Clinical trials: Oncologic
Medical Oncology
Thorough ECG (Electrocardiogram) and Drug Interaction Study With Anetumab Ravtansine and Itraconazole
Characterize the safety, tolerability, ECG effects, pharmacokinetics and immunogenicity of anetumab ravtansine given as single agent and after inhibition of CYP3A4 and P-gp by concomitant administration of itraconazole in…
- Trial name
- NCT02824042
- Testing
- Anetumab ravtansine (BAY94-9343), Itraconazole
- Where
- 18 sites in United States, Australia and 4 more
- Volunteers
- 63 people
- Sponsor
- Bayer
Prostate Cancer, Kidney Cancer
Mind-Body Health in Uro-Oncology: Research Study
In this study, the researchers will examine the effects of post-mindfulness intervention email and text messages to promote maintenance of intervention effects over time in a uro-oncology sample (clinically localized prostate…
- Conditions
- Prostate Cancer, Kidney Cancer, Bladder Cancer
- Trial name
- NCT03852030
- Testing
- Text or email message
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Chemotherapy
The Effect of the 4-7-8 Breathing Technique on Anxiety, Symptom Burden, and Sleep Quality During Chemotherapy
This study aims to determine the effects of the 4-7-8 breathing technique on anxiety, symptom severity, and sleep quality during treatment.
- Trial name
- NCT07828028
- Testing
- 4-7-8 breathing technique, routine care
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Malatya Turgut Ozal University
Drug Monitoring
Microsampling for Therapeutic Drug Monitoring of Oral Oncolytics in Oncology Patients
The aim of the study is to perform a clinical validation of the analytical method for dried blood spot microsampling of cabozantinib, pazopanib, sunitinib, lenvatinib, imatinib, abiraterone, enzalutamide, nivolumab, ipilimumab…
- Trial name
- MSTDM (NCT06545292)
- Testing
- Therapeutic drug monitoring with a dried blood spot and microatainer.
- Where
- Netherlands
- Volunteers
- 360 people
- Sponsor
- Leiden University Medical Center
Surgical Site Infection, Gynecologic Cancer
Effectiveness of Wound Drains for the Prevention Of Surgical sITe infectION
The aim of the present randomized trial is to assess the efficacy of wound drains in terms of reducing the rates of surgical site infection in obese patients with gynecological cancer.
- Conditions
- Surgical Site Infection, Gynecologic Cancer, Wound Drain
- Trial name
- POSITION (NCT05179122)
- Testing
- Surgical drain
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Radiodermatitis, Breast Cancer
Photobiomodulation Therapy for the Prevention of Acute Radiodermatitis in Breast Cancer Patients Undergoing Radiotherapy
Radiodermatitis (RD), an inflammatory skin reaction, occurs in more than 90 percent of cancer patients treated with radiotherapy (RT). This is the result of the radiation causing damage to the epidermal basal skin stem cells.
- Trial name
- LABRA (NCT03924011)
- Testing
- Photobiomodulation therapy (PBMT)
- Where
- 2 sites in Belgium
- Volunteers
- 71 people
- Sponsor
- Hasselt University
Cancer, Older Adults (65 Years and Older)
Cognition in Older Adults With Cancer Receiving Systemic Anti-Cancer Therapy
The majority of cancer diagnoses occur in adults age 65 years and over. This population is also rapidly expanding. There is a growing need for increased understanding about the potential impact of various newer therapies on…
- Conditions
- Cancer, Older Adults (65 Years and Older), Cognition
- Trial name
- CORreCT (NCT07411105)
- Where
- 2 sites in Ireland
- Volunteers
- 30 people
- Sponsor
- Our Lady's Hospice and Care Services
Advanced Solid Tumors
A Study in Adult Subjects With Select Advanced Solid Tumors
To evaluate the safety and tolerability of MEDI1873 in adult subjects with selected advanced solid tumors.
- Trial name
- NCT02583165
- Testing
- MEDI1873
- Where
- 10 sites in United States
- Volunteers
- 40 people
- Sponsor
- MedImmune LLC
Cancer, Immune-related Adverse Event
Immune-Related Adverse Events and Associated Biomarkers in Patients Receiving Cancer Immunotherapy
The purpose of this project is to collect body samples like blood and tissue and health information from people receiving immune-based treatment for cancer.
- Trial name
- IMBARC (NCT06089967)
- Testing
- Medical chart review
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Advanced or Metastatic Solid Tumors
A Dose Escalation/Expansion Study of MDK-703 in Patients With Advanced or Metastatic Solid Tumors
This is an open-label, dose escalation and dose expansion study of MDK-703 as a monotherapy and in combination with other cancer therapies in adult study participants with advanced or metastatic solid tumors.
- Trial name
- ORCHID-1 (NCT05716295)
- Testing
- MDK-703, Checkpoint Inhibitor, Immune
- Where
- 6 sites in United States
- Volunteers
- 26 people
- Sponsor
- Medikine, Inc.
Solid Tumor, Adult
Clinical Trial of the Safety and Efficacy of IBA Proton Therapy System PROTEUS® PLUS (Hebei)
This trial will enroll 47 subjects who will be be treated with the IBA PROTEUS® PLUS Proton Beam radiation Therapy (PBT) medical device.
- Trial name
- NCT07137195
- Testing
- Proton Beam Therapy (PBT)
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Ion Beam Applications
Melanoma, Melanoma Stage IV
Surgery of Melanoma Metastases After Systemic Therapy
To evaluate if surgical removal of residual disease adds benefit in stage IV melanoma patients with partial response or stable disease after a minimum 9 months of first-line PD-1 inhibition.
- Conditions
- Melanoma, Melanoma Stage IV, Metastatic Melanoma, Surgery
- Trial name
- SUMMIST (NCT04242329)
- Testing
- Surgical metastasectomy, Immunotherapy
- Where
- Sweden
- Sponsor
- Vastra Gotaland Region
Merkel Cell Carcinoma, Cutaneous Squamous Cell Carcinoma
Immunotherapy With IFx-Hu2.0 Vaccine for Advanced Non-melanoma Skin Cancers
In this clinical phase I, non-randomized, open-label, uncontrolled, interventional, multi-center trial, 20 adult subjects (≥ 18 years of age) with advanced non-melanoma skin cancers will receive a fixed dose of 0.1 mg of…
- Conditions
- Merkel Cell Carcinoma, Cutaneous Squamous Cell Carcinoma, Non-Melanoma Skin Cancers
- Trial name
- NCT04160065
- Testing
- IFx-Hu2.0
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- TuHURA Biosciences, Inc.
Brain Tumor, Neurofibromatoses
Quality Improvement Project - "My Logbook! - I Know my Way Around!"; ("Mein Logbuch - Ich Kenne Mich Aus!")
In this study, the main goal is to implement and evaluate a novel, evidence-based psycho-educative program for children in oncological care. Patients are provided with booklets tailored to each specific stage of their treatment.
- Conditions
- Brain Tumor, Neurofibromatoses, Sarcoma, Leukemia
- Trial name
- NCT04474678
- Testing
- "My Logbook! - I know my way around!"
- Where
- 22 sites in Austria, Germany and 2 more
- Volunteers
- 240 people
- Sponsor
- Medical University of Vienna
Pancreatic Cancer
BrUOG 295: Adjuvant FOLFOX-A For Resected Pancreatic Cancer: A Phase II Brown University Oncology Research Group Trial
The investigators preliminary data suggests that FOLFOX-A may have equal or superior activity as compared to FOLFIRINOX and appears to be better tolerated.
- Trial name
- NCT02022033
- Testing
- FOLFOXA
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Brown University
Neoplasms
First-in-human Study of AB0024 to Evaluate Safety and Tolerability in Adults With Advanced Solid Tumors
Analysis of safety, tolerability, and PK data will provide information that will guide future development of AB0024.
- Trial name
- NCT01323933
- Testing
- AB0024
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Gilead Sciences
Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL)
A Case Crossover Study of Intermittent Fasting in CLL/SLL
The purpose of this study is to compare the 16/8 intermittent fasting method with the 5:2 Method in a subset of patients with chronic lymphocytic leukemia or small lymphocytic lymphoma at BC Cancer- Victoria.
- Trial name
- NCT05708326
- Testing
- 5:2 Method (intermittent fasting regimen), 16/8 Method (intermittent fast regimen)
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- British Columbia Cancer Agency
Cancer
Open Dialogue About Complementary Alternative Medicine (CAM) Integrated in Conventional Oncology Care
The purpose of this phase two parallel-group randomized controlled trial is to assess the efficacy of open dialogue about CAM integrated in conventional oncology care.
- Trial name
- NCT03857776
- Testing
- Open dialogue about complementary alternative medicine, Standard care
- Where
- Denmark
- Volunteers
- 112 people
- Sponsor
- Vejle Hospital
Childhood Oncology, Mucositis Oral
Oral Mucositis Management in Pediatric Oncology Patients
This study evaluated the impact of an oral mucositis care protocol on the severity of mucositis. The main questions it aims to answer are: -What is the severity of mucositis in parents and children who receive oral mucositis…
- Trial name
- NCT06711315
- Testing
- Oral Mucosit Care Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Zubeyde Ezgi Ercelik
Solid Tumor, Leukemia
Illness Management and Parental Adjustment to Cancer Treatment
The purpose of this study is to test the efficacy of a clinic-based intervention designed to reduce illness uncertainty for parents of children who have been recently diagnosed with cancer.
- Conditions
- Solid Tumor, Leukemia, Lymphoma, Brain Tumor
- Trial name
- IMPACT (NCT02505165)
- Testing
- IMPACT, ESO
- Where
- 3 sites in United States
- Volunteers
- 279 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.