ozogamicin With or Without Chemotherapy in Treating Older Patients With Acute Myeloid Leukemia
RATIONALE: Monoclonal antibodies such as gemtuzumab ozogamicin can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells.
- Trial name
- NCT00006122
- Testing
- cytarabine, etoposide, gemtuzumab ozogamicin
- Where
- 18 sites in Austria, Belgium and 5 more
- Volunteers
- 106 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Medication Adherence, Medication Compliance
Supporting the Medication Adherence of Older Mexican Adults Through External Cues Provided With Ambient Displays
Background: Problems with prospective memory, which refer to the ability to remember future intentions, cause deficits in basic and instrumental activities of daily living, such as taking medications.
- Trial name
- NCT04289246
- Testing
- Medication Ambient Display (MAD)
- Where
- Mexico
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Ovarian Cancer
The Effectiveness of an Online Support Group in Enhancing Recovery Identity and Health-Related Quality of Life
Background Ovarian cancer poses challenges for middle-aged and older patients, impacting physical and self-conceptual aspects. A research gap exists on the impact of online support groups (SPs) on identity synthesis and…
- Trial name
- NCT06145295
- Testing
- mobile online support group (experiment group), offline support group (control group)
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Cancer, Aging
Improving Communication for Cancer Treatment: Addressing Concerns of Older Cancer Patients and Caregivers
To improve patient-centered outcomes for older patients with cancer considering or receiving chemotherapy and their caregivers. To do this, the project team will (a) establish the effectiveness of GA on communication about…
- Conditions
- Cancer, Aging, Communication
- Trial name
- NCT05436327
- Testing
- Geriatric Assessment
- Where
- United States
- Volunteers
- 479 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Acute Leukemias of Ambiguous Lineage, Philadelphia Chromosome Negative Adult Precursor Acute Lymphoblastic Leukemia
Entinostat and Clofarabine in Treating Patients With Newly Diagnosed, Relapsed, or Refractory Poor-Risk Acute Lymphoblastic Leukemia or Bilineage/Biphenotypic Leukemia
This phase I trial studies the side effects and best dose of entinostat when given together with clofarabine in treating patients with newly diagnosed, relapsed, or refractory poor-risk acute lymphoblastic leukemia or…
- Conditions
- Acute Leukemias of Ambiguous Lineage, Philadelphia Chromosome Negative Adult Precursor Acute Lymphoblastic Leukemia, Recurrent Adult Acute Lymphoblastic Leukemia, Untreated Adult Acute Lymphoblastic Leukemia
- Trial name
- NCT01132573
- Testing
- entinostat, clofarabine, pharmacological study
- Where
- 4 sites in United States
- Volunteers
- 27 people
- Sponsor
- National Cancer Institute (NCI)
Chronic Pain, Opioids
I-COPE Study: Opioid Use and Pain Management in Older Adults
Adults over 65 years of age are at higher risk of experiencing chronic pain and adverse events from opioids and opioid use disorder (OUD).
- Conditions
- Chronic Pain, Opioids, Opioid-use Disorder
- Trial name
- I-COPE (NCT04878562)
- Testing
- I-COPE
- Where
- 2 sites in United States
- Volunteers
- 20,000 people
- Sponsor
- University of Chicago
Delirium in Old Age
REPOSE Study: Reducing Delirium by Enhancing Postoperative Sleep With Suvorexant
This research study will evaluate the effectiveness of postoperative administration of a drug called suvorexant, to improve postoperative sleep and decrease the severity of delirium (serious confusion) in adults 65 years and…
- Trial name
- REPOSE (NCT05733286)
- Testing
- Suvorexant 20 mg
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Duke University
Acute Myeloid Leukemia With Gene Mutations, Adult Acute Myeloid Leukemia in Remission
Midostaurin in Treating Older Patients With Mutated Acute Myeloid Leukemia Post-Transplant
This phase 2 trial studies the side effects and how well midostaurin works in treating older patients with acute myeloid leukemia with change in genetic material post-hematopoietic cell transplantation.
- Trial name
- NCT02723435
- Testing
- Midostaurin
- Sponsor
- Stanford University
Depression, Anxiety
Postoperative Anxiety and Depression Among Older Chinese Patients
A multicenter, prospective observational study to describe the socioeconomic characteristics and the occurrence of postoperative anxiety and depression in the Chinese old population.
- Conditions
- Depression, Anxiety, Elderly Patients, Non-cardiac Surgery
- Trial name
- NCT06495840
- Testing
- no intervention
- Where
- China
- Sponsor
- Chinese PLA General Hospital
Cancer
A Geriatric Assessment Electronic Platform for Older Patients With Cancer (eGAP - Electronic Geriatric Assessment Platform)
This project assesses the feasibility and usability of the geriatric assessment platform (electronic Geriatric Assessment Platform or eGAP in 50 older patients with cancer, their caregivers, and their oncology team.
- Trial name
- eGAP (NCT04824859)
- Testing
- Behavioral
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Rochester