Clinical trials: Ondansetron
Postoperative Nausea and Vomiting, Anesthesia Complication
Antiemetic Prophylaxis With Fosaprepitant and Ondansetron in Patients Undergoing Thoracic Surgery
The goal of this clinical trial is to compare the efficacy, safety and feasibility of intravenous Fosaprepitant and Ondansetron for the prevention of postoperative nausea and vomiting in thoracicsurgery patients.
- Conditions
- Postoperative Nausea and Vomiting, Anesthesia Complication, Thoracic Diseases
- Trial name
- NCT05881486
- Testing
- Ondansetron 8mg, Fosaprepitant 150 mg
- Volunteers
- 234 people
- Sponsor
- Qilu Hospital of Shandong University
Hypotension (MeSH: D007022), Bradycardia
Prophylactic Ondansetron and Maternal Hemodynamics During Spinal Anesthesia for Elective Cesarean Section
Spinal anesthesia is the preferred technique for elective cesarean section, but it is frequently complicated by maternal hypotension and bradycardia.
- Trial name
- NCT07883772
- Testing
- Ondansetron
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Aydin Adnan Menderes University
Nausea and Vomiting
the Efficacy and Safety of Ondansetron Oral Soluble Pellicles
The name of this prospective study is a multicenter, open-label, randomized controlled clinical study of the efficacy and safety of Ondansetron Oral Soluble Pellicles for the prevention of delayed nausea and vomiting induced by…
- Trial name
- NCT06282211
- Testing
- Ondansetron Oral Soluble Pellicles
- Where
- China
- Volunteers
- 184 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Hernia, Inguinal
Efficacy of Co-Spinal Ondansetron In Inguinal Herniorrhaphy
Ondansetron, a selective serotonin 5-HT3 receptor antagonist, is well known for its antiemetic effects. However, its ability to reduce hypotension during spinal anesthesia has recently sparked great interest.
- Trial name
- NCT06850740
- Testing
- Ondansetron 8mg, Normal Saline
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Suez Canal University
Idiopathic Scoliosis, Postoperative Nausea and Vomiting
Palonosetron vs Ondansetron In PONV Prophylaxis Among Idiopathic Scoliosis Patients
The goal of this clinical trial is to compare the effectiveness of two antiemetic drugs, palonosetron and ondansetron, when given alongside dexamethasone as a preventive measure against early and delayed postoperative nausea and…
- Trial name
- PONV (NCT05956899)
- Testing
- Palonosetron, Ondansetron
- Where
- Malaysia
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Nausea, Vomiting
To Demonstrate the Relative Bioavailability Study of Ondansetron HCl 24 mg Tablets Under Fasting Conditions
To demonstrate the relative bioavailability study of Ondansetron HCl 24 mg tablets under fasting conditions.
- Trial name
- NCT00946387
- Testing
- Ondansetron HCl 24 mg Tablets (Sandoz, Inc.), Zofran (Ondansetron HCl) 24 mg Tablets (GlaxoSmithKline)
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Sandoz
Major Depressive Disorder (MDD)
A Study in Patients With Major Depressive Disorder
This is a Phase 2a, placebo-controlled, single-blind study in up to 24 patients with major depressive disorder (MDD).
- Trial name
- NCT03642964
- Testing
- CTC-501
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Chase Therapeutics Corporation
Alcoholism
Matching Genotypes and Serotonergic Medications for Alcoholism
Sertraline, a serotonin-specific reuptake inhibitor (SSRI) that increases basal serotonin levels, was shown to reduce alcohol consumption in lower risk/severity and later onset (LOA) but not higher risk/severity earlier onset…
- Trial name
- NCT01113164
- Testing
- Ondansetron and Sertraline
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Brown University
Adverse Effect
Ondansetron for Postspinal Anesthesia Hypotension
The purpose of this study is to investigate the effectiveness of ondansetron for postspinal anesthesia hypotension in patients undergoing cesarean section.
- Trial name
- NCT05475873
- Testing
- normal saline, Ondansetron 4 mg, Ondansetron 8 mg
- Where
- China
- Volunteers
- 120 people
- Sponsor
- General Hospital of Ningxia Medical University
Postoperative Pain Management, Laparoscopic Cholecystectomy
Peritoneal Lavage Using Saline or Saline With Ondansetron for Pain Control After Laparoscopic Cholecystectomy
Brief Summary Background: Laparoscopic cholecystectomy is a common procedure where postoperative pain and nausea/vomiting (PONV) remain significant issues, impairing recovery.
- Conditions
- Postoperative Pain Management, Laparoscopic Cholecystectomy, Ondansetron, Postoperative Nausea and Vomiting
- Trial name
- PLUSO (NCT06632184)
- Testing
- Ondansetron Intraperitoneal Lavage, Saline Intraperitoneal Lavage
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Instituto Mexicano del Seguro Social
Postoperative Nausea, Postoperative Vomiting
Comparison of IV Fluid Loading and Ondansetron in Reduction of PONV After LC
This study is designed to examine the incidence of postoperative nausea and vomiting during 24 hours after elective laparoscopic cholecystectomy in patients receiving preoperative intravenous fluid loading (group F), ondansetron…
- Conditions
- Postoperative Nausea, Postoperative Vomiting, Postoperative Nausea and Vomiting
- Trial name
- NCT03141645
- Testing
- Fluid loading, Ondansetron
- Where
- Thailand
- Volunteers
- 171 people
- Sponsor
- Siriraj Hospital
Postoperative Nausea
How Pregnant Women and Their Babies Metabolize Ondansetron Compared to a Group of Non-pregnant Women
This is called "Aim 1" of the investigators' NIH grant. Ondansetron (Zofran) is a safe and effective drug used in pregnant women to prevent nausea but the investigators do not know what effect pregnancy may have on the metabolism…
- Trial name
- Zofran_PK (NCT01801475)
- Testing
- Ondansetron
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Postoperative Nausea and Vomiting
The Effect of Combining Aprepitant With Ondansetron in High-risk Patients for Postoperative Nausea and Vomiting
PONV (Postoperative nausea and vomiting) is one of most common complications after general anesthesia. Female sex, history of PONV, motion sickness, nonsmoker status, use of volatile agents, duration of anesthesia, opioid…
- Trial name
- NCT01897337
- Testing
- Aprepitant
- Where
- South Korea
- Volunteers
- 125 people
- Sponsor
- Yonsei University
Healthy
Bioequivalence Study of Ondansetron Orally Disintegrating Tablets 8mg Under Fed Conditions
The purpose of this study is to compare the single-dose oral bioavailability of Ondansetron 8 mg orally disintegrating tablets of Ohm Laboratories (A subsidiary of Ranbaxy Pharmaceuticals, USA) with Zofran ODT® 8 mg orally…
- Trial name
- NCT01523119
- Testing
- Ondansetron
- Where
- India
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Postoperative Nausea and Vomiting
Safety and Efficacy of Palonosetron IV to Prevent Postoperative Nausea and Vomiting in Pediatric Patients
The primary objective of this study is to evaluate the efficacy of a single palonosetron IV dose compared to a single ondansetron IV dose in the prevention of postoperative nausea and vomiting through 24 hours after surgery in…
- Trial name
- NCT01395901
- Testing
- Palonosetron, Ondansetron
- Where
- 44 sites in United States, Argentina and 6 more
- Volunteers
- 670 people
- Sponsor
- Helsinn Healthcare SA
Chemotherapy Induced Nausea and Vomiting
Dronabinol Versus Standard Ondansetron Antiemetic Therapy in Preventing Delayed-Onset Chemotherapy-Induced Nausea and Vomiting
The primary purpose of the study is to determine the efficacy of oral dronabinol versus standard ondansetron antiemetic therapy in preventing delayed-onset chemotherapy-induced nausea and vomiting (CINV) or retching by measuring…
- Trial name
- NCT00642512
- Testing
- dronabinol, ondansetron, dronabinol/ondansetron
- Where
- 43 sites in United States
- Volunteers
- 64 people
- Sponsor
- Solvay Pharmaceuticals
Nausea, Vomiting
Aprepitant for the Prevention of Chemotherapy Induced Nausea and Vomiting (CINV) Associated With Highly Emetogenic Chemotherapy (0869-801)(COMPLETED)
A multicenter trial to assess the safety and efficacy of an investigational drug in the prevention of chemotherapy-induced nausea and vomiting (CINV) in patients with confirmed solid tumors who will be treated with a chemotherapy…
- Trial name
- NCT00090207
- Testing
- MK0869, aprepitant / Duration of Treatment: 3 days, Comparator: ondansetron / Duration of Treatment: 4 days
- Volunteers
- 477 people
- Sponsor
- Merck Sharp & Dohme LLC
Nausea and Vomiting in Pregnancy
Effect of Moringa Oleifera, Zingiber Officinale, and Curcuma Xanthorrhiza Extracts for Nausea and Vomiting in First-Trimester Pregnancy
This retrospective cohort study will evaluate the association between adjunctive Moringa oleifera, Zingiber officinale, and Curcuma xanthorrhiza extracts and changes in Pregnancy-Unique Quantification of Emesis and Nausea (PUQE)…
- Trial name
- NCT07833371
- Where
- Indonesia
- Volunteers
- 65 people
- Sponsor
- Maranatha Christian University
Chronic Myeloproliferative Disorders, Leukemia
Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment
RATIONALE: Antiemetic drugs, such as ondansetron, may help to reduce or prevent nausea and vomiting in patients with advanced cancer.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00006348
- Testing
- ondansetron
- Where
- 12 sites in United States
- Volunteers
- 100 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Anesthesia; Adverse Effect, Spinal and Epidural
Prophylaxis Ephedrine or Ondansetron Prevents Hypotension After Spinal Anesthesia for Cesarean Section
Maternal hypotension after spinal anesthesia in parturients undergoing cesarean section is a very common problem leading to several complications to both patients and their babies.
- Trial name
- NCT02194192
- Testing
- Ondansetron, Ephedrine
- Where
- Thailand
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Mahidol University