Clinical trials: Older Women
Kidney Diseases
Graft-first Versus Fistula-first in Older Patients With End-stage Kidney Disease
Many older adults require hemodialysis for advanced chronic kidney disease, but it is not clear which permanent vascular access method (fistula or graft) is best with respect to access effectiveness and patient satisfaction.
- Trial name
- GEMSSTAR (NCT03545113)
- Testing
- Upper arm arteriovenous graft surgery, Upper arm arteriovenous fistula surgery
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Wake Forest University Health Sciences
Aging
Fatigability and Physical Performance: Effects of Resistance Training Variables Manipulation
This study evaluate whether resistance training variables modulate the fatigability (power-duration relationship) and physical performance in adults and older adults
- Trial name
- NCT03619070
- Testing
- Resistance training, LL, Resistance training, HL, Resistance training, HVHL
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Triangulo Mineiro
Urinary Incontinence
Ancillary Study of the Lessening Incontinence With Low-impact Activity Study
The parent trial that supports this ancillary research is a randomized controlled trial to evaluate the efficacy of a group-based yoga intervention to decrease the frequency and impact of urinary incontinence in ambulatory…
- Trial name
- NCT04776720
- Testing
- Yoga Practice Program, Physical Conditioning Program
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Renal Disease, End Stage, Palliative Care
Improving Medical Decision Making for Older Patients With End Stage Renal Disease
The overall objective of this study is to reduce the burden of chronic kidney disease (CKD) and its consequences for an aging U.S. population.
- Conditions
- Renal Disease, End Stage, Palliative Care, Decision Aids
- Trial name
- VIDEO-KD (NCT04347629)
- Testing
- Advance Care Planning Video Decision Aid
- Where
- 9 sites in United States
- Volunteers
- 456 people
- Sponsor
- Tufts Medical Center
Malnutrition Elderly, Kidney Diseases
Methods for Nutrition, Inflammation, Kidney Function, Aging, Body Composition, and Hydration Among Older Patients
The goal of this observational study, is to improve the diagnostic assessment method of malnutrition and kidney diseases, amongst hospitalized and low priority patients, by evaluating modern methodology and biomarkers, with…
- Conditions
- Malnutrition Elderly, Kidney Diseases, Dehydration
- Trial name
- MIKADO (NCT07501195)
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Ove Andersen
Breast Cancer Female
REJOIN Trial for Older Breast Cancer Survivors
The purpose of this pilot intervention study is to assess feasibility and the potential intervention effects of a self-management intervention (combining education- and exercise-based strategies) for improving arthralgia (joint…
- Trial name
- REJOIN (NCT03955627)
- Testing
- Relieving Joint Pain and Improving AI Adherence in Older Breast Cancer Survivors (REJOIN)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Wake Forest University Health Sciences
Human Papillomavirus Infection
Clinical Evaluation of the APTIMA® HPV Assay Using the TIGRIS® System
The purpose of this study is to provide data on the performance of the APTIMA HPV Assay using the TIGRIS System in detecting HPV types that may cause cervical cancer.
- Trial name
- NCT00973362
- Testing
- APTIMA HPV Assay, FDA-Approved HPV DNA Test
- Where
- 17 sites in United States
- Volunteers
- 12,896 people, healthy volunteers welcome
- Sponsor
- Gen-Probe, Incorporated
Breast Cancer, Breast Cancer Female
Abbreviated MBCT for Depression in Older Black or African American Breast Cancer Survivors
The purpose of this research study is to develop and test an intervention designed to improve mood and reduce symptoms of depression.
- Conditions
- Breast Cancer, Breast Cancer Female, Breast Cancer Stage I, Breast Cancer Stage II
- Trial name
- NCT06336538
- Testing
- MBCT
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Case Comprehensive Cancer Center
Chronic Kidney Diseases
Chronic Kidney Disease-Education (CKD-EDU)
The investigators are conducting a study to see which program better helps older patients with kidney disease choose their treatment.
- Trial name
- CKD-EDU (NCT06410144)
- Testing
- Program A, Program B
- Where
- 5 sites in United States
- Volunteers
- 326 people
- Sponsor
- University of Rochester
Depressive Symptoms, Physical Function
Flywheel Resistance Training and Traditional Resistance Training in Older Women With Sedentary Behaviors
There are easily accessible and safe strategies, such as resistance training, that can contribute to reducing depressive symptoms and preserving physical and executive function in older women.
- Conditions
- Depressive Symptoms, Physical Function, Executive Function, Resistance Training
- Trial name
- FET (NCT06758206)
- Testing
- Flywheel Resistance Training, Traditional resistance training
- Where
- 2 sites in Brazil
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Federal University of Vicosa
Urinary Tract Infection (Diagnosis)
'Improving Urinary Tract Infection Diagnosis in Older Patients: Validation of a Biomarker Panel (UTI-GOLD)'
The goal of this study is to improve the diagnosis of urinary tract infections (UTI) in older people (≥65 years). The main research questions are: Research questions What is the optimal cut-off for each individual biomarker…
- Trial name
- UTI-GOLD (NCT06610721)
- Testing
- Urine Biomarkers
- Where
- Netherlands
- Volunteers
- 264 people
- Sponsor
- Leiden University Medical Center
Breast Cancer
Longitudinal ctDNA Surveillance for Older Women With ER+ Breast Cancer Who Omit Surgery
This prospective study recruits patients with ER+/HER2-, non-metastatic breast cancer who omit upfront surgery in favor of primary endocrine therapy for sample collection and prospective circulating tumor DNA (ctDNA) measurement…
- Trial name
- NCT05914792
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Pittsburgh
Breast Cancer Female, Breast Cancer
Transitioning Care: Perspectives of Older Women With Early Breast Cancer on Current Telemedicine Modalities
Explosive growth in the use of telemedicine (video or telephone visits) has followed the onset of the coronavirus disease 2019 (COVID-19) pandemic in order to meet healthcare needs while avoiding unnecessary exposure risks in…
- Trial name
- NCT04990934
- Testing
- Semistructured Interview
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Heat Stress, Temperature Change, Body
Identifying the Limits of Survivability in Heat-exposed Older Females
Climate change increases extreme heat events, elevating global heat-illness risk. Females have reduced heat loss capacity (~5%) compared to males, driven by differences in skin blood flow and sweating responses.
- Conditions
- Heat Stress, Temperature Change, Body, Aging, Thermoregulation
- Trial name
- NCT07032493
- Testing
- Humidity-Ramp Protocol, Above-inflection fixed-condition exposure (5%), Below-inflection fixed-condition exposure (5%)
- Where
- 2 sites in Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Protein Malabsorption
Changes in Plasma Amino Acid Appearance After Adding Bacillus Coagulans GBI-30, 6086 to Milk Protein Concentrate
The purpose of this study is to examine the pattern of plasma amino acid appearance after a two-week daily regimen of milk protein concentrate supplementation with and without the addition of Bacillus coagulans GBI-30, 6086 among…
- Trial name
- ABC (NCT05313178)
- Testing
- Bacillus Coagulans GBI-30, 6086
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Human Papilloma Virus Infection
Clinical Evaluation of the APTIMA® HPV Assay and Comparison With the HR HC2® Test Using LBC ThinPrep® Specimens
To assess and compare the performance of the HR HPV HC2® test (Qiagen/Digene) and the APTIMA® HPV Assay (Hologic) using LBC Specimens (ThinPrep® Pap Test) for the detection of HPV infection and high-grade CIN lesions in a…
- Trial name
- NCT02634190
- Testing
- Thinprep® LBC, APTIMA® HPV Assay, HR HC2® HPV DNA
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Hologic Deutschland GmbH
Breast Cancer
Cognitive Sequelae of Adjuvant Endocrine Therapy for the Treatment of Breast Cancer in Older Women
Breast cancer is the most frequently diagnosed cancer in women with the majority receiving an endocrine therapy (ET) in the adjuvant setting.
- Trial name
- NCT02480218
- Testing
- Neuropsychological test battery
- Where
- Canada
- Volunteers
- 47 people
- Sponsor
- Sunnybrook Health Sciences Centre
Coronavirus Disease (COVID-19)
A Single Heterologous Booster Vaccination Study of TAK-019 in Healthy Japanese Adults (COVID-19)
TAK-019 is a vaccine in development to protect people against Covid-19. The main aims of the study are to learn if TAK-019 can protect people from Covid-19 and to check for side effects from TAK-019 for participants who will…
- Trial name
- NCT05299359
- Testing
- TAK-019
- Where
- 2 sites in Japan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Takeda
Aging, Cognitive Decline
Omega-3 Fatty Acids and Exercise on Mobility and Cognition in Older Women
The study will provide insight into how lifestyle-related interventions, specifically nutrition and exercise can impact the health of older women.
- Trial name
- MOBILE (NCT03228550)
- Testing
- Efamol Active 50+, Aerobic exercise
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bournemouth University
End Stage Renal Disease
Study Response of 13-valent Conjugate Pneumococcal Vaccine in Patients With End Stage Renal Disease
The purpose of the study is to determine the response of 13-valent conjugate pneumococcal vaccine in patients 50 years or older with end stage renal disease on dialysis.
- Trial name
- NCT01974817
- Testing
- 13-valent conjugate pneumococcal vaccine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Michigan State University