Clinical trials: Olfaction
Surgery, Gallbladder
Smell Memory Method for Patients Before Surgery
The research is planned as a randomized controlled experimental at Erzurum Atatürk University Health Application and Research Center.
- Conditions
- Surgery, Gallbladder, Smell
- Trial name
- NCT06414980
- Testing
- Experimental
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Identify Volatile Biomarkers Specific to Malignant Melanoma, Basal Cell Carcinoma and Squamous Cell Carcinoma, Verify That the Volatile Biomarkers Identified Derive From Metabolic Changes in Body Odour and Not Just From Changes in the Surface of Cancerous Lesions
Identification of Olfactory Biomarkers of Skin Cancer From Skin Odor Samples: a Pilot Study
The aim of this research is to determine which volatile organic compounds (odors) are associated with different skin cancers. To this end, odor samples will be taken from various parts of the body, from patients with skin cancers…
- Trial name
- SCENT-SKIN-001 (NCT06493786)
- Testing
- Collection of body odor samples
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Association pour la Recherche Clinique et Immunologique
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Upper Airway Inflammation and Olfaction: Mechanisms of Loss and Recovery
The goal of this clinical trial is to understand the mechanisms leading to olfactory dysfunction (OD) in chronic rhinosinusitis (CRS).
- Trial name
- IMMUNODOR (NCT06776042)
- Testing
- Nasal brushing of the olfactory cleft, Smell testing
- Where
- Belgium
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Olfactory Impairment
Olfactory Cleft Stenosis and Obstruction on Paranasal Sinus CT Scan in Pre Septo Rhinoplasty Patients Without Respiratory Mucosa Pathology : Normal Variants or Pathologic Findings ?
This retrospective studed included patients referred to our institution between December 2013 and december 2021 for septoplasty or septorhinoplasty. All patients underwent pre operatory paranasal sinus CT scan and olfactory test.
- Trial name
- NCT06082193
- Where
- 2 sites in France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Complete Spinal Cord Injuries
Transplantation of Autologous Olfactory Ensheathing Cells in Complete Human Spinal Cord Injury
The purpose of this experimental therapy is an assessment of the safety and feasibility of transplantation of autologous olfactory ensheathing glia and olfactory fibroblasts obtained from the olfactory mucosa in patients with…
- Trial name
- NCT01231893
- Testing
- olfactory mucosa ensheathing cell grafting, rehabilitation, rehabilitation
- Where
- Poland
- Volunteers
- 10 people
- Sponsor
- Wroclaw Medical University
Hyposmia
Treatment of Postviral Olfactory Dysfunction
A decreased sense of smell (hyposmia) is often caused by viral infections, such as COVID-19. Today, the only recommended treatment for hyposmia is olfactory training, a time consuming method with limitations in terms of both…
- Trial name
- NCT06142565
- Testing
- Nose plug, Regular olfactory training
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Karolinska Institutet
Anxiety State, Symptoms and Signs
The Effect of Olfactory Mental Imagery and Cardiovascular Surgery
This study aims to examine the effect of olfactory mental imagery on physiological parameters, anxiety and symptoms after cardiovascular surgery.
- Conditions
- Anxiety State, Symptoms and Signs, Vital Signs
- Trial name
- NCT06221436
- Testing
- Mental Imagery
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul Saglik Bilimleri University
Smoking Cessation, Olfactory Disorder
The ESTxENDS Trial- Substudy on Effects of Using Electronic Nicotine Delivery Systems (ENDS) on Olfactory Function
--> This is a substudy of the main ESTxENDS trial (NCT03589989). Olfactory function outcomes should be considered secondary outcomes of the main smoking cessation outcome formulated in NCT03589989.
- Trial name
- ESTxENDS (NCT04617444)
- Testing
- ENDS (vaporizer/e-cig) and smoking cessation counseling, Smoking cessation counseling
- Where
- 5 sites in Switzerland
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- University of Bern
Olfactory Dysfunction
Clinical Treatment Research of COVID-19-related Olfactory Dysfunction
Studies have demonstrated that patients with COVID-19- related olfactory dysfunction could improve the olfactory function after olfactory training. But the efficacy of oral corticosteroids is controversial.
- Trial name
- NCT05421195
- Testing
- corticosteroids therapy, Olfactory training
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Esophageal Cancer, Extrahepatic Bile Duct Cancer
Epirubicin, Carboplatin, and Capecitabine in Treating Patients With Unresectable Locally Advanced, Metastatic, or Recurrent Solid Tumor
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Conditions
- Esophageal Cancer, Extrahepatic Bile Duct Cancer, Gastric Cancer, Head and Neck Cancer
- Trial name
- NCT00021047
- Testing
- capecitabine, carboplatin, epirubicin hydrochloride
- Where
- 3 sites in United States
- Sponsor
- National Institutes of Health Clinical Center (CC)
Breast Cancer, Colorectal Cancer
Family Quality of Life Among Families With a Member Who is a Cancer Patient
RATIONALE: Developing a questionnaire that can be used to assess the quality of life among people who have a family member with cancer may help the study of cancer in the future.
- Conditions
- Breast Cancer, Colorectal Cancer, Head and Neck Cancer, Lung Cancer
- Trial name
- NCT00544336
- Testing
- questionnaire administration, survey administration, quality-of-life assessment
- Where
- 3 sites in United States
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Vanderbilt-Ingram Cancer Center
Neoplasms, Malnutrition
Oral Nutritional Supplement Preferences in Patients With Cancer
Patients diagnosed with cancer have a particularly high risk of developing malnutrition due to the disease itself and due to symptoms of cancer treatments that can affect food intake such as reduced appetite, nausea, fatigue, and…
- Trial name
- NCT05816369
- Testing
- Taste session of five ONS flavors
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- University of Bergen
Head and Neck Cancer, Oral Complications
Cevimeline in Treating Patients With Dry Mouth Caused by Radiation Therapy for Head and Neck Cancer
RATIONALE: Cevimeline may be effective in treating dry mouth that is caused by radiation therapy for head and neck cancer. It is not yet known if cevimeline is more effective than no therapy in treating dry mouth caused by…
- Conditions
- Head and Neck Cancer, Oral Complications, Radiation Toxicity
- Trial name
- NCT00017511
- Testing
- cevimeline hydrochloride
- Where
- 71 sites in United States
- Sponsor
- Daiichi Sankyo
Schizophrenia
What the Nose Knows: Hedonic Capacity, Psychosocial Interventions and Outcomes in Schizophrenia
This project proposes to conduct the first study of the predictive utility of olfactory hedonic measurement for targeted psychosocial rehabilitation in schizophrenia.
- Trial name
- NCT05282186
- Testing
- Cognitive Enhancement Therapy, Social Skills Training
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Beth Israel Deaconess Medical Center
Cancer
MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma
RATIONALE: MS-275 may stop the growth of cancer cells by blocking the enzymes necessary for their growth. PURPOSE: This phase I trial is studying the side effects and best dose of MS-275 in treating patients with advanced solid…
- Trial name
- NCT00020579
- Testing
- entinostat
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Anosmia
Does Cardiopulmonary Bypass Change Olfaction?
The loss of the sense of smell, anosmia, can have profound effects on the lives of those who suffer from it. In our clinical practice, we have encountered several patients complaining of anosmia after recently undergoing surgery…
- Trial name
- Anosmia (NCT02179554)
- Where
- United Kingdom
- Sponsor
- Manchester University NHS Foundation Trust
Ovarian Cancer
Early Detection of Ovarian Cancer: GC/FT-ICR Mass Spectrometry and Canine Olfaction
RATIONALE: Studying samples of exhaled breath from patients with ovarian epithelial cancer, polycystic ovarian syndrome, or endometriosis and from healthy participants in the laboratory may help doctors identify and learn more…
- Trial name
- NCT00757952
- Testing
- Fourier transform ion cyclotron resonance mass spectrometry, chromatography, diagnostic laboratory biomarker analysis
- Where
- 4 sites in United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Pine Street Foundation
Covid19
Physical Activity and Smell Trainings to Help Individuals With Coronavirus Disease (COVID-19) Recover From Persistent Smell and Taste Impairments - A Pilot Study
The primary objective of this study is to identify efficient treatments to help those with chemosensory losses due to Coronavirus disease (COVID-19).
- Trial name
- CAPS (NCT05037110)
- Testing
- Physical activity, Smell training
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- Université de Montréal
Alcohol Dependence
Feasibility of Integrating Olfactory Stimuli Into Virtual Reality Cue Exposure for Patients With Alcohol Dependence
Alcohol dependence (AD) is a prevalent and burdensome clinical condition with high relapse rates. A central risk factor for relapse is craving for alcohol, which can be evoked by both real-world and virtual cues in immersive…
- Trial name
- NCT07388693
- Testing
- VR Cue-Exposure Including Olfactory Stimuli
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Charite University, Berlin, Germany
COVID-19
Detection Dogs as a Help in the Detection of COVID-19
Canine olfactive detection has proven its efficacy in numerous situations (explosives, drugs, bank notes…) including for early diagnosis of human diseases: various cancers, alert of diabetic or epileptic people in immediate alarm…
- Trial name
- COVDOG (NCT05205655)
- Testing
- collection of odour samples
- Where
- Tunisia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hôpital Universitaire Sahloul