Clinical trials: Oncologic Patients
Breast Cancer, Body Weight Changes
Effects of a Paleolithic Lifestyle Intervention in Breast Cancer Patients Undergoing Radiotherapy
The study aims to test the feasibility and effects of a dietary and physical activity intervention based on evolutionary considerations in an oncological setting.
- Trial name
- NCT04574323
- Testing
- Curative radiotherapy, Paleolithic lifestyle intervention
- Where
- Germany
- Volunteers
- 13 people
- Sponsor
- MVZ Leopoldina GmbH
Therapy-Associated Cancer
" Application of Art Therapy in Oncology: Evaluation of the Symptomatic of Patients Suffering From a Cancerous Disease"
The purpose of this study is to evaluate the impact of art-therapeutic management on a patient with cancer, during chemotherapy treatment, on the reduction of physical or psychological symptoms.
- Trial name
- ARONCO (NCT04195217)
- Testing
- Art therapy
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Centre Hospitalier de Perigueux
Non-small Cell Lung Cancer
The Effects of an Nutritional Intervention on PD-1 ICI in NSCLC
Over 65% of all lung cancer patients experience significant weight loss fuelled by a catabolic state that is represented by enhanced protein breakdown.
- Trial name
- NutriCim (NCT05902260)
- Testing
- Nutritional intervention, Immunotherapy
- Where
- Netherlands
- Volunteers
- 51 people
- Sponsor
- Joachim Aerts, MD PhD
Head and Neck Cancer (H&N)
Screening Psychosocial Distress in Head and Neck Cancer
This prospective, multicenter study aims to assess the presence of psychosocial distress using the Distress Thermometer in patients treated for head and neck cancer at the initiation of their speech-language therapy.
- Trial name
- DEP-VADS-ORTHO (NCT07851818)
- Testing
- Psychosocial distress screening using the Distress Thermometer
- Volunteers
- 80 people
- Sponsor
- Hôpital NOVO
Myelodysplastic Syndromes (MDS)
A Phase 1b/2 Study of Alvocidib Plus Decitabine or Azacitidine in Patients With MDS
Alvocidib, a cyclin-dependent kinase 9 (CDK 9) inhibitor, in time-sequential therapy demonstrated significant clinical activity in secondary AML patients with prior MDS.
- Trial name
- NCT03593915
- Testing
- Alvocidib Plus Decitabine (during dose escalation only) or Azacitidine
- Where
- 12 sites in United States
- Volunteers
- 20 people
- Sponsor
- Sumitomo Pharma America, Inc.
Nursing Caries
Foot Bath Effects on Chemotherapy-Induced Fatigue in Pediatric Oncology
This study aims to evaluate the effects of foot baths on chemotherapy-induced fatigue in pediatric oncology patients. Current literature lacks studies assessing this intervention in the pediatric population.
- Trial name
- FBECIFPO (NCT06529484)
- Testing
- Warm Water Foot Bath Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Koç University
Palliative Care, Cancer
Attitudes Towards Deprescribing Medications in Cancer Patients and Impact of Educational Intervention by a Clinical Pharmacist
Participation in this study consists in responding to some questions from two questionnaires in Romanian about how participants feel about deprescribing, participants' treatment and how participants understand medical…
- Trial name
- NCT06771999
- Testing
- Educational intervention by a clinical pharmacist
- Where
- Romania
- Volunteers
- 120 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Small Cell Lung Cancer
Tempus Small Cell Lung Cancer Observational Study (Sculptor)
The study is a non-interventional evaluation of participants with extensive stage (ES) SCLC who will receive diagnostic and (where possible) post-progression tumor tissue profiling, alongside plasma ctDNA and CTC biomarker…
- Trial name
- NCT05257551
- Testing
- Observation
- Where
- 11 sites in United States
- Volunteers
- 200 people
- Sponsor
- Tempus AI
Advanced Cancer
Safety and Pharmacokinetic Study of CVM-1118 Extended-Release in Advanced Cancer Patients
CVM-1118 Immediate-release (IR) Capsule and CVM-1118 Extended-release (ER) Capsule are proprietary oncology products developed by TaiRx, Inc. for the treatment of patients suffering from advanced cancer.
- Trial name
- NCT04336124
- Testing
- CVM-1118 Extended-Release (ER) Capsules (200 mg/capsule)
- Where
- 2 sites in Taiwan
- Volunteers
- 5 people
- Sponsor
- TaiRx, Inc.
Senior, Oncologic Disease
Changes in Value-Based Assessment in Patients Undergoing Major Oncological Surgery
Introduction The study focuses on analyzing the level of awareness among oncological patients, their perception of their health status, and expectations regarding radical surgical intervention.
- Trial name
- Value-Based As (NCT07481994)
- Where
- Czechia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tomas Bata Hospital, Czech Republic
Cancer, Pain
Study of the Efficacy of Kalinox® 170 Bar in Adult Oncology
In the oncology practice, The National Union of the Centres of Fight Against the Cancer recently published the Standards, Options and Recommendations for the coverage of the pains provoked during the invasive gestures of a short…
- Trial name
- NCT00646945
- Testing
- 50% Oxygen/50% Nitrous oxide premix (Kalinox 170 bar), 50% Oxygen/50% Nitrogen premix
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Air Liquide Santé International
Sepsis in Cancer Patients
Sepsis in Oncology Patients
The overall objective of this prospective observational study is to address the significant knowledge gap that exists around the impact of immune dysfunction on the development and survival from sepsis in patients with cancer.
- Trial name
- SEPONC (NCT06046677)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Aortic Valve Stenosis, Malignancy
Outcomes of Transcatheter Aortic Valve Implantation in Oncology Patients With Severe Aortic Stenosis
As for today, transcatheter aortic valve implantation (TAVI) is indicated only in symptomatic patients with severe aortic stenosis (AS) at high surgical risk.
- Trial name
- TOP-AS (NCT03181997)
- Testing
- Native aortic valve, Transcatheter aortic valve implantation (TAVI)
- Where
- Israel
- Volunteers
- 168 people
- Sponsor
- Rabin Medical Center
Breast Cancer
Adjuvant Systemic Treatment for (ER)-Positive HER2-negative Breast Carcinoma in Women Over 70 According to Genomic Grade (GG): Chemotherapy + Endocrine Treatment Versus Endocrine Treatment
The purpose of the study is to evaluate the benefit of adjuvant chemotherapy on overall survival for elderly patients with breast cancer, in a sub group with a high risk of relapse according to Genomic Grade test.
- Trial name
- ASTER 70s (NCT01564056)
- Testing
- HORMONOTHERAPY, CHEMOTHERAPY then HORMONOTHERAPY
- Where
- 84 sites in Belgium, France
- Volunteers
- 1,989 people
- Sponsor
- UNICANCER
Myelofibrosis, Leukemia, Myelocytic, Acute
A Phase 1/2 Study of CPI-0610 With and Without Ruxolitinib in Patients With Hematologic and Myeloproliferative Malignancies
Phase 1 Part: This was an open-label, sequential dose escalation study of pelabresib (CPI-0610) in patients who had previously been treated for Acute Leukemia, Myelodysplastic/Myeloproliferative Neoplasms.
- Conditions
- Myelofibrosis, Leukemia, Myelocytic, Acute, Myelodysplastic/Myeloproliferative Neoplasm, Myelodysplastic Syndrome (MDS)
- Trial name
- NCT02158858
- Testing
- Pelabresib, Ruxolitinib
- Where
- 48 sites in United States, Belgium and 7 more
- Volunteers
- 336 people
- Sponsor
- Constellation Pharmaceuticals
Mastectomy, Rhomboid Intercostal Block
Effects of Rhomboid Intercostal Block on Postoperative Pain Management and Chronic Pain Incidence in Mastectomies
The goal of this clinical trial is to evaluate the effects of the Rhomboid Intercostal Block (RIB) on postoperative chronic pain prevalence at 3 months (primary outcome) and on acute pain control, total opioid consumption, and…
- Conditions
- Mastectomy, Rhomboid Intercostal Block, Chronic Pain Following Surgical Procedure for Cancer
- Trial name
- NCT06756048
- Testing
- Rhomboid Intercostal Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Koç University
Medical Oncology
Implementing an Evidence-based Computerized Decision Support System Linked to Electronic Health Records to Improve Care for Cancer Patients
Implementing an evidence-based computerized decision support system linked to electronic health records to improve care for cancer patients.
- Trial name
- ONCO-CODES (NCT02645357)
- Testing
- computer reminders on clinical practice, Control group
- Where
- Italy
- Volunteers
- 15,431 people
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Exercise Behavior, Multiple Myeloma
Exercise Phenotyping Prior to Chemotherapy in Newly Diagnosed Multiple Myeloma (MM-Exercise)
MM-Exercise is a prospective, single-centre, observational pilot study of patients with newly diagnosed multiple myeloma who have not yet started chemotherapy and whose resting echocardiogram is unremarkable or only mildly…
- Trial name
- MM-Exercise (NCT07851493)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Technical University of Munich
Cancer
Evaluating the CAREchart@Home™ Program for Enhancing After-hours Cancer Care
The objective of the current project is to pilot the evaluation of the health and economic benefits of having online access to health information in the context of providing telemedicine support for oncology patients receiving…
- Trial name
- NCT04232709
- Testing
- Shared electronic patient record
- Where
- Canada
- Volunteers
- 105 people
- Sponsor
- Women's College Hospital
Rectal Neoplasm
Radiotherapy & Total Neoadjuvant Therapy for Recurrent Rectal Cancer in Previously Irradiated Patients, an Italian Association for Radiotherapy and Clinical Oncology (AIRO)-GI Platform: a Multi-centre Prospective Observational Study
The introduction of neoadjuvant chemoradiation therapy (CRT) and the use of advanced surgical techniques have led to a reduction in mortality and recurrence rates for rectal cancer, the rate of which currently stands at 4-8%.
- Trial name
- RETRY (NCT05984576)
- Testing
- Reirradiation
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
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