Clinical trials: Oncologic Patients
Solid Tumours
Study to Assess the Blood Levels and Safety of Olaparib in Patients With Advanced Solid Tumours and Normal or Impaired Kidney Function
This is a 2-part study in patients with advanced solid tumours. Part A will investigate the PK of olaparib in patients with mild or moderate renal impairment compared to patients with normal renal function; Part B will allow…
- Trial name
- NCT01894256
- Testing
- Olaparib tablet dosing
- Where
- 13 sites in Belgium, Denmark and 3 more
- Volunteers
- 56 people
- Sponsor
- AstraZeneca
Cancer, Anxiety
My Wellbeing Guide: A Novel Tool for Managing Stress and Improving Quality of Life
The purpose of this study is to examine the implementation and effectiveness of the psychosocial eHealth intervention, My Wellbeing Guide, on the proposed primary outcome, depressive symptoms, in patients diagnosed with cancer…
- Conditions
- Cancer, Anxiety, Depressive Symptoms
- Trial name
- R37 (NCT05369429)
- Testing
- My Wellbeing Guide
- Where
- United States
- Volunteers
- 6,516 people
- Sponsor
- Northwestern University
Patient Engagement, Patient Activation
At-home Breast Oncology Care Delivered With E-health Solutions
The COVID-19 pandemic has significantly impacted healthcare service delivery, highlighting the need for high quality virtual patient care.
- Conditions
- Patient Engagement, Patient Activation, Patient Reported Outcome Measures
- Trial name
- ABODE (NCT05989477)
- Testing
- At-home Breast Oncology care Delivered with E-health solutions - ABODE
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University Health Network, Toronto
Neoplasms, Sleep Initiation and Maintenance Disorders
Electrical Grounding and Sleep Quality in Hospitalised Patients With Cancer
Sleep disturbance is one of the most common and most persistent symptoms in patients admitted for cancer care, and the options available during a short hospital stay are limited.
- Conditions
- Neoplasms, Sleep Initiation and Maintenance Disorders, Sleep Quality, Cancer
- Trial name
- NCT07791628
- Testing
- Earthing patch; grounding electrode
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- Chang Gung Memorial Hospital
Laryngeal Cancer
Oncologic and Functional Outcome and Quality of Life in Patients Treated for Laryngeal Cancer
The goal of this observational study is to learn about oncologic and functional outcome and investigate quality of life in patients treated for laryngeal cancer.
- Trial name
- NCT06784401
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Solid Tumor, Brain Tumor
Immune Reconstitution in Oncology Patients Following Autologous Stem Cell Transplant
Autologous stem cell rescue is an established therapy in high risk neuroblastoma and relapsed Hodgkin's lymphoma and an experimental therapy in some other solid and brain tumors to facilitate the use of very intense chemotherapy…
- Conditions
- Solid Tumor, Brain Tumor, Lymphoma
- Trial name
- IROPAST (NCT01540175)
- Testing
- Blood samples obtained
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- St. Jude Children's Research Hospital
Oncology, Biomarker
Prospective Evaluation of Immunological, Molecular-genetic, Image-based and Microbial Analyzes to Characterize Tumor Response and Control in Patients With Inoperable Stage III NSCLC Treated With Chemoradiotherapy Followed by Consolidation Therapy With Durvalumab
This non-interventional single-center explorative biomarker study aims at longitudinal comprehensive characterization (molecular genetics, immunological, morphological, image-based and microbial features) of the patient (host)…
- Conditions
- Oncology, Biomarker, NSCLC, Stage III, Durvalumab
- Trial name
- PRECISION (NCT05027165)
- Testing
- Non-interventional
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- LMU Klinikum
Thoracic Neoplasms, Lung Neoplasms
Thoracic OncoGeriatric Assessment (TOGA) Trials
Our goal is to develop a reliable, physician and patient-friendly, pre-operative Thoracic Onco-Geriatric Assessment (TOGA) to predict surgical risk in geriatric oncology patients with thoracic neoplasms of the lung, esophagus…
- Conditions
- Thoracic Neoplasms, Lung Neoplasms, Esophagus Neoplasms, Pleural Neoplasms
- Trial name
- TOGA (NCT00591981)
- Testing
- TOGA Tools
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Wisconsin, Madison
Hypersensitivity Reactions
Conventional Prophylactic Oral Dexamethasone vs Short-course IV Dexamethasone in Paclitaxel Hypersensitivity
This study is a single center, prospective, randomized, open-label study aimed at determining the most effective means of preventing hypersensitivity reactions in gynecologic oncology patients receiving paclitaxel infusions.
- Trial name
- NCT03598426
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Loma Linda University
Cognitive Decline
CURATE.AI COR-Tx Trial for Post Brain Radiotherapy Patients
Cognitive deficit is common in patients who have undergone whole brain or partial brain radiotherapy. To counteract intellectual deterioration, the conventional strategies includes drug- based treatments such as donezepil and…
- Trial name
- NCT04848935
- Testing
- CURATE.AI
- Where
- 2 sites in Singapore
- Volunteers
- 15 people
- Sponsor
- National University Hospital, Singapore
Virtual Reality, Pain, Acute
Virtual Reality on Pain, Fear, and Emotional Appearance During Phlebotomy in Pediatric Hematology and Oncology Patients
In this study, the effect of virtual reality, which is one of the pain relief methods, on the pain, fear and emotional appearance associated with the procedure, was evaluated in children aged 4-12 years who will undergo…
- Conditions
- Virtual Reality, Pain, Acute, Pediatric Cancer
- Trial name
- VR-PHO (NCT05675358)
- Testing
- Virtual Reality
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 69 people
- Sponsor
- Dokuz Eylul University
Cancer
The Effect of Community-Provided Psychosocial Support Videos on Disease Attitudes and Symptoms
The effects of psychosocial support on the disease process have been studied with many different groups and diseases, and even the psychosocial support needed by the family of the child with a chronic disease has been the subject…
- Trial name
- NCT06011278
- Testing
- Community Supported Videos
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Koç University
Radiation Dermatitis Acute, Radiation Dermatitis
Oral or Topical Catechins for Radiation Dermatitis
Introduction Radiation-induced dermatitis (RID), which includes both acute and chronic forms, affects up to 95% of patients undergoing radiation therapy.
- Conditions
- Radiation Dermatitis Acute, Radiation Dermatitis, Fibrosis; Skin
- Trial name
- OCTOPUS-RD (NCT07149506)
- Testing
- Epicatechin, Epigallocatechin Gallate (EGCG), Saline (0.9% NaCl)
- Where
- Mexico
- Volunteers
- 162 people
- Sponsor
- CARLOS FRANCISCO SAAVEDRA GARCIA
AML, Adult Recurrent, MDS
A Phase 1 Study With LYT-200 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML), or With Relapsed/Refractory, High-risk Myelodysplastic Syndrome (MDS)
A Phase 1 Open-label, Multi-center Study of the Safety, Pharmacokinetics (PK), and Anti-tumor Activity of LYT- 200 in Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML), or with Relapsed/refractory, High-risk…
- Trial name
- NCT05829226
- Testing
- LYT-200, Venetoclax, Azacitidine
- Where
- 9 sites in United States
- Volunteers
- 101 people
- Sponsor
- PureTech
Healthy, no Evidence of Disease
Web-Based Tailored Educational Program in Improving Nurse Communication With Patients About Clinical Trials
This pilot, randomized clinical trial studies a web-based tailored educational program in improving nurse communication with patients about clinical trial treatment options.
- Trial name
- NCT02129517
- Testing
- IMPACT intervention, Online education materials, survey administration
- Where
- United States
- Volunteers
- 1,262 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Colorectal Cancer, Psycho-Oncology
The Effects of Nurse Navigation Program on Symptom Management and Psychosocial Adjustment in Colorectal Cancer Patients
This study was conducted to examine the effect of the nurse navigation program (NNP) applied to patients with colorectal cancer on symptom management and psychosocial adjustment to the disease.
- Conditions
- Colorectal Cancer, Psycho-Oncology, Nursing
- Trial name
- NCT05571098
- Testing
- individualized colorectal cancer education, psycho-oncological counseling, telephone support hotline service
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Saglik Bilimleri Universitesi
Advanced Solid Tumors
A Study of EMB-02 in Participants With Advanced Solid Tumors
The primary purpose of this study is to identify the recommended Phase 2 dose(s) (RP2Ds) and schedule assessed to be safe for EMB-02 and to characterize the safety and tolerability of EMB-02 at the RP2Ds.
- Trial name
- NCT04618393
- Testing
- EMB-02
- Where
- 10 sites in United States, Australia and 1 more
- Volunteers
- 47 people
- Sponsor
- Shanghai EpimAb Biotherapeutics Co., Ltd.
Lymphoma
Home Hospital for Lymphoma
The goal of this research is to evaluate an intervention, which the investigators call "Home Hospital for Lymphoma," that involves remote patient monitoring and home-based supportive care for patients hospitalized with lymphoma…
- Trial name
- NCT04423848
- Testing
- Home Hospital for Lymphoma
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Massachusetts General Hospital
Nutritional Deficiency, Breast Cancer
Tolerance to Immunomodulatory Nutritional Therapy in Oncology Patients Undergoing Chemotherapy and Radiotherapy
The importance of nutritional support is established in some types of neoplasms, especially those involving the digestive tract.
- Conditions
- Nutritional Deficiency, Breast Cancer, Anal Cancer
- Trial name
- NESTLE (NCT07021378)
- Testing
- Dietary Supplement, Control Cohort A, Control cohort B
- Where
- 2 sites in Brazil
- Volunteers
- 16 people
- Sponsor
- D'Or Institute for Research and Education
Resistant or Refractory Solid Tumors
Safety, Tolerability, and Pharmacokinetics of CAL056 Mesylate in Patients With Resistant or Refractory Solid Tumors
This is a multi-center, open-label, dose-escalation, phase I study to evaluate the safety, tolerability, pharmacokinetics (PK), preliminary efficacy, and pharmacodynamics of CAL056 mesylate in cancer patients with resistant or…
- Trial name
- NCT04686383
- Testing
- CAL056 mesylate
- Where
- 3 sites in United States, Taiwan
- Volunteers
- 17 people
- Sponsor
- Calgent Biotechnology Co., Ltd
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