Clinical trials: Oocyte
Infertility
Co-incubation of Oocytes With Sperm: Defining the Optimal Incubation Time
The current pilot study aims to evaluate the fertilization rates between sibling oocytes subjected to short incubation (2h) versus overnight incubation (16-20h).
- Trial name
- NCT04627545
- Testing
- 2h exposure to sperm for IVF, overnight exposure to sperm for IVF
- Where
- United Arab Emirates
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility
Diafert® for Embryo Selection and Fertility Improvement
Prospective, single-center, single-blind, randomized, controlled, two-arm, interventional study.
- Trial name
- DESTINy (NCT02593461)
- Testing
- Daifert, Control Group
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Forest Laboratories
Infertility
Low Dose Human Chorionic Gonadotropin: Influence on the Endometrium
The purpose of the present study is to assess the influence of the administration of low dose hCG on the endometrium. The study is a randomised trial where 2 groups of patients, undergoing a gonadotropin-releasing hormone…
- Trial name
- NCT00976651
- Testing
- human menopausal gonadotropin
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility, Female, Intracytoplasmic Sperm Injections
Piezo-ICSI to Improve the Developmental Potential of Fertilized Oocytes in Aged Infertility Women With Assisted Reproductive Technology
The goal of this clinical trial is to test Piezo-ICSI on improving oocyte fertilization and embryo development in elderly infertile patients undergoing intracytoplasmic sperm injection (ICSI).
- Trial name
- NCT06459778
- Testing
- Piezo-ICSI
- Where
- China
- Volunteers
- 147 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Ovulation, Ovulation Inhibition
Can Ibuprofen Delay Ovulation in Natural Cycle-IVF?
During natural cycle in vitro fertilisation, no gonadotropin stimulation is used to stimulate oocyte production. Ovulation is induced with HCG (human chorionic gonadotropin) and the follicle is retrieved 36 hours later.
- Conditions
- Ovulation, Ovulation Inhibition, Ovulation Inhibition/Drug Effects, Pregnancy
- Trial name
- Ibudelay (NCT02571543)
- Testing
- Ibuprofen
- Where
- Switzerland
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Primary Ovarian Insufficiency, Infertility
Parental Project and Premature Ovarian Insufficiency
One of the main repercussions of POI is infertility. When the diagnosis of POI is announced, the question of fertility is addressed and the patient is often directed towards egg donation or adoption when she has a parental…
- Trial name
- ParentIOP (NCT05310617)
- Testing
- Survey
- Where
- France
- Volunteers
- 324 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infertility
The Effect of Follicular Flushing on Oocyte Retrieval Rate and Embryo Quality
Researchers will investigate the effect of flushing according to follicle size on the success of obtaining oocytes from a single follicle.
- Trial name
- NCT05584436
- Where
- Turkey (Türkiye)
- Volunteers
- 852 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Infertility
The Effect of a Higher Dose of Dehydroepiandrosterone (DHEA) Supplementation in Poor Responders
The supplementation of Dehydroepiandrosterone (DHEA) has been used in some centers for patients with previous poor ovarian reserve and response in an attempt to improve pregnancy outcomes.
- Trial name
- DHEA (NCT02357472)
- Testing
- dehydroepiandrosterone
- Where
- China
- Volunteers
- 60 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Infertility
Oocyte Donor Application Discrepancies
Retrospective observational study comparing information received on Inception Central Donor Recruitment's standardized online egg donor application compared to information reported during a Genetic Risk Assessment (GRA)…
- Trial name
- NCT06362551
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Inception Fertility Research Institute, LLC
Postoperative Pain, IVF
Oral Versus Intravenous Acetaminophen for Postoperative Pain Control
The investigators are going to study the difference in postoperative pain control after administration of oral versus intravenous formulation of acetaminophen
- Trial name
- NCT04662567
- Testing
- acetaminophen
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Northwell Health
Infertility
Randomized Controlled Trial Comparing Slow-freezing to Vitrification of Oocytes
Preservation of fertility is limited. Current methods include embryo cryopreservation and while still experimental, ovarian cryopreservation.
- Trial name
- NCT00777387
- Testing
- slow-freeze, vitrification
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Infertility
Extending the hCG OPU Interval
Our and others experience suggest that in some cases delaying oocyte pick up (OPU) for more than 39 hours after hCG injection may be of benefit.
- Trial name
- DelOPU (NCT02871154)
- Testing
- Delaying oocyte pick up beyond 39 hours post hCG
- Volunteers
- 20 people
- Sponsor
- The Baruch Padeh Medical Center, Poriya
IVF Outcomes
HELIOS Advanced: Human Oocyte Illumination to Enhance Development
Oocytes need a lot of energy to complete meiosis and fertilize successfully. As women get older, the "power plants" of the cells (called mitochondria) don't work as well.
- Trial name
- HELIOS-A (NCT07425080)
- Testing
- Photobiomodulation
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Columbia University
Controlled Ovaria Stimulation
Desogestrel (DSG) and Corifolitropin (FSH-CTP) Alfa for Ovarian Stimulation in Donors
Currently, controlled ovarian stimulation (COS) in oocyte donors is performed by daily injections of gonadotropins( recombinant FSH) plus a GnRH Antagonist usually form 5th-6th stimulation day until ovulation induction with a…
- Trial name
- NCT03354494
- Testing
- Desogestrel (DSG) and Corifolitropin (FSH-CTP) Alfa
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fundacion Dexeus
Disorder of Phosphate, Calcium and Vitamin D Metabolism, Female Infertility Due to Diminished Ovarian Reserve
Vitamin D Influence on Oocyte Donation
Objective: To investigate the correlation between total and bioavailable serum 25-OH vitamin D, ovarian reserve and ovarian response to controlled stimulation in egg donors.
- Conditions
- Disorder of Phosphate, Calcium and Vitamin D Metabolism, Female Infertility Due to Diminished Ovarian Reserve, Hormonal Requirement, Reproductive Disorder
- Trial name
- NCT02341365
- Testing
- vitamin D,AMH, AFC, reproductive outcome egg recipients
- Volunteers
- 269 people
- Sponsor
- IVI Madrid
Infertility, Female, Ovarian Insufficiency
Benefit of Follicular Flushing During Oocyte Retrieval for Poor Responder Patient in an Assisted Reproductive Technology Program
The object of this study is to determine the benefit of follicular flushing with a double channel needle in a poor responder population for a maximum number of oocytes to be retrieved.
- Trial name
- NCT01329302
- Testing
- Direct aspiration needle Echo tip® Cook® single Lumen and Follicular flushing with double lumen needle Echo tip® Cook® Double Lumen Aspiration
- Where
- France
- Volunteers
- 257 people
- Sponsor
- University Hospital, Strasbourg, France
Embryo Hypoxia
Influence of Manipulation of Oocytes and Embryos in Low Oxygen Tension on Assisted Reproduction Technology Outcome
Nowadays, most assisted reproduction laboratories attempt to maintain as much as possible ex vivo culture conditions comparable to those in vivo.
- Trial name
- NCT04424784
- Testing
- 5% O2
- Where
- China
- Volunteers
- 1,160 people
- Sponsor
- The University of Hong Kong-Shenzhen Hospital
Luteinised Follicular Cyst
Effects of Letrozole During the Luteal Phase After Controlled Ovarian Stimulation in Oocyte Donors.
The objective of this trial is to determine whether the use of letrozole during the luteal phase in oocyte donors diminishes the ovarian volume, as well as to evaluate its effect on the duration of the luteal phase, taking into…
- Trial name
- LETRODON (NCT06244745)
- Testing
- Administration of letrozole
- Where
- Spain
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
Fertility Issues
The Combination of Sperm Selection by IMSI and Hyaluronic Acid Binding Assay May Improve ICSI Outcome.
In this prospective randomized sibling-oocytes blinded study, investigators examine the combination of two sperm selection methods that logically seem to complete each other, and potentially may improve ICSI outcomes.
- Trial name
- NCT06156722
- Testing
- Sperm selection by IMSI, Sperm selection by IMSI and spermslow
- Where
- Israel
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Infertility, Female
Impact of Gonadotrophin Releasing Hormone Analogues on Oocyte and Embryo Quality
The first In-Vitro Fertilization cycles were performed in natural unstimulated cycles. Today gonadotrophins are administered to induce multiple follicular development and controlled ovarian hyperstimulation.
- Trial name
- NCT03139474
- Testing
- Gonadotropin-Releasing Hormone Analogue, Gonadotropin releasing hormone antagonist
- Volunteers
- 120 people
- Sponsor
- Assiut University