Clinical trials: Oncologic
Radiation Oncology
Radiation Treatment Plan Evaluation Learning Tool Pilot Project
This study involves both the development of a novel learning tool, the Radiation Treatment Plan Evaluation Learning Module, as well as a pilot program to validate this tool as an effective resource to teach treatment plan review…
- Trial name
- NCT06115811
- Testing
- Radiation Treatment Plan Evaluation Learning Tool
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Oncology
PEWS Implementation in an LMIC Setting
The PEWS implementation study will be undertaken with the following objectives: 1. Assess the effectiveness of implementation of PEWS and resuscitation training to identify patients at risk for clinical deterioration and to…
- Trial name
- PEWSPAL (NCT04180306)
- Testing
- pediatric early warning scoring system and resuscitation curriculum
- Where
- 2 sites in Palestinian Territories
- Volunteers
- 1,850 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Understanding Needs of Older Patients Prior to Starting Cancer Treatment
A geriatric assessment (GA) is a structured approach to identifying and addressing the strengths and vulnerabilities of older adults with cancer.
- Trial name
- PGA (NCT07225920)
- Testing
- Survey Administration, Interview, Educational Intervention
- Where
- 42 sites in United States, Puerto Rico
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Diffuse Large B-cell Lymphoma, Hodgkin Lymphoma
BMS_PD-L1_onco : Assessment of the PD-L1 Protein as a Biomarker in Oncology and Hematology
Diffuse large B-cell lymphomas (DLBCLs) represent 25 to 30% of adult non-Hodgkin lymphomas in western countries. DLBCLs are aggressive cancer but potentially curable with multi-agent chemotherapy.
- Conditions
- Diffuse Large B-cell Lymphoma, Hodgkin Lymphoma, Metastatic Breastcancer, Non-small Cell Lung Cancer
- Trial name
- BMS_PD-L1 (NCT01660776)
- Where
- 4 sites in France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Palliative Care, Caregivers
A Problem-Solving Intervention for Family Caregivers in Palliative Oncology
In congruence with the National Cancer Institute's commitment to supporting families of individuals with cancer across the full disease trajectory, the investigators seek to examine the feasibility of a technologically-mediated…
- Conditions
- Palliative Care, Caregivers, Medical Oncology
- Trial name
- NCT02427490
- Testing
- Problem-Solving Intervention, Unenhanced Monitoring
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Hematopoietic/Lymphoid Cancer
Stress Management Intervention for Caregivers of Patients Undergoing Bone Marrow Transplant (BMT)
RATIONALE: A stress management intervention may be more effective than usual care in improving quality of life in caregivers of patients undergoing bone marrow transplant.
- Trial name
- NCT00833898
- Testing
- Paced respiration as part of PEPRR, PEPRR
- Where
- 2 sites in United States
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Psychological Distress, Genetic Testing
Psychological Support and Psycho-Emotional Trajectories in Cancer Genetics.
Undergoing a cancer genetic testing pathway and receiving results regarding a personal or familial cancer predisposition can generate substantial, multifaceted psycho-emotional distress for patients.
- Conditions
- Psychological Distress, Genetic Testing, Hereditary Neoplastic Syndromes, Neoplasms
- Trial name
- PsyOncoGen (NCT07695506)
- Testing
- Patients undergoing their first cancer genetic testing consultation who choose to utilise the clinical psychological support offered by the unit, Patients undergoing their first cancer genetic testing consultation who choose to follow the care pathway without utilising the systematically offered clinical psychological support.
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chemotherapy
Evaluating the Effectiveness of ChemoNurs: A Mobile Chemotherapy Drug Guide for Oncology Nurses
This study aimed to evaluate the effectiveness of a mobile chemotherapy drug guide application, ChemoNurs, developed for oncology nurses, in improving their knowledge and attitudes toward chemotherapy practices.
- Trial name
- NCT06976450
- Testing
- ChemoNurs Mobile Application Group, Personal Smartphone
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Koç University
Communication
Assertiveness Training for Communication Skills
This study aims to determine the effect of virtual reality-based assertiveness training on strengthening the communication skills of oncology nurses.
- Trial name
- NCT07575048
- Testing
- Assertiveness Skills Training
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Amasya University
Oncology
A Phase I, Open-label Study to Assess Bioavailability of a Single Oral Dose of AZD9291 vs an IV Dose of [14C]AZD9291
The Sponsor is developing the study drug, AZD9291, for the potential treatment of nonsmall cell lung cancer. Lung cancer has been the most common cancer in the world for several decades and represents 12.8% of all new cancer…
- Trial name
- NCT02491944
- Testing
- AZD9291, [14C]AZD9291
- Where
- United Kingdom
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Rehabilitation, Post-Operative Condition
High-Intensity-Interval-Training in Geriatric Rehabilitation - A Feasibility Study
Study with Patients (40-60 participants) above the age of 65. There will be a comparison of regular training on ergometer (10 trainings within 2 weeks, 40 min each) to high intensity interval training on ergometer (6 trainings…
- Conditions
- Rehabilitation, Post-Operative Condition, Deconditioning After Acute Hospital, Oncology
- Trial name
- NCT04025385
- Testing
- High Intensity Interval Training
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Klinik Valens
Cancer
EXCEL-Punjabi: A Culturally Tailored Exercise Oncology Pilot Feasibility Intervention
The goal of this pilot feasibility study is to explore the feasibility and exploratory effects of a culturally-tailored exercise oncology intervention in Punjabi-speaking individuals of South Asian heritage and their support…
- Trial name
- EXCEL-Punjabi (NCT07643389)
- Testing
- EXCEL-Punjabi
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Non-small Cell Lung Cancer, Metastatic Lung Cancer
Emulation of the KEYNOTE-189 Trial Using Electronic Health Records
Investigators are building an empirical evidence base supporting the utility of real-world data through the emulation of randomized controlled trials in the oncology setting.
- Trial name
- NCT05908799
- Testing
- Pembrolizumab + Pemetrexed-Platinum, Pemetrexed-Platinum
- Where
- United States
- Volunteers
- 1,854 people, healthy volunteers welcome
- Sponsor
- Aetion, Inc.
Burnout, Compassion Fatigue
The Effect of Mindfulness Meditation
Cancer is a disease that causes the most deaths worldwide and is challenging for patients and caregivers both physically and psychosocially.
- Conditions
- Burnout, Compassion Fatigue, Psychological Well-Being
- Trial name
- NCT06282913
- Testing
- Mindfulness Meditation
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital
Venous Thrombosis
Study of Arixtra (Fondaparinux Sodium) to Prevent Blood Clots in Women Undergoing Abdominopelvic Surgery for Likely Gynecologic Malignancy
This is a randomized trial to compare intermittent compression devices with or without post-operative Arixtra (fondaparinux sodium) in women undergoing major abdominal surgery for known or presumed gynecologic malignancies.
- Trial name
- NCT00539942
- Testing
- Arixtra (fondaparinux sodium), Intermittent compression devices (ICD)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Neoplasms
ACS Community Access to Resources Education and Support
The goal of this study is to evaluate the pilot phase of ACS Cares to identify key implementation outcomes and assess effectiveness of the program to improve distress, enhance communication, and reduce missed appointments and…
- Trial name
- ACS CARES (NCT06285929)
- Testing
- ACS CARES Student Navigation
- Where
- 4 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- American Cancer Society, Inc.
Distal Femoral Musculoskeletal Tumors, Megaprosthesis
Analysis of Spatiotemporal Gait Parameters in Patients With Megaprosthesis.
The main objective of the study is to evaluate spatiotemporal parameters of gait in tumoral patients with megaprosthesis of the distal femur.
- Trial name
- MP-GP (NCT05202873)
- Testing
- Gait analysis
- Where
- Spain
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Cardenal Herrera University
Stage IV Non-small Cell Lung Cancer
Randomized Controlled Clinical Study of Drug Therapy Combined With Thoracic Radiotherapy for Non-oligometastatic NSCLC
To investigate whether radiotherapy combined with drug therapy is beneficial to non- oligometastatic stage IV NSCLC
- Trial name
- NCT05176067
- Testing
- Thoracic Three-dimensional Radiotherapy
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Guizhou Medical University
Oncology, Nurse
Communication Skill and Related Factors Among Oncology Nurses
This study is a 1-year quantitative method research.Data collection will be divided into oncology nurses and cancer patients.To explore the related factors of clinical oncology nurses on the psychological aspects of cancer…
- Conditions
- Oncology, Nurse, Communication
- Trial name
- NCT05788809
- Where
- Taiwan
- Volunteers
- 527 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Advanced Cancer
Oncology Associated Symptoms & Individualized Strategies
Nearly 20% of Americans and 41% of Iowans live in rural or non-metropolitan areas.(1) Lack of access to providers, long travel distances, and a disconnected health system contribute to increased distress and lower quality-of-life…
- Trial name
- OASIS (NCT03122249)
- Testing
- Advanced Cancer Symptom Management
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stephanie Gilbertson-White