Clinical trials: Olfaction Disorders
COVID-19
Detection Dogs as a Help in the Detection of COVID-19
Canine olfactive detection has proven its efficacy in numerous situations (explosives, drugs, bank notes…) including for early diagnosis of human diseases: various cancers, alert of diabetic or epileptic people in immediate alarm…
- Trial name
- COVDOG (NCT05205655)
- Testing
- collection of odour samples
- Where
- Tunisia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hôpital Universitaire Sahloul
Anosmia
Investigating the Efficacy of OMT to Recover Olfactory Perception After COVID-19
One of the most widespread symptoms of COVID-19 is loss of the sense of smell. There are very few treatments for helping individuals recover their sense of smell.
- Trial name
- NCT06766279
- Testing
- Osteopathic Manipulative Treatment
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Burrell College of Health Sciences
Disorder of Consciousness
Olfactory Stimulation in Severe Brain Injury
The management of patients with disorders of consciousness (DoC) represents a topic of great importance and topicality in the medical-scientific field because of the complexity and extent of associated disabilities and the…
- Trial name
- NCT05747170
- Testing
- Olfactory sstimulation
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Orthopedic Disorder of Spine, Smell Disorder
Olfaction Changes in Patients Undergoing Spine Surgery
This observational prospective study evaluates perioperative olfaction alterations, comprising changes in threshold value, discrimination and identification, which occur in spine patients.
- Trial name
- NCT04194788
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Preterm, Infant, Premature, Diseases
The Effect of Lullaby and Breastmilk Smell on Preterm Newborns
The goal of this clinical trial is to investigate the effect of live lullaby from mother voice, and breast milk smell on pyhsiological parameters, comfort and maternal attachment levels of preterm newborns who are between 35-37…
- Conditions
- Preterm, Infant, Premature, Diseases, Postpartum Depression, Mother-Infant Interaction
- Trial name
- NCT05830955
- Testing
- Lullaby group, Breast milk group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Dental Anxiety, Dental Pain
Pain Perception: on Relationships Between Dental Anxiety and Olfaction
the objective of this study is to evaluate the ability of olfaction in obtaining positive emotional and behavioral responses toward dental anxiety and pain in patients undergoing different dental procedures.
- Conditions
- Dental Anxiety, Dental Pain, Essential Oil
- Trial name
- NCT05369936
- Testing
- Aromatherapy
- Where
- Saudi Arabia
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Qassim University
Obesity
Mechanisms Underlying Individual Variations of Taste and Smell in Obesity
Background: Changes to the sense of taste or smell can change eating behavior. This may contribute to obesity. Researchers want to see how taste and smell perceptions that affect food choices may differ between people with…
- Trial name
- NCT04714892
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder
Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)
Background: Alcohol use disorder (AUD) is the most common substance use disorder in the world. Long-term AUD can affect a person s sense of taste and smell.
- Trial name
- NCT05677321
- Where
- United States
- Volunteers
- 475 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Anosmia, Ageusia
Efficacy of Photobiomodulation in the Rehabilitation of Olfactory Dysfunctions Induced by Long COVID-19
On January 30, 2020, the WHO (World Health Organization) declared the new coronavirus pandemic as the sixth public health emergency of international concern.
- Conditions
- Anosmia, Ageusia, COVID-19, Rehabilitation
- Trial name
- NCT06423495
- Testing
- low-intensity laser treatment
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gaffree & Guinle Universitary Hospital
Acromegaly, Olfactory Disorder
Olfactory Function and Olfactory Bulb Volume in Acromegaly Patients
A prospective, controlled, single blinded study was planned. 20 patients with Acromegaly (Acromegaly Group) and 20 healthy subjects (Control Group) were planned to include in the study.
- Trial name
- NCT04138537
- Testing
- OB volume, CCCRC test
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Dysphagia, Stroke
Changes in Sensitivity, Taste and Smell in Stroke Patients
This study evaluates changes in swallowing using endoscopic swallowing studies and measuring of pharyngeal sensitivity, taste and smell in stroke patients.
- Trial name
- 5S (NCT03240965)
- Testing
- FEES (flexible endoscopic evaluation of swallowing), Sensitivity threshold, Taste-/smell-test
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Opioid Dependence, Obesity
The Impact of Methadone Maintenance Therapy on Food Reward Processing in Opioid Dependence
Methadone maintenance therapy (MMT) has shown clear efficacy for relieving opioid withdrawal symptoms and reducing the morbidity and mortality of opioid dependence.
- Trial name
- NCT03575273
- Testing
- Sniffin' Sticks Odor Identification and Hedonic Scale, Sucrose Taste Preference Assessment, Food Preferences Task
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
COVID-19
α-synuclein Seeding Activity in the Olfactory Mucosa in COVID-19
Loss of the sense of smell is a characteristic feature of COVID-19 and likely related to viral invasion of the olfactory mucosa but is also a prodromal feature of PD.
- Trial name
- NCT05401773
- Testing
- Real-time Quaking-Induced Conversion (RT-QuIC)
- Where
- Austria
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Seasonal Allergic Rhinitis
Treatment of Olfactory Dysfunction in Seasonal Allergic Rhinitis
People with allergies frequently complain of a loss or reduction in the sense of smell. In this study, the investigators propose to perform a randomized, double blind, placebo controlled parallel study of subjects with nasal…
- Trial name
- NCT00361439
- Testing
- Mometasone
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Oral Complication, Dysgeusia
Oral and Olfactory Complications of Recovered COVID-19 Patients
This cohort study aims to investigate the long-standing chemosensory disorders and oral manifestation after recovery of the COVID-19 illness.
- Conditions
- Oral Complication, Dysgeusia, Olfactory Disorder
- Trial name
- NCT04791436
- Testing
- Gustatory and olfactory function test, Molecular assessment of saliva
- Where
- Germany
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Neurotoxic Effect of Sevoflurane-Based Anaesthesia
Evaluation of Neurotoxic Effect of Sevoflurane-Based AnaesthesiaGuided by Short-Term Olfactory Identification
Nowadays there is increasing doubts about the safety of anesthesia . Anesthesiologists have to console the worried patients, who are anxious about the potential risks of anesthetic-induced brain damage, by suggesting that any…
- Trial name
- NCT03726580
- Testing
- Sevoflurane
- Where
- Egypt
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Tanta University
Olfaction, Diet
The Effects of Acute Caloric Deprivation on Odour Identification and Food Reward
The purpose of this study is to determine how the modality of energy depletion can differently impact appetite hormones, ad libitum food intake, food hedonics, and olfaction.
- Conditions
- Olfaction, Diet, Exercise, Energy Depletion
- Trial name
- DEXDER (NCT02653378)
- Testing
- DIET, EX
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Parkinson Disease
PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort
The Parkinson Progression Marker Initiative (PPMI) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital outcomes, and imaging, biologic and genetic markers of…
- Trial name
- PPMI (NCT04477785)
- Where
- 50 sites in United States, Austria and 10 more
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Michael J. Fox Foundation for Parkinson's Research
Migraine Headache
Bioavailability of DHE Administered by I123 POD Device, IV Injection, and Migranal Nasal Spray in Healthy Adults
A Phase I clinical trial to compare the bioavailability of dihydroergotamine mesylate (DHE) following a single dose administration of INP104 (DHE administered by I123 Precision Olfactory Delivery (POD) Device Nasal Spray) to that…
- Trial name
- NCT03401346
- Testing
- INP104, Dihydroergotamine Mesylate (DHE), Migranal Nasal Spray
- Where
- Australia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Impel Pharmaceuticals
Obesity
The Sense of Small and Inhibition in Obesity
The aim of this research is to verify whether inhibitory control ability is different between a group of individuals with obesity and a group of individuals with normal weight in the presence of olfactory stimuli, different for…
- Trial name
- Smell_OB (NCT05768672)
- Testing
- Experimental Task
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano