Clinical trials: Oncologic
Fear of Cancer Recurrence, Cancer Survivorship
Acceptance and Commitment Therapy (ACT) Versus Cognitive Behavioural Therapy (CBT) for Fear of Cancer Recurrence (FCR) in Cancer Survivors and Their Spouses
Fear of cancer recurrence (FCR) is one of the most significant psychological burdens faced by cancer survivors. FCR describes the fear, worry, or concern relating to the possibility that cancer will come back or progress, and is…
- Trial name
- CARE-Pilot (NCT07749560)
- Testing
- ACT couple intervention, CBT couple intervention
- Volunteers
- 128 people
- Sponsor
- University Center of Tumor Diseases, Frankfurt University Hospital
Emergence Delirium, Post-Operative Cognitive Dysfunction
Post Operative Cognitive Dysfunction After Oncologic Surgery
Aim of this trial is to define if Post-Operative Cognitive Dysfunction, detected analyzing changes between pre-operative and post-operative Neurocognitive Test, and Postoperative Delirium, relate to concentration of effector's…
- Trial name
- NCT03774420
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Padova
Breast Cancer Invasive, Prostate Cancer
AVI Didactic Experience for Latinx Patient Treatment Adherence and Non-English Speaker Trial Enrollment Study in Rad Onc
The study aims to develop educational media interventions to prepare Latinx Spanish-speaking radiation oncology patients for a course of breast or prostate cancer radiation therapy and to foster receptivity and informed…
- Trial name
- ADELANTE (NCT05351424)
- Testing
- Audiovisual Intervention- Radiation Therapy Education, ASTRO Radiation Therapy for Breast or Prostate Cancer Brochure, Audiovisual Intervention- Cancer Clinical Trials Education
- Where
- 2 sites in United States
- Volunteers
- 194 people
- Sponsor
- Columbia University
Advanced Cancer, Metastatic Cancer
FS222 First in Human Study in Patients With Advanced Malignancies
This study will be conducted in adult participants diagnosed with advanced tumours to characterize the safety, tolerability, pharmacokinetics (PK), and activity of FS222.
- Trial name
- NCT04740424
- Testing
- FS222
- Where
- 21 sites in Australia, Georgia and 5 more
- Volunteers
- 260 people
- Sponsor
- invoX Pharma Limited
Acute Myeloid Leukemia
A Collaborative Palliative and Oncology Care Model for Patients With Acute Myeloid Leukemia
This research study is evaluating the impact a collaborative palliative care and oncology team will have on the quality of life, symptoms, mood, and end of life outcomes of patients with acute myeloid leukemia (AML).
- Trial name
- NCT02975869
- Testing
- Standard Leukemia Care, Palliative Care
- Where
- 4 sites in United States
- Volunteers
- 160 people
- Sponsor
- Massachusetts General Hospital
Metastatic Breast Cancer
A Clinical Trial to Compare Efficacy and Tolerability of Faslodex With Arimidex in Patients With Advanced Breast Cancer
The purpose of this study is to compare the efficacy and tolerability of Faslodex (fulvestrant) with Arimidex (anastrozole) in postmenopausal women with hormone receptor positive advanced breast cancer.
- Trial name
- FIRST (NCT00274469)
- Testing
- fulvestrant, anastrozole
- Where
- 41 sites in United States, Brazil and 7 more
- Volunteers
- 205 people
- Sponsor
- AstraZeneca
Malignant Tumor of Ill-defined Site
LCI-NOS-PAIN-001: A Prospective, Pharmacogenomic-Driven Study of Pain Management in Oncology Outpatients
About half of all cancer patients seen in oncology clinics have pain at initial assessment; pain relief within a one-month period is seen in approximately one third of these patients and pain worsening in about one fifth.
- Trial name
- NCT02542397
- Testing
- Pharmacogenomic Testing
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Wake Forest University Health Sciences
Gynecological Cancers
Nomogram Control of Predictive Factors of Early Withdrawal After Gynecologic Oncology Surgery in the Enhanced Recovery After Surgery (ERAS) Protocol and Assessment of Practices
Validation of a predictive nomogram of a short hospital stay (less than two days after surgery) on a prospective cohort of patients.
- Trial name
- NomogramGyneco (NCT03470870)
- Testing
- Comparative analysis of the characteristics
- Where
- France
- Volunteers
- 370 people
- Sponsor
- Institut Paoli-Calmettes
Adult Cancer Survivors, Adult Cancer Patients
Holistic Evaluation of Approaches to Long-term Health & Survivorship
This study aims at investigating behaviors of cancer patient regarding complementary and alternative medicine (CAM) with mixed methodology.
- Trial name
- HEALTHS (NCT07745205)
- Testing
- Interventional mixed-methods evaluation of cancer patient's behaviour regarding CAMs (focus groups), Quantitative evaluation of cancer patient's use of CAM's
- Where
- Belgium
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Jules Bordet Institute
Anesthesia, General, Surgical Oncology
General Anesthetics in CAncer REsection Surgery (GA-CARES) Trial
This is a large pragmatic multicenter trial comparing maintenance of general anesthesia with total intravenous anesthesia using propofol versus volatile agent (sevoflurane, isoflurane, or desflurane) during cancer surgery.
- Trial name
- GA-CARES (NCT03034096)
- Testing
- Propofol, Volatile Agent
- Where
- 5 sites in United States
- Volunteers
- 1,826 people
- Sponsor
- Stony Brook University
Recurrent Childhood Acute Myeloid Leukemia, Recurrent Childhood Acute Lymphoblastic Leukemia
Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling
Functional precision medicine (FPM) is a relatively new approach to cancer therapy based on direct exposure of patient- isolated tumor cells to clinically approved drugs and integrates ex vivo drug sensitivity testing (DST) and…
- Conditions
- Recurrent Childhood Acute Myeloid Leukemia, Recurrent Childhood Acute Lymphoblastic Leukemia, Recurrent Childhood Large Cell Lymphoma, Refractory Childhood Acute Lymphoblastic Leukemia
- Trial name
- NCT05857969
- Testing
- Functional Precision Medicine
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Florida International University
Oncologic Disease, Cancer
Oral Cryotherapy Applied to Patients Undergoing Chemotherapy
Taste alteration can cause problems such as loss of appetite, inadequate energy intake and weight loss in oncology patients, increasing the risk of malnutrition and negatively affecting the quality of life of patients.
- Conditions
- Oncologic Disease, Cancer, Chemotherapy
- Trial name
- NCT06594354
- Testing
- ICE
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Karadeniz Technical University
Oncologic Complications, Symptoms and Signs
Integrative Oncology for Patient Symptoms
The use of complementary and integrative medicine (CIM) among oncology patients is widespread, with a large body of research-based evidence supporting the ability of these therapies to alleviate symptoms related to cancer and its…
- Trial name
- NCT04940780
- Testing
- Acupuncture, Touch Therapies
- Where
- Israel
- Volunteers
- 750 people
- Sponsor
- Shaare Zedek Medical Center
Oncology, Solid Tumor
Live Biotherapeutic Product MRx0518 and Pembrolizumab Combination Study in Solid Tumors
This is an open label, safety and preliminary efficacy study of MRx0518 in combination with pembrolizumab in patients with solid tumours (non small cell lung cancer, renal cell carcinoma, bladder cancer or melanoma).
- Conditions
- Oncology, Solid Tumor, Non Small Cell Lung Cancer, Renal Cell Carcinoma
- Trial name
- NCT03637803
- Testing
- MRx0518, Pembrolizumab 25 MG/1 ML Intravenous Solution [KEYTRUDA]
- Where
- 5 sites in United States
- Volunteers
- 63 people
- Sponsor
- 4D pharma plc
Cancer
mychoiceTM Implementation With Medical Oncology Patients
This is a pragmatic, non-randomized mixed-methods evaluation study designed to evaluate the feasibility and acceptability of delivering the mychoiceTM tool to new Medical Oncology patients as well as to more deeply explore its…
- Trial name
- NCT06222242
- Testing
- mychoiceTM
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Fox Chase Cancer Center
Oncology, Chemotherapeutic Toxicity
EMR Chemotoxicity Risk Calculator To Decrease Chemotherapy Toxicity
This study will formally test the quality improvement intervention of an EMR based tool that informs medical oncologists visiting a patient for the first time of potential risk of chemotherapy toxicity.
- Conditions
- Oncology, Chemotherapeutic Toxicity, Metastatic Solid Tumor
- Trial name
- NCT05809557
- Testing
- Chemotherapy toxicity tool, Oncology Consultation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Metastatic Uveal Melanoma in the Liver
Intrahepatic Delivery of SD-101 by Pressure-Enabled Regional Immuno-oncology (PERIO), With Checkpoint Blockade in Adults With Metastatic Uveal Melanoma
This study is an open-label, phase 1/1b study of the pressure-enabled hepatic artery infusion of SD-101, a TLR 9 agonist, alone or in combination with intravenous checkpoint blockade in adults with metastatic uveal melanoma.
- Trial name
- NCT04935229
- Testing
- SD-101, Nivolumab, Ipilimumab
- Where
- 10 sites in United States
- Volunteers
- 67 people
- Sponsor
- TriSalus Life Sciences, Inc.
Cancer
The CASCADE Project
People with cancer, treated for cancer, or have been recently treated for cancer are at a higher risk of becoming rapidly unwell. This is referred to as an oncological emergency and can be life-threatening.
- Trial name
- CASCADE (NCT06117592)
- Testing
- Education, training and assessment intervention
- Volunteers
- 1,400 people
- Sponsor
- The Christie NHS Foundation Trust
Colorectal Cancer
Endoscopic Optical Imaging for Precision Oncology Treatment Applied to Colorectal Tumours (Elios-Color-on-Specimen)
The Institute of Image-Guided Surgery (IHU) of Strasbourg is a translational research Institute aiming to develop hybrid surgery techniques.
- Trial name
- NCT04101292
- Testing
- Characterization of tumor tissue by fluorescence
- Sponsor
- IHU Strasbourg
Bladder Cancer
Enhancing Patient Comfort and Reducing Anxiety During Flexible Cystoscopy and Bladder Instillation in Bladder Cancer Patients: A Randomized Controlled Trial and Observational Study
The goal of this clinical trial is to learn if certain comfort-enhancing interventions can reduce pain and anxiety during flexible cystoscopy and bladder instillation in patients with bladder cancer.
- Trial name
- Flexi-comfort (NCT07204301)
- Testing
- Optimized Timing of Intravesical Lidocaine Gel, Calming Music During Procedure, Visual Distraction with Screen Content
- Where
- Canada
- Volunteers
- 378 people
- Sponsor
- Western University, Canada
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