Clinical trials: Oncologic
Breast Neoplasm, Prostatic Neoplasm
Assessing Effectiveness and Implementation of an EHR Tool to Assess Heart Health Among Survivors
The objective of this hybrid effectiveness-implementation study is to examine the effects of an EHR-based cardiovascular health assessment tool (AH-HA) among breast, prostate, colorectal, endometrial, and Hodgkin and non-Hodgkin…
- Conditions
- Breast Neoplasm, Prostatic Neoplasm, Colorectal Neoplasms, Endometrial Neoplasms
- Trial name
- AH-HA (NCT03935282)
- Testing
- AH-HA Tool in the EPIC EHR
- Where
- 12 sites in United States
- Volunteers
- 645 people
- Sponsor
- Wake Forest University Health Sciences
Colonic Neoplasms
Laparoscopic Versus Open Surgery for Colon Cancer With Visceral Obesity
This study aims to elucidate whether there is a difference in long-term prognosis between laparoscopic surgery and open surgery in colon cancer patients with visceral obesity.
- Trial name
- LOVO (NCT07314996)
- Testing
- Laparoscopic surgery, Open surgery
- Where
- China
- Volunteers
- 664 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Financial Stress, Pediatric Cancer
Financial and Insurance Assistance- Oncology Financial and Legal Navigation Program
The overall objective of this study was to develop and evaluate FINassist (Financial and Insurance Navigation Assistance), a patient-centered, interdisciplinary team-based oncology financial and legal navigation program.
- Trial name
- NCT05876325
- Testing
- FINassist Patient, FINassist Caregiver
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Jean Edward
Educational Activities
Parent Educational Discharge Support Strategies
After the initial hospitalization, parents of children newly diagnosed with cancer assume responsibility for assessing and managing their care; however, parents are often overwhelmed with information received throughout the…
- Trial name
- NCT03227068
- Testing
- PEDSS - symptom management, PEDSS - support for the caregiver
- Where
- 16 sites in United States, Saudi Arabia
- Volunteers
- 289 people
- Sponsor
- Duke University
Leukemia, Lymphocytic, Acute, Leukemia, Myeloid, Acute
High- Fiber/ Low-fat Diet for Prevention of Recurrent Clostridioides Difficile Infection in Oncology
The primary objective of the study is to determine whether dietary intervention to increase fiber and decrease fat reduces C. difficile infection recurrence in a cohort of oncology patients.
- Conditions
- Leukemia, Lymphocytic, Acute, Leukemia, Myeloid, Acute, Lymphoma, Clostridium Difficile Infection
- Trial name
- NCT04940468
- Testing
- Diet Intervention
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- University of Colorado, Denver
Melanoma, Breast Cancer
Survival Monitoring in Russian Cancer Registries
This study aims to establish a holistic framework for continuous cancer survival surveillance in Russian regions with high-quality population-based cancer registry data.
- Conditions
- Melanoma, Breast Cancer, Oncology, Colon Cancer
- Trial name
- SURVIMON (NCT06043947)
- Where
- Russia
- Volunteers
- 100,000 people
- Sponsor
- N.N. Petrov National Medical Research Center of Oncology
Carcinoma, Renal Cell
Study of Patients With Metastatic and/or Advanced Renal Cell Carcinoma, Treated With Sunitinib/Axitinib.
Research Questions: To understand the clinical outcomes of patients treated with sunitinib in first line and axitinib in second line in a real world setting as therapies for metastatic and/or advanced renal cell carcinoma (mRCC).
- Trial name
- NCT04033991
- Testing
- Sunitinib, Axitinib
- Where
- United Kingdom
- Volunteers
- 684 people
- Sponsor
- Pfizer
Cardiotoxicity, Lung Cancer Stage III
Cardiotoxicity in Locally Advanced Lung Cancer Patients Treated With Chemoradiation Therapy
This observational cohort will evaluate the cardiovascular effects of chemoradiation used to treat locally advanced, non-small cell lung cancer.
- Conditions
- Cardiotoxicity, Lung Cancer Stage III, Lung Cancer Stage II, Radiation Toxicity
- Trial name
- CLARITY (NCT04305613)
- Testing
- Chemoradiation
- Where
- 8 sites in United States
- Volunteers
- 221 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Non Functioning Pancreatic Endocrine Tumor
Long-term Prognosis for Non-functional Neuroendocrine Tumors of the Pancreatic Body and Tail ≤ 3cm
This study aims to quantify the malignant potential of non-functional neuroendocrine tumors of the pancreatic body and tail ≤ 3 cm by collecting real-world data from large pancreatic centers across the country, and to evaluate…
- Trial name
- NCT05907824
- Testing
- Histopathological review, long-term prognosis and quality of life follow-up
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Fudan University
Solid Tumor, Adult
DT-9081 Study in Participants With Advanced, Recurrent or Metastatic Solid Tumours
This is a Phase 1, multicentre, open-label, dose-escalation study to determine a recommended phase 2 dose (RP2D) of DT-9081, followed by an expansion study of DT-9081 in participants with advanced, recurrent or metastatic solid…
- Trial name
- EPRAD (NCT05582850)
- Testing
- DT-9081 - dose escalation, DT-9081 - expansion
- Where
- 4 sites in Belgium, France
- Volunteers
- 29 people
- Sponsor
- Domain Therapeutics SA
Cancer Patients
NEMO - an App for Side Effect Management in Oncology
This study investigates the use of digital and standardized documentation by patients of frequently occurring adverse events in oncological therapies.
- Trial name
- NEMO (NCT04493450)
- Testing
- Documentation of cancer treatment side effects
- Where
- Germany
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Thomas Seufferlein
Advanced Cancer, Various, NOS
Existential Distress in Advanced Cancer: Comparing a Short-term Psychodynamic Psychotherapy (ORPHYS) to Treatment as Usual (TAU)
The psychological challenges faced by patients with incurable cancer and their caregivers include an uncertain future, fear of dying and uncontrollable suffering, grief, and loneliness.
- Trial name
- NCT07312760
- Testing
- ORPHYS (ShORt-term psychodynamic psychotherapy in serious PHYSical illness), TAU (Treatment As Usual: Standard psycho-oncological care)
- Where
- 3 sites in Germany
- Volunteers
- 160 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Physical Activity, Mobile Application
HopeMove App in Pediatric Cancer Patients
This pilot feasibility study aims to assess the acceptability, usability, safety, and initial effects of the HopeMove mobile health app on fatigue in adolescents aged 13 to 18 years undergoing hematology-oncology treatment.
- Trial name
- NCT07274358
- Testing
- HopeMove Mobile Application
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Koç University
Recurrent or Metastatic Cervical Cancer
A Study of AK104（ an Anti-PD-1 and Anti-CTLA-4 Bispecific Antibody) in Recurrent or Metastatic Cervical Cancer
This is a multicenter, open-label, phase II clinical study conducted in China. All subjects will receive AK104 in combination with standard treatment regimens or AK104 alone. The primary end point is safety.
- Trial name
- NCT04868708
- Testing
- AK104, Bevacizumab, Paclitaxel
- Where
- 2 sites in China
- Volunteers
- 50 people
- Sponsor
- Akeso
Gynecologic Cancers, Postoperative Pain Management
Effectiveness of Combined Fascial Plane Blocks for Postoperative Pain in Gynecologic Oncology Surgery
The goal of this prospective observational study is to compare the effectiveness of different postoperative analgesic techniques in patients undergoing major abdominal surgery for gynecologic oncology.
- Trial name
- NCT07312825
- Testing
- Group 1:The Transversus Abdominis Plane (TAP) block, Group 2: TAP Block + Quadratus Lumborum Block (QLB), Group 3: TAP Block + Rectus Sheath Block (RSB)
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Advanced Solid Tumors
A Study of BMS-986482 Alone or as Combination Therapy in Participants With Advanced Solid Tumors
The purpose of this study is to investigate the safety and efficacy of BMS-986482 alone and as combination therapy in participants with advanced solid tumors.
- Trial name
- NCT06697197
- Testing
- BMS-986482, Pumitamig
- Where
- 21 sites in United States, Belgium and 7 more
- Volunteers
- 286 people
- Sponsor
- Bristol-Myers Squibb
Wide Spectrum of Diseases, Hematologic Diseases
Data Collection of Standard Care and Evaluation of NHLBI Patients and Donors
Background: Researchers seek ways to study people s medical problems in order to teach and further general knowledge. The ability to assess and treat people with a wide range of diseases is critical to training people to be good…
- Trial name
- NCT04450927
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Breast Cancer
Potential Protective Role of SGLT-2 Inhibitors for Chemotherapy-induced Cardiotoxicity
The purpose of this study is to evaluate whether dapagliflozin reduces chemotherapy-induced cardiotoxicity in participants with breast cancer treated with (neo-)adjuvant Anthracycline-based chemotherapy +/- trastuzumab.
- Trial name
- PROTECT (NCT06341842)
- Testing
- Dapagliflozin 10mg Tab
- Where
- Italy
- Volunteers
- 316 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Breast Cancer, Colorectal Cancer
Effect of Kefir on Symptom Management and Quality of Life in Oncology
This study was planned as a randomized controlled prospective experimental study to determine the effect of kefir on symptom management and quality of life in oncology patients receiving chemotherapy.
- Trial name
- NCT06517420
- Testing
- kefir consumption
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Izmir Bakircay University
Cancer
Implementation of Shared Decision-Making in Cancer Care
This study aims to evaluate a theoretically and empirically grounded implementation program designed to foster shared decision-making in routine cancer care. The intervention program consists of several components (e.g.
- Trial name
- PREPARED (NCT03393351)
- Testing
- Shared decision-making program, Usual Care
- Where
- 3 sites in Germany
- Volunteers
- 2,131 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
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