Clinical trials: Olfactory Dysfunction
Olfactory Dysfunction, Wellbeing
Impact of Smell Testing on Health Outcomes
Smell dysfunction is frequent yet neglected. The sense of smell plays a crucial role in signaling disease, safety, and overall quality of life.
- Trial name
- NCT07222891
- Testing
- Patient-centered information and education
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Monell Chemical Senses Center
Traumatic Olfactory Nerve Injury With Anosmia (Diagnosis), Effect of Drug
The Effect of Platelet-rich Plasma Nasal Injection in the Treatment of Traumatic Olfactory Dysfunction
The purpose of this study is to explore the efficacy of injecting high-concentration platelet plasma combined with hyaluronic acid into the nasal olfactory mucosa in the treatment of traumatic anosmia.
- Trial name
- PRP (NCT06290219)
- Testing
- platelet-rich plasma combined with hyaluronic acid, Zinc Gluconate 10 MG Oral Tablet, 4 bottles of phenyl ethyl alcohol, lemon, eucalyptus, and clove oil
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taichung Veterans General Hospital
Parosmia
Ivermectin Nasal Drops in Post COVID-19 Parosmia
The current study will be a pilot study for a randomized controlled trial conducted on patients recruited from the outpatient clinic of the Otorhinolaryngology Department, Menoufia Faculty of Medicine To evaluate the effect of…
- Trial name
- NCT05269030
- Testing
- Ivermectin Topical, Budesonide Nasal
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Menoufia University
Mild Cognitive Impairment
Observation of Inhalation of CXMCI-01 Essential Oil on Patients With Mild Cognitive Impairment
Memory declined and cognitive impairment are common complaints in neurology clinics. Before diagnosing as dementia, individuals will undergo a transition period, including mild cognitive impairment (MCI).
- Trial name
- CXMCI-01-MCI (NCT06902181)
- Testing
- Experimental Group - 100% CXMCI-01 Essential Oil
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- China Medical University Hospital
Postoperative Cognitive Dysfunction
Postoperative Cognitive Dysfunction: Correlations With Olfactory Dysfunction and Related Gene Changes
To study on the Postoperative Cognitive Dysfunction: Correlations With Olfactory Dysfunction and Related Gene Changes.To explore whether the olfactory dysfunction could be used as a predictor of POCD and to provide reference for…
- Trial name
- NCT02992600
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Han Yuan
Alzheimer Disease, Late Onset, Mild Cognitive Impairment
Establish Diagnostic and Prognostic Models for Preclinical AD Patients Based on Multimodal MRI, Behavioral, Genetic, and Plasma Biomarkers
To establish the diagnostic and prognostic models that could help the preclinical identification of subjects at higher risk of clinical progression to mild cognitive impairment and dementia based on combined features of baseline…
- Conditions
- Alzheimer Disease, Late Onset, Mild Cognitive Impairment, Subjective Cognitive Decline
- Trial name
- NCT06561906
- Testing
- Multimodal magnetic resonance imaging scanning, behavioral, genetic and plasma biomarker testing
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Glioblastoma Multiforme, Adult, Glioblastoma or Gliosarcoma
Prognostic Potential of Olfactory Function in Glioblastoma: a Prospective Observational Study
The study aims to investigate the prognostic significance of olfactory function in patients with glioblastoma. We are examining olfactory function at various points during therapy and correlating the results with survival data.
- Conditions
- Glioblastoma Multiforme, Adult, Glioblastoma or Gliosarcoma, Glioblastoma, Adult
- Trial name
- OLFGBM (NCT06954636)
- Testing
- olfactory testing (threshold and identification test)
- Where
- 2 sites in Germany
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Sied Kebir
Mild Cognitive Impairment, Early Alzheimer's Disease
Development and Evaluation of Computerized Olfactory Training Program for Cognitive Decline in Early Alzheimer's Disease
The purpose of this study is to determine whether daily treatment with this new treatment approach, called COT would be effective in protecting the memory and brain regions of people who are already showing signs of memory loss.
- Conditions
- Mild Cognitive Impairment, Early Alzheimer's Disease, Memory Impairment
- Trial name
- NCT05122598
- Testing
- COT
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Evon Medics LLC
Smell Dysfunction, Taste Disorders
The Study of Quadruple Therapy Intranasal Insulin, Zinc, Gabapentin, Ice Cube Stimulation for Post COVID-19 Smell and Taste Dysfunctions
post covid-19 smell and taste dysfunction are common globally and affect the quality of life and also have phycological impact and anxiety, also affect on economy as the patients not able to do cooking or buy prepared foods and…
- Conditions
- Smell Dysfunction, Taste Disorders, Taste Disorder, Secondary, Sweet, Taste Disorder, Secondary, Bitter
- Trial name
- COVID-19 (NCT05104424)
- Testing
- Insulin aspart
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Saudi Arabia
Down Syndrome, Cognitive Decline
GnRH Therapy on Cognition in Down Syndrome
Down syndrome (DS) is the most common chromosomal disorder; with the increasing life expectancy, about 80% of DS adults reach age 65 years old.
- Conditions
- Down Syndrome, Cognitive Decline, Alzheimer Disease, Early Onset, Olfaction Disorders
- Trial name
- NCT04390646
- Testing
- GnRH, gonadorelin acetate, 0.9% NaCl
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- Nelly Pitteloud
Smell Dysfunction
The Effectiveness of Steroid Nasal Drops in the Olfactory Cleft Combined With Olfactory Training for Patients With PIOD
This study aims to evaluate the effectiveness of hormone nasal drops in the olfactory cleft combined with olfactory training for treating postinfectious olfactory dysfunction (PIOD).
- Trial name
- PIOD (NCT07386860)
- Testing
- Steroid nasal drops combined with olfactory training
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Type 2 Diabetes Mellitus, Mild Cognitive Impairment
LIGHT-MCI Trial: GLP-1 Agonist, SGLT2 Inhibitor, and DPP-4 Inhibitor for MCI Remission in Type 2 Diabetes
This is an investigator-led prospective, randomized, open label, parallel study to explore and evaluate the therapeutic effects of Liraglutide, Empagliflozin and Linagliptin on the cognitive function in T2DM patients with mild…
- Trial name
- LIGHT-MCI (NCT05313529)
- Testing
- Liraglutide, Empagliflozin, Linagliptin
- Where
- 5 sites in China
- Volunteers
- 396 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Olfactory Impairment
The Efficacy of Modified Olfactory Training for Patients With Olfactory Dysfunction
The goal of this clinical trial is to validate the effectiveness of the modified olfactory training device, the main questions it aims to answer are: Is it possible that the device can treat olfactory disorders in adults?…
- Trial name
- NCT06353139
- Testing
- Modified olfactory training device
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Dementia, DM
Early Detection of Cognitive Dysfunction in Diabetes
The rate of cognitive decline due to ageing is increased 1.5-fold to 2.0-fold in individuals with type 2 diabetes.There are no established specific treatment measures to prevent or ameliorate cognitive impairments in patients…
- Conditions
- Dementia, DM, MCI
- Trial name
- NCT01830998
- Where
- 3 sites in China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Wuhan General Hospital of Guangzhou Military Command
Hyposmia
Treatment of Postviral Olfactory Dysfunction
A decreased sense of smell (hyposmia) is often caused by viral infections, such as COVID-19. Today, the only recommended treatment for hyposmia is olfactory training, a time consuming method with limitations in terms of both…
- Trial name
- NCT06142565
- Testing
- Nose plug, Regular olfactory training
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Karolinska Institutet
Periodontitis, Olfactory Dysfunction
Olfactory Function and Oral Malodor in Periodontitis Before and After Periodontal Therapy
This prospective cohort study investigated the relationship between oral malodor and olfactory function in adults with generalized periodontitis.
- Conditions
- Periodontitis, Olfactory Dysfunction, Halitosis
- Trial name
- NCT07424300
- Testing
- Scaling and Root Planing (SRP)
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- Batman University
Hyposmia, COVID-19
Olfactory Training as a Treatment for Olfactory Dysfunction Post COVID-19
Olfactory dysfunction is a defining symptom of COVID-19 infection. Studies have demonstrated improved olfaction in patients with post infectious olfactory dysfunction after an olfactory training (OT).
- Conditions
- Hyposmia, COVID-19, Parosmia, Anosmia
- Trial name
- OTTODC19 (NCT05384561)
- Testing
- Smell training
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Université du Québec à Trois-Rivières
Olfactory Dysfunction, Anosmia
Topical Versus Injection PRP for Olfactory Dysfunction
The goal of this clinical trial is to determine whether two different delivery methods of autologous platelet-rich plasma (PRP) can improve olfactory function in adults with persistent olfactory dysfunction lasting more than…
- Conditions
- Olfactory Dysfunction, Anosmia, Hyposmia
- Trial name
- TOP-IN (NCT07151703)
- Testing
- Intranasal Injection of Autologous PRP, Carrier-Assisted Topical Application of Autologous PRP, platelet-rich plasma
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Olfactory Dysfunction, Post Viral Olfactory Dysfunction (PVOD)
The Efficacy of Modified Olfactory Training Method for Patients With Post-viral Olfactory Dysfunction
The goal of this clinical trial is to validate the effectiveness of the modified olfactory training device, the main questions it aims to answer are: Is the modified olfactory training device effective in treating patients with…
- Trial name
- NCT06829706
- Testing
- Conventional olfactory training device, Modified olfactory training device
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking University Third Hospital
SARS-CoV-2 Infection, Cognitive Disorder
Investigation of the Persistence of SARS-CoV-2 in the Olfactory Mucosa of Patients With Prolonged Symptoms of COVID-19
NEUROCOVID is a prospective multicenter study comparing the proportion of patients with SARS-CoV-2 viral RNA at the level of the olfactory clefts in a group of cases compared to a group of controls as well as the correlations…
- Trial name
- NEUROCOVID (NCT05220241)
- Testing
- Nasopharyngeal swab for RT-PCR SARS-CoV-2
- Where
- 2 sites in France
- Volunteers
- 51 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild