Clinical trials: Older Women
Sarcopenic Obesity, Sarcopenia
Evaluation Of DNA Methylation Pattern In Healthy, Sarcopenic, Obese And Sarcopenic Obese Older Women: A Cross-Sectional Study
INTRODUCTION: Sarcopenic obesity (SO), a functional and clinical condition, is characterized by the coexistence of obesity, marked by excess fat mass and sarcopenia, characterized by reduced strength and muscle mass.
- Conditions
- Sarcopenic Obesity, Sarcopenia, Obesity, Epigenesis, Genetic
- Trial name
- NCT06618430
- Testing
- None (Observational Study)
- Where
- Brazil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Diabetes Mellitus, Type 2, Healthy
Sedentary Behavior in Older Women With and Without Type 2 Diabetes
Sedentary behavior has been linked to cardiovascular morbidity and mortality, and is particularly common in older adults with type 2 diabetes.
- Trial name
- SitWise (NCT04262128)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Mammography, Medical Overuse
A Multi-Level Strategy for De-implementing Mammography Overuse Among Older Women
This project aims to advance methodological and theoretical approaches for developing, selecting, refining, and piloting a multilevel de-implementation strategy to reduce the overuse of screening mammography in women aged ≥75…
- Conditions
- Mammography, Medical Overuse, Evidence-based Practice, Older Adults
- Trial name
- NCT07511621
- Testing
- Enhanced Usual Care (EUC), Multilevel De-Implementation Strategy
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Columbia University
Lymphomas Non-Hodgkin's B-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma
A Study to Investigate Safety of INT2104 Infusions in Participants Aged 18 Years of Age and Older Who Have B-cell Cancers That Came Back After Previous Treatment
The purpose of this first-in-human study is to evaluate the safety and tolerability of INT2104 when administered to humans in a broad population of participants with refractory/relapsing B-cell malignancies.
- Trial name
- INVISE (NCT06539338)
- Testing
- INT2104
- Where
- 3 sites in Australia, Spain
- Volunteers
- 10 people
- Sponsor
- Kite, A Gilead Company
Old Age; Debility, Age-Related Sarcopenia
Muscle Quality, Fall Concern and Lower Extremity Functionality in Older Women
The aim of the study was to investigate the effects of muscle quality on fear of fall, and lower extremity functionality in older women.
- Trial name
- NCT05758792
- Testing
- Muscle Quality Index
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people
- Sponsor
- Pamukkale University
Healthy
Pharmacologic Effects of Darifenacin and Tolterodine on Cardiovascular Parameters in Healthy Subjects
This study will evaluate the pharmacologic effects of exposure to darifenacin and tolterodine on cardiovascular parameters in healthy subjects 50 years of age and older
- Trial name
- NCT00703703
- Testing
- Darifenacin, Tolterodine
- Where
- 21 sites in United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Novartis
Chronic Kidney Disease
Effects of a Walking Intervention in Older Patients With Chronic Kidney Disease: Feasibility Study
Chronic kidney disease (CKD) affects more than 26 million individuals (13 percent) of the U.S. population, with a projected 70 percent increase by the year 2015 to over 40 million individuals.
- Trial name
- NCT02155127
- Testing
- walking
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Utah
Older Adults, Balance, Dance
Dance and Blood Flow Restriction as Balance Training for Older Women
Falls are one of the leading causes of hospitalization and mortality among older adults (aged 65+) in Canada. Falls result from postural instability following age-related declines in muscle strength which begin in the 5th decade…
- Conditions
- Older Adults, Balance, Dance, Blood Flow Restriction (BFR) Training Effects, Telehealth
- Trial name
- NCT07011784
- Testing
- Blood flow restriction in combination with dance classes, Dance classes alone
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Concordia University, Montreal
65 Years Older, CHF - Congestive Heart Failure
Comparing Sarcopenia , Physical, Psychological and Social Frailty in Hospitalized Older Women Congestive Heart Failure in Metropolitan and Rural Settings
Frailty-encompassing sarcopenia, physical, psychological, and social frailty-is common among older adults with congestive heart failure (CHF) and contributes to adverse outcomes such as rehospitalization, mortality, and poor…
- Conditions
- 65 Years Older, CHF - Congestive Heart Failure, Social Communication, Sarcopenia in Elderly
- Trial name
- NCT07100366
- Testing
- ChatGPT, community social
- Volunteers
- 200 people
- Sponsor
- Chang Gung University of Science and Technology
Coronavirus Disease (COVID-19)
A Study of TAK-919 in Healthy Japanese Adults (COVID-19)
TAK-919 is a vaccine in development to protect people against Covid-19. The main aims of the study are to learn if TAK-919 can protect people from Covid-19 and to check for side effects from TAK-919.
- Trial name
- NCT04677660
- Testing
- TAK-919
- Where
- 2 sites in Japan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Takeda
Urinary Incontinence in Old Age
Telehealth in the Rehabilitation of Urinary Incontinence in Older Women
The goal of this randomized clinical trial is to compare the effectiveness of a pelvic floor rehabilitation program in a face-to-face versus remote in community-dwelling elderly women with urinary incontinence.
- Trial name
- NCT06200922
- Testing
- Pelvic physiotherapy
- Where
- Brazil
- Volunteers
- 69 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Obesity, Overweight
Dietary Effects on Weight Loss and Lipid Profile in Sedentary Women
Negative-calorie diet is among the popular dieting guides for weight loss; however, there is still little knowledge about this method.
- Conditions
- Obesity, Overweight, Life Style
- Trial name
- NCT03066882
- Testing
- NCD, LCD
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- P.L.Shupik National Medical Academy of Post-Graduate Education
Physical Activity
Smart Walk 50+: Feasibility of a Smartphone-delivered Physical Activity Program for African American Women 50 Years and Older
The purpose of this study is to establish the acceptability and feasibility of a culturally relevant, theory-based smartphone-delivered physical activity intervention among African American women aged 50-65 years.
- Trial name
- NCT04073355
- Testing
- Physical Activity
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Urinary Incontinence,Stress, Urinary Incontinence, Urge
Association of Urinary Incontinence With Depression, Insomnia, Frailty and Falls in Older Adults
The aim of our study is to provide a holistic analysis of the geriatric syndromes associated with urinary incontinence, which can result in significant adverse outcomes in the elderly, and to explore the gender-specific…
- Conditions
- Urinary Incontinence,Stress, Urinary Incontinence, Urge, Depressive Disorder, Insomnia
- Trial name
- NCT06627400
- Where
- Turkey (Türkiye)
- Volunteers
- 635 people
- Sponsor
- Kastamonu University
Sarcopenia, Aging
Effect of Incorporating Lean Beef Into a Protein-rich Diet During Resistance Training on Muscle and Tendon Strength in Older Women
Loss of muscle mass and strength is a well-established outcome of normal aging. Muscle strength and mobility are also dependent on the quality and strength of connective tissue, which surrounds skeletal muscle.
- Trial name
- NCT04347447
- Testing
- Exercise training
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Purdue University
Older Adults (65 Years and Older), Chronic Kidney Disease (CKD)
Pramipexole and the Risk of Serious Adverse Events
This is a population-based cohort study assessing whether initiation of a higher dose of pramipexole (0.25 or 0.375 mg/day), compared with a lower dose (0.125 mg/day), in older adults with advanced chronic kidney disease (CKD)…
- Trial name
- NCT07382960
- Testing
- Pramipexole
- Where
- Canada
- Volunteers
- 1,100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Endometrial Serous Adenocarcinoma, Fallopian Tube Carcinoma
Comprehensive Patient Questionnaires in Predicting Complications in Older Patients With Gynecologic Cancer Undergoing Surgery
This research trial studies comprehensive patient questionnaires in predicting complications in older patients with gynecologic cancer undergoing surgery.
- Conditions
- Endometrial Serous Adenocarcinoma, Fallopian Tube Carcinoma, Malignant Female Reproductive System Neoplasm, Ovarian Carcinoma
- Trial name
- NCT02315469
- Testing
- Comprehensive Geriatric Assessment, Questionnaire Administration
- Where
- 393 sites in United States, Canada
- Volunteers
- 190 people
- Sponsor
- NRG Oncology
Low Physical Activity Level, Central Obesity
Physical Activity on Prescription in Overweight Older Adults
This randomized controlled study evaluates the effect of individualized physical activity on prescription (PAP) in older overweight adults.
- Conditions
- Low Physical Activity Level, Central Obesity, Metabolic Syndrome
- Trial name
- NCT02320760
- Testing
- Physical activity on prescription
- Volunteers
- 102 people
- Sponsor
- Karolinska Institutet
Prevention of Stroke or Systemic Embolism, Atrial Fibrillation
A Study to Learn How Well the Study Treatment Asundexian Works and How Safe it is Compared to Apixaban to Prevent Stroke or Systemic Embolism in People With Irregular and Often Rapid Heartbeat (Atrial Fibrillation), and at Risk for Stroke
Researchers are looking for a better way to treat people with atrial fibrillation (AF) and prevent stroke or systemic embolism (blood clots travelling through the blood stream to plug another vessel).
- Trial name
- OCEANIC-AF (NCT05643573)
- Testing
- Asundexian (BAY2433334), Apixaban
- Where
- 1,069 sites in United States, Argentina and 36 more
- Volunteers
- 14,830 people
- Sponsor
- Bayer
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Exercise During Chemotherapy in Older Women With Stage I-III Breast Cancer
This clinical trial evaluates the feasibility of exercise during chemotherapy in older women with stage I-III breast cancer. Previous studies have reported that exercise may reduce the chemotherapy-toxicity risk.
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT05025059
- Testing
- Discussion, Exercise Intervention, Informational Intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center